Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery

Bioconjugate Chemistry

Volumn 21, Issue 8, 2010, Pages 1448-1454

  Mahon, Kerry P ^a   Love, Kevin T ^a   Whitehead, Kathryn A ^a   Qin, June ^b   Akinc, Akin ^b   Leshchiner, Elizaveta ^a   Leshchiner, Ignaty ^a   Langer, Robert ^a   Anderson, Daniel G ^a  

^a Massachusetts Institute of Technology   (United States)

^b ALNYLAM PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MODIFICATION; ETHERS; LANTHANUM COMPOUNDS; VECTORS;

ALKYL CHAIN LENGTHS; AMINE FUNCTIONAL GROUPS; CHAIN BRANCHING; COMBINATORIAL APPROACH; DELIVERY METHODS; DELIVERY VECTOR; IN-VITRO; LUCIFERASE REPORTER SYSTEM; RNA INTERFERENCE; SIRNA DELIVERY;

RNA;

ALKYL GROUP; AMINE; BLOOD CLOTTING FACTOR 7; CARBAMIC ACID DERIVATIVE; ETHER DERIVATIVE; HYDROXYL GROUP; LIPID; LIPIDOID; LUCIFERASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CHEMICAL MODIFICATION; COMBINATORIAL CHEMISTRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; FEMALE; GENE DELIVERY SYSTEM; GENE INACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN TARGETING; REPORTER GENE; RNA INTERFERENCE; SINGLE DRUG DOSE;

EID: 77955816614     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc100041r     Document Type: Article

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