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Volumn 8, Issue 1, 2011, Pages 4-11

Revisiting immune exhaustion during HIV infection

Author keywords

HIV; Immune activation; LAG 3; PD 1; SIV; T cell exhaustion; Tim 3

Indexed keywords

BIOLOGICAL MARKER; CD38 ANTIGEN; CELL SURFACE PROTEIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 2; LYMPHOCYTE ACTIVATION GENE 3; MEMBRANE PROTEIN; PROGRAMMED DEATH 1 LIGAND 1; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING MOLECULE 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 79952705605     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-010-0066-0     Document Type: Review
Times cited : (173)

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    • Jin HT, Anderson AC, Tan WG, et al. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci USA 2010;107(33):14733-8. In this study, the authors evaluate Tim-3 and PD-1 coexpression during LCMV infection in the mouse, showing PD-1+Tim-3+ CD8+ T cells had more severe T-cell exhaustion. Combined inhibition of PD-1 and Tim-3 synergistically improved CD8+ T-cell responses.
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