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Volumn 5, Issue 5, 2006, Pages 707-716

Therapeutic vaccination in chronic hepatitis B virus carriers

Author keywords

Chronic infection; Clinical trial; DNA vaccine; Hepatitis B; Immunotherapy; Vaccination

Indexed keywords

ADEFOVIR; ADEFOVIR DIPIVOXIL; ALUMINUM HYDROXIDE; BIOHEP B; DNA VACCINE; ENTECAVIR; HEPATITIS B CORE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; INTERLEUKIN 12; INTERLEUKIN 2; LAMIVUDINE; MEINYU; PEGINTERFERON; PHOSPHORYL LIPID A; PLASMID DNA; QS 21; RECOMBINANT HEPATITIS B VACCINE; TENOFOVIR; UNCLASSIFIED DRUG; VACCINIA VACCINE;

EID: 33845877461     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.5.5.707     Document Type: Review
Times cited : (43)

References (70)
  • 1
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Lee WM. Hepatitis B virus infection. N. Engl. J. Med. 337(24), 1733-1745 (1997).
    • (1997) N. Engl. J. Med , vol.337 , Issue.24 , pp. 1733-1745
    • Lee, W.M.1
  • 3
    • 0034235528 scopus 로고    scopus 로고
    • Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group
    • Liaw YF, Leung NW, Chang TT et al. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. Gastroenterology 119(1), 172-180 (2000).
    • (2000) Gastroenterology , vol.119 , Issue.1 , pp. 172-180
    • Liaw, Y.F.1    Leung, N.W.2    Chang, T.T.3
  • 4
    • 21244447705 scopus 로고    scopus 로고
    • Peginterferon α-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B
    • Lau GK, Piratvisuth T, Luo KX et al. Peginterferon α-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N. Engl. J. Med. 352(26), 2682-2695 (2005).
    • (2005) N. Engl. J. Med , vol.352 , Issue.26 , pp. 2682-2695
    • Lau, G.K.1    Piratvisuth, T.2    Luo, K.X.3
  • 5
    • 0642374132 scopus 로고    scopus 로고
    • Resistance of HBV to adefovir dipivoxil: A case for combination antiviral therapy?
    • Aloman C, Wands JR. Resistance of HBV to adefovir dipivoxil: a case for combination antiviral therapy? Hepatology 38(6), 1584-1587 (2003).
    • (2003) Hepatology , vol.38 , Issue.6 , pp. 1584-1587
    • Aloman, C.1    Wands, J.R.2
  • 6
    • 0041853784 scopus 로고    scopus 로고
    • Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase
    • Angus P, Vaughan R, Xiong S et al. Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase. Gastroenterology 125(2), 292-297 (2003).
    • (2003) Gastroenterology , vol.125 , Issue.2 , pp. 292-297
    • Angus, P.1    Vaughan, R.2    Xiong, S.3
  • 7
    • 0141596012 scopus 로고    scopus 로고
    • Immunomodulatory drugs and therapeutic vaccine in chronic hepatitis B infection
    • Lebray P, Vallet-Pichard A, Michel ML et al. Immunomodulatory drugs and therapeutic vaccine in chronic hepatitis B infection. J. Hepatol. 39 (Suppl. 1), S151-S159 (2003).
    • (2003) J. Hepatol , vol.39 , Issue.SUPPL. 1
    • Lebray, P.1    Vallet-Pichard, A.2    Michel, M.L.3
  • 8
    • 0028916425 scopus 로고
    • Hepatitis B virus immunopathogenesis
    • Chisari FV. Hepatitis B virus immunopathogenesis. Annu. Rev. Immunol. 13, 29-60 (1995).
    • (1995) Annu. Rev. Immunol , vol.13 , pp. 29-60
    • Chisari, F.V.1
  • 9
    • 14944375587 scopus 로고    scopus 로고
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat. Rev. Immunol. 5(3), 215-229 (2005). •• Assesses recent advances in our understanding of viral hepatitis, mechanisms of virus-host interaction in acute hepatitis B and C and immunological aspects of chronic hepatitis.
