메뉴 건너뛰기




Volumn 9, Issue 6, 2014, Pages 565-585

Strategies to eliminate HBV infection

Author keywords

covalently closed circular DNA; cure; elimination; eradication; HBV; host; IL 21; IL 7; immunity; PD 1; PD L1; receptor; RNAi; seroconvesrion; therapeutic vaccination; Toll like receptor; treatment; vaccines; viral entry; virus

Indexed keywords

ADEFOVIR; ANTIVIRUS AGENT; CIRCULAR DNA; COMPLEMENTARY DNA; COVALENTLY CLOSED CIRCULAR DNA; DNA VACCINE; ENTECAVIR; GS 4774; GS 9620; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; HOST FACTOR; INTERLEUKIN 21; INTERLEUKIN 7; LAMIVUDINE; PEGINTERFERON ALPHA; PROGRAMMED DEATH 1 LIGAND 1; RECOMBINANT INTERLEUKIN 21; RECOMBINANT INTERLEUKIN 7; TELBIVUDINE; TENOFOVIR; TG 1050; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

EID: 84905258651     PISSN: 17460794     EISSN: 17460808     Source Type: Journal    
DOI: 10.2217/fvl.14.36     Document Type: Review
Times cited : (46)

References (185)
  • 1
    • 84857358267 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis B virus infection: New estimates of age-specifc HBsAg seroprevalence and endemicity
    • Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specifc HBsAg seroprevalence and endemicity. Vaccine 30(12), 2212-2219 (2012).
    • (2012) Vaccine , vol.30 , Issue.12 , pp. 2212-2219
    • Ott, J.J.1    Stevens, G.A.2    Groeger, J.3    Wiersma, S.T.4
  • 2
    • 48549107919 scopus 로고    scopus 로고
    • Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon alpha-2b
    • Buster EH, Flink HJ, Cakaloglu Y et al. Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon alpha-2b. Gastroenterology 135(2), 459-467 (2008).
    • (2008) Gastroenterology , vol.135 , Issue.2 , pp. 459-467
    • Buster, E.H.1    Flink, H.J.2    Cakaloglu, Y.3
  • 3
    • 1542724805 scopus 로고    scopus 로고
    • Long-term follow-up of alpha-interferon treatment of patients with chronic hepatitis B
    • van Zonneveld M, Honkoop P, Hansen BE et al. Long-term follow-up of alpha-interferon treatment of patients with chronic hepatitis B. Hepatology 39(3), 804-810 (2004).
    • (2004) Hepatology , vol.39 , Issue.3 , pp. 804-810
    • Van Zonneveld, M.1    Honkoop, P.2    Hansen, B.E.3
  • 4
    • 77952725714 scopus 로고    scopus 로고
    • Durability of peginterferon alfa-2b treatment at 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B
    • Wong VW, Wong GL, Yan KK et al. Durability of peginterferon alfa-2b treatment at 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B. Hepatology 51(6), 1945-1953 (2010).
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 1945-1953
    • Wong, V.W.1    Wong, G.L.2    Yan, K.K.3
  • 5
    • 70649104668 scopus 로고    scopus 로고
    • Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa
    • Buster EH, Hansen BE, Lau GK et al. Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa. Gastroenterology 137(6), 2002-2009 (2009).
    • (2009) Gastroenterology , vol.137 , Issue.6 , pp. 2002-2009
    • Buster, E.H.1    Hansen, B.E.2    Lau, G.K.3
  • 6
    • 19944428132 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: A randomised trial
    • Janssen HL, van Zonneveld M, Senturk H et al. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial. Lancet 365(9454), 123-129 (2005).
    • (2005) Lancet , vol.365 , Issue.9454 , pp. 123-129
    • Janssen, H.L.1    Van Zonneveld, M.2    Senturk, H.3
  • 7
    • 80055059164 scopus 로고    scopus 로고
    • Shorter durations and lower doses of peginterferon alfa-2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or C
    • Liaw YF, Jia JD, Chan HL et al. Shorter durations and lower doses of peginterferon alfa-2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or C. Hepatology 54(5), 1591-1599 (2011).
    • (2011) Hepatology , vol.54 , Issue.5 , pp. 1591-1599
    • Liaw, Y.F.1    Jia, J.D.2    Chan, H.L.3
  • 8
    • 33644818518 scopus 로고    scopus 로고
    • A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    • Chang TT, Gish RG, de Man R et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N. Engl. J. Med. 354 (10), 1001-1010 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.10 , pp. 1001-1010
    • Chang, T.T.1    Gish, R.G.2    De Man, R.3
  • 9
    • 77956639159 scopus 로고    scopus 로고
    • Long-term entecavir therapy results in the reversal of fbrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B
    • Chang TT, Liaw YF, Wu SS et al. Long-term entecavir therapy results in the reversal of fbrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B. Hepatology 52(3), 886-893 (2010).
    • (2010) Hepatology , vol.52 , Issue.3 , pp. 886-893
    • Chang, T.T.1    Liaw, Y.F.2    Wu, S.S.3
  • 10
    • 84873726484 scopus 로고    scopus 로고
    • Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: A 5-year open-label follow-up study
    • Marcellin P, Gane E, Buti M et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet 381(9865), 468-475 (2013).
    • (2013) Lancet , vol.381 , Issue.9865 , pp. 468-475
    • Marcellin, P.1    Gane, E.2    Buti, M.3
  • 11
    • 78650477355 scopus 로고    scopus 로고
    • Three-year effcacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B
    • Heathcote EJ, Marcellin P, Buti M et al. Three-year effcacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B. Gastroenterology 140(1), 132-143 (2011).
    • (2011) Gastroenterology , vol.140 , Issue.1 , pp. 132-143
    • Heathcote, E.J.1    Marcellin, P.2    Buti, M.3
  • 12
    • 72949113706 scopus 로고    scopus 로고
    • Loss of HBsAg antigen during treatment with entecavir or lamivudine in nucleoside-naive HBeAg-positive patients with chronic hepatitis B
    • Gish RG, Chang TT, Lai CL et al. Loss of HBsAg antigen during treatment with entecavir or lamivudine in nucleoside-naive HBeAg-positive patients with chronic hepatitis B. J. Viral Hepat. 17(1), 16-22 (2010).
    • (2010) J. Viral Hepat. , vol.17 , Issue.1 , pp. 16-22
    • Gish, R.G.1    Chang, T.T.2    Lai, C.L.3
  • 13
    • 33644858331 scopus 로고    scopus 로고
    • Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
    • Iloeje UH, Yang HI, Su J et al. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 130(3), 678-686 (2006).
    • (2006) Gastroenterology , vol.130 , Issue.3 , pp. 678-686
    • Iloeje, U.H.1    Yang, H.I.2    Su, J.3
  • 14
    • 29944436855 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    • Chen CJ, Yang HI, Su J et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 295(1), 65-73 (2006).
    • (2006) JAMA , vol.295 , Issue.1 , pp. 65-73
    • Chen, C.J.1    Yang, H.I.2    Su, J.3
  • 15
    • 84880932862 scopus 로고    scopus 로고
    • Prediction models of long-term cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profles
    • Lee MH, Yang HI, Liu J et al. Prediction models of long-term cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: risk scores integrating host and virus profles. Hepatology 58(2), 546-554 (2013).
    • (2013) Hepatology , vol.58 , Issue.2 , pp. 546-554
    • Lee, M.H.1    Yang, H.I.2    Liu, J.3
  • 16
    • 74549149960 scopus 로고    scopus 로고
    • Global control of hepatitis B virus: Does treatment-induced antigenic change affect immunization? Bull
    • Clements CJ, Coghlan B, Creati M, Locarnini S, Tedder RS, Torresi J. Global control of hepatitis B virus: does treatment-induced antigenic change affect immunization? Bull. World Health Organ. 88(1), 66-73 (2010).
    • (2010) World Health Organ. , vol.88 , Issue.1 , pp. 66-73
    • Clements, C.J.1    Coghlan, B.2    Creati, M.3    Locarnini, S.4    Tedder, R.S.5    Torresi, J.6
  • 17
    • 84885960469 scopus 로고    scopus 로고
    • Hepatitis B antivirals and resistance
    • Devi U, Locarnini S. Hepatitis B antivirals and resistance. Curr. Opin. Virol. 3(5), 495-500 (2013).
    • (2013) Curr. Opin. Virol. , vol.3 , Issue.5 , pp. 495-500
    • Devi, U.1    Locarnini, S.2
  • 18
    • 77953431554 scopus 로고    scopus 로고
    • Molecular genesis of drug-resistant and vaccine-escape HBV mutants
    • Locarnini SA, Yuen L. Molecular genesis of drug-resistant and vaccine-escape HBV mutants. Antiviral Ther. 15(3 Pt B), 451-461 (2010)
    • (2010) Antiviral Ther. , vol.15 , Issue.3 PART B , pp. 451-461
    • Locarnini, S.A.1    Yuen, L.2
  • 19
    • 84862664371 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of chronic hepatitis B virus infection
    • European Association For The Study Of The L.
    • European Association For The Study Of The L. EASL clinical practice guidelines: Management of chronic hepatitis B virus infection. J. Hepatol. 57(1), 167-185 (2012).
    • (2012) J. Hepatol. , vol.57 , Issue.1 , pp. 167-185
  • 20
    • 38349108753 scopus 로고    scopus 로고
    • Long-term outcome of chronic hepatitis B in Caucasian patients: Mortality after 25 years
    • Fattovich G, Olivari N, Pasino M, D'Onofrio M, Martone E, Donato F. Long-term outcome of chronic hepatitis B in Caucasian patients: mortality after 25 years. Gut 57(1), 84-90 (2008).
