메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages 317-331

Development and clinical applications of siRNA-encapsulated lipid nanoparticles in cancer

Author keywords

cancer; delivery; ionizable cationic lipids; lipid nanoparticle; potent; siRNA

Indexed keywords


EID: 84905820173     PISSN: 17584299     EISSN: 17584302     Source Type: Journal    
DOI: 10.2217/clp.14.27     Document Type: Review
Times cited : (17)

References (115)
  • 2
    • 84874293805 scopus 로고    scopus 로고
    • WHO fact sheet. http://globocan.iarc.fr/Pages/fact-sheets-cancer.aspx
    • WHO Fact Sheet.
  • 4
    • 64049096916 scopus 로고    scopus 로고
    • The microeconomics of personalized medicine: Today's challenge and tomorrow's promise
    • Davis JC, Furstenthal L, Desai AA et al. The microeconomics of personalized medicine: Today's challenge and tomorrow's promise. Nat. Rev. Drug Discov. 8(4), 279-286 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , Issue.4 , pp. 279-286
    • Davis, J.C.1    Furstenthal, L.2    Desai, A.A.3
  • 5
    • 84858433310 scopus 로고    scopus 로고
    • Personal omics profiling reveals dynamic molecular and medical phenotypes
    • Chen R, Mias GI, Li-Pook-Than J et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 148(6), 1293-1307 (2012).
    • (2012) Cell 148 , vol.6 , pp. 1293-1307
    • Chen, R.1    Mias, G.I.2    Li-Pook-Than, J.3
  • 6
    • 84855929701 scopus 로고    scopus 로고
    • Systems cancer medicine: Towards realization of predictive preventive personalized and participatory P4) medicine
    • Tian Q, Price ND, Hood L. Systems cancer medicine: Towards realization of predictive, preventive, personalized and participatory (P4) medicine. J. Intern. Med. 271(2), 111-121 (2012).
    • (2012) J. Intern. Med. , vol.271 , Issue.2 , pp. 111-121
    • Tian, Q.1    Price, N.D.2    Hood, L.3
  • 7
    • 80053498304 scopus 로고    scopus 로고
    • Systems biology and the future of medicine wiley interdiscip
    • Loscalzo J, Barabasi AL. Systems biology and the future of medicine. Wiley Interdiscip. Rev. Syst. Biol. Med. 3(6), 619-627 (2011).
    • (2011) Rev. Syst. Biol. Med. , vol.3 , Issue.6 , pp. 619-627
    • Loscalzo, J.1    Barabasi, A.L.2
  • 8
    • 0142181185 scopus 로고    scopus 로고
    • RNA interference and chemically modified siRNAs
    • Manoharan M. RNA interference and chemically modified siRNAs. Nucleic Acids Res. Suppl. (3), 115-116 (2003).
    • (2003) Nucleic Acids Res. Suppl. , vol.3 , pp. 115-116
    • Manoharan, M.1
  • 9
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391(6669), 806-811 (1998).
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 10
    • 0033634682 scopus 로고    scopus 로고
    • Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference
    • Parrish S, Fleenor J, Xu S, Mello C, Fire A. Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference. Mol. Cell 6(5), 1077-1087 (2000).
    • (2000) Mol. Cell , vol.6 , Issue.5 , pp. 1077-1087
    • Parrish, S.1    Fleenor, J.2    Xu, S.3    Mello, C.4    Fire, A.5
  • 11
    • 33745614074 scopus 로고    scopus 로고
    • Position-specific chemical modification of siRNAs reduces 'off-Target' transcript silencing
    • Jackson AL, Burchard J, Leake D et al. Position-specific chemical modification of siRNAs reduces 'off-Target' transcript silencing. RNA 12(7), 1197-1205 (2006).
    • (2006) RNA , vol.12 , Issue.7 , pp. 1197-1205
    • Jackson, A.L.1    Burchard, J.2    Leake, D.3
  • 12
    • 57349134691 scopus 로고    scopus 로고
    • Chemical modification of siRNAs for in vivo use
    • Behlke MA. Chemical modification of siRNAs for in vivo use. Oligonucleotides 18(4), 305-319 (2008).
    • (2008) Oligonucleotides , vol.18 , Issue.4 , pp. 305-319
    • Behlke, M.A.1
  • 13
    • 32944454941 scopus 로고    scopus 로고
    • Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge AD, Bola G, Lee AC, Maclachlan I. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 13(3), 494-505 (2006).
    • (2006) Mol. Ther. , vol.13 , Issue.3 , pp. 494-505
    • Judge, A.D.1    Bola, G.2    Lee, A.C.3    Maclachlan, I.4
  • 14
    • 65649085603 scopus 로고    scopus 로고
    • Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice
    • Judge AD, Robbins M, Tavakoli I et al. Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J. Clin. Invest. 119(3), 661-673 (2009).
    • (2009) J. Clin. Invest. , vol.119 , Issue.3 , pp. 661-673
    • Judge, A.D.1    Robbins, M.2    Tavakoli, I.3
  • 15
    • 79960038814 scopus 로고    scopus 로고
    • Chemical modification of small interfering RNA
    • Bramsen JB, Kjems J. Chemical modification of small interfering RNA. Meth. Mol. Biol. 721, 77-103 (2011).
    • (2011) Meth. Mol. Biol. , vol.721 , pp. 77-103
    • Bramsen, J.B.1    Kjems, J.2
  • 16
    • 84865526525 scopus 로고    scopus 로고
    • Designing chemically modified oligonucleotides for targeted gene silencing
    • Deleavey GF, Damha MJ. Designing chemically modified oligonucleotides for targeted gene silencing. Chem. Biol. 19(8), 937-954 (2012).