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat. Rev. Immunol. 5(3), 215-229 (2005). •• Assesses recent advances in our understanding of viral hepatitis, mechanisms of virus-host interaction in acute hepatitis B and C and immunological aspects of chronic hepatitis.
  • 10
    • 2442682870 scopus 로고    scopus 로고
    • + T cells. This reinforces the therapeutic approach of inhibiting HBV by using antiviral drugs before using vaccines to boost HBV-specific immunity
    • + T cells. This reinforces the therapeutic approach of inhibiting HBV by using antiviral drugs before using vaccines to boost HBV-specific immunity
  • 11
    • 0033951066 scopus 로고    scopus 로고
    • Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines
    • McClary H, Koch R, Chisari FV, Guidotti LG. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J. Virol. 74(5), 2255-2264 (2000).
    • (2000) J. Virol , vol.74 , Issue.5 , pp. 2255-2264
    • McClary, H.1    Koch, R.2    Chisari, F.V.3    Guidotti, L.G.4
  • 12
    • 0033998463 scopus 로고    scopus 로고
    • Intrahepatic induction of α/β interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice
    • Wieland SF, Guidotti, LG, Chisari FV. Intrahepatic induction of α/β interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice. J. Virol. 74(9), 4165-4173 (2000).
    • (2000) J. Virol , vol.74 , Issue.9 , pp. 4165-4173
    • Wieland, S.F.1    Guidotti, L.G.2    Chisari, F.V.3
  • 13
    • 2342588229 scopus 로고    scopus 로고
    • Genomic analysis of the host response to hepatitis B virus infection
    • Wieland S, Thimme R, Purcell RH, Chisari FV. Genomic analysis of the host response to hepatitis B virus infection. Proc. Natl Acad. Sci. USA 101(17), 6669-6674 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.17 , pp. 6669-6674
    • Wieland, S.1    Thimme, R.2    Purcell, R.H.3    Chisari, F.V.4
  • 14
    • 0037379219 scopus 로고    scopus 로고
    • Tumor necrosis factor á inhibition of hepatitis B virus replication involves disruption of capsid integrity through activation of NF-κB
    • Biermer M, Puro R, Schneider RJ. Tumor necrosis factor á inhibition of hepatitis B virus replication involves disruption of capsid integrity through activation of NF-κB. J. Virol. 77(7), 4033-4042 (2003).
    • (2003) J. Virol , vol.77 , Issue.7 , pp. 4033-4042
    • Biermer, M.1    Puro, R.2    Schneider, R.J.3
  • 15
    • 33744808242 scopus 로고    scopus 로고
    • The immune response during hepatitis B virus infection
    • Bertoletti A, Gehring AJ. The immune response during hepatitis B virus infection. J. Gen. Virol. 87(Pt 6), 1439-1449 (2006).
    • (2006) J. Gen. Virol , vol.87 , Issue.PART 6 , pp. 1439-1449
    • Bertoletti, A.1    Gehring, A.J.2
  • 16
    • 0038461904 scopus 로고    scopus 로고
    • Bertoletti A, Ferrari C. Kinetics of the immune response during HBV and HCV infection. Hepatology 38(1), 4-13 (2003). • Highlights the role of the innate immune system in protecting the host from viral infection and discusses how early events after infection might influence the development of the adaptive immune response to HBV and hepatitis C virus infection.
    • Bertoletti A, Ferrari C. Kinetics of the immune response during HBV and HCV infection. Hepatology 38(1), 4-13 (2003). • Highlights the role of the innate immune system in protecting the host from viral infection and discusses how early events after infection might influence the development of the adaptive immune response to HBV and hepatitis C virus infection.
  • 17
    • 0022444194 scopus 로고
    • Evidence for a deficiency of interferon production in patients with chronic hepatitis B virus infection acquired in adult life
    • Ikeda T, Lever AM, Thomas HC. Evidence for a deficiency of interferon production in patients with chronic hepatitis B virus infection acquired in adult life. Hepatology 6(5), 962-965 (1986).