    • (2008) Gut , vol.57 , Issue.1 , pp. 84-90
    • Fattovich, G.1    Olivari, N.2    Pasino, M.3    D'Onofrio, M.4    Martone, E.5    Donato, F.6
  • 21
    • 78649365376 scopus 로고    scopus 로고
    • HBsAg seroclearance: Prognostic value for the response to treatment and the long-term outcome
    • Moucari R, Marcellin P. [HBsAg seroclearance: prognostic value for the response to treatment and the long-term outcome]. Gastroenterol. Clin Biol. 34(Suppl. 2), S119-S125 (2010).
    • (2010) Gastroenterol Clin. Biol. , vol.34 , Issue.SUPPL. 2
    • Moucari, R.1    Marcellin, P.2
  • 22
    • 84887306215 scopus 로고    scopus 로고
    • Hepatitis B surface antigen seroclearance in patients with chronic hepatitis B infection: A clinical study J
    • Ruan P, Xu SY, Zhou BP, Huang J, Gong ZJ. Hepatitis B surface antigen seroclearance in patients with chronic hepatitis B infection: a clinical study J. Int. Med. Res. 41(5), 1732-1739 (2013).
    • (2013) Int. Med. Res. , vol.41 , Issue.5 , pp. 1732-1739
    • Ruan, P.1    Xu, S.Y.2    Zhou, B.P.3    Huang, J.4    Gong, Z.J.5
  • 23
    • 77956641178 scopus 로고    scopus 로고
    • Endpoints of hepatitis B treatment
    • Chotiyaputta W, Lok AS. Endpoints of hepatitis B treatment. J. Viral Hepat. 17(10), 675-684 (2010).
    • (2010) J. Viral Hepat. , vol.17 , Issue.10 , pp. 675-684
    • Chotiyaputta, W.1    Lok, A.S.2
  • 24
    • 36549058611 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen quantitation can refect hepatitis B virus in the liver and predict treatment response
    • Chan HL, Wong VW, Tse AM et al. Serum hepatitis B surface antigen quantitation can refect hepatitis B virus in the liver and predict treatment response. Clin. Gastroenterol. Hepatol. 5(12), 1462-1468 (2007).
    • (2007) Clin. Gastroenterol. Hepatol. , vol.5 , Issue.12 , pp. 1462-1468
    • Chan, H.L.1    Wong, V.W.2    Tse, A.M.3
  • 25
    • 77952716572 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen and hepatitis B e antigen titers: Disease phase infuences correlation with viral load and intrahepatic hepatitis B virus markers
    • Thompson AJ, Nguyen T, Iser D et al. Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase infuences correlation with viral load and intrahepatic hepatitis B virus markers. Hepatology 51(6), 1933-1944 (2010).
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 1933-1944
    • Thompson, A.J.1    Nguyen, T.2    Iser, D.3
  • 26
    • 22544481160 scopus 로고    scopus 로고
    • Stealth and cunning: Hepatitis B and hepatitis C viruses
    • Wieland SF, Chisari FV Stealth and cunning: hepatitis B and hepatitis C viruses. J. Virol. 79(15), 9369-9380 (2005).
    • (2005) J. Virol. , vol.79 , Issue.15 , pp. 9369-9380
    • Wieland, S.F.1    Chisari, F.V.2
  • 28
    • 0034011395 scopus 로고    scopus 로고
    • Clinical relevance of hepatitis B viral mutations
    • Hunt CM, McGill JM, Allen MI, Condreay LD. Clinical relevance of hepatitis B viral mutations. Hepatology 31(5), 1037-1044 (2000).
    • (2000) Hepatology , vol.31 , Issue.5 , pp. 1037-1044
    • Hunt, C.M.1    McGill, J.M.2    Allen, M.I.3    Condreay, L.D.4
  • 29
    • 84863517149 scopus 로고    scopus 로고
    • Presence of precore and core promoter mutants limits the probability of response to peginterferon in hepatitis B e antigen-positive chronic hepatitis B
    • Sonneveld MJ, Rijckborst V, Zeuzem S et al. Presence of precore and core promoter mutants limits the probability of response to peginterferon in hepatitis B e antigen-positive chronic hepatitis B. Hepatology 56(1), 67-75 (2012).
    • (2012) Hepatology , vol.56 , Issue.1 , pp. 67-75
    • Sonneveld, M.J.1    Rijckborst, V.2    Zeuzem, S.3
  • 30
    • 0029586311 scopus 로고
    • The precore/core promoter mutant (T1762A1764) of hepatitis B virus: Clinical signifcance and an easy method for detection
    • Takahashi K, Aoyama K, Ohno N et al. The precore/core promoter mutant (T1762A1764) of hepatitis B virus: clinical signifcance and an easy method for detection. J. Gen. Virol. 76(Pt 12), 3159-3164 (1995).
    • (1995) J. Gen. Virol. , vol.76 , Issue.PART 12 , pp. 3159-3164
    • Takahashi, K.1    Aoyama, K.2    Ohno, N.3
  • 31
    • 0029829534 scopus 로고    scopus 로고
    • Two core promotor mutations identifed in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication
    • Baumert TF, Rogers SA, Hasegawa K, Liang TJ. Two core promotor mutations identifed in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication. J. Clin. Invest. 98(10), 2268-2276 (1996).
    • (1996) J. Clin. Invest. , vol.98 , Issue.10 , pp. 2268-2276
    • Baumert, T.F.1    Rogers, S.A.2    Hasegawa, K.3    Liang, T.J.4
  • 32
    • 0036021185 scopus 로고    scopus 로고
    • Core promoter mutations (A(1762)T and G(1764)A) and viral genotype in chronic hepatitis B and hepatocellular carcinoma in Guangxi
    • Fang ZL, Yang J, Ge X et al. Core promoter mutations (A(1762)T and G(1764)A) and viral genotype in chronic hepatitis B and hepatocellular carcinoma in Guangxi, China. J. Med. Virol. 68(1), 33-40 (2002).
    • (2002) China. J. Med. Virol. , vol.68 , Issue.1 , pp. 33-40
    • Fang, Z.L.1    Yang, J.2    Ge, X.3
  • 33
    • 84984549253 scopus 로고    scopus 로고
    • Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers
    • Kao JH, Chen PJ, Lai MY, Chen DS. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 124(2), 327-334 (2003).
    • (2003) Gastroenterology , vol.124 , Issue.2 , pp. 327-334
    • Kao, J.H.1    Chen, P.J.2    Lai, M.Y.3    Chen, D.S.4
  • 34
    • 4644305114 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes: Do they play a role in the outcome of HBV infection?
    • Fung SK, Lok AS. Hepatitis B virus genotypes: do they play a role in the outcome of HBV infection? Hepatology 40(4), 790-792 (2004).
    • (2004) Hepatology , vol.40 , Issue.4 , pp. 790-792
    • Fung, S.K.1    Lok, A.S.2
  • 35
    • 84894849675 scopus 로고    scopus 로고
    • Risk factors for long-term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults
    • Ito K, Yotsuyanagi H, Yatsuhashi H et al. Risk factors for long-term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults. Hepatology 59(1), 89-97 (2014).
    • (2014) Hepatology , vol.59 , Issue.1 , pp. 89-97
    • Ito, K.1    Yotsuyanagi, H.2    Yatsuhashi, H.3
  • 36
    • 78650770247 scopus 로고    scopus 로고
    • The clinical implications of hepatitis B virus genotype: Recent advances
    • Lin CL, Kao JH. The clinical implications of hepatitis B virus genotype: recent advances. J. Gastrenterol. Hepatol. 26(Suppl. 1), 123-130 (2011).
    • (2011) J. Gastrenterol. Hepatol. , vol.26 , Issue.SUPPL. 1 , pp. 123-130
    • Lin, C.L.1    Kao, J.H.2
  • 38
    • 20444505037 scopus 로고    scopus 로고
    • Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy
    • Sung JJ, Wong ML, Bowden S et al. Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy. Gastroenterology 128(7), 1890-1897 (2005).
    • (2005) Gastroenterology , vol.128 , Issue.7 , pp. 1890-1897
    • Sung, J.J.1    Wong, M.L.2    Bowden, S.3
  • 39
    • 2942532722 scopus 로고    scopus 로고
    • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy
    • Werle-Lapostolle B, Bowden S, Locarnini S et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 126(7), 1750-1758 (2004).
    • (2004) Gastroenterology , vol.126 , Issue.7 , pp. 1750-1758
    • Werle-Lapostolle, B.1    Bowden, S.2    Locarnini, S.3
  • 40
    • 13844250599 scopus 로고    scopus 로고
    • New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA
    • Zoulim F. New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA. J. Hepatol. 42(3), 302-308 (2005).
    • (2005) J. Hepatol. , vol.42 , Issue.3 , pp. 302-308
    • Zoulim, F.1
  • 41
    • 0025329760 scopus 로고
    • In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplifed by an intracellular pathway
    • Wu TT, Coates L, Aldrich CE, Summers J, Mason WS. In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplifed by an intracellular pathway. Virology 175(1), 255-261 (1990).
    • (1990) Virology , vol.175 , Issue.1 , pp. 255-261
    • Wu, T.T.1    Coates, L.2    Aldrich, C.E.3    Summers, J.4    Mason, W.S.5
  • 43
    • 79953015941 scopus 로고    scopus 로고
    • A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese
    • An P, Winkler C, Guan L, O'Brien SJ, Zeng Z, Consortium HBVS. A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese. J. Infect. Dis. 203(7), 943-947 (2011).
