Protection of C. elegans from Anoxia by HYL-2 ceramide synthase

Science

Volumn 324, Issue 5925, 2009, Pages 381-384

  Menuz, Vincent ^a   Howell, Kate S ^a,b   Gentina, Sébastien ^a   Epstein, Sharon ^a   Riezman, Isabelle ^a   Fornallaz Mulhauser, Monique ^a   Hengartner, Michael O ^c   Gomez, Marie ^a   Riezman, Howard ^a   Martinou, Jean Claude ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE;

ANOXIA; ENZYME ACTIVITY; MUTATION; NEMATODE; SURVIVAL;

ANOXIA; ARTICLE; BIOGENESIS; CAENORHABDITIS ELEGANS; CERAMIDE SYNTHASE HYL 2 GENE; CONTROLLED STUDY; GENE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL HYPOXIA; CERAMIDES; GENE DELETION; GENES, HELMINTH; MUTATION; OXIDOREDUCTASES; OXYGEN; RECEPTOR, INSULIN; SACCHAROMYCES CEREVISIAE; SPHINGOMYELINS; SUBSTRATE SPECIFICITY; TRANSFORMATION, GENETIC; TRANSGENES;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 65249102170     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1168532     Document Type: Article

References (24)

1. B. A. Scott, M. S. Avidan, C. M. Crowder, Science 296, 2388 (2002); published online 13 June 2002 (10.1126/science.1072302).
2. P. A. Padilla, T. G. Nystul, R. A. Zager, A. C. Johnson, M. B. Roth, Mol. Biol. Cell 13, 1473 (2002).
3. T. G. Nystul, J. P. Goldmark, P. A. Padilla, M. B. Roth, Science 302, 1038 (2003).
4. C. Shen, D. Nettleton, M. Jiang, S. K. Kim, J. A. Powell-Coffman, J. Biol. Chem. 280, 20580 (2005).
5. A. R. Mendenhall, B. LaRue, P. A. Padilla, Genetics 174, 1173 (2006).
6. D. Hoogewijs et al., BMC Genom. 8, 356 (2007).
7. N. Dasgupta, A. M. Patel, B. A. Scott, C. M. Crowder, Curr. Biol. 17, 1954 (2007).
8. V. A. Hajeri, A. M. Stewart, L. L. Moore, P. A. Padilla, Cell Div. 3, 6 (2008).
9. H. Jiang, R. Guo, J. A. Powell-Coffman, Proc. Natl. Acad. Sci. U.S.A. 98, 7916 (2001).
10. Materials and methods are available as supporting material on Science Online.
11. B. Vallee, H. Riezman, EMBO J. 24, 730 (2005).
12. Y. Pewzner-Jung, S. Ben-Dor, A. H. Futerman, J. Biol. Chem. 281, 25001 (2006).
13. N. Kageyama-Yahara, H. Riezman, Biochem. J. 398, 585 (2006).
14. D. J. Chitwood, W. R. Lusby, M. J. Thompson, J. P. Kochansky, O. W. Howarth, Lipids 30, 567 (1995).
15. J. C. Jiang, P. A. Kirchman, M. Zagulski, J. Hunt, S. M. Jazwinski, Genome Res. 8, 1259 (1998).
16. S. Spassieva et al., J. Biol. Chem. 281, 33931 (2006).
17. The lifespan of hyl-1(lf) mutants is shown in fig. S3.
18. Y. Mizutani, A. Kihara, Y. Igarashi, Biochem. J. 390, 263 (2005).
19. Y. Mizutani, A. Kihara, Y. Igarashi, Biochem. J. 398, 531 (2006).
20. C. Riebeling, J. C. Allegood, E. Wang, A. H. Merrill Jr., A. H. Futerman, J. Biol. Chem. 278, 43452 (2003).
21. X. Deng et al., Science 322, 110 (2008).
22. Y. A. Hannun, L. M. Obeid, Nat. Rev. Mol. Cell Biol. 9, 139 (2008).
23. B. Zanolari et al., EMBO J. 19, 2824 (2000).
24. We thank F. Solary for help with analysis of aging; Y. Mattenberger and D. Courvoisier from the Clinical Research Center University of Geneva and Geneva University Hospitals for statistical support; S. Herzig for artwork; S. Mitani and the Japanese National Bioresource Project for tm strains; and J. Hodgkin for providing strains CB5670, CB6166, CB5439, and CB5430. Some nematodes were provided by the Caenorhabditis Genome Center, which is funded by the NIH National Center for Research Resources. This work was funded by the Swiss National Science Foundation [subsidies 3100A0-109419/2 (J.-C.M.), 3100A0-114189 (H.R.), 3100A0-105907/1 (M.G.), and 3100A0-113889 (M.O.H.)], the Human Frontiers Science Program Organization (H.R.), the Swiss SystemsX.ch initiative (H.R.) evaluated by the Swiss National Science Foundation, the Roche Foundation (V.M.), Ernest Boninchi subsidy for the purchase of the anoxic chamber, the Canton of Zurich (M.O.H.), the Ernst Hadorm Foundation (M.O.H.), and the Geneva Department of Education.