    • (2012) Chem. Biol. , vol.19 , Issue.8 , pp. 937-954
    • Deleavey, G.F.1    Damha, M.J.2
  • 17
    • 33748069824 scopus 로고    scopus 로고
    • SiRNA and isRNA: Two edges of one sword
    • Schlee M, Hornung V, Hartmann G. siRNA and isRNA: Two edges of one sword. Mol. Ther. 14(4), 463-470 (2006).
    • (2006) Mol. Ther. , vol.14 , Issue.4 , pp. 463-470
    • Schlee, M.1    Hornung, V.2    Hartmann, G.3
  • 20
    • 54949095836 scopus 로고    scopus 로고
    • Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
    • Robbins M, Judge A, Ambegia E et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum. Gene Ther. 19(10), 991-999 (2008).
    • (2008) Hum. Gene Ther. , vol.19 , Issue.10 , pp. 991-999
    • Robbins, M.1    Judge, A.2    Ambegia, E.3
  • 21
    • 84864544432 scopus 로고    scopus 로고
    • Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles
    • Nakayama T, Butler JS, Sehgal A et al. Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles. Mol. Ther. 20(8), 1582-1589 (2012).
    • (2012) Mol. Ther. , vol.20 , Issue.8 , pp. 1582-1589
    • Nakayama, T.1    Butler, J.S.2    Sehgal, A.3
  • 22
    • 35148815670 scopus 로고    scopus 로고
    • Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
    • Wolfrum C, Shi S, Jayaprakash KN et al. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat. Biotechnol. 25(10), 1149-1157 (2007).
    • (2007) Nat. Biotechnol. , vol.25 , Issue.10 , pp. 1149-1157
    • Wolfrum, C.1    Shi, S.2    Jayaprakash, K.N.3
  • 23
    • 61349120741 scopus 로고    scopus 로고
    • Direct CNS delivery of siRNA mediates robust silencing in oligodendrocytes
    • Querbes W, Ge P, Zhang W et al. Direct CNS delivery of siRNA mediates robust silencing in oligodendrocytes. Oligonucleotides 19(1), 23-29 (2009).
    • (2009) Oligonucleotides , vol.19 , Issue.1 , pp. 23-29
    • Querbes, W.1    Ge, P.2    Zhang, W.3
  • 24
    • 77952675911 scopus 로고    scopus 로고
    • Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery
    • Chen Q, Butler D, Querbes W et al. Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery. J. Control. Release 144(2), 227-232 (2010).
    • (2010) J. Control. Release , vol.144 , Issue.2 , pp. 227-232
    • Chen, Q.1    Butler, D.2    Querbes, W.3
  • 25
    • 79952143445 scopus 로고    scopus 로고
    • Versatile site-specific conjugation of small molecules to siRNA using click chemistry
    • Yamada T, Peng CG, Matsuda S et al. Versatile site-specific conjugation of small molecules to siRNA using click chemistry. J. Org. Chem. 76(5), 1198-1211 (2011).
    • (2011) J. Org. Chem. , vol.76 , Issue.5 , pp. 1198-1211
    • Yamada, T.1    Peng, C.G.2    Matsuda, S.3
  • 26
    • 84905856815 scopus 로고    scopus 로고
    • Alnylam. www.alnylam.com/web/wp-content/uploads/2012/08/ IRTNNNConjugate080612.pdf
    • Alnylam
  • 28
    • 84903383091 scopus 로고    scopus 로고
    • Alnylam Pharmaceuticals. www.alnylam.com/web/wp-content/uploads/2013/07/ ALN-AT3-preclin-ISTH-July2013.pdf
    • Alnylam Pharmaceuticals.
  • 30
    • 84865079107 scopus 로고    scopus 로고
    • Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
    • Jayaraman M, Ansell SM, Mui BL et al. Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew Chem. Int. Ed. Engl. 51(34), 8529-8533 (2012).
    • (2012) Angew Chem. Int. Ed. Engl. , vol.51 , Issue.34 , pp. 8529-8533
    • Jayaraman, M.1    Ansell, S.M.2    Mui, B.L.3
  • 31
    • 33748331337 scopus 로고    scopus 로고
    • RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy
    • Santel A, Aleku M, Keil O et al. RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy. Gene Ther. 13(18), 1360-1370 (2006).
    • (2006) Gene Ther. , vol.13 , Issue.18 , pp. 1360-1370
    • Santel, A.1    Aleku, M.2    Keil, O.3
  • 32
    • 33746883220 scopus 로고    scopus 로고
    • A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
    • Santel A, Aleku M, Keil O et al. A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. Gene Ther. 13(16), 1222-1234 (2006).
    • (2006) Gene Ther. , vol.13 , Issue.16 , pp. 1222-1234
    • Santel, A.1    Aleku, M.2    Keil, O.3
  • 33
    • 57149086661 scopus 로고    scopus 로고
    • Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression
    • Aleku M, Schulz P, Keil O et al. Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression. Cancer Res. 68(23), 9788-9798 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.23 , pp. 9788-9798
    • Aleku, M.1    Schulz, P.2    Keil, O.3
  • 34
    • 78349299473 scopus 로고    scopus 로고
    • Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models
    • Santel A, Aleku M, Roder N et al. Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models. Clin. Cancer Res. 16(22), 5469-5480 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.22 , pp. 5469-5480
    • Santel, A.1    Aleku, M.2    Roder, N.3
  • 35
    • 84855168044 scopus 로고    scopus 로고
    • Phase i clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors
    • Strumberg D, Schultheis B, Traugott U et al. Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors. Int. J. Clin. Pharmacol. Ther. 50(1), 76-78 (2012).