    • (2011) J. Infect. Dis. , vol.203 , Issue.7 , pp. 943-947
    • An, P.1    Winkler, C.2    Guan, L.3    O'Brien, S.J.4    Zeng, Z.5    Consortium, H.B.V.S.6
  • 44
    • 84862785334 scopus 로고    scopus 로고
    • Genetic variants in human leukocyte antigen/DP-DQ infuence both hepatitis B virus clearance and hepatocellular carcinoma development
    • Hu L, Zhai X, Liu J et al. Genetic variants in human leukocyte antigen/DP-DQ infuence both hepatitis B virus clearance and hepatocellular carcinoma development. Hepatology 55(5), 1426-1431 (2012).
    • (2012) Hepatology , vol.55 , Issue.5 , pp. 1426-1431
    • Hu, L.1    Zhai, X.2    Liu, J.3
  • 45
    • 80052709252 scopus 로고    scopus 로고
    • A genome-wide association study of chronic hepatitis B identifed novel risk locus in a Japanese population
    • Mbarek H, Ochi H, Urabe Y et al. A genome-wide association study of chronic hepatitis B identifed novel risk locus in a Japanese population. Hum. Mol. Genet. 20(19), 3884-3892 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , Issue.19 , pp. 3884-3892
    • Mbarek, H.1    Ochi, H.2    Urabe, Y.3
  • 46
    • 84862668325 scopus 로고    scopus 로고
    • Genome-wide association study confrming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean
    • Nishida N, Sawai H, Matsuura K et al. Genome-wide association study confrming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. PLoS ONE 7(6), e39175 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.6
    • Nishida, N.1    Sawai, H.2    Matsuura, K.3
  • 47
    • 79952365546 scopus 로고    scopus 로고
    • Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: Two independent case-control studies
    • Wang L, Wu XP, Zhang W et al. Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies. PLoS ONE 6(3), e17608 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.3
    • Wang, L.1    Wu, X.P.2    Zhang, W.3
  • 48
    • 67349160018 scopus 로고    scopus 로고
    • A genome-wide association study identifes variants in the HLA-DP locus associated with chronic hepatitis B in Asians
    • Kamatani Y, Wattanapokayakit S, Ochi H et al. A genome-wide association study identifes variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat. Genet. 41(5), 591-595 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.5 , pp. 591-595
    • Kamatani, Y.1    Wattanapokayakit, S.2    Ochi, H.3
  • 49
    • 0028077560 scopus 로고
    • HLA and hepatitis B infection
    • Almarri A, Batchelor JR. HLA and hepatitis B infection. Lancet 344(8931), 1194-1195 (1994).
    • (1994) Lancet , vol.344 , Issue.8931 , pp. 1194-1195
    • Almarri, A.1    Batchelor, J.R.2
  • 50
    • 0142213434 scopus 로고    scopus 로고
    • Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B
    • Jiang YG, Wang YM, Liu TH, Liu J. Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B. World J. Gastroenterol. 9(10), 2221-2225 (2003).
    • (2003) World J. Gastroenterol. , vol.9 , Issue.10 , pp. 2221-2225
    • Jiang, Y.G.1    Wang, Y.M.2    Liu, T.H.3    Liu, J.4
  • 51
    • 0041761207 scopus 로고    scopus 로고
    • Immunogenetics of the response to HBsAg vaccination
    • Milich DR, Leroux-Roels GG. Immunogenetics of the response to HBsAg vaccination. Autoimmun. Rev. 2(5), 248-257 (2003).
    • (2003) Autoimmun. Rev. , vol.2 , Issue.5 , pp. 248-257
    • Milich, D.R.1    Leroux-Roels, G.G.2
  • 52
    • 0034085348 scopus 로고    scopus 로고
    • Association between hepatitis B virus infection and HLA-DR type in Korea
    • Ahn SH, Han KH, Park JY et al. Association between hepatitis B virus infection and HLA-DR type in Korea. Hepatology 31(6), 1371-1373 (2000).
    • (2000) Hepatology , vol.31 , Issue.6 , pp. 1371-1373
    • Ahn, S.H.1    Han, K.H.2    Park, J.Y.3
  • 53
    • 0038205507 scopus 로고    scopus 로고
    • Infuence of HLA class II molecules on the outcome of hepatitis B virus infection in population of Zhejiang Province in China
    • Meng XQ, Chen HG, Ma YL, Liu KZ. Infuence of HLA class II molecules on the outcome of hepatitis B virus infection in population of Zhejiang Province in China. Hepatobiliary Pancreat. Dis. Int. 2(2), 230-233 (2003).
    • (2003) Hepatobiliary Pancreat. Dis. Int. , vol.2 , Issue.2 , pp. 230-233
    • Meng, X.Q.1    Chen, H.G.2    Ma, Y.L.3    Liu, K.Z.4
  • 54
    • 56549105058 scopus 로고    scopus 로고
    • Association of human leukocyte antigen polymorphism with outcomes of hepatitis B virus infection
    • Ramezani A, Hasanjani Roshan MR, Kalantar E et al. Association of human leukocyte antigen polymorphism with outcomes of hepatitis B virus infection. J. Gastrenterol. Hepatol. 23(11), 1716-1721 (2008).
    • (2008) J. Gastrenterol. Hepatol. , vol.23 , Issue.11 , pp. 1716-1721
    • Ramezani, A.1    Hasanjani Roshan, M.R.2    Kalantar, E.3
  • 55
    • 0001624087 scopus 로고    scopus 로고
    • Class II HLA alleles and hepatitis B virus persistence in African Americans
    • Thio CL, Carrington M, Marti D et al. Class II HLA alleles and hepatitis B virus persistence in African Americans. J. Infect. Dis. 179(4), 1004-1006 (1999).
    • (1999) J. Infect. Dis. , vol.179 , Issue.4 , pp. 1004-1006
    • Thio, C.L.1    Carrington, M.2    Marti, D.3
  • 56
    • 33845990247 scopus 로고    scopus 로고
    • Association of human leukocyte antigen polymorphism with hepatitis B virus infection and genotypes
    • Zhang SY, Gu HX, Li D et al. Association of human leukocyte antigen polymorphism with hepatitis B virus infection and genotypes. Jpn. J. Infect. Dis. 59(6), 353-357 (2006).
    • (2006) Jpn. J. Infect. Dis. , vol.59 , Issue.6 , pp. 353-357
    • Zhang, S.Y.1    Gu, H.X.2    Li, D.3
  • 57
    • 79955630080 scopus 로고    scopus 로고
    • Understanding the host genetics of chronic hepatitis B and C
    • Thursz M, Yee L, Khakoo S. Understanding the host genetics of chronic hepatitis B and C. Semin. Liver Dis. 31(2), 115-127 (2011).
    • (2011) Semin. Liver Dis. , vol.31 , Issue.2 , pp. 115-127
    • Thursz, M.1    Yee, L.2    Khakoo, S.3
  • 58
    • 33745134040 scopus 로고    scopus 로고
    • Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence
    • Frodsham AJ, Zhang L, Dumpis U et al. Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. Proc. Natl Acad. Sci. USA 103(24), 9148-9153 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.24 , pp. 9148-9153
    • Frodsham, A.J.1    Zhang, L.2    Dumpis, U.3
  • 59
    • 84876430054 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in chronic hepatitis B virus infections: Towards restoration of immune control of viral infection
    • Bertoletti A, Ferrari C. Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Postgrad. Med. J. 89(1051), 294-304 (2013).
    • (2013) Postgrad. Med. J. , vol.89 , Issue.1051 , pp. 294-304
    • Bertoletti, A.1    Ferrari, C.2
  • 60
    • 84879327902 scopus 로고    scopus 로고
    • Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
    • Yan H, Zhong G, Xu G et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife 1, e00049 (2012).
    • (2012) ELife , vol.1
    • Yan, H.1    Zhong, G.2    Xu, G.3
  • 61
    • 13744257618 scopus 로고    scopus 로고
    • Effcient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein
    • Gripon P, Cannie I, Urban S. Effcient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein. J. Virol. 79(3), 1613-1622 (2005).
    • (2005) J. Virol. , vol.79 , Issue.3 , pp. 1613-1622
    • Gripon, P.1    Cannie, I.2    Urban, S.3
  • 62
    • 75449106643 scopus 로고    scopus 로고
    • Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction
    • Schulze A, Schieck A, Ni Y, Mier W, Urban S. Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction. J. Virol. 84(4), 1989-2000 (2010).
    • (2010) J. Virol. , vol.84 , Issue.4 , pp. 1989-2000
    • Schulze, A.1    Schieck, A.2    Ni, Y.3    Mier, W.4    Urban, S.5
  • 63
    • 40449096921 scopus 로고    scopus 로고
    • Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein
    • Petersen J, Dandri M, Mier W et al Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nat. Biotechnol. 26(3), 335-341 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , Issue.3 , pp. 335-341
    • Petersen, J.1    Dandri, M.2    Mier, W.3
  • 64
    • 84876295707 scopus 로고    scopus 로고
    • The entry inhibitor Myrcludex-B effciently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
    • Volz T, Allweiss L, Ben MM et al. The entry inhibitor Myrcludex-B effciently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus. J. Hepatol. 58(5), 861-867 (2013).
    • (2013) J. Hepatol. , vol.58 , Issue.5 , pp. 861-867
    • Volz, T.1    Allweiss, L.2    Ben, M.M.3
  • 65
    • 0347928672 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids
    • Deres K, Schroder CH, Paessens A et al. Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids. Science 299(5608), 893-896 (2003).
