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Volumn 134, Issue 4, 2011, Pages 1127-1139

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

Author keywords

astrocytes; neuropathic pain; proliferation; rats; STAT3

Indexed keywords

FLAVOPIRIDOL; JANUS KINASE; STAT3 PROTEIN;

EID: 79953660904     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awr025     Document Type: Article
Times cited : (269)

References (69)
  • 1
    • 32244442392 scopus 로고    scopus 로고
    • Mechanisms of disease: Neuropathic pain - A clinical perspective
    • DOI 10.1038/ncpneuro0113, PII N0113
    • Baron R. Mechanisms of disease: neuropathic pain-a clinical perspective. Nat Clin Pract Neurol 2006; 2: 95-106. (Pubitemid 43210250)
    • (2006) Nature Clinical Practice Neurology , vol.2 , Issue.2 , pp. 95-106
    • Baron, R.1
  • 3
    • 35648982325 scopus 로고    scopus 로고
    • Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury
    • DOI 10.1093/brain/awm179
    • Byrnes KR, Stoica BA, Fricke S, Di Giovanni S, Faden AI. Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain 2007; 130: 2977-92. (Pubitemid 350033958)
    • (2007) Brain , vol.130 , Issue.11 , pp. 2977-2992
    • Byrnes, K.R.1    Stoica, B.A.2    Fricke, S.3    Di Giovanni, S.4    Faden, A.I.5
  • 6
    • 67651048942 scopus 로고    scopus 로고
    • Neuropathic pain: A maladaptive response of the nervous system to damage
    • Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci 2009; 32: 1-32.
    • (2009) Annu Rev Neurosci , vol.32 , pp. 1-32
    • Costigan, M.1    Scholz, J.2    Woolf, C.J.3
  • 8
    • 0032079675 scopus 로고    scopus 로고
    • Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior
    • DOI 10.1002/(SICI)1098-1136(199805) 23:1<75::AID-GLIA7>3.0.CO;2-3
    • Coyle DE. Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior. Glia 1998; 23: 75-83. (Pubitemid 28174047)
    • (1998) GLIA , vol.23 , Issue.1 , pp. 75-83
    • Coyle, D.E.1
  • 10
    • 77951533730 scopus 로고    scopus 로고
    • SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury
    • Dominguez E, Mauborgne A, Mallet J, Desclaux M, Pohl M. SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury. J Neurosci 2010; 30: 5754-66.
    • (2010) J Neurosci , vol.30 , pp. 5754-66
    • Dominguez, E.1    Mauborgne, A.2    Mallet, J.3    Desclaux, M.4    Pohl, M.5
  • 11
    • 51849153310 scopus 로고    scopus 로고
    • JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat
    • Dominguez E, Rivat C, Pommier B, Mauborgne A, Pohl M. JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat. J Neurochem 2008; 107: 50-60.
    • (2008) J Neurochem , vol.107 , pp. 50-60
    • Dominguez, E.1    Rivat, C.2    Pommier, B.3    Mauborgne, A.4    Pohl, M.5
  • 12
    • 38849178118 scopus 로고    scopus 로고
    • Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain
    • DOI 10.1016/j.pain.2007.05.002, PII S0304395907002473
    • Echeverry S, Shi XQ, Zhang J. Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain 2008; 135: 37-47. (Pubitemid 351193080)
    • (2008) Pain , vol.135 , Issue.1-2 , pp. 37-47
    • Echeverry, S.1    Shi, X.Q.2    Zhang, J.3
  • 13
    • 40449101837 scopus 로고    scopus 로고
    • Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway
    • DOI 10.1523/JNEUROSCI.5652-07.2008
    • Gadea A, Schinelli S, Gallo V. Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway. J Neurosci 2008; 28: 2394-408. (Pubitemid 351348181)
    • (2008) Journal of Neuroscience , vol.28 , Issue.10 , pp. 2394-2408
    • Gadea, A.1    Schinelli, S.2    Gallo, V.3
  • 14
    • 65249114367 scopus 로고    scopus 로고
    • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    • Gao YJ, Zhang L, Samad OA, Suter MR, Yasuhiko K, Xu ZZ, et al. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci 2009; 29: 4096-108.