    • (2012) Int. J. Clin. Pharmacol. Ther. , vol.50 , Issue.1 , pp. 76-78
    • Strumberg, D.1    Schultheis, B.2    Traugott, U.3
  • 37
    • 23044506285 scopus 로고    scopus 로고
    • Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
    • Landen CN Jr, Chavez-Reyes A, Bucana C et al. Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res. 65(15), 6910-6918 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.15 , pp. 6910-6918
    • Landen Jr., C.N.1    Chavez-Reyes, A.2    Bucana, C.3
  • 38
    • 33846978083 scopus 로고    scopus 로고
    • Intraperitoneal delivery of liposomal siRNA for therapy of advanced ovarian cancer
    • Landen CN, Merritt WM, Mangala LS et al. Intraperitoneal delivery of liposomal siRNA for therapy of advanced ovarian cancer. Cancer Biol. Ther. 5(12), 1708-1713 (2006).
    • (2006) Cancer Biol. Ther. , vol.5 , Issue.12 , pp. 1708-1713
    • Landen, C.N.1    Merritt, W.M.2    Mangala, L.S.3
  • 40
    • 77951699994 scopus 로고    scopus 로고
    • Sustained small interfering RNA delivery by mesoporous silicon particles
    • Tanaka T, Mangala LS, Vivas-Mejia PE et al. Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res. 70(9), 3687-3696 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.9 , pp. 3687-3696
    • Tanaka, T.1    Mangala, L.S.2    Vivas-Mejia, P.E.3
  • 41
    • 68049144915 scopus 로고    scopus 로고
    • Dual targeting of EphA2 and FAK in ovarian carcinoma
    • Shahzad MM, Lu C, Lee JW et al. Dual targeting of EphA2 and FAK in ovarian carcinoma. Cancer Biol. Ther. 8(11), 1027-1034 (2009).
    • (2009) Cancer Biol. Ther. , vol.8 , Issue.11 , pp. 1027-1034
    • Shahzad, M.M.1    Lu, C.2    Lee, J.W.3
  • 42
    • 69949155656 scopus 로고    scopus 로고
    • A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo
    • Hatakeyama H, Ito E, Akita H et al. A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. J. Control. Release 139(2), 127-132 (2009).
    • (2009) J. Control. Release , vol.139 , Issue.2 , pp. 127-132
    • Hatakeyama, H.1    Ito, E.2    Akita, H.3
  • 43
    • 84873433098 scopus 로고    scopus 로고
    • Melittin derived peptides for nanoparticle based siRNA transfection
    • Hou KK, Pan H, Lanza GM, Wickline SA. Melittin derived peptides for nanoparticle based siRNA transfection. Biomaterials 34(12), 3110-3119 (2013).
    • (2013) Biomaterials , vol.34 , Issue.12 , pp. 3110-3119
    • Hou, K.K.1    Pan, H.2    Lanza, G.M.3    Wickline, S.A.4
  • 44
    • 50149101511 scopus 로고    scopus 로고
    • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
    • Frank-Kamenetsky M, Grefhorst A, Anderson NN et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc. Natl Acad. Sci. USA 105(33), 11915-11920 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.33 , pp. 11915-11920
    • Frank-Kamenetsky, M.1    Grefhorst, A.2    Anderson, N.N.3
  • 45
    • 77349109732 scopus 로고    scopus 로고
    • Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery
    • Li J, Chen YC, Tseng YC, Mozumdar S, Huang L. Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery. J. Control. Release 142(3), 416-421 (2010).
    • (2010) J. Control. Release , vol.142 , Issue.3 , pp. 416-421
    • Li, J.1    Chen, Y.C.2    Tseng, Y.C.3    Mozumdar, S.4    Huang, L.5
  • 46
    • 84857911904 scopus 로고    scopus 로고
    • Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor
    • Li J, Yang Y, Huang L. Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor. J. Control. Release 158(1), 108-114 (2012).
    • (2012) J. Control. Release , vol.158 , Issue.1 , pp. 108-114
    • Li, J.1    Yang, Y.2    Huang, L.3
  • 47
    • 84857795022 scopus 로고    scopus 로고
    • Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis
    • Yang Y, Li J, Liu F, Huang L. Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis. Mol. Ther. 20(3), 609-615 (2012).
    • (2012) Mol. Ther. , vol.20 , Issue.3 , pp. 609-615
    • Yang, Y.1    Li, J.2    Liu, F.3    Huang, L.4
  • 48
    • 84861595819 scopus 로고    scopus 로고
    • Efficient and safe delivery of siRNA using anionic lipids: Formulation optimization studies
    • Kapoor M, Burgess DJ. Efficient and safe delivery of siRNA using anionic lipids: Formulation optimization studies. Int. J. Pharma. 432(1-2), 80-90 (2012).
    • (2012) Int. J. Pharma. , vol.432 , Issue.1-2 , pp. 80-90
    • Kapoor, M.1    Burgess, D.J.2
  • 49
    • 84876500255 scopus 로고    scopus 로고
    • Cellular uptake mechanisms of novel anionic siRNA lipoplexes
    • Kapoor M, Burgess DJ. Cellular uptake mechanisms of novel anionic siRNA lipoplexes. Pharm. Res. 30(4), 1161-1175 (2013).
