Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection

European Journal of Immunology

Volumn 31, Issue 7, 2001, Pages 2071-2079

  Bcher, Wulf O ^a   Dekel, Benjamin ^b   Schwerin, Wibke ^c   Geissler, Michael ^b   Hoffmann, Sina ^d   Rohwer, Andreas ^e   Arditti, Fabian ^a,c   Cooper, Aric ^b   Bernhard, Helga ^d   Berrebi, Alain ^a   Rose John, Stefan ^a,b   Shaul, Yosef ^a   Galle, Peter R ^f   Lhr, Hanns F ^e   Reisner, Yair ^d  

^a I Department of Internal Medicine   (Germany)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c UNIVERSITY OF FREIBURG   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e KAPLAN HOSPITAL   (Israel)

^f UNIVERSITY OF KIEL   (Germany)

Author keywords

Hepatitis B virus; Immunotherapy; Trimera mouse model

Indexed keywords

COMPLEMENTARY DNA; DNA VACCINE; EPITOPE; HEPATITIS B CORE ANTIGEN; HEPATITIS B VACCINE; PLASMID DNA; TETANUS TOXOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; B LYMPHOCYTE; BONE MARROW TRANSPLANTATION; BORRELIA BURGDORFERI; CHIMERA; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; DENDRITIC CELL; DNA VECTOR; DONOR; DRUG MEGADOSE; HELPER CELL; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C VIRUS; IMMUNIZATION; IN VIVO STUDY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; VACCINATION; VIRUS INDUCTION; WHOLE BODY RADIATION;

ANIMALS; ANTIGENS; CELLS, CULTURED; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HEPATITIS B ANTIBODIES; HEPATITIS B CORE ANTIGENS; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERFERON TYPE II; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MICE, SCID; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER; VACCINES, DNA;

EID: 0034933688     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200107)31:7<2071::AID-IMMU2071>3.0.CO;2-D     Document Type: Article

References (48)

1. Clinical aspects of heptatitis B virus infection
2. Cytotoxic T cells and viral hepatitis
3. A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus
4. A severe combined immunodeficiency mutation in the mouse
5. Time-dependent induction of protective anti-influenza immune responses in human peripheral blood lymphocyte/SCID mice
6. Transfer of a functional human immune system to mice with severe combined immunodeficiency
7. Specific antibody production to a recall or a neoantigen by SCID mice reconstituted with human peripheral blood lymphocytes
8. Immunoglobulin production in severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood mononuclear cells
9. Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood
10. The human immune system in hu-PBL-SCID mice
11. Limited B cell repertoire in severe immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans
12. Limits of the human-PBL-SCID mice model: Severe restriction of the V beta T-cell repertoire of engrafted human T cells
13. Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras
14. Induction of primary antigen-specific immune reponses in SCID-hu-PBL by coupled T-B epitopes
15. Antigen-specific T cell responses in human peripheral blood leucocyte (hu-PBL)-mouse chimera conditioned with radiation and an antibody directed against the mouse IL-2 receptor beta-chain
16. Engraftment of human peripheral blood lymphocytes in normal strains of mice
17. The Trimera mouse: A novel system for the generation of human monoclonal antibodies and models for human diseases
18. Engrafted human T and B lymphocytes form mixed follicles in lymphoid organs of human/mouse and human/rat chimera
19. Human → mouse radiation chimera do not develop Epstein-Barr virus lymphoma
20. Human/mouse radiation chimera are capable of mounting a human primary humoral response
21. Generation of primary antigen-specific human cytotoxic T lymphocytes in human/mouse radiation chimera
22. Antigen specific B and T cells in the human/mouse radiation chimera following immunization in vivo
23. Hepatitis C virus viremia in SCID → BNX mouse chimera
24. Human interleukin-6 facilitates hepatitis B virus infection in vitro and in vivo
25. The HBV-trimera mouse: A model for human HBV infection and evaluation of anti-HBV therapeutic agents
26. Reduced hepatitis B virus surface antigen-specific Th1 helper cell frequency of chronic HBV carriers is associated with a failure to produce antigen-specific antibodies in human/mouse radiation chimera
27. Dendritic cells and the control of immunity
28. Cellular and humoral immune response to hepatitis B virus structural proteins in mice after DNA-based immunization
29. Enhanced dendritic cell maturation by TNF-alpha or cytidine-phosphate-guanosine DNA drives T cell activation In vitro and therapeutic anti-tumor immune responses in vivo
30. APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells
31. Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus-induced cytotoxic T cell response
32. Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein
33. Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection
34. Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: Interaction with HLA and T-cell receptor
35. Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection
36. Immunity to Lyme disease: Protection, pathology and persistence
37. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: Implications for the initiation of anti-Leishmania immunity
38. + T cells
39. Human dendritic cell (DC)- based anti-infective therapy: Engineering DCs to secrete functional IFN-γ and IL-12
40. Quantitative and functional analysis of core specific T helper cell and CTL activities in acute and chronic hepatitis B
41. Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors
42. MHC class I-restricted CTL responses to exogenous antigens
43. The hepatitis nucleocapsid as a vaccine carrier moiety
44. Immunotherapy of chronic hepatitis B by anti HBV vaccine
45. Ongoing murine T1 or T2 immune responses to the hepatitis B surface antigen are excluded from the liver that expresses transgene-encoded hepatitis B surface antigen
46. The gp130-stimulating designer cytokine hyper-IL-6 promotes the expansion of human hematopoietic progenitor cell capable to differentiate into functional dendritic cells
47. + hemopoietic progenitor cells
48. Kinetics of hepatitis B surface (HBs)-specific immune responses in acute and chronic hepatitis B or after HBs vaccination. Stimulation of the in vitro antibody response by interferon-γ