IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B

Journal of Clinical Investigation

Volumn 121, Issue 3, 2011, Pages 1154-1162

  Publicover, Jean ^a   Goodsell, Amanda ^a   Nishimura, Stephen ^a   Vilarinho, Silvia ^a,d   Wang, Zhi En ^a   Avanesyan, Lia ^b   Spolski, Rosanne ^c   Leonard, Warren J ^c   Cooper, Stewart ^a,b   Baron, Jody L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR;

ACUTE HEPATITIS; ADOPTIVE TRANSFER; ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; BLOOD SAMPLING; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GROUPS BY AGE; HELPER CELL; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; VIRAL CLEARANCE;

ANIMALS; ANTIGENS; B-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; HEPATITIS B; HUMANS; INFLAMMATION; INTERLEUKINS; LIVER; MALE; MICE; MICE, INBRED C57BL; TIME FACTORS;

EID: 79952220107     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI44198     Document Type: Article

References (26)

1. Lee WM. Hepatitis B virus infection. N Engl J Med. 1997;337(24):1733- 1745. (Pubitemid 27527771)
2. Robinson WS. Hepatitis B virus and hepatitis D virus. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 4th ed. New York, New York, USA: Churchill Livingstone; 1995:1406-1439.
3. Ganem D, Prince AM. Hepatitis B virus infection - natural history and clinical consequences. N Engl J Med. 2004;350(11):1118-1129. (Pubitemid 38298992)
4. Liang TJ. Hepatitis B: the virus and disease. Hepatology. 2009;49(5 suppl):S13-S21.
5. Chisari FV, Isogawa M, Wieland SF. Pathogenesis of hepatitis B virus infection. Pathol Biol (Paris). 2010; 58(4):258-266.
6. Milich DR, Jones J, Hughes J, Maruyama T. Role of T-cell tolerance in the persistence of hepatitis B virus infection. J Immunother Emphasis Tumor Immunol. 1993;14(3):226-233. (Pubitemid 23319212)
7. Milich DR, Jones JE, Hughes JL, Price J, Raney AK, McLachlan A. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc Natl Acad Sci U S A. 1990;87(17):6599-6603.
8. Pungpapong S, Kim WR, Poterucha JJ. Natural history of hepatitis B virus infection: an update for clinicians. Mayo Clin Proc. 2007;82(8):967-975. (Pubitemid 47206372)
9. Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002;16(4):583-594. (Pubitemid 34442582)
10. Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc Natl Acad Sci U S A. 2007; 104(46):18187-18192. (Pubitemid 350210842)
11. Chisari FV, et al. Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol. 1986;60(3):880-887. (Pubitemid 17179261)
12. Guidotti LG, Matzke B, Schaller H, Chisari FV. High-level hepatitis B virus replication in transgenic mice. J Virol. 1995;69(10):6158-6169.
13. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 1992; 68(5):869-877.
14. Baumert TF, Thimme R, von Weizsacker F. Pathogenesis of hepatitis B virus infection. World J Gastroenterol. 2007;13(1):82-90. (Pubitemid 46165465)
15. Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol. 1995;13:29-60.
16. Ozaki K, et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol. 2004; 173(9):5361-5371. (Pubitemid 39392119)
17. Ozaki K, et al. A critical role for IL-21 in regulating immunoglobulin production. Science. 2002; 298(5598):1630-1634. (Pubitemid 35387203)
18. Spolski R, Leonard WJ. IL-21 and T follicular helper cells. Int Immunol. 2010;22(1):7-12.
19. Elsaesser H, Sauer K, Brooks DG. IL-21 is required to control chronic viral infection. Science. 2009; 324(5934):1569-1572.
20. Frohlich A, et al. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science. 2009;324(5934):1576-1580.
21. Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009;324(5934):1572-1576.
22. Wieland S, Thimme R, Purcell RH, Chisari FV. Genomic analysis of the host response to hepatitis B virus infection. Proc Natl Acad Sci U S A. 2004; 101(17):6669-6674. (Pubitemid 38586032)
23. Guerau-de-Arellano M, Martinic M, Benoist C, Mathis D. Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. J Exp Med. 2009;206(6):1245-1252.
24. Asabe S, et al. The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol. 2009;83(19):9652-9662.
25. Wiwi CA, Gupte M, Waxman DJ. Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. Mol Endocrinol. 2004;18(8):1975-1987. (Pubitemid 39006502)
26. Nurieva R, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 2007;448(7152):480-483. (Pubitemid 47123514)