    • (2003) Science , vol.299 , Issue.5608 , pp. 893-896
    • Deres, K.1    Schroder, C.H.2    Paessens, A.3
  • 66
    • 20444421508 scopus 로고    scopus 로고
    • A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly
    • Stray SJ, Bourne CR, Punna S, Lewis WG, Finn MG, Zlotnick A. A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly. Proc. Natl Acad. Sci. USA 102(23), 8138-8143 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.23 , pp. 8138-8143
    • Stray, S.J.1    Bourne, C.R.2    Punna, S.3    Lewis, W.G.4    Finn, M.G.5    Zlotnick, A.6
  • 67
    • 33845868485 scopus 로고    scopus 로고
    • BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly
    • Stray SJ, Zlotnick A. BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. J. Mol. Recognit. 19(6), 542-548 (2006).
    • (2006) J. Mol. Recognit. , vol.19 , Issue.6 , pp. 542-548
    • Stray, S.J.1    Zlotnick, A.2
  • 68
    • 52249120971 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly
    • Wu GY, Zheng XJ, Yin CC et al. Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly. J. Chemother. 20(4), 458-467 (2008).
    • (2008) J. Chemother. , vol.20 , Issue.4 , pp. 458-467
    • Wu, G.Y.1    Zheng, X.J.2    Yin, C.C.3
  • 69
    • 72049111233 scopus 로고    scopus 로고
    • 2, 4-Diaryl-4, 6, 7, 8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly
    • Zhu X, Zhao G, Zhou X et al. 2, 4-Diaryl-4, 6, 7, 8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly. Bioorg. Med. Chem. Lett. 20(1), 299-301 (2010).
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , Issue.1 , pp. 299-301
    • Zhu, X.1    Zhao, G.2    Zhou, X.3
  • 70
    • 80054867708 scopus 로고    scopus 로고
    • The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication
    • Billioud G, Pichoud C, Puerstinger G, Neyts J, Zoulim F. The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication. Antiviral Res. 92(2), 271-276 (2011).
    • (2011) Antiviral Res. , vol.92 , Issue.2 , pp. 271-276
    • Billioud, G.1    Pichoud, C.2    Puerstinger, G.3    Neyts, J.4    Zoulim, F.5
  • 71
    • 0036721178 scopus 로고    scopus 로고
    • Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro
    • Delaney WEt, Edwards R, Colledge D et al. Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro. Antimicrobial Agents Chemother. 46(9), 3057-3060 (2002).
    • (2002) Antimicrobial Agents Chemother. , vol.46 , Issue.9 , pp. 3057-3060
    • Delaney, W.E.T.1    Edwards, R.2    Colledge, D.3
  • 72
    • 34548641466 scopus 로고    scopus 로고
    • The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packaging
    • Feld JJ, Colledge D, Sozzi V, Edwards R, Littlejohn M, Locarnini SA. The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packaging. Antiviral Res. 76(2), 168-177 (2007).
    • (2007) Antiviral Res. , vol.76 , Issue.2 , pp. 168-177
    • Feld, J.J.1    Colledge, D.2    Sozzi, V.3    Edwards, R.4    Littlejohn, M.5    Locarnini, S.A.6
  • 73
    • 78650580448 scopus 로고    scopus 로고
    • Trapping of hepatitis B virus capsid assembly intermediates by phenylpropenamide assembly accelerators
    • Katen SP, Chirapu SR, Finn MG, Zlotnick A. Trapping of hepatitis B virus capsid assembly intermediates by phenylpropenamide assembly accelerators. ACS Chem. Biol. 5(12), 1125-1136 (2010).
    • (2010) ACS Chem. Biol. , vol.5 , Issue.12 , pp. 1125-1136
    • Katen, S.P.1    Chirapu, S.R.2    Finn, M.G.3    Zlotnick, A.4
  • 74
    • 84881478439 scopus 로고    scopus 로고
    • Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure
    • Katen SP, Tan Z, Chirapu SR, Finn MG, Zlotnick A. Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure. Structure 21(8), 1406-1416 (2013).
    • (2013) Structure , vol.21 , Issue.8 , pp. 1406-1416
    • Katen, S.P.1    Tan, Z.2    Chirapu, S.R.3    Finn, M.G.4    Zlotnick, A.5
  • 75
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B virus infection-natural history and clinical consequences
    • Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N. Engl. J. Med. 350(11), 1118-1129 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , Issue.11 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 76
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat. Rev. Immunol. 5(3), 215-229 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , Issue.3 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 77
    • 70349435373 scopus 로고    scopus 로고
    • Temporal analysis of early immune responses in patients with acute hepatitis B virus infection
    • Dunn C, Peppa D, Khanna P et al. Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology 137(4), 1289-1300 (2009).
    • (2009) Gastroenterology , vol.137 , Issue.4 , pp. 1289-1300
    • Dunn, C.1    Peppa, D.2    Khanna, P.3
  • 78
    • 36749061308 scopus 로고    scopus 로고
    • A substituted tetrahydro-tetrazolo-pyrimidine is a specifc and novel inhibitor of hepatitis B virus surface antigen secretion
    • Dougherty AM, Guo H, Westby G et al. A substituted tetrahydro-tetrazolo-pyrimidine is a specifc and novel inhibitor of hepatitis B virus surface antigen secretion. Antimicrobial Agents Chemother. 51(12), 4427-4437 (2007).
    • (2007) Antimicrobial Agents Chemother. , vol.51 , Issue.12 , pp. 4427-4437
    • Dougherty, A.M.1    Guo, H.2    Westby, G.3
  • 80
    • 80051865054 scopus 로고    scopus 로고
    • thesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. J. Med. Chem.
    • Yu W, Goddard C, Clearfeld E et al. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. J. Med. Chem. 54(16), 5660-5670 (2011).
    • (2011) Design, Syn , vol.54 , Issue.16 , pp. 5660-5670
    • Yu, W.1    Goddard, C.2    Clearfeld, E.3
  • 81
    • 70349255525 scopus 로고    scopus 로고
    • The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells
    • Op den Brouw ML, Binda RS, Geijtenbeek TB, Janssen HL, Woltman AM. The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells. Virology 393(1), 84-90 (2009).
    • (2009) Virology , vol.393 , Issue.1 , pp. 84-90
    • Op Den Brouw, M.L.1    Binda, R.S.2    Geijtenbeek, T.B.3    Janssen, H.L.4    Woltman, A.M.5
  • 82
    • 67650435788 scopus 로고    scopus 로고
    • HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells
    • Xu Y, Hu Y, Shi B et al. HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells. Mol. Immunol. 46(13), 2640-2646 (2009).
    • (2009) Mol. Immunol. , vol.46 , Issue.13 , pp. 2640-2646
    • Xu, Y.1    Hu, Y.2    Shi, B.3
  • 83
    • 37449014458 scopus 로고    scopus 로고
    • Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
    • Korba BE, Montero AB, Farrar K et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 77(1), 56-63 (2008).
    • (2008) Antiviral Res. , vol.77 , Issue.1 , pp. 56-63
    • Korba, B.E.1    Montero, A.B.2    Farrar, K.3
  • 84
    • 84867882831 scopus 로고    scopus 로고
    • Host factors involved in hepatitis B virus maturation, assembly, and egress
    • Prange R. Host factors involved in hepatitis B virus maturation, assembly, and egress. Med. Microbiol. Immunol. 201(4), 449-461 (2012).
    • (2012) Med. Microbiol. Immunol. , vol.201 , Issue.4 , pp. 449-461
    • Prange, R.1
  • 85
    • 33947303039 scopus 로고    scopus 로고
    • Glucosidase inhibitors as antiviral agents for hepatitis B and C
    • Durantel D, Alotte C, Zoulim F. Glucosidase inhibitors as antiviral agents for hepatitis B and C. Curr. Opin. Invest. Drugs 8(2), 125-129 (2007).
    • (2007) Curr. Opin. Invest. Drugs , vol.8 , Issue.2 , pp. 125-129
    • Durantel, D.1    Alotte, C.2    Zoulim, F.3
  • 86
    • 34547568125 scopus 로고    scopus 로고
    • Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity
    • Lazar C, Durantel D, Macovei A et al. Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity. Antiviral Res. 76(1), 30-37 (2007).
    • (2007) Antiviral Res. , vol.76 , Issue.1 , pp. 30-37
    • Lazar, C.1    Durantel, D.2    Macovei, A.3
  • 87
    • 0034988078 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: Therapeutic implications
    • Mehta A, Carrouee S, Conyers B et al. Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications. Hepatology 33(6), 1488-1495 (2001).
    • (2001) Hepatology , vol.33 , Issue.6 , pp. 1488-1495
    • Mehta, A.1    Carrouee, S.2    Conyers, B.3
  • 88
    • 0032560488 scopus 로고    scopus 로고
    • Alpha-glucosidase inhibitors as potential broad based anti-viral agents
    • Mehta A, Zitzmann N, Rudd PM, Block TM, Dwek RA. Alpha-glucosidase inhibitors as potential broad based anti-viral agents. FEBS Lett. 430(1-2), 17-22 (1998).
    • (1998) FEBS Lett. , vol.430 , Issue.1-2 , pp. 17-22
    • Mehta, A.1    Zitzmann, N.2    Rudd, P.M.3    Block, T.M.4    Dwek, R.A.5
  • 89
    • 33845445964 scopus 로고    scopus 로고
    • Alpha-Glucosidase inhibitors have a prolonged antiviral effect against hepatitis B virus through the sustained inhibition of the large and middle envelope glycoproteins
    • Simsek E, Lu X, Ouzounov S, Block TM, Mehta AS. alpha-Glucosidase inhibitors have a prolonged antiviral effect against hepatitis B virus through the sustained inhibition of the large and middle envelope glycoproteins. Antiviral Chem. Chemother. 17(5), 259-267 (2006).
