Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Nishida, Nao ^a,b   Sawai, Hiromi ^b   Matsuura, Kentaro ^c   Sugiyama, Masaya ^a   Ahn, Sang Hoon ^d   Park, Jun Yong ^d   Hige, Shuhei ^e   Kang, Jong Hon ^f   Suzuki, Kazuyuki ^g   Kurosaki, Masayuki ^h   Asahina, Yasuhiro ^h   Mochida, Satoshi ⁱ   Watanabe, Masaaki ^j   Tanaka, Eiji ^k   Honda, Masao ^l   Kaneko, Shuichi ^l   Orito, Etsuro ^m   Itoh, Yoshito ⁿ   Mita, Eiji ^o   Tamori, Akihiro ^p   Murawaki, Yoshikazu ^q   Hiasa, Yoichi ^r   Sakaida, Isao ^s   Korenaga, Masaaki ^t   Hino, Keisuke ^t   Ide, Tatsuya ^u   Kawashima, Minae ^b   Mawatari, Yoriko ^a,b   Sageshima, Megumi ^b   Ogasawara, Yuko ^b   Koike, Asako ^v   Izumi, Namiki ^h   Han, Kwang Hyub ^d   Tanaka, Yasuhito ^c   Tokunaga, Katsushi ^b   Mizokami, Masashi ^a   more..

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^d Yonsei University College of Medicine   (South Korea)

^e HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f TEINE KEIJINKAI HOSPITAL   (Japan)

^g IWATE MEDICAL UNIVERSITY   (Japan)

^h MUSASHINO RED CROSS HOSPITAL   (Japan)

ⁱ SAITAMA MEDICAL UNIVERSITY   (Japan)

^j KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^k SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^l KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^m NAGOYA DAINI RED CROSS HOSPITAL   (Japan)

ⁿ KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^o OSAKA NATIONAL HOSPITAL   (Japan)

^p OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^q TOTTORI UNIVERSITY   (Japan)

^r EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^s YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^t KAWASAKI MEDICAL SCHOOL   (Japan)

^u KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^v HITACHI LTD   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ASIAN; CARCINOGENESIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ETHNIC GROUP; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; HEPATITIS B; HEREDITY; HLA DP GENE; HLA DPA1 GENE; HLA DPB1 GENE; HUMAN; INFECTION PREVENTION; JAPANESE; KOREAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; PATHOGENESIS; POPULATION RESEARCH; REPLICATION STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; VIRAL CLEARANCE; VIRUS CARRIER; DNA MICROARRAY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETICS; GENOTYPE; HAPLOTYPE; HEPATITIS B VIRUS; IMMUNOLOGY; JAPAN; KOREA; MALE; PREVALENCE; PRINCIPAL COMPONENT ANALYSIS; REMISSION; RISK; VIROLOGY;

HLA DP ANTIGEN; HLA DPA1 ANTIGEN; HLA DPB1 ANTIGEN; HLA-DPA1 ANTIGEN; HLA-DPB1 ANTIGEN;

FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HAPLOTYPES; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HLA-DP ALPHA-CHAINS; HLA-DP ANTIGENS; HLA-DP BETA-CHAINS; HUMANS; JAPAN; KOREA; LINKAGE DISEQUILIBRIUM; MALE; ODDS RATIO; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; PRINCIPAL COMPONENT ANALYSIS; REMISSION INDUCTION;

EID: 84862668325     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039175     Document Type: Article

References (22)

1. Arauz-Ruiz P, Norder H, Robertson BH, Magnius LO, (2002) Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol 83: 2059-2073.
2. Hoofnagle JH, Doo E, Liang TJ, Fleischer R, Lok ASF, (2007) Management of hepatitis B: Summary of a clinical research workshop. Hepatology 45: 1056-1075.
3. Yokosuka O, Kurosaki M, Imazeki F, Arase Y, Tanaka Y, et al. (2011) Management of hepatitis B: Consensus of the Japan society of Hepatology 2009. Hepatol Res 41: 1-21.
4. Tada H, Uga N, Fuse Y, Shimizu M, Nemoto Y, et al. (1992) Prevention of perinatal transmission of hepatitis B virus carrier state. Acta Paediatr Jpn 34: 656-659.
5. Stevens CE, Toy PT, Taylor PE, Lee T, Yip HY, (1992) Prospects for control of hepatitis B virus infection: implications of childhood vaccination and long-term protection. Pediatrics 90: 170-173.
6. Szmuness W, (1979) Large-scale efficacy trials of hepatitis B vaccines in the USA: baseline data and protocols. J Med Virol 4: 327-340.
7. Kwon H, Lok AS, (2011) Hepatitis B therapy. Nat Rev Gastroenterol Hepatol 8: 275-284.
8. Kobayashi M, Ikeda K, Arase Y, Suzuki F, Akuta N, et al. (2008) Change of Hepatitis B virus genotypes in acute and chronic infections in Japan. J Med Virol 80: 1880-1884.
9. Yano K, Tamada Y, Yatsuhashi H, Komori A, Abiru S, et al. (2010) Dynamic epidemiology of acute viral hepatitis in Japan. Intervirology 53: 70-75.
10. Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, et al. (2009) A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 41: 591-595.
11. Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, et al. (2011) A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum Mol Genet 20: 3884-3892.
12. Li J, Yang D, He Y, Wang M, Wen Z, et al. (2011) Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. PLoS ONE 6: e24221.
13. Guo X, Zhang Y, Li J, Ma J, Wei Z, et al. (2011) Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. Hepatol 53: 422-428.
14. Thursz MR, Kwiatkowski D, Allsopp CEM, Greenwood BM, Thomas HC, et al. (1995) Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N Engl J Med 332: 1065-1069.
15. Godkin A, Davenport M, Hill AVS, (2005) Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness. Hepatology 41: 1383-1390.
16. An P, Winkler C, Guan L, O'Brien SJ, Zeng Z, et al. (2011) A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese. J Infect Dis 203: 943-947.
17. Wang L, Wu X-P, Zhang W, Zhu D-H, Wang Y, et al. (2011) Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control study.
18. Hu L, Zhai X, Liu J, Chu M, Pan S, et al. (2011) Genetic variants in HLA-DP/DQ influence both hepatitis B virus clearance and Hepatocellular carcinoma development. Hepatology (in press).
19. Nishida N, Koike A, Tajima A, Ogasawara Y, Ishibashi Y, et al. (2008) Evaluating the performance of Affymetrix SNP Array 6.0 platform. BMC Genomics 9: 431.
20. Miyagawa T, Nishida N, Ohashi J, Kimura R, Fujimoto A, et al. (2008) Appropriate data cleaning methods for genome-wide association study. J Hum Genet 53: 886-893.
21. Nishida N, Tanabe T, Takasu M, Suyama A, Tokunaga K, (2007) Further development of multiplex single nucleotide polymorphism typing method, the DigiTag2 assay. Anal Biochem 364: 78-85.
22. Nishida N, Mawatari Y, Sageshima M, Tokunaga K, (2012) Highly parallel and short-acting amplification with locus-specific primers to detect single nucleotide polymorphisms by the DigiTag2 assay. PLoS ONE 7: e29967.