    • (1986) Hepatology , vol.6 , Issue.5 , pp. 962-965
    • Ikeda, T.1    Lever, A.M.2    Thomas, H.C.3
  • 18
    • 0033199973 scopus 로고    scopus 로고
    • Virus-specific lymphokine production differs quantitatively but not qualitatively in acute and chronic hepatitis B infection
    • Jung MC, Hartmann B, Gerlach JT et al. Virus-specific lymphokine production differs quantitatively but not qualitatively in acute and chronic hepatitis B infection. Virology 261(2), 165-172 (1999).
    • (1999) Virology , vol.261 , Issue.2 , pp. 165-172
    • Jung, M.C.1    Hartmann, B.2    Gerlach, J.T.3
  • 19
    • 0025992498 scopus 로고
    • Hepatic interferon-α gene transcripts and products in liver specimens from acute and chronic hepatitis B virus infection
    • Nouri-Aria KT, Arnold J, Davison F et al. Hepatic interferon-α gene transcripts and products in liver specimens from acute and chronic hepatitis B virus infection. Hepatology 13(6), 1029-1034 (1991).
    • (1991) Hepatology , vol.13 , Issue.6 , pp. 1029-1034
    • Nouri-Aria, K.T.1    Arnold, J.2    Davison, F.3
  • 20
    • 20644471859 scopus 로고    scopus 로고
    • Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B
    • Penna A, Del Prete G, Cavalli A et al. Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology 25(4), 1022-1027 (1997).
    • (1997) Hepatology , vol.25 , Issue.4 , pp. 1022-1027
    • Penna, A.1    Del Prete, G.2    Cavalli, A.3
  • 21
    • 0030008076 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection
    • Rehermann B, Lau D, Hoofnagle JH, Chisari FV. Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. J. Clin. Invest. 97(7), 1655-1665 (1996).
    • (1996) J. Clin. Invest , vol.97 , Issue.7 , pp. 1655-1665
    • Rehermann, B.1    Lau, D.2    Hoofnagle, J.H.3    Chisari, F.V.4
  • 22
    • 0032169470 scopus 로고    scopus 로고
    • Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B
    • Boni C, Bertoletti A, Penna A et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J. Clin. Invest. 102(5), 968-975 (1998).
    • (1998) J. Clin. Invest , vol.102 , Issue.5 , pp. 968-975
    • Boni, C.1    Bertoletti, A.2    Penna, A.3
  • 23
    • 12444252951 scopus 로고    scopus 로고
    • Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
    • Boni C, Penna A, Bertoletti A et al. Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B. J. Hepatol. 39(4), 595-605 (2003).
    • (2003) J. Hepatol , vol.39 , Issue.4 , pp. 595-605
    • Boni, C.1    Penna, A.2    Bertoletti, A.3
  • 24
    • 17744383748 scopus 로고    scopus 로고
    • Boni C, Penna A, Ogg GS et al. Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology 33(4), 963-971 (2001). •• Study showing that lamivudine treatment in chronic hepatitis B can restore cytotoxic T lymphocyte (CTL) reactivity. This effect may enhance the probability that T cell-based immune therapies delivered after antiviral treatment can successfully reconstitute a protective CTL response able to cure chronic HBV infection.
    • Boni C, Penna A, Ogg GS et al. Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology 33(4), 963-971 (2001). •• Study showing that lamivudine treatment in chronic hepatitis B can restore cytotoxic T lymphocyte (CTL) reactivity. This effect may enhance the probability that T cell-based immune therapies delivered after antiviral treatment can successfully reconstitute a protective CTL response able to cure chronic HBV infection.
  • 25
    • 0036176535 scopus 로고    scopus 로고
    • Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen
    • Lau GK, Suri D, Liang R et al. Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen. Gastroenterology 122(3), 614-624 (2002).
    • (2002) Gastroenterology , vol.122 , Issue.3 , pp. 614-624
    • Lau, G.K.1    Suri, D.2    Liang, R.3
  • 26
    • 0029050353 scopus 로고
    • Transplantation of hepatitis B immune lymphocytes as means for adoptive transfer of immunity to hepatitis B virus
    • Shouval D, Ilan Y. Transplantation of hepatitis B immune lymphocytes as means for adoptive transfer of immunity to hepatitis B virus. J. Hepatol. 23(1), 98-101 (1995).