    • (2006) Antiviral Chem. Chemother. , vol.17 , Issue.5 , pp. 259-267
    • Simsek, E.1    Lu, X.2    Ouzounov, S.3    Block, T.M.4    Mehta, A.S.5
  • 90
    • 80051535219 scopus 로고    scopus 로고
    • Genome engineering with zinc-fnger nucleases
    • Carroll D. Genome engineering with zinc-fnger nucleases. Genetics 188(4), 773-782 (2011).
    • (2011) Genetics , vol.188 , Issue.4 , pp. 773-782
    • Carroll, D.1
  • 92
    • 77952011493 scopus 로고    scopus 로고
    • Zinc-fnger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs
    • Cradick TJ, Keck K, Bradshaw S, Jamieson AC, McCaffrey AP. Zinc-fnger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs. Mol. Ther. 18(5), 947-954 (2010).
    • (2010) Mol. Ther. , vol.18 , Issue.5 , pp. 947-954
    • Cradick, T.J.1    Keck, K.2    Bradshaw, S.3    Jamieson, A.C.4    McCaffrey, A.P.5
  • 93
    • 84858023570 scopus 로고    scopus 로고
    • Versatile and effcient genome editing in human cells by combining zinc-fnger nucleases with adeno-associated viral vectors
    • Handel EM, Gellhaus K, Khan K et al. Versatile and effcient genome editing in human cells by combining zinc-fnger nucleases with adeno-associated viral vectors. Hum Gene Ther. 23(3), 321-329 (2012).
    • (2012) Hum Gene Ther. , vol.23 , Issue.3 , pp. 321-329
    • Handel, E.M.1    Gellhaus, K.2    Khan, K.3
  • 94
    • 84864378861 scopus 로고    scopus 로고
    • Identifcation of disubstituted sulfonamide compounds as specifc inhibitors of hepatitis B virus covalently closed circular DNA formation
    • Cai D, Mills C, Yu W et al. Identifcation of disubstituted sulfonamide compounds as specifc inhibitors of hepatitis B virus covalently closed circular DNA formation. Antimicrobial Agents Chemother. 56(8), 4277-4288 (2012).
    • (2012) Antimicrobial Agents Chemother. , vol.56 , Issue.8 , pp. 4277-4288
    • Cai, D.1    Mills, C.2    Yu, W.3
  • 95
    • 84896029673 scopus 로고    scopus 로고
    • Specifc and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
    • Lucifora J, Xia Y, Reisinger F et al. Specifc and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 343 (6176), 1221-1228 (2014).
    • (2014) Science , vol.343 , Issue.6176 , pp. 1221-1228
    • Lucifora, J.1    Xia, Y.2    Reisinger, F.3
  • 96
    • 84856514985 scopus 로고    scopus 로고
    • IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
    • Belloni L, Allweiss L, Guerrieri F et al. IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J. Clin. Invest. 122(2), 529-537 (2012).
    • (2012) J. Clin. Invest. , vol.122 , Issue.2 , pp. 529-537
    • Belloni, L.1    Allweiss, L.2    Guerrieri, F.3
  • 97
    • 0031688116 scopus 로고    scopus 로고
    • Antisense RNA complementary to hepatitis B virus specifcally inhibits viral replication
    • Zu Putlitz J, Wieland S, Blum HE, Wands JR. Antisense RNA complementary to hepatitis B virus specifcally inhibits viral replication. Gastroenterology 115(3), 702-713 (1998).
    • (1998) Gastroenterology , vol.115 , Issue.3 , pp. 702-713
    • Zu Putlitz, J.1    Wieland, S.2    Blum, H.E.3    Wands, J.R.4
  • 98
    • 0030743739 scopus 로고    scopus 로고
    • Intracellular application of hairpin ribozyme genes against hepatitis B virus
    • Welch PJ, Tritz R, Yei S, Barber J, Yu M. Intracellular application of hairpin ribozyme genes against hepatitis B virus. Gene Ther. 4(7), 736-743 (1997).
    • (1997) Gene Ther. , vol.4 , Issue.7 , pp. 736-743
    • Welch, P.J.1    Tritz, R.2    Yei, S.3    Barber, J.4    Yu, M.5
  • 99
    • 21844432688 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus by lentiviral vector delivered antisense RNA and hammerhead ribozymes
    • Nash KL, Alexander GJ, Lever AM. Inhibition of hepatitis B virus by lentiviral vector delivered antisense RNA and hammerhead ribozymes. J. Viral Hepat. 12(4), 346-356 (2005).
    • (2005) J. Viral Hepat. , vol.12 , Issue.4 , pp. 346-356
    • Nash, K.L.1    Alexander, G.J.2    Lever, A.M.3
  • 100
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon GJ. RNA interference. Nature 418(6894), 244-251 (2002).
    • (2002) Nature , vol.418 , Issue.6894 , pp. 244-251
    • Hannon, G.J.1
  • 101
    • 38049161918 scopus 로고    scopus 로고
    • RNAi for treating hepatitis B viral infection
    • Chen Y, Cheng G, Mahato RI. RNAi for treating hepatitis B viral infection. Pharm. Res. 25(1), 72-86 (2008).
    • (2008) Pharm. Res. , vol.25 , Issue.1 , pp. 72-86
    • Chen, Y.1    Cheng, G.2    Mahato, R.I.3
  • 102
    • 0038449221 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA
    • Klein C, Bock CT, Wedemeyer H et al. Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA. Gastroenterology 125(1), 9-18 (2003).
    • (2003) Gastroenterology , vol.125 , Issue.1 , pp. 9-18
    • Klein, C.1    Bock, C.T.2    Wedemeyer, H.3
  • 103
    • 0038023197 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus in mice by RNA interference
    • McCaffrey A P, Nakai H, Pandey K et al. Inhibition of hepatitis B virus in mice by RNA interference. Nat. Biotechnol. 21(6), 639-644 (2003).
    • (2003) Nat. Biotechnol. , vol.21 , Issue.6 , pp. 639-644
    • McCaffrey, A.P.1    Nakai, H.2    Pandey, K.3
  • 104
    • 23444445660 scopus 로고    scopus 로고
    • Potent and persistent in vivo anti-HBV activity of chemically modifed siRNAs
    • Morrissey DV, Lockridge JA, Shaw L et al. Potent and persistent in vivo anti-HBV activity of chemically modifed siRNAs. Nat. Biotechnol. 23(8), 1002-1007 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , Issue.8 , pp. 1002-1007
    • Morrissey, D.V.1    Lockridge, J.A.2    Shaw, L.3
  • 105
    • 0037382795 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus expression and replication by RNA interference
    • Shlomai A, Shaul Y. Inhibition of hepatitis B virus expression and replication by RNA interference. Hepatology 37(4), 764-770 (2003).
    • (2003) Hepatology , vol.37 , Issue.4 , pp. 764-770
    • Shlomai, A.1    Shaul, Y.2
  • 106
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 124(4), 783-801 (2006).
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 107
    • 79251543296 scopus 로고    scopus 로고
    • Hepatitis B virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell function
    • Woltman AM, Op den Brouw ML, Biesta PJ, Shi CC, Janssen HL. Hepatitis B virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell function. PLoS ONE 6(1), e15324 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.1
    • Woltman, A.M.1    Op Den Brouw, M.L.2    Biesta, P.J.3    Shi, C.C.4    Janssen, H.L.5
  • 108
    • 2342588229 scopus 로고    scopus 로고
    • Genomic analysis of the host response to hepatitis B virus infection
    • Wieland S, Thimme R, Purcell RH, Chisari FV. Genomic analysis of the host response to hepatitis B virus infection. Proc. Natl Acad. Sci. USA 101(17), 6669-6674 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.17 , pp. 6669-6674
    • Wieland, S.1    Thimme, R.2    Purcell, R.H.3    Chisari, F.V.4
  • 109
    • 15244349785 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in immunity
    • Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat. Immunol. 5(12), 1219-1226 (2004).
    • (2004) Nat. Immunol. , vol.5 , Issue.12 , pp. 1219-1226
    • Colonna, M.1    Trinchieri, G.2    Liu, Y.J.3
  • 110
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet M, Cao W, Liu YJ. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8(8), 594-606 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , Issue.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.J.3
  • 111
    • 77954631301 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 3 on peripheral blood dendritic cells in HBeAg positive patients with chronic hepatitis B
    • An BY, Xie Q, Lin LY et al. [Expression of Toll-like receptor 3 on peripheral blood dendritic cells in HBeAg positive patients with chronic hepatitis B]. Zhonghua gan zang bing za zhi 15(10) 729-733 (2007).
    • (2007) Zhonghua Gan Zang Bing Za Zhi , vol.15 , Issue.10 , pp. 729-733
    • An, B.Y.1    Xie, Q.2    Lin, L.Y.3
  • 112
    • 49149128080 scopus 로고    scopus 로고
    • Expression profles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients
    • Chen Z, Cheng Y, Xu Y et al. Expression profles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin. Immunol. 128(3), 400-408 (2008).
    • (2008) Clin. Immunol. , vol.128 , Issue.3 , pp. 400-408
    • Chen, Z.1    Cheng, Y.2    Xu, Y.3
  • 113
    • 77957263266 scopus 로고    scopus 로고
    • Impaired Toll-like receptor 7 and 9 signaling: From chronic viral infections to cancer
    • Hirsch I, Caux C, Hasan U, Bendriss-Vermare N, Olive D. Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer. Trends Immunol. 31(10), 391-397 (2010).
    • (2010) Trends Immunol. , vol.31 , Issue.10 , pp. 391-397
    • Hirsch, I.1    Caux, C.2    Hasan, U.3    Bendriss-Vermare, N.4    Olive, D.5
  • 114
    • 84890131632 scopus 로고    scopus 로고
    • Decreased expression of toll like receptor signaling molecules in chronic HBV infected patients
    • Momeni M, Zainodini N, Bidaki R et al. Decreased expression of toll like receptor signaling molecules in chronic HBV infected patients. Hum. Immunol. 75(1), 15-19 (2014).
    • (2014) Hum. Immunol. , vol.75 , Issue.1 , pp. 15-19
    • Momeni, M.1    Zainodini, N.2    Bidaki, R.3
  • 115
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • Isogawa M, Robek MD, Furuichi Y, Chisari F V. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J. Virol. 79(11), 7269-7272 (2005).
    • (2005) J. Virol. , vol.79 , Issue.11 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3    Chisari, F.V.4
  • 116
    • 0033998463 scopus 로고    scopus 로고
    • Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice
    • Wieland SF, Guidotti LG, Chisari F V. Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice. J. Virol. 74(9), 4165-4173 (2000).
    • (2000) J. Virol. , vol.74 , Issue.9 , pp. 4165-4173
    • Wieland, S.F.1    Guidotti, L.G.2    Chisari, F.V.3
  • 117
    • 84862851678 scopus 로고    scopus 로고
    • Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections
    • Zhang X, Kraft A, Broering R, Schlaak JF, Dittmer U, Lu M. Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections. Expert. Opin. Drug Discov. 7(7), 597-611 (2012).
    • (2012) Expert. Opin. Drug Discov. , vol.7 , Issue.7 , pp. 597-611
    • Zhang, X.1    Kraft, A.2    Broering, R.3    Schlaak, J.F.4    Dittmer, U.5    Lu, M.6
  • 118
    • 33646347356 scopus 로고    scopus 로고
    • Toll-like receptor signaling in the liver
    • Schwabe RF, Seki E, Brenner DA. Toll-like receptor signaling in the liver. Gastroenterology 130(6), 1886-1900 (2006).
    • (2006) Gastroenterology , vol.130 , Issue.6 , pp. 1886-1900
    • Schwabe, R.F.1    Seki, E.2    Brenner, D.A.3
  • 119
    • 33846492518 scopus 로고    scopus 로고
    • Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein
    • Visvanathan K, Skinner NA, Thompson AJ et al. Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein. Hepatology 45(1), 102-110 (2007).
    • (2007) Hepatology , vol.45 , Issue.1 , pp. 102-110
    • Visvanathan, K.1    Skinner, N.A.2    Thompson, A.J.3
  • 120
    • 80052444371 scopus 로고    scopus 로고
    • The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pat hway
    • Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, Mansell A. The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pat hway. J. Hepatol. 55(4), 762-769 (2011).
    • (2011) J. Hepatol. , vol.55 , Issue.4 , pp. 762-769
    • Lang, T.1    Lo, C.2    Skinner, N.3    Locarnini, S.4    Visvanathan, K.5    Mansell, A.6
  • 121
    • 77955381494 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: Implications for immune evasion
    • Wang H, Ryu WS. Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion. PLoS Pathog. 6(7), e1000986 (2010).
    • (2010) PLoS Pathog. , vol.6 , Issue.7
    • Wang, H.1    Ryu, W.S.2
  • 122
    • 77955290279 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase inhibits RIG-I-and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3
    • Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z. Hepatitis B virus polymerase inhibits RIG-I-and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3. J. Gen. Virol. 91(Pt 8), 2080-2090 (2010).
    • (2010) J. Gen. Virol. , vol.91 , Issue.PART 8 , pp. 2080-2090
    • Yu, S.1    Chen, J.2    Wu, M.3    Chen, H.4    Kato, N.5    Yuan, Z.6
  • 123
    • 65449117568 scopus 로고    scopus 로고
    • Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells
    • Wu J, Meng Z, Jiang M et al. Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells. Hepatology 49 (4), 1132-1140 (2009).
    • (2009) Hepatology , vol.49 , Issue.4 , pp. 1132-1140
    • Wu, J.1    Meng, Z.2    Jiang, M.3
  • 124
    • 84878276077 scopus 로고    scopus 로고
    • GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees
    • Lanford RE, Guerra B, Chavez D et al. GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology 144 (7), 1508-1517, 1517 e1501-1510 (2013).
    • (2013) Gastroenterology , vol.144 , Issue.7 , pp. 1508-1517
    • Lanford, R.E.1    Guerra, B.2    Chavez, D.3
  • 125
    • 84878077286 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist
    • Lopatin U, Wolfgang G, Tumas D et al. Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist. Antiviral Ther. 18 (3), 409-418 (2013)
    • (2013) Antiviral Ther. , vol.18 , Issue.3 , pp. 409-418
    • Lopatin, U.1    Wolfgang, G.2    Tumas, D.3
  • 126
    • 84905231364 scopus 로고    scopus 로고
    • A Study Evaluating GS-9620 in Virologically Suppressed Subjects With Chronic Hepatitis B Virus Infection
    • A Study Evaluating GS-9620 in Virologically Suppressed Subjects With Chronic Hepatitis B Virus Infection. http://clinicaltrials.gov/show/NCT01590654
  • 127
    • 84905267394 scopus 로고    scopus 로고
    • A Study Evaluating GS-9620 in Treatment Naive Subjects With Chronic Hepatitis B
    • A Study Evaluating GS-9620 in Treatment Naive Subjects With Chronic Hepatitis B. http://clinicaltrials.gov/show/NCT01590641
  • 128
    • 79955386270 scopus 로고    scopus 로고
    • Immunotherapeutic effects of IL-7 during a chronic viral infection in mice
    • Nanjappa SG, Kim EH, Suresh M. Immunotherapeutic effects of IL-7 during a chronic viral infection in mice. Blood 117(19), 5123-5132 (2011).
    • (2011) Blood , vol.117 , Issue.19 , pp. 5123-5132
    • Nanjappa, S.G.1    Kim, E.H.2    Suresh, M.3
  • 129
    • 79951713941 scopus 로고    scopus 로고
    • IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology
    • Pellegrini M, Calzascia T, Toe JG et al. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 144(4), 601-613 (2011).
    • (2011) Cell , vol.144 , Issue.4 , pp. 601-613
    • Pellegrini, M.1    Calzascia, T.2    Toe, J.G.3
  • 130
    • 84877893902 scopus 로고    scopus 로고
    • Promoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines
    • Toe JG, Pellegrini M, Mak TW. Promoting immunity during chronic infection-the therapeutic potential of common gamma-chain cytokines. Mol. Immunol. 56(1-2), 38-47 (2013).
    • (2013) Mol. Immunol. , vol.56 , Issue.1-2 , pp. 38-47
    • Toe, J.G.1    Pellegrini, M.2    Mak, T.W.3
  • 131
    • 79955418828 scopus 로고    scopus 로고
    • Harnessing the biology of IL-7 for therapeutic application
    • Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat. Rev. Immunol. 11(5), 330-342 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , Issue.5 , pp. 330-342
    • Mackall, C.L.1    Fry, T.J.2    Gress, R.E.3
  • 134
    • 67649217469 scopus 로고    scopus 로고
    • IL-21 is required to control chronic viral infection
    • Elsaesser H, Sauer K, Brooks DG. IL-21 is required to control chronic viral infection. Science 324 (5934), 1569-1572 (2009).
    • (2009) Science , vol.324 , Issue.5934 , pp. 1569-1572
    • Elsaesser, H.1    Sauer, K.2    Brooks, D.G.3
  • 135
    • 67649234772 scopus 로고    scopus 로고
    • IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    • Frohlich A, Kisielow J, Schmitz I et al. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 324 (5934), 1576-1580 (2009).
    • (2009) Science , vol.324 , Issue.5934 , pp. 1576-1580
    • Frohlich, A.1    Kisielow, J.2    Schmitz, I.3
  • 136
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324 (5934), 1572-1576 (2009).
    • (2009) Science , vol.324 , Issue.5934 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 137
    • 79952220107 scopus 로고    scopus 로고
    • IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B
    • Publicover J, Goodsell A, Nishimura S et al. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J. Clin Invest. 121(3), 1154-1162 (2011).
    • (2011) J. Clin. Invest. , vol.121 , Issue.3 , pp. 1154-1162
    • Publicover, J.1    Goodsell, A.2    Nishimura, S.3
  • 138
    • 84862801307 scopus 로고    scopus 로고
    • High serum IL-21 levels after 12 weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B
    • Ma SW, Huang X, Li YY et al. High serum IL-21 levels after 12 weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B. J. Hepatol. 56(4), 775-781 (2012).
    • (2012) J. Hepatol. , vol.56 , Issue.4 , pp. 775-781
    • Ma, S.W.1    Huang, X.2    Li, Y.Y.3
  • 139
    • 77951134921 scopus 로고    scopus 로고
    • Interleukin-21: Updated review of Phase i and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma
    • Hashmi MH, Van Veldhuizen PJ. Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma. Expert Opin. Biol. Ther. 10 (5), 807-817 (2010).
    • (2010) Expert Opin. Biol. Ther. , vol.10 , Issue.5 , pp. 807-817
    • Hashmi, M.H.1    Van Veldhuizen, P.J.2
  • 140
    • 34247117935 scopus 로고    scopus 로고
    • Characterization of hepatitis B virus (HBV)-specifc T-cell dysfunction in chronic HBV infection
    • Boni C, Fisicaro P, Valdatta C et al. Characterization of hepatitis B virus (HBV)-specifc T-cell dysfunction in chronic HBV infection. J. Virol. 81(8), 4215-4225 (2007).
    • (2007) J. Virol. , vol.81 , Issue.8 , pp. 4215-4225
    • Boni, C.1    Fisicaro, P.2    Valdatta, C.3
  • 141
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specifc T cells is associated with T-cell exhaustion and disease progression
    • Day CL, Kaufmann DE, Kiepiela P et al. PD-1 expression on HIV-specifc T cells is associated with T-cell exhaustion and disease progression. Nature 443(7109), 350-354 (2006).
    • (2006) Nature , vol.443 , Issue.7109 , pp. 350-354
    • Day, C.L.1    Kaufmann, D.E.2    Kiepiela, P.3
  • 142
    • 3242677686 scopus 로고    scopus 로고
    • PD-L1-defcient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells
    • Latchman YE, Liang SC, Wu Y et al. PD-L1-defcient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl Acad. Sci. USA 101(29), 10691-10696 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.29 , pp. 10691-10696
    • Latchman, Y.E.1    Liang, S.C.2    Wu, Y.3
  • 144
    • 33645863160 scopus 로고    scopus 로고
    • The PD-1-PD-L pathway in immunological tolerance
    • Okazaki T, Honjo T. The PD-1-PD-L pathway in immunological tolerance. Trends Immunol. 27(4), 195-201 (2006).
    • (2006) Trends Immunol. , vol.27 , Issue.4 , pp. 195-201
    • Okazaki, T.1    Honjo, T.2
  • 146
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, Wherry EJ, Masopust D et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439(7077), 682-687 (2006).
    • (2006) Nature , vol.439 , Issue.7077 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3
  • 147
    • 10344226171 scopus 로고    scopus 로고
    • PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells
    • Cai G, Karni A, Oliveira EM, Weiner HL, Hafer DA, Freeman GJ. PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cell. Immunol. 230(2), 89-98 (2004).
    • (2004) Cell. Immunol. , vol.230 , Issue.2 , pp. 89-98
    • Cai, G.1    Karni, A.2    Oliveira, E.M.3    Weiner, H.L.4    Hafer, D.A.5    Freeman, G.J.6
  • 148
    • 60549087784 scopus 로고    scopus 로고
    • PD-1 blockade in rhesus macaques: Impact on chronic infection and prophylactic vaccination
    • Finnefrock AC, Tang A, Li F et al. PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination. J. Immunol. 182(2), 980-987 (2009).
    • (2009) J. Immunol. , vol.182 , Issue.2 , pp. 980-987
    • Finnefrock, A.C.1    Tang, A.2    Li, F.3
  • 149
    • 33749324118 scopus 로고    scopus 로고
    • Reinvigorating exhausted HIV-specifc T cells via PD-1-PD-1 ligand blockade
    • Freeman GJ, Wherry EJ, Ahmed R, Sharpe AH. Reinvigorating exhausted HIV-specifc T cells via PD-1-PD-1 ligand blockade. J. Exp. Med. 203(10), 2223-2227 (2006).
    • (2006) J. Exp. Med. , vol.203 , Issue.10 , pp. 2223-2227
    • Freeman, G.J.1    Wherry, E.J.2    Ahmed, R.3    Sharpe, A.H.4
  • 150
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIV-specifc CD8+ T cells leads to reversible immune dysfunction
    • Trautmann L, Janbazian L, Chomont N et al. Upregulation of PD-1 expression on HIV-specifc CD8+ T cells leads to reversible immune dysfunction. Nat. Med. 12(10), 1198-1202 (2006).
    • (2006) Nat. Med. , vol.12 , Issue.10 , pp. 1198-1202
    • Trautmann, L.1    Janbazian, L.2    Chomont, N.3
  • 151
    • 33750691709 scopus 로고    scopus 로고
    • PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specifc CD8 exhaustion
    • Urbani S, Amadei B, Tola D et al. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specifc CD8 exhaustion. J. Virol. 80(22), 11398-11403 (2006).
    • (2006) J. Virol. , vol.80 , Issue.22 , pp. 11398-11403
    • Urbani, S.1    Amadei, B.2    Tola, D.3
  • 152
    • 62249172189 scopus 로고    scopus 로고
    • Enhancing SIV-specifc immunity in vivo by PD-1 blockade
    • Velu V, Titanji K, Zhu B et al. Enhancing SIV-specifc immunity in vivo by PD-1 blockade. Nature 458(7235), 206-210 (2009).
    • (2009) Nature , vol.458 , Issue.7235 , pp. 206-210
    • Velu, V.1    Titanji, K.2    Zhu, B.3
  • 153
    • 80054095779 scopus 로고    scopus 로고
    • The expression of PD-1 ligands and their involvement in regulation of T cell functions in acute and chronic woodchuck hepatitis virus infection
    • Zhang E, Zhang X, Liu J et al. The expression of PD-1 ligands and their involvement in regulation of T cell functions in acute and chronic woodchuck hepatitis virus infection. PLoS ONE 6(10), e26196 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.10
    • Zhang, E.1    Zhang, X.2    Liu, J.3
  • 154
    • 84893805242 scopus 로고    scopus 로고
    • Enhancing virus-specifc immunity in vivo by combining therapeutic vaccination and pd-l1 blockade in chronic hepadnaviral infection
    • Liu J, Zhang E, Ma Z et al. Enhancing virus-specifc immunity in vivo by combining therapeutic vaccination and pd-l1 blockade in chronic hepadnaviral infection. PLoS Pathog. 10(1), e1003856 (2014).
    • (2014) PLoS Pathog. , vol.10 , Issue.1
    • Liu, J.1    Zhang, E.2    Ma, Z.3
  • 155
    • 75149117314 scopus 로고    scopus 로고
    • Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B
    • 693, e681-e684
    • Fisicaro P, Valdatta C, Massari M et al. Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B. Gastroenterology 138(2), 682-693, 693 e681-e684 (2010).
    • (2010) Gastroenterology , vol.138 , Issue.2 , pp. 682-693
    • Fisicaro, P.1    Valdatta, C.2    Massari, M.3
  • 156
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366(26), 2455-2465 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 157
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 158
    • 37149016672 scopus 로고    scopus 로고
    • + regulatory T cells correlate with chronic hepatitis B infection
    • + regulatory T cells correlate with chronic hepatitis B infection. Immunology 123(1), 57-65 (2008).
    • (2008) Immunology , vol.123 , Issue.1 , pp. 57-65
    • Peng, G.1    Li, S.2    Wu, W.3    Sun, Z.4    Chen, Y.5    Chen, Z.6
  • 159
    • 84864359147 scopus 로고    scopus 로고
    • Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B
    • Otano I, Suarez L, Dotor J et al. Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B. Hepatology 56(2), 474-483 (2012).
    • (2012) Hepatology , vol.56 , Issue.2 , pp. 474-483
    • Otano, I.1    Suarez, L.2    Dotor, J.3
  • 160
    • 35448967046 scopus 로고    scopus 로고
    • Vaccines and immunotherapies against hepatitis B and hepatitis C viruses
    • Inchauspe G, Michel ML. Vaccines and immunotherapies against hepatitis B and hepatitis C viruses. J. Viral Hepat. 14(Suppl. 1), 97-103 (2007).
    • (2007) J. Viral Hepat. , vol.14 , Issue.SUPPL. 1 , pp. 97-103
    • Inchauspe, G.1    Michel, M.L.2
  • 162
    • 77955421572 scopus 로고    scopus 로고
    • Hepatitis B vaccines: Protective effcacy and therapeutic potential
    • Michel ML, Tiollais P. Hepatitis B vaccines: protective effcacy and therapeutic potential. Pathol. Biol. (Paris) 58(4), 288-295 (2010).
    • (2010) Pathol. Biol. (Paris) , vol.58 , Issue.4 , pp. 288-295
    • Michel, M.L.1    Tiollais, P.2
  • 163
    • 70449698040 scopus 로고    scopus 로고
    • Therapeutic vaccination and novel strategies to treat chronic HBV infection
    • Bertoletti A, Gehring A. Therapeutic vaccination and novel strategies to treat chronic HBV infection. Expert Rev. Gastroenterol. Hepatol. 3(5), 561-569 (2009).
    • (2009) Expert Rev. Gastroenterol. Hepatol. , vol.3 , Issue.5 , pp. 561-569
    • Bertoletti, A.1    Gehring, A.2
  • 164
    • 50149120755 scopus 로고    scopus 로고
    • A randomized controlled Phase IIb trial of antigen-antibody immunogenic complex therapeutic vaccine in chronic hepatitis B patients
    • Xu DZ, Zhao K, Guo LM et al. A randomized controlled Phase IIb trial of antigen-antibody immunogenic complex therapeutic vaccine in chronic hepatitis B patients. PLoS ONE 3(7), e2565 (2008).
    • (2008) PLoS ONE , vol.3 , Issue.7
    • Xu, D.Z.1    Zhao, K.2    Guo, L.M.3
  • 165
    • 33846650945 scopus 로고    scopus 로고
    • Therapeutic effect of hepatitis B surface antigen-antibody complex is associated with cytolytic and non-cytolytic immune responses in hepatitis B patients
    • Yao X, Zheng B, Zhou J et al. Therapeutic effect of hepatitis B surface antigen-antibody complex is associated with cytolytic and non-cytolytic immune responses in hepatitis B patients. Vaccine 25(10), 1771-1779 (2007).
    • (2007) Vaccine , vol.25 , Issue.10 , pp. 1771-1779
    • Yao, X.1    Zheng, B.2    Zhou, J.3
  • 166
    • 84882811237 scopus 로고    scopus 로고
    • Results of a Phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and fndings
    • Xu DZ, Wang XY, Shen XL et al. Results of a Phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: experiences and fndings. J. Hepatol. 59(3), 450-456 (2013).
    • (2013) J. Hepatol. , vol.59 , Issue.3 , pp. 450-456
    • Xu, D.Z.1    Wang, X.Y.2    Shen, X.L.3
  • 167
    • 0034933688 scopus 로고    scopus 로고
    • Induction of strong hepatitis B virus (HBV) specifc T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection
    • Bocher WO, Dekel B, Schwerin W et al. Induction of strong hepatitis B virus (HBV) specifc T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection. Eur. J. Immunol. 31(7), 2071-2079 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , Issue.7 , pp. 2071-2079
    • Bocher, W.O.1    Dekel, B.2    Schwerin, W.3
  • 169
    • 34547763401 scopus 로고    scopus 로고
    • Phase i clinical trial in healthy adults of a nasal vaccine candidate containing recombinant hepatitis B surface and core antigens
    • Betancourt AA, Delgado CA, Estevez ZC et al. Phase I clinical trial in healthy adults of a nasal vaccine candidate containing recombinant hepatitis B surface and core antigens. Int. J. Infect. Dis. 11(5), 394-401 (2007).
    • (2007) Int. J. Infect. Dis. , vol.11 , Issue.5 , pp. 394-401
    • Betancourt, A.A.1    Delgado, C.A.2    Estevez, Z.C.3
  • 170
    • 84886429890 scopus 로고    scopus 로고
    • HBsAg HBcAg and combined HBsAg/HBcAg-based therapeutic vaccines in treating chronic hepatitis B virus infection
    • Akbar SM, Al-Mahtab M, Uddin MH, Khan MS. HBsAg, HBcAg, and combined HBsAg/HBcAg-based therapeutic vaccines in treating chronic hepatitis B virus infection. Hepatobiliary Pancreat. Dis. Int. 12(4), 363-369 (2013).
    • (2013) Hepatobiliary Pancreat. Dis. Int. , vol.12 , Issue.4 , pp. 363-369
    • Akbar, S.M.1    Al-Mahtab, M.2    Uddin, M.H.3    Khan, M.S.4
  • 171
    • 84878830519 scopus 로고    scopus 로고
    • Recombinant yeast therapeutic vaccines expressing hepatitis B virus (HBV) X, S, and core antigens generate antigen specifc T cell responses and tumorprotection in mice
    • Abstract 375
    • Guo Z, Kemmler CB, Mann DL et al. Recombinant yeast therapeutic vaccines expressing hepatitis B virus (HBV) X, S, and core antigens generate antigen specifc T cell responses and tumorprotection in mice. Hepatology 56(4 Suppl.), Abstract 375 (2012).
    • (2012) Hepatology , vol.56 , Issue.4 SUPPL.
    • Guo, Z.1    Kemmler, C.B.2    Mann, D.L.3
  • 172
    • 84878830519 scopus 로고    scopus 로고
    • Recombinantyeast therapeutic vaccines expressing hepatitis B virus (HBV) X, S, andcore antigens generate antigen specifc T cell responses in clinicalimmune cell samples from healthy volunteers
    • Abstract 372
    • Kemmler CB, Mann DL, King TH et al. Recombinantyeast therapeutic vaccines expressing hepatitis B virus (HBV) X, S, andcore antigens generate antigen specifc T cell responses in clinicalimmune cell samples from healthy volunteers. Hepatology 56(4 Suppl.), Abstract 372 (2012).
    • (2012) Hepatology , vol.56 , Issue.4 SUPPL.
    • Kemmler, C.B.1    Mann, D.L.2    King, T.H.3
  • 173
    • 84905231362 scopus 로고    scopus 로고
    • TG1050, a viral-vectorbased immunotherapeutic designed to treat chronic hepatitis B induces immuneresponses with properties similar to those displayed by HBV resolving patientsand has an early antiviral effect in a HBV tolerant model
    • Abstract 33
    • Martin P, Dubois C, Jacquier E et al. TG1050, a viral-vectorbased immunotherapeutic designed to treat chronic hepatitis B induces immuneresponses with properties similar to those displayed by HBV resolving patientsand has an early antiviral effect in a HBV tolerant model. Hepatology 224A, Abstract 33 (2013).
    • (2013) Hepatology , vol.224 A
    • Martin, P.1    Dubois, C.2    Jacquier, E.3
  • 174
    • 33645871300 scopus 로고    scopus 로고
    • Human clinical trials of plasmid DNA vaccines
    • Liu MA, Ulmer JB. Human clinical trials of plasmid DNA vaccines. Adv. Genet. 55, 25-40 (2005).
    • (2005) Adv. Genet. , vol.55 , pp. 25-40
    • Liu, M.A.1    Ulmer, J.B.2
  • 175
    • 77649282342 scopus 로고    scopus 로고
    • Changes to the natural killer cell repertoire after therapeutic hepatitis B DNA vaccination
    • Scott-Algara D, Mancini-Bourgine M, Fontaine H, Pol S, Michel ML. Changes to the natural killer cell repertoire after therapeutic hepatitis B DNA vaccination. PLoS ONE 5(1), e8761 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.1
    • Scott-Algara, D.1    Mancini-Bourgine, M.2    Fontaine, H.3    Pol, S.4    Michel, M.L.5
  • 176
    • 33745753413 scopus 로고    scopus 로고
    • Correlation of antiviral T-cell responses with suppression of viral rebound in chronic hepatitis B carriers: A proof-of-concept study
    • Yang SH, Lee CG, Park SH et al. Correlation of antiviral T-cell responses with suppression of viral rebound in chronic hepatitis B carriers: a proof-of-concept study. Gene Ther. 13 (14), 1110-1117 (2006).
    • (2006) Gene Ther. , vol.13 , Issue.14 , pp. 1110-1117
    • Yang, S.H.1    Lee, C.G.2    Park, S.H.3
  • 177
    • 37349054681 scopus 로고    scopus 로고
    • Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections
    • Depla E, Van der Aa A, Livingston BD et al. Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections. J. Virol. 82(1), 435-450 (2008).
    • (2008) J. Virol. , vol.82 , Issue.1 , pp. 435-450
    • Depla, E.1    Van Der Aa, A.2    Livingston, B.D.3
  • 178
    • 33845877461 scopus 로고    scopus 로고
    • Therapeutic vaccination in chronic hepatitis B virus carriers
    • Pol S, Michel ML. Therapeutic vaccination in chronic hepatitis B virus carriers. Expert Rev. Vaccine 5(5), 707-716 (2006).
    • (2006) Expert Rev. Vaccine , vol.5 , Issue.5 , pp. 707-716
    • Pol, S.1    Michel, M.L.2
  • 179
    • 68249151151 scopus 로고    scopus 로고
    • Effcacy of pre-S-containing HBV vaccine combined with lamivudine in the treatment of chronic HBV infection
    • Senturk H, Tabak F, Ozaras R et al. Effcacy of pre-S-containing HBV vaccine combined with lamivudine in the treatment of chronic HBV infection. Dig. Dis. Sci. 54(9), 2026-2030 (2009).
    • (2009) Dig. Dis. Sci. , vol.54 , Issue.9 , pp. 2026-2030
    • Senturk, H.1    Tabak, F.2    Ozaras, R.3
  • 180
    • 12444252951 scopus 로고    scopus 로고
    • Tra nsient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
    • Boni C, Penna A, Bertoletti A et al. Tra nsient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B. J. Hepatol. 39(4), 595-605 (2003).
    • (2003) J. Hepatol. , vol.39 , Issue.4 , pp. 595-605
    • Boni, C.1    Penna, A.2    Bertoletti, A.3
  • 181
    • 17744383748 scopus 로고    scopus 로고
    • Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: New perspectives for immune therapy
    • Boni C, Penna A, Ogg GS et al. Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology 33(4), 963-971 (2001).
    • (2001) Hepatology , vol.33 , Issue.4 , pp. 963-971
    • Boni, C.1    Penna, A.2    Ogg, G.S.3
  • 182
    • 84555192394 scopus 로고    scopus 로고
    • Rep 9AC is a potent HBSAG release inhibitor which clears serum HBSAG and elicits SVRS in patients with chronic hepatitis B
    • Al-Mahtab M, Bazinet M, Vaillant A, Sheikh B. Rep 9AC is a potent HBSAG release inhibitor which clears serum HBSAG and elicits SVRS in patients with chronic hepatitis B. J. Hepatol. 54, S25-S44 (2011).
    • (2011) J. Hepatol. , vol.54
    • Al-Mahtab, M.1    Bazinet, M.2    Vaillant, A.3    Sheikh, B.4
  • 183
    • 84878830519 scopus 로고    scopus 로고
    • Recombinant yeast therapeutic vaccines expressinghep-atitis B virus (HBV) X, S, and core antigens generate antigen specifc Tcell responses and tumor protection in mice
    • Guo Z, Charles B. Kemmler CB, Mann DL et al. Recombinant yeast therapeutic vaccines expressinghep-atitis B virus (HBV) X, S, and core antigens generate antigen specifc Tcell responses and tumor protection in mice. Hepatology 56(4 Suppl.), 373A-375A (2012).
    • (2012) Hepatology , vol.56 , Issue.4 SUPPL.
    • Guo, Z.1    Charles, B.2    Kemmler, C.B.3    Mann, D.L.4
  • 185
    • 84905285395 scopus 로고    scopus 로고
    • Safety and Effcacy of GS-4774 for the Treatment of Chronic Hepatitis B
    • Safety and Effcacy of GS-4774 for the Treatment of Chronic Hepatitis B. http://clinicaltrials.gov/show/NCT01943799


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.