A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCF

Molecular Biology of the Cell

Volumn 16, Issue 10, 2005, Pages 4893-4904

  Liu, Zhengchang ^a   Spírek, Mário ^a   Thornton, Janet ^a   Butow, Ronald A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

E3 UBIQUITIN LIGASE SCF GRR1; LEUCINE; PROTEIN 14 3 3; PROTEIN BMH1P; PROTEIN BMH2P; PROTEIN LST8P; PROTEIN MKS1P; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RTG1P; TRANSCRIPTION FACTOR RTG2P; TRANSCRIPTION FACTOR RTG3P; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ACIDITY; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CELL NUCLEUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; RETROGRADE SIGNALING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; UBIQUITINATION; YEAST;

AMINO ACID SEQUENCE; BINDING SITES; LEUCINE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES;

EID: 26244451589     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E05-06-0516     Document Type: Article

References (36)

1. Bernard, F., and Andre, B. (2001). Ubiquitin and the SCF(Grr1) ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in Saccharomyces cerevisiae. FEBS Lett. 496, 81-85.
2. Biswas, G., Adebanjo, O. A., Freedman, B. D., Anandatheerthavarada, H. K., Vijayasarathy, C., Zaidi, M., Kotlikoff, M., and Avadhani, N. G. (1999). Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO J. 18, 522-533.
3. Biswas, G., Anandatheerthavarada, H. K., Zaidi, M., and Avadhani, N. G. (2003). Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J. Cell Biol. 161, 507-519.
4. Butow, R. A., and Avadhani, N. G. (2004). Mitochondrial signaling: the retrograde response. Mol. Cell 14, 1-15.
5. Chaudhri, M., Scarabel, M., and Aitken, A. (2003). Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo. Biochem. Biophys. Res. Commun. 300, 679-685.
6. Chen, E. J., and Kaiser, C. A. (2003). LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J. Cell Biol. 161, 333-347.
7. Deshaies, R. J. (1999). SCF and Cullin/Ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15, 435-467.
8. Dilova, I., Chen, C.-Y., and Powers, T. (2002). Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae. Curr. Biol. 12, 389-395.
9. Epstein, C. B., Waddle, J. A., Hale, I. V., W., Dave, V., Thornton, J., Macatee, T. L., Garner, H. R., and Butow, R. A. (2001). Genome-wide responses to mitochondrial dysfunctions. Mol. Biol. Cell 12, 297-308.
10. Flick, K. M., Spielewoy, N., Kalashnikova, T. I., Guaderrama, M., Zhu, Q., Chang, H. C., and Wittenberg, C. (2003). Grr1-dependent inactivation of Mth1 mediates glucose-induced dissociation of Rgt1 from HXT gene promoters. Mol. Biol. Cell 14, 3230-3241.
11. Gelperin, D., Weigle, J., Nelson, K., Roseboom, P., Irie, K., Matsumoto, K., and Lemmon, S. (1995). 14-3-3 proteins: potential roles in vesicular transport and Ras signaling in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 92, 11539-11543.
12. Hallstrom, T. C., and Moye-Rowley, S. (2000). Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J. Biol. Chem. 275, 34347-37356.
13. Hsiung, Y. G., Chang, H. C., Pellequer, J. L., La Valle, R., Lanker, S., and Wittenberg, C. (2001). F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat. Mol. Cell. Biol. 21, 2506-2520.
14. Jia, Y., Rothermel, B., Thornton, J., and Butow, R. A. (1997). A basic helix-loop-helix zipper transcription complex functions in a signaling pathway from mitochondria to the nucleus. Mol. Cell. Biol. 17, 1110-1117.
15. Kobe, B., and Deisenhofer, J. (1995). A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature 374, 183-186.
16. Komeili, A., Wedaman, K. P., O'Shea, E. K., and Powers, T. (2000). Mechanism of metabolic control: target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J. Cell Biol. 151, 863-878.
17. Lanker, S., Valdivieso, M. H., and Wittenberg, C. (1996). Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation. Science 271, 1597-1601.
18. Lee, D. H., and Goldberg, A. L. (1996). Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae. J. Biol. Chem. 271, 27280-27284.
19. Li, F. N., and Johnston, M. (1997). Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1, coupling glucose sensing to gene expression and the cell cycle. EMBO J. 16, 5629-5638.
20. Liao, X., and Butow, R. A. (1993). RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell 72, 61-71.
21. Liu, Z., and Butow, R. A. (1999). A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function. Mol. Cell. Biol. 19, 6720-6728.
22. Liu, Z., Sekito, T., Epstein, C. B., and Butow, R. A. (2001). RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J. 20, 7209-7219.
23. Liu, Z., Sekito, T., Spirek, M., Thornton, J., and Butow, R. A. (2003). Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Mol. Cell 12, 401-411.
24. Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., and Hall, M. N. (2002). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell. Biol. 10, 457-468.
25. Luo, Y., Bond, J. D., and Ingram, V. M. (1997). Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases. Proc. Natl. Acad. Sci. USA 94, 9705-9710.
26. Patton, E. E., Willems, A. R., Sa, D., Kuras, L., Thomas, D., Craig, K. L., and Tyers, M. (1998). Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev. 12, 692-705.
27. Rose, M. D., Winston, F., and Heiter, P. (1990). Methods in Yeast Genetics: A Laboratory Course Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
28. Sekito, T., Liu, Z., Thornton, J., and Butow, R. A. (2002). RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to the formation of the yeast prion [URE3]. Mol. Biol. Cell 13, 795-804.
29. Sekito, T., Thornton, J., and Butow, R. A. (2000). Mitochondria-to- nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol. Biol. Cell 11, 2103-2115.
30. Shamji, A. F., Kuruvilla, F. G., and Schreiber, S. L. (2000). Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr. Biol. 10, 1574-1581.
31. Skowyra, D., Craig, K. L., Tyers, M., Elledge, S. J., and Harper, J. W. (1997). F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219.
32. Tate, J. J., Cox, K. H., Rai, R., and Cooper, T. G. (2002). Mks1p is required for negative regulation of retrograde gene expression in Saccharotnyces cerevisiae but does not affect nitrogen catabolite repression-sensitive gene expression. J. Biol. Chem. 277, 20477-20482.
33. Verma, R., Feldman, R. M., and Deshaies, R. J. (1997). SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Mol. Biol. Cell 8, 1427-1437.
34. Wedaman, K. P., Reinke, A., Anderson, S., Yates, J., 3rd, McCaffery, J. M., and Powers, T. (2003). Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol. Biol. Cell 14, 1204-1220.
35. Yaffe, M. B., Rittinger, K., Volinia, S., Caron, P. R., Aitken, A., Leffers, H., Gamblin, S. J., Smerdon, S. J., and Cantley, L. C. (1997). The structural basis for 14-3- 3, phosphopeptide binding specificity. Cell 91, 961-971.
36. Yang, H.-Y., Wen, Y.-Y., Chen, C.-H., Lozano, G., and Lee, M.-H. (2003). 14-3-3σ positively regulates p53 and suppresses tumor growth. Mol. Cell. Biol. 23, 7096-7107.