    • (1995) J. Hepatol , vol.23 , Issue.1 , pp. 98-101
    • Shouval, D.1    Ilan, Y.2
  • 27
    • 30944449094 scopus 로고    scopus 로고
    • Lamivudine plus interleukin-12 combination therapy in chronic hepatitis B: Antiviral and immunological activity
    • Rigopoulou EI, Suri D, Chokshi S et al. Lamivudine plus interleukin-12 combination therapy in chronic hepatitis B: antiviral and immunological activity. Hepatology 42(5), 1028-1036 (2005).
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1028-1036
    • Rigopoulou, E.I.1    Suri, D.2    Chokshi, S.3
  • 28
    • 0028244646 scopus 로고
    • Specific vaccine therapy in chronic hepatitis B infection
    • Pol S, Driss F, Michel M-L et al. Specific vaccine therapy in chronic hepatitis B infection. Lancet 344, 342 (1994).
    • (1994) Lancet , vol.344 , pp. 342
    • Pol, S.1    Driss, F.2    Michel, M.-L.3
  • 29
    • 0344080577 scopus 로고    scopus 로고
    • Therapeutic vaccination in the immunotolerant phase of children with chronic hepatitis B infection
    • Dikici B, Kalayci AG, Ozgenc F et al. Therapeutic vaccination in the immunotolerant phase of children with chronic hepatitis B infection. Pediatr. Infect. Dis. J. 22(4), 345-349 (2003).
    • (2003) Pediatr. Infect. Dis. J , vol.22 , Issue.4 , pp. 345-349
    • Dikici, B.1    Kalayci, A.G.2    Ozgenc, F.3
  • 30
    • 0041657605 scopus 로고    scopus 로고
    • Specific hepatitis B vaccine therapy in inactive HBsAg carriers: A randomized controlled trial
    • Yalcin K, Acar M, Degertekin H. Specific hepatitis B vaccine therapy in inactive HBsAg carriers: a randomized controlled trial. Infection 31(4), 221-225 (2003).
    • (2003) Infection , vol.31 , Issue.4 , pp. 221-225
    • Yalcin, K.1    Acar, M.2    Degertekin, H.3
  • 31
    • 0034948510 scopus 로고    scopus 로고
    • Efficacy and limitations of a specific immunotherapy in chronic hepatitis B
    • Pol S, Nalpas B, Driss F et al. Efficacy and limitations of a specific immunotherapy in chronic hepatitis B. J. Hepatol. 34(6), 917-921 (2001).
    • (2001) J. Hepatol , vol.34 , Issue.6 , pp. 917-921
    • Pol, S.1    Nalpas, B.2    Driss, F.3
  • 32
    • 0033050827 scopus 로고    scopus 로고
    • Couillin I, Pol S, Mancini M et al. Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens. J. Infect. Dis. 180(1), 15-26 (1999). • One of the first studies of vaccine therapy for chronic hepatitis B, showing that it was possible to reactivate envelope-specific T-helper cells after injection of conventional recombinant vaccine.
    • Couillin I, Pol S, Mancini M et al. Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens. J. Infect. Dis. 180(1), 15-26 (1999). • One of the first studies of vaccine therapy for chronic hepatitis B, showing that it was possible to reactivate envelope-specific T-helper cells after injection of conventional recombinant vaccine.
  • 33
    • 0141535249 scopus 로고    scopus 로고
    • Cytokine-dependent anti-viral role of CD4-positive T cells in therapeutic vaccination against chronic hepatitis B viral infection
    • Ren F, Hino K, Yamaguchi Y et al. Cytokine-dependent anti-viral role of CD4-positive T cells in therapeutic vaccination against chronic hepatitis B viral infection. J. Med. Virol. 71(3), 376-384 (2003).
    • (2003) J. Med. Virol , vol.71 , Issue.3 , pp. 376-384
    • Ren, F.1    Hino, K.2    Yamaguchi, Y.3
  • 34
    • 0037019913 scopus 로고    scopus 로고
    • + T-cell proliferative response in chronic hepatitis B carriers
    • + T-cell proliferative response in chronic hepatitis B carriers. Vaccine 20(29-30), 3598-3612 (2002).