    • (2013) Pharm. Res. , vol.30 , Issue.4 , pp. 1161-1175
    • Kapoor, M.1    Burgess, D.J.2
  • 50
    • 84655167822 scopus 로고    scopus 로고
    • Phosphorylatable short peptide conjugated low molecular weight chitosan for efficient siRNA delivery and target gene silencing
    • Kong F, Liu G, Sun B et al. Phosphorylatable short peptide conjugated low molecular weight chitosan for efficient siRNA delivery and target gene silencing. Int. J. Pharma. 422(1-2), 445-453 (2012).
    • (2012) Int. J. Pharma. , vol.422 , Issue.1-2 , pp. 445-453
    • Kong, F.1    Liu, G.2    Sun, B.3
  • 51
    • 33748636431 scopus 로고    scopus 로고
    • Linear cyclodextrin-containing polymers and their use as delivery agents
    • Heidel JD. Linear cyclodextrin-containing polymers and their use as delivery agents. Expert Opin. Drug Deliv. 3(5), 641-646 (2006).
    • (2006) Expert Opin. Drug Deliv. , vol.3 , Issue.5 , pp. 641-646
    • Heidel, J.D.1
  • 53
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: Entering the mainstream
    • Allen TM, P.R. Cullis: Drug delivery systems: Entering the mainstream. Science 303, 1818-1822 (2004).
    • (2004) Science , vol.303 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 55
    • 0023447252 scopus 로고
    • Lipofection: A highly efficient, lipid-mediated DNA-Transfection procedure
    • Felgner PL, Gadek TR, Holm M et al. Lipofection: A highly efficient, lipid-mediated DNA-Transfection procedure. Proc. Natl Acad. Sci. USA 84(21), 7413-7417 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , Issue.21 , pp. 7413-7417
    • Felgner, P.L.1    Gadek, T.R.2    Holm, M.3
  • 56
    • 0032991616 scopus 로고    scopus 로고
    • Stabilized plasmid-lipid particles: Construction and characterization
    • Wheeler JJ, Palmer L, Ossanlou M et al. Stabilized plasmid-lipid particles: Construction and characterization. Gene Ther. 6(2), 271-281 (1999).
    • (1999) Gene Ther. , vol.6 , Issue.2 , pp. 271-281
    • Wheeler, J.J.1    Palmer, L.2    Ossanlou, M.3
  • 57
    • 0035039280 scopus 로고    scopus 로고
    • Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes
    • Maurer N, Wong KF, Stark H et al. Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes. Biophys. J. 80(5), 2310-2326 (2001).
    • (2001) Biophys. J. , vol.80 , Issue.5 , pp. 2310-2326
    • Maurer, N.1    Wong, K.F.2    Stark, H.3
  • 58
    • 0030822970 scopus 로고    scopus 로고
    • Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA
    • Mok KW, Cullis PR. Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA. Biophys. J. 73(5), 2534-2545 (1997).
    • (1997) Biophys. J. , vol.73 , Issue.5 , pp. 2534-2545
    • Mok, K.W.1    Cullis, P.R.2
  • 59
    • 0033036668 scopus 로고    scopus 로고
    • Stabilized plasmid-lipid particles: Factors influencing plasmid entrapment and transfection properties
    • Mok KW, Lam AM, Cullis PR. Stabilized plasmid-lipid particles: Factors influencing plasmid entrapment and transfection properties. Biochim. Biophys. Acta 1419(2), 137-150 (1999).
    • (1999) Biochim. Biophys. Acta , vol.1419 , Issue.2 , pp. 137-150
    • Mok, K.W.1    Lam, A.M.2    Cullis, P.R.3
  • 60
    • 0034881060 scopus 로고    scopus 로고
    • Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line
    • Leonetti C, Biroccio A, Benassi B et al. Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line. Cancer Gene Ther. 8(6), 459-468 (2001).
    • (2001) Cancer Gene Ther. , vol.8 , Issue.6 , pp. 459-468
    • Leonetti, C.1    Biroccio, A.2    Benassi, B.3
  • 61
    • 0034893986 scopus 로고    scopus 로고
    • Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles
    • Mui B, Raney SG, Semple SC, Hope MJ. Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles. J. Pharmacol. Exp. Ther. 298(3), 1185-1192 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , Issue.3 , pp. 1185-1192
    • Mui, B.1    Raney, S.G.2    Semple, S.C.3    Hope, M.J.4
  • 62
    • 0035830624 scopus 로고    scopus 로고
    • Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: Formation of novel small multilamellar vesicle structures
    • Semple SC, Klimuk SK, Harasym TO et al. Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: Formation of novel small multilamellar vesicle structures. Biochim. Biophys. Acta 1510(1-2), 152-166 (2001).
    • (2001) Biochim. Biophys. Acta , vol.1510 , Issue.1-2 , pp. 152-166
    • Semple, S.C.1    Klimuk, S.K.2    Harasym, T.O.3
  • 63
    • 23444445660 scopus 로고    scopus 로고
    • Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
    • Morrissey DV, Lockridge JA, Shaw L et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotechnol. 23(8), 1002-1007 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , Issue.8 , pp. 1002-1007
    • Morrissey, D.V.1    Lockridge, J.A.2    Shaw, L.3
  • 64
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann TS, Lee AC, Akinc A et al. RNAi-mediated gene silencing in non-human primates. Nature 441(7089), 111-114 (2006).
    • (2006) Nature , vol.441 , Issue.7089 , pp. 111-114
    • Zimmermann, T.S.1    Lee, A.C.2    Akinc, A.3
  • 65
    • 84881292568 scopus 로고    scopus 로고
    • Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics
    • Maier MA, Jayaraman M, Matsuda S et al. Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Mol. Ther. 21(8), 1570-1578 (2013).
