Macrophages accumulate in the gut mucosa of untreated HIV-infected patients

Journal of Infectious Diseases

Volumn 209, Issue 5, 2014, Pages 739-748

  Allers, Kristina ^a   Fehr, Mira ^a   Conrad, Kristina ^a   Epple, Hans Jörg ^a   Schürmann, Dirk ^a   Geelhaar Karsch, Anika ^a   Schinnerling, Katina ^a   Moos, Verena ^a   Schneider, Thomas ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

gut mucosa; HIV; HIV immune pathogenesis; mucosal immune system; mucosal macrophages; phagocytosis

Indexed keywords

GUT MUCOSA; HIV; HIV IMMUNE PATHOGENESIS; MUCOSAL IMMUNE SYSTEM; MUCOSAL MACROPHAGES; PHAGOCYTOSIS;

ADULT; AGED; CHEMOKINE CCL2; CHEMOKINE CCL5; CHEMOKINE CXCL10; CHEMOKINE CXCL9; DUODENUM; FEMALE; GASTROINTESTINAL TRACT; HIV INFECTIONS; HIV-1; HUMANS; INTEGRIN BETA CHAINS; INTERLEUKIN-1BETA; INTESTINAL MUCOSA; MACROPHAGES; MALE; MIDDLE AGED; MONOCYTES; PHAGOCYTOSIS; RECEPTORS, CCR2; YOUNG ADULT;

EID: 84894251437     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit547     Document Type: Article

References (47)

1. Bull DM, Bookman MA. Isolation and functional characterization of human intestinal mucosal lymphoid cells. J Clin Invest 1977; 59:966-74.
2. Schenk M, Mueller C. Adaptations of intestinal macrophages to an antigen-rich environment. Semin Immunol 2007; 19:84-93.
3. Smith PD, Smythies LE, Shen R, Greenwell-Wild T, Gliozzi M, Wahl SM. Intestinal macrophages and response to microbial encroachment. Mucosal Immunol 2011; 4:31-42.
4. Hirotani T, Lee PY, Kuwata H, et al. The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J Immunol 2005; 174:3650-7.
5. Smythies LE, Sellers M, Clements RH, et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest 2005; 115:66-75.
6. Smith PD, Smythies LE, Mosteller-Barnum M, et al. Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS-and IgA-mediated activities. J Immunol 2001; 167:2651-6.
7. Smythies LE, Shen R, Bimczok D, et al. Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation. J Biol Chem 2010; 285:19593-604.
8. Qualls JE, Kaplan AM, van Rooijen N, Cohen DA. Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukoc Biol 2006; 80:802-15.
9. Pull SL, Doherty JM, Mills JC, Gordon JI, Stappenbeck TS. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci USA 2005; 102:99-104.
10. Epple HJ, Schneider T, Troeger H, et al. Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIVinfected patients. Gut 2009; 58:220-7.
11. Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-71.
12. Brenchley JM, Price DA, Douek DC. HIV disease: fallout from a mucosal catastrophe? Nat Immunol 2006; 7:235-9.
13. Giorgi JV, Hultin LE, McKeating JA, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999; 179:859-70.
14. Hazenberg MD, Otto SA, van Benthem BH, et al. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 2003; 17:1881-8.
15. Derdeyn CA, Silvestri G. Viral and host factors in the pathogenesis of HIV infection. Curr Opin Immunol 2005; 17:366-73.
16. Lim SG, Condez A, Poulter LW. Mucosal macrophage subsets of the gut in HIV: decrease in antigen-presenting cell phenotype. Clin Exp Immunol 1993; 92:442-7.
17. Estes JD, Harris LD, Klatt NR, et al. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS Pathog 2010; 6:e1001052.
18. Aebischer T, Bumann D, Epple HJ, et al. Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines. Gut 2008; 57:1065-72.
19. Epple HJ, Allers K, Troger H, et al. Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect. Gastroenterology 2010; 139:1289-300.
20. Allers K, Loddenkemper C, Hofmann J, et al. Gut mucosal FOXP3+ regulatory CD4+ T cells and Nonregulatory CD4+ T cells are differentially affected by simian immunodeficiency virus infection in rhesus macaques. J Virol 2010; 84:3259-69.
21. Moos V, Schmidt C, Geelhaar A, et al. Impaired immune functions of monocytes and macrophages in Whipple's disease. Gastroenterology 2010; 138:210-20.
22. Schneider T, Zippel T, Schmidt W, et al. Increased immunoglobulin G production by short term cultured duodenal biopsy samples from HIV infected patients. Gut 1998; 42:357-61.
23. Allers K, Hutter G, Hofmann J, et al. Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 2011; 117:2791-9.
24. Mora JR, Bono MR, Manjunath N, et al. Selective imprinting of guthoming T cells by Peyer's patch dendritic cells. Nature 2003; 424:88-93.
25. Platt AM, Bain CC, Bordon Y, Sester DP, Mowat AM. An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation. J Immunol 2010; 184:6843-54.
26. Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 2003; 19:71-82.
27. Benoit M, Desnues B, Mege JL. Macrophage polarization in bacterial infections. J Immunol 2008; 181:3733-9.
28. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004; 25:677-86.
29. Gong D, ShiW, Yi SJ, Chen H, Groffen J, Heisterkamp N. TGFbeta signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol 2012; 13:31.
30. Hearps AC, Maisa A, Cheng WJ, et al. HIV infection induces agerelated changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy. AIDS 2012; 26:843-53.
31. Law SK, Micklem KJ, Shaw JM, et al. A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur J Immunol 1993; 23:2320-5.
32. Radzun HJ, Kreipe H, Bodewadt S, Hansmann ML, Barth J, Parwaresch MR. Ki-M8 monoclonal antibody reactive with an intracytoplasmic antigen of monocyte/macrophage lineage. Blood 1987; 69:1320-7.
33. Fabriek BO, Dijkstra CD, van den Berg TK. The macrophage scavenger receptor CD163. Immunobiology 2005; 210:153-60.
34. Backe E, Schwarting R, Gerdes J, Ernst M, Stein H. Ber-MAC3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen. J Clin Pathol 1991; 44:936-45.
35. Van den Heuvel MM, Tensen CP, van As JH, et al. Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation. J Leukoc Biol 1999; 66:858-66.
36. Fuentes-Duculan J, Suarez-Farinas M, Zaba LC, et al. A subpopulation of CD163-positive macrophages is classically activated in psoriasis. J Invest Dermatol 2010; 130:2412-22.
37. Fabriek BO, van Bruggen R, Deng DM, et al. The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria. Blood 2009; 113:887-92.
38. Kunisch E, Fuhrmann R, Roth A, Winter R, Lungershausen W, Kinne RW. Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry. Ann Rheum Dis 2004; 63:774-84.
39. Reeves RK, Evans TI, Gillis J, Johnson RP. Simian immunodeficiency virus infection induces expansion of alpha4beta7+ and cytotoxic CD56 + NK cells. J Virol 2010; 84:8959-63.
40. Reeves RK, Evans TI, Gillis J, et al. SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa. J Infect Dis 2012; 206:1462-8.
41. Grimm MC, Elsbury SK, Pavli P, Doe WF. Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa. J Leukoc Biol 1996; 59:804-12.
42. Peters W, Cyster JG, Mack M, et al. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol 2004; 172:7647-53.
43. Kurihara T,Warr G, Loy J, Bravo R. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med 1997; 186:1757-62.
44. Robben PM, LaRegina M, KuzielWA, Sibley LD. Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis. J Exp Med 2005; 201:1761-9.
45. Traynor TR, Kuziel WA, Toews GB, Huffnagle GB. CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection. J Immunol 2000; 164:2021-7.
46. Conrad SM, Strauss-Ayali D, Field AE, Mack M, Mosser DM. Leishmaniaderived murine monocyte chemoattractant protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophages. Infect Immun 2007; 75:653-65.
47. Hofer U, Schlaepfer E, Baenziger S, et al. Inadequate clearance of translocated bacterial products in HIV-infected humanized mice. PLoS Pathog 2010; 6:e1000867.