    • (2002) Vaccine , vol.20 , Issue.29-30 , pp. 3598-3612
    • Jung, M.C.1    Gruner, N.2    Zachoval, R.3
  • 35
    • 0344927219 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis B virus infection via oral immune regulation toward hepatitis B virus proteins
    • Safadi R, Israeli E, Papo O et al. Treatment of chronic hepatitis B virus infection via oral immune regulation toward hepatitis B virus proteins. Am. J. Gastroenterol. 98(11), 2505-2515 (2003).
    • (2003) Am. J. Gastroenterol , vol.98 , Issue.11 , pp. 2505-2515
    • Safadi, R.1    Israeli, E.2    Papo, O.3
  • 37
    • 0033566963 scopus 로고    scopus 로고
    • + natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns
    • + natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns. J. Immunol. 163(4), 2314-2321 (1999).
    • (1999) J. Immunol , vol.163 , Issue.4 , pp. 2314-2321
    • Doherty, D.G.1    Norris, S.2    Madrigal-Estebas, L.3
  • 38
    • 0023217305 scopus 로고
    • Modulation of the immunological response to hepatitis B virus by antibodies
    • Celis E, Abraham KG, Miller RW. Modulation of the immunological response to hepatitis B virus by antibodies. Hepatology 7(3), 563-568 (1987).
    • (1987) Hepatology , vol.7 , Issue.3 , pp. 563-568
    • Celis, E.1    Abraham, K.G.2    Miller, R.W.3
  • 39
    • 0029047836 scopus 로고
    • Hepatitis B vaccine and anti-HBs complex as approach for vaccine therapy [letter]
    • Wen YM, Wu XH, Hu DC, Zhang QP, Guo SQ. Hepatitis B vaccine and anti-HBs complex as approach for vaccine therapy [letter]. Lancet 345(8964), 1575-1576 (1995).
    • (1995) Lancet , vol.345 , Issue.8964 , pp. 1575-1576
    • Wen, Y.M.1    Wu, X.H.2    Hu, D.C.3    Zhang, Q.P.4    Guo, S.Q.5
  • 40
    • 0036200712 scopus 로고    scopus 로고
    • Clinical and immunological efficacy of intradermal vaccine plus lamivudine with or without interleukin-2 in patients with chronic hepatitis B
    • Dahmen A, Herzog-Hauff S, Bocher WO, Galle PR, Lohr HF. Clinical and immunological efficacy of intradermal vaccine plus lamivudine with or without interleukin-2 in patients with chronic hepatitis B. J. Med. Virol. 66(4), 452-460 (2002).
    • (2002) J. Med. Virol , vol.66 , Issue.4 , pp. 452-460
    • Dahmen, A.1    Herzog-Hauff, S.2    Bocher, W.O.3    Galle, P.R.4    Lohr, H.F.5
  • 41
    • 11844306534 scopus 로고    scopus 로고
    • In vivo immunization by vaccine therapy following virus suppression by lamivudine: A novel approach for treating patients with chronic hepatitis B
    • Horiike N, Fazle Akbar SM, Michitaka K et al. In vivo immunization by vaccine therapy following virus suppression by lamivudine: a novel approach for treating patients with chronic hepatitis B. J. Clin. Virol. 32(2), 156-161 (2005).
    • (2005) J. Clin. Virol , vol.32 , Issue.2 , pp. 156-161
    • Horiike, N.1    Fazle Akbar, S.M.2    Michitaka, K.3
  • 42
    • 0028876917 scopus 로고
    • Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans
    • Vitiello A, Ishioka G, Grey HM et al. Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans. J. Clin. Invest. 95(1), 341-349 (1995).
    • (1995) J. Clin. Invest , vol.95 , Issue.1 , pp. 341-349
    • Vitiello, A.1    Ishioka, G.2    Grey, H.M.3
  • 43
    • 0032769963 scopus 로고    scopus 로고
    • A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. The CY1899 T Cell Vaccine Study Group
    • Heathcote J, McHutchison J, Lee S et al. A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. The CY1899 T Cell Vaccine Study Group. Hepatology 30(2), 531-536 (1999).
    • (1999) Hepatology , vol.30 , Issue.2 , pp. 531-536
    • Heathcote, J.1    McHutchison, J.2    Lee, S.3
  • 44
    • 0031204408 scopus 로고    scopus 로고
    • The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection
    • Livingston BD, Crimi C, Grey H et al. The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection. J. Immunol. 159(3), 1383-1392 (1997).
    • (1997) J. Immunol , vol.159 , Issue.3 , pp. 1383-1392
    • Livingston, B.D.1    Crimi, C.2    Grey, H.3
  • 45
    • 0033104746 scopus 로고    scopus 로고
    • Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans
    • Livingston BD, Alexander J, Crimi C et al. Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans. J. Immunol. 162(5), 3088-3095 (1999).
    • (1999) J. Immunol , vol.162 , Issue.5 , pp. 3088-3095
    • Livingston, B.D.1    Alexander, J.2    Crimi, C.3
  • 46
    • 0027369829 scopus 로고
    • DNA based immunization for hepatitis B induces continuous secretion of antigen and high levels of circulating antibody
    • Davis HL, Michel M-L, Whalen RG. DNA based immunization for hepatitis B induces continuous secretion of antigen and high levels of circulating antibody. Hum. Mol. Genet. 2, 1847-1851 (1993).
    • (1993) Hum. Mol. Genet , vol.2 , pp. 1847-1851
    • Davis, H.L.1    Michel, M.-L.2    Whalen, R.G.3
  • 47
    • 0029982850 scopus 로고    scopus 로고
    • DNA vaccine for hepatitis B: Evidence for immunogenicity in chimpanzees and comparison with other vaccines
    • Davis HL, McCluskie MJ, Gerin JL, Purcell RH. DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines. Proc. Natl Acad. Sci. USA 93(14), 7213-7218 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , Issue.14 , pp. 7213-7218
    • Davis, H.L.1    McCluskie, M.J.2    Gerin, J.L.3    Purcell, R.H.4
  • 48
    • 8944253295 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
    • Sato Y, Roman M, Tighe H et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273(5273), 352-354 (1996).
    • (1996) Science , vol.273 , Issue.5273 , pp. 352-354
    • Sato, Y.1    Roman, M.2    Tighe, H.3
  • 49
    • 0029051321 scopus 로고
    • DNA-mediated immunization to the hepatitis B surface antigen in mice: Aspects of the humoral response mimic hepatitis B viral infection in humans
    • Michel M-L, Davis HL, Schleef M et al. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. Proc. Natl Acad. Sci. USA 92, 5307-5311 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 5307-5311
    • Michel, M.-L.1    Davis, H.L.2    Schleef, M.3
  • 50
    • 0030063276 scopus 로고    scopus 로고
    • DNA-based immunization against the envelope proteins of the hepatitis B virus
    • Mancini M, Davis HL, Tiollais P, Michel ML. DNA-based immunization against the envelope proteins of the hepatitis B virus. J. Biotechnol. 44, 47-57 (1996).
    • (1996) J. Biotechnol , vol.44 , pp. 47-57
    • Mancini, M.1    Davis, H.L.2    Tiollais, P.3    Michel, M.L.4
  • 51
    • 0034666835 scopus 로고    scopus 로고
    • Multiepitopic HLA-A*0201- restricted immune response against hepatitis B surface antigen after DNA-based immunization
    • Loirat D, Lemonnier FA, Michel ML. Multiepitopic HLA-A*0201- restricted immune response against hepatitis B surface antigen after DNA-based immunization. J. Immunol. 165(8), 4748-4755 (2000).
    • (2000) J. Immunol , vol.165 , Issue.8 , pp. 4748-4755
    • Loirat, D.1    Lemonnier, F.A.2    Michel, M.L.3
  • 52
    • 0029985146 scopus 로고    scopus 로고
    • Mancini M, Hadchouel M, Davis HL et al. DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state. Proc. Natl Acad. Sci. USA 93(22), 12496-12501 (1996). • Pioneer study of first demonstration of potential immunotherapeutic application of DNA-mediated immunization against an infectious disease.