    • (2009) J Neurosci , vol.29 , pp. 4096-108
    • Gao, Y.J.1    Zhang, L.2    Samad, O.A.3    Suter, M.R.4    Yasuhiko, K.5    Xu, Z.Z.6
  • 15
    • 0026051875 scopus 로고
    • Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury
    • Garrison CJ, Dougherty PM, Kajander KC, Carlton SM. Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury. Brain Res 1991; 565: 1-7.
    • (1991) Brain Res , vol.565 , pp. 1-7
    • Garrison, C.J.1    Dougherty, P.M.2    Kajander, K.C.3    Carlton, S.M.4
  • 16
    • 0029068714 scopus 로고
    • Microglial turnover in the injured CNS: Activated microglia undergo delayed DNA fragmentation following peripheral nerve injury
    • Gehrmann J, Banati RB. Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury. J Neuropathol Exp Neurol 1995; 54: 680-8.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 680-8
    • Gehrmann, J.1    Banati, R.B.2
  • 17
    • 67650819339 scopus 로고    scopus 로고
    • Spinal astrogliosis in pain models: Cause and effects
    • Hald A. Spinal astrogliosis in pain models: cause and effects. Cell Mol Neurobiol 2009; 29: 609-19.
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 609-19
    • Hald, A.1
  • 18
    • 0030828073 scopus 로고    scopus 로고
    • Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
    • DOI 10.1007/s004120050256
    • Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalli T, Brinkley BR, et al. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 1997; 106: 348-60. (Pubitemid 27510848)
    • (1997) Chromosoma , vol.106 , Issue.6 , pp. 348-360
    • Hendzel, M.J.1    Wei, Y.2    Mancini, M.A.3    Van Hooser, A.4    Ranalli, T.5    Brinkley, B.R.6    Bazett-Jones, D.P.7    Allis, C.D.8
  • 19
    • 49049091210 scopus 로고    scopus 로고
    • STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury
    • Herrmann JE, Imura T, Song B, Qi J, Ao Y, Nguyen TK, et al. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci 2008; 28: 7231-43.
    • (2008) J Neurosci , vol.28 , pp. 7231-43
    • Herrmann, J.E.1    Imura, T.2    Song, B.3    Qi, J.4    Ao, Y.5    Nguyen, T.K.6
  • 21
    • 28444486336 scopus 로고    scopus 로고
    • The function of microglia through purinergic receptors: Neuropathic pain and cytokine release
    • DOI 10.1016/j.pharmthera.2005.07.001, PII S0163725805001567
    • Inoue K. The function of microglia through purinergic receptors: neuropathic pain and cytokine release. Pharmacol Ther 2006; 109: 210-26. (Pubitemid 41740822)
    • (2006) Pharmacology and Therapeutics , vol.109 , Issue.1-2 , pp. 210-226
    • Inoue, K.1
  • 22
    • 70450212126 scopus 로고    scopus 로고
    • Microglia and neuropathic pain
    • Inoue K, Tsuda M. Microglia and neuropathic pain. Glia 2009; 57: 1469-79.
    • (2009) Glia , vol.57 , pp. 1469-79
    • Inoue, K.1    Tsuda, M.2
  • 23
    • 34447502253 scopus 로고    scopus 로고
    • Possible role of spinal astrocytes in maintaining chronic pain sensitization: Review of current evidence with focus on bFGF/JNK pathway
    • DOI 10.1017/S1740925X07000403, PII S1740925X07000403
    • Ji RR, Kawasaki Y, Zhuang ZY, Wen YR, Decosterd I. Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway. Neuron Glia Biol 2006; 2: 259-69. (Pubitemid 47074743)
    • (2006) Neuron Glia Biology , vol.2 , Issue.4 , pp. 259-269
    • Ji, R.-R.1    Kawasaki, Y.2    Zhuang, Z.-Y.3    Wen, Y.-R.4    Decosterd, I.5
  • 24
    • 48249124939 scopus 로고    scopus 로고
    • Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury
    • Katsura H, Obata K, Miyoshi K, Kondo T, Yamanaka H, Kobayashi K, et al. Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury. Glia 2008; 56: 723-33.
    • (2008) Glia , vol.56 , pp. 723-33
    • Katsura, H.1    Obata, K.2    Miyoshi, K.3    Kondo, T.4    Yamanaka, H.5    Kobayashi, K.6
  • 26
    • 0026727999 scopus 로고
    • An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992; 50: 355-63.
    • (1992) Pain , vol.50 , pp. 355-63
    • Kim, S.H.1    Chung, J.M.2
  • 27
    • 33947517578 scopus 로고    scopus 로고
    • Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury
    • DOI 10.1002/glia.20483
    • Kozai T, Yamanaka H, Dai Y, Obata K, Kobayashi K, Mashimo T, et al. Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury. Glia 2007; 55: 595-603. (Pubitemid 46474301)
    • (2007) GLIA , vol.55 , Issue.6 , pp. 595-603
    • Kozai, T.1    Yamanaka, H.2    Dai, Y.3    Obata, K.4    Kobayashi, K.5    Mashimo, T.6    Noguchi, K.7
  • 30
    • 69149085109 scopus 로고    scopus 로고
    • Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation
    • Maeda T, Kiguchi N, Kobayashi Y, Ikuta T, Ozaki M, Kishioka S. Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation. Proc Natl Acad Sci USA 2009; 106: 13076-81.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13076-81
    • Maeda, T.1    Kiguchi, N.2    Kobayashi, Y.3    Ikuta, T.4    Ozaki, M.5    Kishioka, S.6
  • 32
    • 70349984436 scopus 로고    scopus 로고
    • Current challenges in glia-pain biology
    • McMahon SB, Malcangio M. Current challenges in glia-pain biology. Neuron 2009; 64: 46-54.
    • (2009) Neuron , vol.64 , pp. 46-54
    • McMahon, S.B.1    Malcangio, M.2
  • 33
    • 57749200564 scopus 로고    scopus 로고
    • Pathological and protective roles of glia in chronic pain
    • Milligan ED, Watkins LR. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 2009; 10: 23-36.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 23-36
    • Milligan, E.D.1    Watkins, L.R.2
  • 34
    • 58149391974 scopus 로고    scopus 로고
    • Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury
    • Miyoshi K, Obata K, Kondo T, Okamura H, Noguchi K. Interleukin-18- mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. J Neurosci 2008; 28: 12775-87.
    • (2008) J Neurosci , vol.28 , pp. 12775-87
    • Miyoshi, K.1    Obata, K.2    Kondo, T.3    Okamura, H.4    Noguchi, K.5
  • 35
    • 0032968705 scopus 로고    scopus 로고
    • Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice
    • DOI 10.1046/j.1460-9568.1999.00641.x
    • Murphy PG, Ramer MS, Borthwick L, Gauldie J, Richardson PM, Bisby MA. Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice. Eur J Neurosci 1999; 11: 2243-53. (Pubitemid 29292318)
    • (1999) European Journal of Neuroscience , vol.11 , Issue.7 , pp. 2243-2253
    • Murphy, P.G.1    Ramer, M.S.2    Borthwick, L.3    Gauldie, J.4    Richardson, P.M.5    Bisby, M.A.6
  • 37
    • 0033153149 scopus 로고    scopus 로고
    • Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: Involvement of a calcium-independent protein kinase C, extracellular signal- regulated protein kinase pathway distinct from the phosphatidylinositol- specific phospholipase C/calcium pathway
    • Neary JT, Kang Y, Bu Y, Yu E, Akong K, Peters CM. Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C/calcium pathway. J Neurosci 1999; 19: 4211-20. (Pubitemid 29241075)
    • (1999) Journal of Neuroscience , vol.19 , Issue.11 , pp. 4211-4220
    • Neary, J.T.1    Kang, Y.2    Bu, Y.3    Yu, E.4    Akong, K.5    Peters, C.M.6
  • 38
    • 33750367331 scopus 로고    scopus 로고
    • Spinal Glial Activation Contributes to Postoperative Mechanical Hypersensitivity in the Rat
    • DOI 10.1016/j.jpain.2006.04.004, PII S1526590006007607
    • Obata H, Eisenach JC, Hussain H, Bynum T, Vincler M. Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat. J Pain 2006; 7: 816-22. (Pubitemid 44636363)
    • (2006) Journal of Pain , vol.7 , Issue.11 , pp. 816-822
    • Obata, H.1    Eisenach, J.C.2    Hussain, H.3    Bynum, T.4    Vincler, M.5
  • 40
    • 71449108959 scopus 로고    scopus 로고
    • Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyei-cosatetraenoic acid-induced vascular smooth muscle cell migration
    • Potula HS, Wang D, Quyen DV, Singh NK, Kundumani-Sridharan V, Karpurapu M, et al. Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyei-cosatetraenoic acid-induced vascular smooth muscle cell migration. J Biol Chem 2009; 284: 31142-55.
    • (2009) J Biol Chem , vol.284 , pp. 31142-55
    • Potula, H.S.1    Wang, D.2    Quyen, D.V.3    Singh, N.K.4    Kundumani-Sridharan, V.5    Karpurapu, M.6
  • 41
    • 33746570647 scopus 로고    scopus 로고
    • Tracking STAT nuclear traffic
    • DOI 10.1038/nri1885, PII NRI1885
    • Reich NC, Liu L. Tracking STAT nuclear traffic. Nat Rev Immunol 2006; 6: 602-12. (Pubitemid 44134093)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.8 , pp. 602-612
    • Reich, N.C.1    Liu, L.2
  • 42
    • 77949727731 scopus 로고    scopus 로고
    • Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro
    • Sarafian TA, Montes C, Imura T, Qi J, Coppola G, Geschwind DH, et al. Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro. PLoS One 2010; 5: e9532.
    • (2010) PLoS One , vol.5
    • Sarafian, T.A.1    Montes, C.2    Imura, T.3    Qi, J.4    Coppola, G.5    Geschwind, D.H.6
  • 43
    • 0036829011 scopus 로고    scopus 로고
    • Can we conquer pain?
    • DOI 10.1038/nn942
    • Scholz J, Woolf CJ. Can we conquer pain? Nat Neurosci 2002; 5 (Suppl): 1062-7. (Pubitemid 35247200)
    • (2002) Nature Neuroscience , vol.5 , Issue.SUPPL. , pp. 1062-1067
    • Scholz, J.1    Woolf, C.J.2
  • 44
    • 35548937457 scopus 로고    scopus 로고
    • The neuropathic pain triad: Neurons, immune cells and glia
    • DOI 10.1038/nn1992, PII NN1992
    • Scholz J, Woolf CJ. The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 2007; 10: 1361-8. (Pubitemid 350014681)
    • (2007) Nature Neuroscience , vol.10 , Issue.11 , pp. 1361-1368
    • Scholz, J.1    Woolf, C.J.2
  • 47
    • 52349106749 scopus 로고    scopus 로고
    • Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function
    • Shinohara A, Koyanagi S, Hamdan AM, Matsunaga N, Aramaki H, Ohdo S. Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function. Life Sci 2008; 83: 574-80.
    • (2008) Life Sci , vol.83 , pp. 574-80
    • Shinohara, A.1    Koyanagi, S.2    Hamdan, A.M.3    Matsunaga, N.4    Aramaki, H.5    Ohdo, S.6
  • 48
    • 70449678738 scopus 로고    scopus 로고
    • Molecular dissection of reactive astrogliosis and glial scar formation
    • Sofroniew MV. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 2009; 32: 638-47.
    • (2009) Trends Neurosci , vol.32 , pp. 638-47
    • Sofroniew, M.V.1
  • 50
    • 2442496280 scopus 로고    scopus 로고
    • Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: Key signaling pathway for astrogliosis in vivo?
    • DOI 10.1074/jbc.M309304200
    • Sriram K, Benkovic SA, Hebert MA, Miller DB, O'Callaghan JP. Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegen-eration: key signaling pathway for astrogliosis in vivo? J Biol Chem 2004; 279: 19936-47. (Pubitemid 38623436)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.19 , pp. 19936-19947
    • Sriram, K.1    Benkovic, S.A.2    Hebert, M.A.3    Miller, D.B.4    O'Callaghan, J.P.5
  • 51
    • 42649097577 scopus 로고    scopus 로고
    • Do glial cells control pain?
    • DOI 10.1017/S1740925X08000100, PII S1740925X08000100
    • Suter MR, Wen YR, Decosterd I, Ji RR. Do glial cells control pain? Neuron Glia Biol 2007; 3: 255-68. (Pubitemid 351594231)
    • (2007) Neuron Glia Biology , vol.3 , Issue.3 , pp. 255-268
    • Suter, M.R.1    Wen, Y.-R.2    Decosterd, I.3    Ji, R.-R.4
  • 52
    • 0347917093 scopus 로고    scopus 로고
    • Cell-cycle targeted therapies
    • DOI 10.1016/S1470-2045(03)01321-4
    • Swanton C. Cell-cycle targeted therapies. Lancet Oncol 2004; 5: 27-36. (Pubitemid 38072557)
    • (2004) Lancet Oncology , vol.5 , Issue.1 , pp. 27-36
    • Swanton, C.1
  • 53
    • 0347814979 scopus 로고    scopus 로고
    • Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain
    • DOI 10.1016/j.neuint.2003.06.002, PII S0197018603003024
    • Tanga FY, Raghavendra V, DeLeo JA. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Neurochem Int 2004; 45: 397-407. (Pubitemid 38625630)
    • (2004) Neurochemistry International , vol.45 , Issue.2-3 , pp. 397-407
    • Tanga, F.Y.1    Raghavendra, V.2    DeLeo, J.A.3
  • 54
    • 33646766812 scopus 로고    scopus 로고
    • Role of astrocytic S100β in behavioral hypersensitivity in rodent models of neuropathic pain
    • DOI 10.1016/j.neuroscience.2006.02.070, PII S0306452206003046
    • Tanga FY, Raghavendra V, Nutile-McMenemy N, Marks A, Deleo JA. Role of astrocytic S100beta in behavioral hypersensitivity in rodent models of neuropathic pain. Neuroscience 2006; 140: 1003-10. (Pubitemid 43767469)
    • (2006) Neuroscience , vol.140 , Issue.3 , pp. 1003-1010
    • Tanga, F.Y.1    Raghavendra, V.2    Nutile-McMenemy, N.3    Marks, A.4    DeLeo, J.A.5
  • 55
    • 33845209203 scopus 로고    scopus 로고
    • BrdU immunohistochemistry for studying adult neurogenesis: Paradigms, pitfalls, limitations, and validation
    • DOI 10.1016/j.brainresrev.2006.08.002, PII S0165017306001044
    • Taupin P. BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation. Brain Res Rev 2007; 53: 198-214. (Pubitemid 44854215)
    • (2007) Brain Research Reviews , vol.53 , Issue.1 , pp. 198-214
    • Taupin, P.1
  • 56
    • 63849192564 scopus 로고    scopus 로고
    • P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation
    • Trang T, Beggs S, Wan X, Salter MW. P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J Neurosci 2009; 29: 3518-28.
    • (2009) J Neurosci , vol.29 , pp. 3518-28
    • Trang, T.1    Beggs, S.2    Wan, X.3    Salter, M.W.4
  • 57
    • 13144276331 scopus 로고    scopus 로고
    • Neuropathic pain and spinal microglia: A big problem from molecules in 'small' glia
    • DOI 10.1016/j.tins.2004.12.002, PII S0166223604003698
    • Tsuda M, Inoue K, Salter MW. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci 2005; 28: 101-7. (Pubitemid 40178927)
    • (2005) Trends in Neurosciences , vol.28 , Issue.2 , pp. 101-107
    • Tsuda, M.1    Inoue, K.2    Salter, M.W.3
  • 59
    • 0042968804 scopus 로고    scopus 로고
    • 4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    • DOI 10.1038/nature01786
    • Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 2003; 424: 778-83. (Pubitemid 37021707)
    • (2003) Nature , vol.424 , Issue.6950 , pp. 778-783
    • Tsuda, M.1    Shigemoto-Mogami, Y.2    Koizumi, S.3    Mizokoshi, A.4    Kohsaka, S.5    Salter, M.W.6    Inoue, K.7
  • 60
    • 34249714208 scopus 로고    scopus 로고
    • Age-related changes in the spinal cord microglial and astrocytic response profile to nerve injury
    • DOI 10.1016/j.bbi.2006.10.007, PII S0889159106003461, Neuropathic Pain, Glia and Cytokines
    • