The retrograde response: A conserved compensatory reaction to damage from within and from without

Progress in Molecular Biology and Translational Science

Volumn 127, Issue , 2014, Pages 133-154

  Jazwinski, S Michal ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

C. elegans; Ceramide signaling; Compensation; Interorganelle communication; Mitochondrial quality control; Retrograde response; Yeast

Indexed keywords

ARTICLE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL COMMUNICATION; CELL CYCLE CHECKPOINT; CELL FUNCTION; DROSOPHILA MELANOGASTER; GENE EXPRESSION; HYPEROSMOTIC STRESS; INTRACELLULAR SIGNALING; LIFE EXTENSION; LIFESPAN; LONGEVITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUALITY CONTROL; RETROGRADE RESPONSE; SACCHAROMYCES CEREVISIAE; TRANSACTIVATION; TRANSCRIPTION INITIATION; UNFOLDED PROTEIN RESPONSE; YEAST CELL; ANIMAL; CYTOLOGY; HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EID: 84906668555     PISSN: 18771173     EISSN: 18780814     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394625-6.00005-2     Document Type: Chapter

References (129)

1. R.A. Butow, and N.G. Avadhani Mitochondrial signaling: the retrograde response Mol Cell 14 2004 1 15 (Pubitemid 38469905)
2. S.M. Jazwinski Molecular mechanisms of yeast longevity Trends Microbiol 7 1999 247 252 (Pubitemid 29317306)
3. D.E. Shore, and G. Ruvkun A cytoprotective perspective on longevity regulation Trends Cell Biol 23 2013 409 420
4. V.S. Parikh, M.M. Morgan, R. Scott, L.S. Clements, and R.A. Butow The mitochondrial genotype can influence nuclear gene expression in yeast Science 235 1987 576 580 (Pubitemid 17009656)
5. Z. Liu, and R.A. Butow Mitochondrial retrograde signaling Annu Rev Genet 40 2006 159 185 (Pubitemid 44956783)
6. B.A. Rothermel, A.W. Shyjan, J.L. Etheredge, and R.A. Butow Transactivation by Rtg1p, a basic helix-loop-helix protein that functions in communication between mitochondria and the nucleus in yeast J Biol Chem 270 1995 29476 29482
7. B.A. Rothermel, J.L. Thornton, and R.A. Butow Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains J Biol Chem 272 1997 19801 19807 (Pubitemid 27340073)
8. T. Sekito, J. Thornton, and R.A. Butow Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p Mol Biol Cell 11 2000 2103 2115 (Pubitemid 30408067)
9. X. Liao, and R.A. Butow RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus Cell 72 1993 61 71 (Pubitemid 23029693)
10. Y. Jia, B. Rothermel, J. Thornton, and R.A. Butow A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus Mol Cell Biol 17 1997 1110 1117 (Pubitemid 27097340)
11. R. Jothi, S. Balaji, and A. Wuster et al. Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture Mol Syst Biol 5 2009 294
12. V. Srinivasan, A. Kriete, A. Sacan, and S.M. Jazwinski Comparing the yeast retrograde response and NF-kappa B stress responses: implications for aging Aging Cell 9 2010 933 941
13. E.V. Koonin Yeast protein controlling inter-organelle communication is related to bacterial phosphatases containing the Hsp 70-type ATP-binding domain Trends Biochem Sci 19 1994 156 157 (Pubitemid 24115428)
14. T. Sekito, Z. Liu, J. Thornton, and R.A. Butow RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3] Mol Biol Cell 13 2002 795 804 (Pubitemid 34250347)
15. I. Dilova, C.Y. Chen, and T. Powers Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae Curr Biol 12 2002 389 395 (Pubitemid 34209286)
16. I. Dilova, S. Aronova, J.C. Chen, and T. Powers Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes J Biol Chem 279 2004 46527 46535 (Pubitemid 39518296)
17. Z. Liu, T. Sekito, M. Spirek, J. Thornton, and R.A. Butow Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p Mol Cell 12 2003 401 411 (Pubitemid 37238927)
18. Z. Liu, M. Spirek, J. Thornton, and R.A. Butow A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1 Mol Biol Cell 16 2005 4893 4904 (Pubitemid 41416468)
19. A. Komeili, K.P. Wedaman, E.K. O'Shea, and T. Powers Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors J Cell Biol 151 2000 863 878
20. S. Giannattasio, Z. Liu, J. Thornton, and R.A. Butow Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression J Biol Chem 280 2005 42528 42535 (Pubitemid 43049209)
21. A. Breitkreutz, H. Choi, and J.R. Sharom et al. A global protein kinase and phosphatase interaction network in yeast Science 328 2010 1043 1046
22. H. Forsberg, and P.O. Ljungdahl Sensors of extracellular nutrients in Saccharomyces cerevisiae Curr Genet 40 2001 91 109 (Pubitemid 32962894)
23. K.J. Roberg, S. Bickel, N. Rowley, and C.A. Kaiser Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8 Genetics 147 1997 1569 1584 (Pubitemid 27525454)
24. A. Matsuura, and Y. Anraku Characterization of the MKS1 gene, a new negative regulator of the Ras-cyclic AMP pathway in Saccharomyces cerevisiae Mol Gen Genet 238 1993 6 16 (Pubitemid 23130627)
25. P.A. Kirchman, S. Kim, C.Y. Lai, and S.M. Jazwinski Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae Genetics 152 1999 179 190 (Pubitemid 29222525)
26. J. Sun, S.P. Kale, A.M. Childress, C. Pinswasdi, and S.M. Jazwinski Divergent roles of RAS1 and RAS2 in yeast longevity J Biol Chem 269 1994 18638 18645 (Pubitemid 24224105)
27. S. Kawai, J. Urban, M. Piccolis, N. Panchaud, C. De Virgilio, and R. Loewith Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae Eukaryot Cell 10 2011 1367 1369
28. J. Urban, A. Soulard, and A. Huber et al. Sch9 is a major target of TORC1 in Saccharomyces cerevisiae Mol Cell 26 2007 663 674 (Pubitemid 46856238)
29. P. Fabrizio, F. Pozza, S.D. Pletcher, C.M. Gendron, and V.D. Longo Regulation of longevity and stress resistance by Sch9 in yeast Science 292 2001 288 290 (Pubitemid 32295387)
30. A. Zhang, Y. Shen, W. Gao, and J. Dong Role of Sch9 in regulating Ras-cAMP signal pathway in Saccharomyces cerevisiae FEBS Lett 585 2011 3026 3032
31. M.M. Pastor, M. Proft, and A. Pascual-Ahuir Mitochondrial function is an inducible determinant of osmotic stress adaptation in yeast J Biol Chem 284 2009 30307 30317
32. C. Ruiz-Roig, N. Noriega, A. Duch, F. Posas, and E. de Nadal The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms Mol Biol Cell 23 2012 4286 4296
33. M.V. Miceli, J.C. Jiang, A. Tiwari, J.F. Rodriguez-Quinones, and S.M. Jazwinski Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan Front Genet 2 2011 102
34. D.K. Woo, T.L. Phang, J.D. Trawick, and R.O. Poyton Multiple pathways of mitochondrial-nuclear communication in yeast: intergenomic signaling involves ABF1 and affects a different set of genes than retrograde regulation Biochim Biophys Acta 1789 2009 135 145
35. C.Y. Lai, E. Jaruga, C. Borghouts, and S.M. Jazwinski A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae Genetics 162 2002 73 87
36. C. Borghouts, A. Benguria, J. Wawryn, and S.M. Jazwinski Rtg2 protein links metabolism and genome stability in yeast longevity Genetics 166 2004 765 777 (Pubitemid 38391741)
37. S.M. Jazwinski Metabolic control and gene dysregulation in yeast aging Ann N Y Acad Sci 908 2000 21 30 (Pubitemid 30461989)
38. S. Chen, D. Liu, R.L. Finley Jr., and M.L. Greenberg Loss of mitochondrial DNA in the yeast cardiolipin synthase crd1 mutant leads to up-regulation of the protein kinase Swe1p that regulates the G2/M transition J Biol Chem 285 2010 10397 10407
39. S. Vaena de Avalos, X. Su, M. Zhang, Y. Okamoto, W. Dowhan, and Y.A. Hannun The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae J Biol Chem 280 2005 7170 7177 (Pubitemid 40341274)
40. S. Vaena de Avalos, Y. Okamoto, and Y.A. Hannun Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae J Biol Chem 279 2004 11537 11545 (Pubitemid 38401654)
41. H. Kitagaki, L.A. Cowart, and N. Matmati et al. ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae J Biol Chem 284 2009 10818 10830
42. J. Zhou, Q. Zhong, G. Li, and M.L. Greenberg Loss of cardiolipin leads to longevity defects that are alleviated by alterations in stress response signaling J Biol Chem 284 2009 18106 18114
43. S. Chen, M. Tarsio, P.M. Kane, and M.L. Greenberg Cardiolipin mediates cross-talk between mitochondria and the vacuole Mol Biol Cell 19 2008 5047 5058
44. A.L. Hughes, and D.E. Gottschling An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast Nature 492 2012 261 265
45. G. Garipler, and C.D. Dunn Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae Genetics 194 2013 285 290
46. S. Gebre, R. Connor, and Y. Xia et al. Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion Cell Cycle 11 2012 2176 2188
47. A.D. Barbosa, H. Osorio, and K.J. Sims et al. Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells Mol Microbiol 81 2011 515 527
48. J.T. Nickels, and J.R. Broach A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae Genes Dev 10 1996 382 394
49. K. Tripathi, N. Matmati, W.J. Zheng, Y.A. Hannun, and B.K. Mohanty Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae Genetics 189 2011 533 547
50. G. Garipler, N. Mutlu, N.A. Lack, and C.D. Dunn Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae Proc Natl Acad Sci USA 111 2014 1473 1478
51. V. Teixeira, T.C. Medeiros, R. Vilaca, P. Moradas-Ferreira, and V. Costa Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells Microbial Cell 1 2014 21 36
52. C.B. Epstein, J.A. Waddle, and W.t. Hale et al. Genome-wide responses to mitochondrial dysfunction Mol Biol Cell 12 2001 297 308 (Pubitemid 33051576)
53. A. Traven, J.M. Wong, D. Xu, M. Sopta, and C.J. Ingles Interorganellar communication. Altered nuclear gene expression profiles in a yeast mitochondrial DNA mutant J Biol Chem 276 2001 4020 4027
54. W.C. Small, R.D. Brodeur, and A. Sandor et al. Enzymatic and metabolic studies on retrograde regulation mutants of yeast Biochemistry 34 1995 5569 5576
55. T.C. Hallstrom, and W.S. Moye-Rowley Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae J Biol Chem 275 2000 37347 37356 (Pubitemid 32004837)
56. E. Balzi, M. Wang, S. Leterme, L. Van Dyck, and A. Goffeau PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1 J Biol Chem 269 1994 2206 2214 (Pubitemid 24035434)
57. J.C. Jiang, P.A. Kirchman, M. Zagulski, J. Hunt, and S.M. Jazwinski Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human Genome Res 8 1998 1259 1272 (Pubitemid 29039098)
58. I. Guillas, P.A. Kirchman, and R. Chuard et al. C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p EMBO J 20 2001 2655 2665 (Pubitemid 32938550)
59. S. Schorling, B. Vallee, W.P. Barz, H. Riezman, and D. Oesterhelt Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisiae Mol Biol Cell 12 2001 3417 3427 (Pubitemid 33108475)
60. M. Kolaczkowski, A. Kolaczkowska, B. Gaigg, R. Schneiter, and W.S. Moye-Rowley Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae Eukaryot Cell 3 2004 880 892 (Pubitemid 39098864)
61. N.K. Egilmez, J.B. Chen, and S.M. Jazwinski Specific alterations in transcript prevalence during the yeast life span J Biol Chem 264 1989 14312 14317 (Pubitemid 19214260)
62. N.P. D'Mello, A.M. Childress, D.S. Franklin, S.P. Kale, C. Pinswasdi, and S.M. Jazwinski Cloning and characterization of LAG1, a longevity-assurance gene in yeast J Biol Chem 269 1994 15451 15459 (Pubitemid 24202126)
63. R.C. Dickson Roles for sphingolipids in Saccharomyces cerevisiae Adv Exp Med Biol 688 2010 217 231
64. J. Liu, X. Huang, B.R. Withers, E. Blalock, K. Liu, and R.C. Dickson Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan Aging Cell 12 2013 833 841
65. K. Kaibuchi, A. Miyajima, K. Arai, and K. Matsumoto Possible involvement of RAS-encoded proteins in glucose-induced inositolphospholipid turnover in Saccharomyces cerevisiae Proc Natl Acad Sci USA 83 1986 8172 8176 (Pubitemid 17182463)
66. S. Shama, C.Y. Lai, J.M. Antoniazzi, J.C. Jiang, and S.M. Jazwinski Heat stress-induced life span extension in yeast Exp Cell Res 245 1998 379 388 (Pubitemid 28565780)
67. H. Conrad-Webb, and R.A. Butow A polymerase switch in the synthesis of rRNA in Saccharomyces cerevisiae Mol Cell Biol 15 1995 2420 2428
68. D.A. Sinclair, and L. Guarente Extrachromosomal rDNA circles - a cause of aging in yeast Cell 91 1997 1033 1042 (Pubitemid 28027835)
69. M.G. Pray-Grant, D. Schieltz, and S.J. McMahon et al. The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway Mol Cell Biol 22 2002 8774 8786 (Pubitemid 35397190)
70. S. Kim, K. Ohkuni, E. Couplan, and S.M. Jazwinski The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity Biogerontology 5 2004 305 316 (Pubitemid 41449158)
71. K.L. Huisinga, and B.F. Pugh A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae Mol Cell 13 2004 573 585 (Pubitemid 38299384)
72. S. Kim, A. Benguria, C.Y. Lai, and S.M. Jazwinski Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae Mol Biol Cell 10 1999 3125 3136 (Pubitemid 29489550)
73. G. Heeren, M. Rinnerthaler, and P. Laun et al. The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1 Aging 1 2009 622 636
74. A. Caballero, A. Ugidos, and B. Liu et al. Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing Mol Cell 42 2011 390 400
75. M.A. Holbrook, and J.R. Menninger Erythromycin slows aging of Saccharomyces cerevisiae J Gerontol A Biol Sci Med Sci 57 2002 B29 B36
76. I. Kim, S. Rodriguez-Enriquez, and J.J. Lemasters Selective degradation of mitochondria by mitophagy Arch Biochem Biophys 462 2007 245 253 (Pubitemid 46876640)
77. I. Kissova, B. Salin, J. Schaeffer, S. Bhatia, S. Manon, and N. Camougrand Selective and non-selective autophagic degradation of mitochondria in yeast Autophagy 3 2007 329 336 (Pubitemid 46986337)
78. I. Kissova, M. Deffieu, S. Manon, and N. Camougrand Uth1p is involved in the autophagic degradation of mitochondria J Biol Chem 279 2004 39068 39074 (Pubitemid 39296069)
79. B.K. Kennedy, N.R. Austriaco Jr., J. Zhang, and L. Guarente Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae Cell 80 1995 485 496
80. D. Journo, A. Mor, and H. Abeliovich Aup1-mediated regulation of Rtg3 during mitophagy J Biol Chem 284 2009 35885 35895
81. M.H. Barros, B. Bandy, E.B. Tahara, and A.J. Kowaltowski Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae J Biol Chem 279 2004 49883 49888 (Pubitemid 39577795)
82. Y. Kamada, K. Yoshino, and C. Kondo et al. Tor directly controls the Atg1 kinase complex to regulate autophagy Mol Cell Biol 30 2010 1049 1058
83. K. Thevissen, W.L. Yen, and D. Carmona-Gutierrez et al. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae FEMS Microbiol Lett 303 2010 163 168