    • Mancini M, Hadchouel M, Davis HL et al. DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state. Proc. Natl Acad. Sci. USA 93(22), 12496-12501 (1996). • Pioneer study of first demonstration of potential immunotherapeutic application of DNA-mediated immunization against an infectious disease.
  • 53
    • 0032534059 scopus 로고    scopus 로고
    • Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-γ-secreting T cells after DNA-based immunization
    • Mancini M, Hadchouel M, Tiollais P, Michel ML. Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-γ-secreting T cells after DNA-based immunization. J. Immunol. 161, 5564-5570 (1998).
    • (1998) J. Immunol , vol.161 , pp. 5564-5570
    • Mancini, M.1    Hadchouel, M.2    Tiollais, P.3    Michel, M.L.4
  • 54
    • 0031964789 scopus 로고    scopus 로고
    • Protective efficacy of DNA vaccines against duck hepatitis B virus infection
    • Triyatni M, Jilbert AR, Qiao M, Miller DS, Burrell CJ. Protective efficacy of DNA vaccines against duck hepatitis B virus infection. J. Virol. 72(1), 84-94 (1998).
    • (1998) J. Virol , vol.72 , Issue.1 , pp. 84-94
    • Triyatni, M.1    Jilbert, A.R.2    Qiao, M.3    Miller, D.S.4    Burrell, C.J.5
  • 55
    • 0033042313 scopus 로고    scopus 로고
    • Protective and therapeutic effect of DNA-based immunization against hepadnavirus large envelope protein
    • Rollier C, Sunyach C, Barraud L et al. Protective and therapeutic effect of DNA-based immunization against hepadnavirus large envelope protein. Gastroenterology 116(3), 658-665 (1999).
    • (1999) Gastroenterology , vol.116 , Issue.3 , pp. 658-665
    • Rollier, C.1    Sunyach, C.2    Barraud, L.3
  • 56
    • 0034000449 scopus 로고    scopus 로고
    • Maternally transferred antibodies from DNA-immunized avians protect offspring against hepadnavirus infection
    • Rollier C, Charollois C, Jamard C, Trepo C, Cova L. Maternally transferred antibodies from DNA-immunized avians protect offspring against hepadnavirus infection. J. Virol. 74(10), 4908-4911 (2000).
    • (2000) J. Virol , vol.74 , Issue.10 , pp. 4908-4911
    • Rollier, C.1    Charollois, C.2    Jamard, C.3    Trepo, C.4    Cova, L.5
  • 57
    • 0032889271 scopus 로고    scopus 로고
    • Immunization of woodchucks with plasmids expressing woodchuck hepatitis virus (WHV) core antigen and surface antigen suppresses WHV infection
    • Lu M, Hilken G, Kruppenbacher J et al. Immunization of woodchucks with plasmids expressing woodchuck hepatitis virus (WHV) core antigen and surface antigen suppresses WHV infection. J. Virol. 73(1), 281-289 (1999).
    • (1999) J. Virol , vol.73 , Issue.1 , pp. 281-289
    • Lu, M.1    Hilken, G.2    Kruppenbacher, J.3
  • 58
    • 0030752483 scopus 로고    scopus 로고
    • Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus
    • Prince AM, Whalen R, Brotman B. Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus. Vaccine 15(8), 916-919 (1997).
    • (1997) Vaccine , vol.15 , Issue.8 , pp. 916-919
    • Prince, A.M.1    Whalen, R.2    Brotman, B.3
  • 59
    • 0035140812 scopus 로고    scopus 로고
    • DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee
    • Pancholi P, Lee DH, Liu Q et al. DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee. Hepatology 33(2), 448-454 (2001).
    • (2001) Hepatology , vol.33 , Issue.2 , pp. 448-454
    • Pancholi, P.1    Lee, D.H.2    Liu, Q.3
  • 60
    • 33645871300 scopus 로고    scopus 로고
    • Human clinical trials of plasmid DNA vaccines
    • Liu MA, Ulmer JB. Human clinical trials of plasmid DNA vaccines. Adv. Genet. 55, 25-40 (2005).