    • (2013) Mol. Ther. , vol.21 , Issue.8 , pp. 1570-1578
    • Maier, M.A.1    Jayaraman, M.2    Matsuda, S.3
  • 66
    • 76349111051 scopus 로고    scopus 로고
    • Rational design of cationic lipids for siRNA delivery
    • Semple SC, Akinc A, Chen J et al. Rational design of cationic lipids for siRNA delivery. Nat. Biotechnol. 28(2), 172-176 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , Issue.2 , pp. 172-176
    • Semple, S.C.1    Akinc, A.2    Chen, J.3
  • 67
    • 0035946613 scopus 로고    scopus 로고
    • Roles of lipid polymorphism in intracellular delivery
    • Hafez IM, Cullis PR. Roles of lipid polymorphism in intracellular delivery. Adv. Drug Rev. 47(2-3), 139-148 (2001).
    • (2001) Adv. Drug Rev. , vol.47 , Issue.2-3 , pp. 139-148
    • Hafez, I.M.1    Cullis, P.R.2
  • 68
    • 0034882516 scopus 로고    scopus 로고
    • On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
    • Hafez IM, Maurer N, Cullis PR. On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids. Gene Ther. 8(15), 1188-1196 (2001).
    • (2001) Gene Ther. , vol.8 , Issue.15 , pp. 1188-1196
    • Hafez, I.M.1    Maurer, N.2    Cullis, P.R.3
  • 69
    • 84881408604 scopus 로고    scopus 로고
    • Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery
    • Alabi CA, Love KT, Sahay G et al. Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery. Proc. Natl Acad. Sci. USA 110(32), 12881-12886 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , Issue.32 , pp. 12881-12886
    • Alabi, C.A.1    Love, K.T.2    Sahay, G.3
  • 70
    • 84880304273 scopus 로고    scopus 로고
    • Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape
    • Gilleron J, Querbes W, Zeigerer A et al. Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape. Nat. Biotechnol. 31(7), 638-646 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , Issue.7 , pp. 638-646
    • Gilleron, J.1    Querbes, W.2    Zeigerer, A.3
  • 71
    • 84883118140 scopus 로고    scopus 로고
    • Safety and efficacy of RNAi therapy for transthyretin amyloidosis
    • Coelho T, Adams D, Silva A et al. Safety and efficacy of RNAi therapy for transthyretin amyloidosis. N. Engl. J. Med. 369(9), 819-829 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , Issue.9 , pp. 819-829
    • Coelho, T.1    Adams, D.2    Silva, A.3
  • 72
    • 84877120847 scopus 로고    scopus 로고
    • First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement
    • Tabernero J, Shapiro GI, Lorusso PM et al. First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement. Cancer Discov. 3(4), 406-417 (2013).
    • (2013) Cancer Discov. , vol.3 , Issue.4 , pp. 406-417
    • Tabernero, J.1    Shapiro, G.I.2    Lorusso, P.M.3
  • 75
    • 43049176170 scopus 로고    scopus 로고
    • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
    • Akinc A, Zumbuehl A, Goldberg M et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat. Biotechnol. 26(5), 561-569 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , Issue.5 , pp. 561-569
    • Akinc, A.1    Zumbuehl, A.2    Goldberg, M.3
  • 76
    • 0038293017 scopus 로고    scopus 로고
    • Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery
    • Akinc A, Lynn DM, Anderson DG, Langer R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. J. Am. Chem. Soc. 125(18), 5316-5323 (2003).
    • (2003) J. Am. Chem. Soc. , vol.125 , Issue.18 , pp. 5316-5323
    • Akinc, A.1    Lynn, D.M.2    Anderson, D.G.3    Langer, R.4
  • 77
    • 8644275490 scopus 로고    scopus 로고
    • A polymer library approach to suicide gene therapy for cancer
    • Anderson DG, Peng W, Akinc A et al. A polymer library approach to suicide gene therapy for cancer. Proc. Natl Acad. Sci. USA 101(45), 16028-16033 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.45 , pp. 16028-16033
    • Anderson, D.G.1    Peng, W.2    Akinc, A.3
  • 78
    • 67349183756 scopus 로고    scopus 로고
    • Development of lipidoid-siRNA formulations for systemic delivery to the liver
    • Akinc A, Goldberg M, Qin J et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Mol. Ther. 17(5), 872-879 (2009).
    • (2009) Mol. Ther. , vol.17 , Issue.5 , pp. 872-879
    • Akinc, A.1    Goldberg, M.2    Qin, J.3
  • 79
    • 76649098887 scopus 로고    scopus 로고
    • Lipid-like materials for low-dose, in vivo gene silencing
    • Love KT, Mahon KP, Levins CG et al. Lipid-like materials for low-dose, in vivo gene silencing. Proc. Natl Acad. Sci. USA 107(5), 1864-1869 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.5 , pp. 1864-1869
    • Love, K.T.1    Mahon, K.P.2    Levins, C.G.3
  • 80
    • 77955816614 scopus 로고    scopus 로고
    • Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery
    • Mahon KP, Love KT, Whitehead KA et al. Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery. Bioconjug. Chem. 21(8), 1448-1454 (2010).
    • (2010) Bioconjug. Chem. , vol.21 , Issue.8 , pp. 1448-1454
    • Mahon, K.P.1    Love, K.T.2    Whitehead, K.A.3
  • 81
    • 56749131859 scopus 로고    scopus 로고
    • Assessing siRNA pharmacodynamics in a luciferase-expressing mouse
    • Svensson RU, Shey MR, Ballas ZK et al. Assessing siRNA pharmacodynamics in a luciferase-expressing mouse. Mol. Ther. 16(12), 1995-2001 (2008).
