Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

Brain

Volumn 137, Issue 8, 2014, Pages 2193-2209

  Chen, Gang ^a   Park, Chul Kyu ^a   Xie, Rou Gang ^a   Berta, Temugin ^a   Nedergaard, Maiken ^b   Ji, Ru Rong ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

carbenoxolone (CBX); CXCL1; CXCR2; hemichannels; neuro glial interaction

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; CARBENOXOLONE; CONNEXIN 43; CXCL1 CHEMOKINE; GAP 26; GAP 27; PROTEIN INHIBITOR; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTE CULTURE; CELL COMMUNICATION; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; CYTOKINE RELEASE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD; SPINAL CORD DORSAL HORN; SYNAPTIC TRANSMISSION; UPREGULATION;

CARBENOXOLONE (CBX); CXCL1; CXCR2; HEMICHANNELS; NEURO-GLIAL INTERACTION;

ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; CELLS, CULTURED; CHEMOKINE CXCL1; CHEMOKINES; CONNEXIN 43; DISEASE MODELS, ANIMAL; HYPERALGESIA; INJECTIONS, SPINAL; MICE; MICE, TRANSGENIC; NEURALGIA; PEPTIDES; RECEPTORS, INTERLEUKIN-8B; SPINAL CORD; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84905025755     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awu140     Document Type: Article

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