    • (2005) Adv. Genet , vol.55 , pp. 25-40
    • Liu, M.A.1    Ulmer, J.B.2
  • 61
    • 0033566813 scopus 로고    scopus 로고
    • Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment
    • Calarota SA, Leandersson AC, Bratt G et al. Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. J. Immunol. 163(4), 2330-2338 (1999).
    • (1999) J. Immunol , vol.163 , Issue.4 , pp. 2330-2338
    • Calarota, S.A.1    Leandersson, A.C.2    Bratt, G.3
  • 62
    • 17444435761 scopus 로고    scopus 로고
    • Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients
    • Calarota S, Bratt G, Nordlund S et al. Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients. Lancet 351(9112), 1320-1325 (1998).
    • (1998) Lancet , vol.351 , Issue.9112 , pp. 1320-1325
    • Calarota, S.1    Bratt, G.2    Nordlund, S.3
  • 63
    • 0033575486 scopus 로고    scopus 로고
    • Phase I safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device
    • Tacket CO, Roy MJ, Widera G et al. Phase I safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device. Vaccine 17(22), 2826-2829 (1999).
    • (1999) Vaccine , vol.17 , Issue.22 , pp. 2826-2829
    • Tacket, C.O.1    Roy, M.J.2    Widera, G.3
  • 64
    • 0034703836 scopus 로고    scopus 로고
    • Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine
    • Roy MJ, Wu MS, Barr LJ et al. Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine. Vaccine 19(7-8), 764-778 (2001).
    • (2001) Vaccine , vol.19 , Issue.7-8 , pp. 764-778
    • Roy, M.J.1    Wu, M.S.2    Barr, L.J.3
  • 65
    • 0142199964 scopus 로고    scopus 로고
    • Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination
    • Rottinghaus ST, Poland GA, Jacobson RM, Barr LJ, Roy MJ. Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination. Vaccine 21(31), 4604-4608 (2003).
    • (2003) Vaccine , vol.21 , Issue.31 , pp. 4604-4608
    • Rottinghaus, S.T.1    Poland, G.A.2    Jacobson, R.M.3    Barr, L.J.4    Roy, M.J.5
  • 66
    • 4644313122 scopus 로고    scopus 로고
    • Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers
    • Mancini-Bourgine M, Fontaine H, Scott-Algara D et al. Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers. Hepatology 40(4), 874-882 (2004).
    • (2004) Hepatology , vol.40 , Issue.4 , pp. 874-882
    • Mancini-Bourgine, M.1    Fontaine, H.2    Scott-Algara, D.3
  • 67
    • 33745753413 scopus 로고    scopus 로고
    • Yang SH, Lee CG, Park SH et al. Correlation of antiviral T-cell responses with suppression of viral rebound in chronic hepatitis B carriers: a proof-ofconcept study. Gene Ther. 13(4), 1110-1117 (2006) (EPub ahead of print).
    • Yang SH, Lee CG, Park SH et al. Correlation of antiviral T-cell responses with suppression of viral rebound in chronic hepatitis B carriers: a proof-ofconcept study. Gene Ther. 13(4), 1110-1117 (2006) (EPub ahead of print).
  • 68
  • 69
    • 11344257404 scopus 로고    scopus 로고
    • CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
    • Cooper CL, Davis HL, Morris ML et al. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study. J. Clin. Immunol. 24(6), 693-701 (2004).
    • (2004) J. Clin. Immunol , vol.24 , Issue.6 , pp. 693-701
    • Cooper, C.L.1    Davis, H.L.2    Morris, M.L.3
  • 70
    • 23244456102 scopus 로고    scopus 로고
    • Donnelly JJ, Wahren B, Liu MA. DNA vaccines: progress and challenges. J. Immunol. 175(2), 633-639 (2005). • Provides a background of DNA vaccines including immunological mechanisms that play a role in their ability to generate immune responses. It also highlights the challenges encountered in the efforts to translate efficacy in preclinical models into clinical realities.
    • Donnelly JJ, Wahren B, Liu MA. DNA vaccines: progress and challenges. J. Immunol. 175(2), 633-639 (2005). • Provides a background of DNA vaccines including immunological mechanisms that play a role in their ability to generate immune responses. It also highlights the challenges encountered in the efforts to translate efficacy in preclinical models into clinical realities.


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