    • (2008) Mol. Ther. , vol.16 , Issue.12 , pp. 1995-2001
    • Svensson, R.U.1    Shey, M.R.2    Ballas, Z.K.3
  • 82
    • 84873413702 scopus 로고    scopus 로고
    • Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA
    • Lin PJ, Tam YY, Hafez I et al. Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA. Nanomedicine 9(2), 233-246 (2013).
    • (2013) Nanomedicine , vol.9 , Issue.2 , pp. 233-246
    • Lin, P.J.1    Tam, Y.Y.2    Hafez, I.3
  • 83
    • 84880274434 scopus 로고    scopus 로고
    • Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
    • Sahay G, Querbes W, Alabi C et al. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat. Biotechnol. 31(7), 653-658 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , Issue.7 , pp. 653-658
    • Sahay, G.1    Querbes, W.2    Alabi, C.3
  • 84
    • 84863201108 scopus 로고    scopus 로고
    • Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo
    • Lee JB, Zhang K, Tam YY et al. Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo. Int. J. Cancer 131(5), E781-790 (2012).
    • (2012) Int. J. Cancer , vol.131 , Issue.5
    • Lee, J.B.1    Zhang, K.2    Tam, Y.Y.3
  • 85
    • 82955233888 scopus 로고    scopus 로고
    • Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells
    • Basha G, Novobrantseva TI, Rosin N et al. Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol. Ther. 19(12), 2186-2200 (2011).
    • (2011) Mol. Ther. , vol.19 , Issue.12 , pp. 2186-2200
    • Basha, G.1    Novobrantseva, T.I.2    Rosin, N.3
  • 86
    • 84868338479 scopus 로고    scopus 로고
    • Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA
    • Belliveau NM, Huft J, Lin PJ et al. Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA. Mol. Ther. Nucleic Acids 1, e37 (2012).
    • (2012) Mol. Ther. Nucleic Acids , vol.1
    • Belliveau, N.M.1    Huft, J.2    Lin, P.J.3
  • 87
    • 84859796841 scopus 로고    scopus 로고
    • Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing
    • Zhigaltsev IV, Belliveau N, Hafez I et al. Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing. Langmuir 28(7), 3633-3640 (2012).
    • (2012) Langmuir , vol.28 , Issue.7 , pp. 3633-3640
    • Zhigaltsev, I.V.1    Belliveau, N.2    Hafez, I.3
  • 88
    • 84865714123 scopus 로고    scopus 로고
    • Lipid nanoparticles containing siRNA synthesized by microfluidic mixing exhibit an electron-dense nanostructured core
    • Leung AK, Hafez IM, Baoukina S et al. Lipid nanoparticles containing siRNA synthesized by microfluidic mixing exhibit an electron-dense nanostructured core. J. Phys. Chem. C Nanomater. Interfaces 116(34), 18440-18450 (2012).
    • (2012) J. Phys. Chem. C Nanomater. Interfaces , vol.116 , Issue.34 , pp. 18440-18450
    • Leung, A.K.1    Hafez, I.M.2    Baoukina, S.3
  • 89
    • 77954243341 scopus 로고    scopus 로고
    • Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
    • Akinc A, Querbes W, De S et al. Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol. Ther. 18(7), 1357-1364 (2010).
    • (2010) Mol. Ther. , vol.18 , Issue.7 , pp. 1357-1364
    • Akinc, A.1    Querbes, W.2    De, S.3
  • 90
    • 79952803061 scopus 로고    scopus 로고
    • Dicetyl phosphate-Tetraethylenepentamine-based liposomes for systemic siRNA delivery
    • Asai T, Matsushita S, Kenjo E et al. Dicetyl phosphate- Tetraethylenepentamine-based liposomes for systemic siRNA delivery. Bioconjug. Chem. 22(3), 429-435 (2011).
    • (2011) Bioconjug. Chem. , vol.22 , Issue.3 , pp. 429-435
    • Asai, T.1    Matsushita, S.2    Kenjo, E.3
  • 91
    • 0034730671 scopus 로고    scopus 로고
    • Localization of sterically stabilized liposomes in experimental rat Klebsiella pneumoniae pneumonia: Dependence on circulation kinetics and presence of poly(ethylene)glycol coating
    • Schiffelers RM, Bakker-Woudenberg IA, Storm G et al. Localization of sterically stabilized liposomes in experimental rat Klebsiella pneumoniae pneumonia: Dependence on circulation kinetics and presence of poly(ethylene)glycol coating. Biochim Biophys Acta 1468(1-2), 253-261 (2000).
    • (2000) Biochim Biophys Acta , vol.1468 , Issue.1-2 , pp. 253-261
    • Schiffelers, R.M.1    Bakker-Woudenberg, I.A.2    Storm, G.3
  • 92
    • 84891786396 scopus 로고    scopus 로고
    • Influence of polyethylene glycol lipid desorption rates on pharmacokinetics and pharmacodynamics of siRNA lipid nanoparticles
    • Mui BL, Tam YK, Jayaraman M et al. Influence of polyethylene glycol lipid desorption rates on pharmacokinetics and pharmacodynamics of siRNA lipid nanoparticles. Mol. Ther. Nucleic Acids 2, e139 (2013).
    • (2013) Mol. Ther. Nucleic Acids , vol.2
    • Mui, B.L.1    Tam, Y.K.2    Jayaraman, M.3
  • 93
    • 84879460063 scopus 로고    scopus 로고
    • Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA
    • Tam YY, Chen S, Zaifman J et al. Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA. Nanomedicine 9(5), 665-674 (2013).