84. G. Lavieu, F. Scarlatti, and G. Sala et al. Sphingolipids in macroautophagy Methods Mol Biol 445 2008 159 173
85. S. Aronova, K. Wedaman, and P.A. Aronov et al. Regulation of ceramide biosynthesis by TOR complex 2 Cell Metab 7 2008 148 158 (Pubitemid 351168557)
86. B. Kornmann, and P. Walter ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology J Cell Sci 123 2010 1389 1393
87. B. Kornmann, C. Osman, and P. Walter The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections Proc Natl Acad Sci USA 108 2011 14151 14156
88. O.M. de Brito, and L. Scorrano Mitofusin 2 tethers endoplasmic reticulum to mitochondria Nature 456 2008 605 610
89. G. Biswas, W. Tang, N. Sondheimer, M. Guha, S. Bansal, and N.G. Avadhani A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling J Biol Chem 283 2008 12586 12594
90. 12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk EMBO J 18 1999 522 533 (Pubitemid 29057237)
91. X. Wang, D. Winter, and G. Ashrafi et al. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility Cell 147 2011 893 906
92. D. Narendra, A. Tanaka, D.F. Suen, and R.J. Youle Parkin-induced mitophagy in the pathogenesis of Parkinson disease Autophagy 5 2009 706 708
93. K.H. Berger, and M.P. Yaffe Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae Mol Cell Biol 18 1998 4043 4052 (Pubitemid 28287928)
94. L.G. Nijtmans, L. de Jong, and M. Artal Sanz et al. Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins EMBO J 19 2000 2444 2451 (Pubitemid 30323534)
95. P.A. Kirchman, M.V. Miceli, R.L. West, J.C. Jiang, S. Kim, and S.M. Jazwinski Prohibitins and Ras2 protein cooperate in the maintenance of mitochondrial function during yeast aging Acta Biochim Pol 50 2003 1039 1056 (Pubitemid 38608834)
96. X. Wang, X. Zuo, B. Kucejova, and X.J. Chen Reduced cytosolic protein synthesis suppresses mitochondrial degeneration Nat Cell Biol 10 2008 1090 1097
97. J. Schleit, S.C. Johnson, and C.F. Bennett et al. Molecular mechanisms underlying genotype-dependent responses to dietary restriction Aging Cell 12 2013 1050 1061
98. A. Dillin, A.L. Hsu, and N. Arantes-Oliveira et al. Rates of behavior and aging specified by mitochondrial function during development Science 298 2002 2398 2401 (Pubitemid 36014215)
99. S.S. Lee, R.Y. Lee, A.G. Fraser, R.S. Kamath, J. Ahringer, and G. Ruvkun A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity Nat Genet 33 2003 40 48 (Pubitemid 36068680)
100. D. Cristina, M. Cary, A. Lunceford, C. Clarke, and C. Kenyon A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans PLoS Genet 5 2009 e1000450
101. S.J. Lee, A.B. Hwang, and C. Kenyon Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity Curr Biol 20 2010 2131 2136
102. A.P. Gomes, N.L. Price, and A.J. Ling et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging Cell 155 2013 1624 1638
103. V. Menuz, K.S. Howell, and S. Gentina et al. Protection of C. elegans from anoxia by HYL-2 ceramide synthase Science 324 2009 381 384
104. R. Mehta, K.A. Steinkraus, and G.L. Sutphin et al. Proteasomal regulation of the hypoxic response modulates aging in C. elegans Science 324 2009 1196 1198
105. P. Tedesco, J. Jiang, J.Q. Wang, S.M. Jazwinski, and T.E. Johnson Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1 Age 30 2008 43 52
106. J. Durieux, S. Wolff, and A. Dillin The cell-non-autonomous nature of electron transport chain-mediated longevity Cell 144 2011 79 91
107. L. Walter, A. Baruah, H.W. Chang, H.M. Pace, and S.S. Lee The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans PLoS Biol 9 2011 e1001084
108. W. Yang, and S. Hekimi Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans Aging Cell 9 2010 433 447
109. J.L. Liu, D. Desjardins, R. Branicky, L.B. Agellon, and S. Hekimi Mitochondrial oxidative stress alters a pathway in Caenorhabditis elegans strongly resembling that of bile acid biosynthesis and secretion in vertebrates PLoS Genet 8 2012 e1002553
110. Q. Zhao, J. Wang, I.V. Levichkin, S. Stasinopoulos, M.T. Ryan, and N.J. Hoogenraad A mitochondrial specific stress response in mammalian cells EMBO J 21 2002 4411 4419 (Pubitemid 34984328)
111. C.E. Senkal, S. Ponnusamy, J. Bielawski, Y.A. Hannun, and B. Ogretmen Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways FASEB J 24 2010 296 308
112. J.M. Heo, N. Livnat-Levanon, and E.B. Taylor et al. A stress-responsive system for mitochondrial protein degradation Mol Cell 40 2010 465 480
113. C.J. Mousley, K. Tyeryar, and K.E. Ile et al. Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast Mol Biol Cell 19 2008 4785 4803
114. J.M. Copeland, J. Cho, and T. Lo Jr. et al. Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain Curr Biol 19 2009 1591 1598
115. J. Liu, Q. Wu, and D. He et al. Drosophila sbo regulates lifespan through its function in the synthesis of coenzyme Q in vivo J Genet Genomics 38 2011 225 234
116. J. Lapointe, and S. Hekimi Early mitochondrial dysfunction in long-lived Mclk1 +/- mice J Biol Chem 283 2008 26217 26227
117. C. Dell'agnello, S. Leo, and A. Agostino et al. Increased longevity and refractoriness to Ca(2 +)-dependent neurodegeneration in Surf1 knockout mice Hum Mol Genet 16 2007 431 444 (Pubitemid 46323179)
118. C.C. Caldeira da Silva, F.M. Cerqueira, L.F. Barbosa, M.H. Medeiros, and A.J. Kowaltowski Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity Aging Cell 7 2008 552 560 (Pubitemid 351998615)
119. A. Heddi, P. Lestienne, D.C. Wallace, and G. Stepien Mitochondrial DNA expression in mitochondrial myopathies and coordinated expression of nuclear genes involved in ATP production J Biol Chem 268 1993 12156 12163 (Pubitemid 23168184)
120. M.V. Miceli, and S.M. Jazwinski Common and cell type-specific responses of human cells to mitochondrial dysfunction Exp Cell Res 302 2005 270 280 (Pubitemid 39550468)
121. J.J. Collier, T.T. Doan, M.C. Daniels, J.R. Schurr, J.K. Kolls, and D.K. Scott c-Myc is required for the glucose-mediated induction of metabolic enzyme genes J Biol Chem 278 2003 6588 6595 (Pubitemid 36800922)
122. L. Hayflick, and P.S. Moorhead The serial cultivation of human diploid cell strains Exp Cell Res 25 1961 585 621
123. J.F. Passos, G. Saretzki, and S. Ahmed et al. Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence PLoS Biol 5 2007 e110
124. S.M. Jazwinski, and A. Kriete The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction Front Physiol 3 2012 139
125. M.P. Duyao, D.J. Kessler, D.B. Spicer, and G.E. Sonenshein Binding of NF-KB-like factors to regulatory sequences of the c-myc gene Curr Top Microbiol Immunol 166 1990 211 220
126. I. Semsei, S.Y. Ma, and R.G. Cutler Tissue and age specific expression of the myc proto-oncogene family throughout the life span of the C57BL/6J mouse strain Oncogene 4 1989 465 471
127. S. Campaner, M. Doni, and P. Hydbring et al. Cdk2 suppresses cellular senescence induced by the c-myc oncogene Nat Cell Biol 12 2010 54 59, pp. 1-14
128. S.M. Jazwinski Longevity, genes, and aging Science 273 1996 54 59 (Pubitemid 26255419)
129. S. Shama, P.A. Kirchman, J.C. Jiang, and S.M. Jazwinski Role of RAS2 in recovery from chronic stress: effect on yeast life span Exp Cell Res 245 1998 368 378 (Pubitemid 28565779)