    • (2013) Nanomedicine , vol.9 , Issue.5 , pp. 665-674
    • Tam, Y.Y.1    Chen, S.2    Zaifman, J.3
  • 94
    • 67649849650 scopus 로고    scopus 로고
    • Folate-Targeted therapeutic and imaging agents for cancer
    • Low PS, Kularatne SA. Folate-Targeted therapeutic and imaging agents for cancer. Curr. Opin. Chem. Biol. 13(3), 256-262 (2009).
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , Issue.3 , pp. 256-262
    • Low, P.S.1    Kularatne, S.A.2
  • 95
    • 77953416910 scopus 로고    scopus 로고
    • Targeting of nanoparticles: Folate receptor
    • Kularatne SA, Low PS. Targeting of nanoparticles: Folate receptor. Methods Mol. Biol. 624, 249-265 (2010).
    • (2010) Methods Mol. Biol. , vol.624 , pp. 249-265
    • Kularatne, S.A.1    Low, P.S.2
  • 96
    • 54949125913 scopus 로고    scopus 로고
    • Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts
    • Yoshizawa T, Hattori Y, Hakoshima M, Koga K, Maitani Y. Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts. Eur. J. Pharm. Biopharm. 70(3), 718-725 (2008).
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , Issue.3 , pp. 718-725
    • Yoshizawa, T.1    Hattori, Y.2    Hakoshima, M.3    Koga, K.4    Maitani, Y.5
  • 97
    • 78149279338 scopus 로고    scopus 로고
    • Synthesis and biological analysis of prostate-specific membrane antigen-Targeted anticancer prodrugs
    • Kularatne SA, Venkatesh C, Santhapuram HK et al. Synthesis and biological analysis of prostate-specific membrane antigen-Targeted anticancer prodrugs. J. Med. Chem. 53(21), 7767-7777 (2010).
    • (2010) J. Med. Chem. , vol.53 , Issue.21 , pp. 7767-7777
    • Kularatne, S.A.1    Venkatesh, C.2    Santhapuram, H.K.3
  • 98
    • 67249105432 scopus 로고    scopus 로고
    • Design, syn thesis, and preclinical evaluation of prostate-specific membrane antigen targeted (99m)Tc-radioimaging agents
    • Kularatne SA, Zhou Z, Yang J, Post CB, Low PS. Design, synthesis, and preclinical evaluation of prostate-specific membrane antigen targeted (99m)Tc-radioimaging agents. Mol. Pharm. 6(3), 790-800 (2009).
    • (2009) Mol. Pharm. , vol.6 , Issue.3 , pp. 790-800
    • Kularatne, S.A.1    Zhou, Z.2    Yang, J.3    Post, C.B.4    Low, P.S.5
  • 99
    • 67249157547 scopus 로고    scopus 로고
    • Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand
    • Kularatne SA, Wang K, Santhapuram HK, Low PS. Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand. Mol. Pharm. 6(3), 780-789 (2009).
    • (2009) Mol. Pharm. , vol.6 , Issue.3 , pp. 780-789
    • Kularatne, S.A.1    Wang, K.2    Santhapuram, H.K.3    Low, P.S.4
  • 100
    • 84864129727 scopus 로고    scopus 로고
    • Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment
    • Gomes-Da-Silva LC, Santos AO, Bimbo LM et al. Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment. Int. J. Pharma. 434(1-2), 9-19 (2012).
    • (2012) Int. J. Pharma. , vol.434 , Issue.1-2 , pp. 9-19
    • Gomes-Da-Silva, L.C.1    Santos, A.O.2    Bimbo, L.M.3
  • 101
    • 84859902594 scopus 로고    scopus 로고
    • Asymmetric liposome particles with highly efficient encapsulation of siRNA and without nonspecific cell penetration suitable for target-specific delivery
    • Mokhtarieh AA, Cheong S, Kim S, Chung BH, Lee MK. Asymmetric liposome particles with highly efficient encapsulation of siRNA and without nonspecific cell penetration suitable for target-specific delivery. Biochim. Biophys. Acta 1818(7), 1633-1641 (2012).
    • (2012) Biochim. Biophys. Acta , vol.1818 , Issue.7 , pp. 1633-1641
    • Mokhtarieh, A.A.1    Cheong, S.2    Kim, S.3    Chung, B.H.4    Lee, M.K.5
  • 102
    • 33645470864 scopus 로고    scopus 로고
    • Methods for the preparation of protein-oligonucleotide-lipid constructs
    • Takasaki J, Raney SG, Chikh G et al. Methods for the preparation of protein-oligonucleotide-lipid constructs. Bioconjug. Chem. 17(2), 451-458 (2006).
    • (2006) Bioconjug. Chem. , vol.17 , Issue.2 , pp. 451-458
    • Takasaki, J.1    Raney, S.G.2    Chikh, G.3
  • 103
    • 33645471676 scopus 로고    scopus 로고
    • Micelles as intermediates in the preparation of protein-liposome conjugates
    • Takasaki J, Ansell SM. Micelles as intermediates in the preparation of protein-liposome conjugates. Bioconjug. Chem. 17(2), 438-450 (2006).
    • (2006) Bioconjug. Chem. , vol.17 , Issue.2 , pp. 438-450
    • Takasaki, J.1    Ansell, S.M.2
  • 104
    • 84870344208 scopus 로고    scopus 로고
    • An MRI-visible non-viral vector for targeted Bcl-2 siRNA delivery to neuroblastoma
    • Shen M, Gong F, Pang P et al. An MRI-visible non-viral vector for targeted Bcl-2 siRNA delivery to neuroblastoma. Int. J. Nanomed. 7, 3319-3332 (2012).
    • (2012) Int. J. Nanomed. , vol.7 , pp. 3319-3332
    • Shen, M.1    Gong, F.2    Pang, P.3
  • 105
    • 80054758401 scopus 로고    scopus 로고
    • Targeted delivery to neuroblastoma of novel siRNA-Anti-GD2-liposomes prepared by dual asymmetric centrifugation and sterol-based post-insertion method
    • Adrian JE, Wolf A, Steinbach A, Rossler J, Suss R. Targeted delivery to neuroblastoma of novel siRNA-Anti-GD2-liposomes prepared by dual asymmetric centrifugation and sterol-based post-insertion method. Pharm. Res. 28(9), 2261-2272 (2011).
    • (2011) Pharm. Res. , vol.28 , Issue.9 , pp. 2261-2272
    • Adrian, J.E.1    Wolf, A.2    Steinbach, A.3    Rossler, J.4    Suss, R.5
  • 106
    • 80051509854 scopus 로고    scopus 로고
    • Galactose-modified cationic liposomes as a liver-Targeting delivery system for small interfering RNA
    • Sonoke S, Ueda T, Fujiwara K, Kuwabara K, Yano J. Galactose-modified cationic liposomes as a liver-Targeting delivery system for small interfering RNA. Biol. Pharm. Bull. 34(8), 1338-1342 (2011).
    • (2011) Biol. Pharm. Bull. , vol.34 , Issue.8 , pp. 1338-1342
    • Sonoke, S.1    Ueda, T.2    Fujiwara, K.3    Kuwabara, K.4    Yano, J.5
  • 107
    • 84875772283 scopus 로고    scopus 로고
    • Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: A pilot study
    • Kobayashi E, Iyer AK, Hornicek FJ, Amiji MM, Duan Z. Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: A pilot study. Clin. Orthop. Relat. Res. 471(3), 915-925 (2013).
    • (2013) Clin. Orthop. Relat. Res. , vol.471 , Issue.3 , pp. 915-925
    • Kobayashi, E.1    Iyer, A.K.2    Hornicek, F.J.3    Amiji, M.M.4    Duan, Z.5
  • 108
    • 84885023432 scopus 로고    scopus 로고
    • Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasis
    • Wang Y, Xu Z, Guo S et al. Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasis. Mol. Ther. 21(10), 1919-1929 (2013).
    • (2013) Mol. Ther. , vol.21 , Issue.10 , pp. 1919-1929
    • Wang, Y.1    Xu, Z.2    Guo, S.3
  • 109
    • 84861710914 scopus 로고    scopus 로고
    • Hyaluronan-modified and regular multilamellar liposomes provide sub-cellular targeting to macrophages, without eliciting a pro-inflammatory response
    • Glucksam-Galnoy Y, Zor T, Margalit R. Hyaluronan-modified and regular multilamellar liposomes provide sub-cellular targeting to macrophages, without eliciting a pro-inflammatory response. J. Control. Release 160(2), 388-393 (2012).
    • (2012) J. Control. Release , vol.160 , Issue.2 , pp. 388-393
    • Glucksam-Galnoy, Y.1    Zor, T.2    Margalit, R.3
  • 110
    • 33750503424 scopus 로고    scopus 로고
    • Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
    • Cheng J, Teply BA, Sherifi I et al. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 28(5), 869-876 (2007).
    • (2007) Biomaterials , vol.28 , Issue.5 , pp. 869-876
    • Cheng, J.1    Teply, B.A.2    Sherifi, I.3
  • 111
    • 81355148433 scopus 로고    scopus 로고
    • Aptamer-conjugated nanomaterials and their applications
    • Yang L, Zhang X, Ye M et al. Aptamer-conjugated nanomaterials and their applications. Adv. Drug Rev. 63(14-15), 1361-1370 (2011).
    • (2011) Adv. Drug Rev. , vol.63 , Issue.14-15 , pp. 1361-1370
    • Yang, L.1    Zhang, X.2    Ye, M.3
  • 112
    • 7044231886 scopus 로고    scopus 로고
    • Anisamide-Targeted stealth liposomes: A potent carrier for targeting doxorubicin to human prostate cancer cells
    • Banerjee R, Tyagi P, Li S, Huang L. Anisamide-Targeted stealth liposomes: A potent carrier for targeting doxorubicin to human prostate cancer cells. Int. J. Cancer 112(4), 693-700 (2004).
    • (2004) Int. J. Cancer , vol.112 , Issue.4 , pp. 693-700
    • Banerjee, R.1    Tyagi, P.2    Li, S.3    Huang, L.4
  • 113
    • 42549142820 scopus 로고    scopus 로고
    • Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA
    • Li SD, Chono S, Huang L. Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA. Mol. Ther. 16(5), 942-946 (2008).
    • (2008) Mol. Ther. , vol.16 , Issue.5 , pp. 942-946
    • Li, S.D.1    Chono, S.2    Huang, L.3
  • 114
    • 38549103632 scopus 로고    scopus 로고
    • Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles
    • Li SD, Chono S, Huang L. Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles. J. Control. Release 126(1), 77-84 (2008).
    • (2008) J. Control. Release , vol.126 , Issue.1 , pp. 77-84
    • Li, S.D.1    Chono, S.2    Huang, L.3
  • 115
    • 52049121804 scopus 로고    scopus 로고
    • An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor
    • Chono S, Li SD, Conwell CC, Huang L. An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor. J. Control. Release 131(1), 64-69 (2008).
    • (2008) J. Control. Release , vol.131 , Issue.1 , pp. 64-69
    • Chono, S.1    Li, S.D.2    Conwell, C.C.3    Huang, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.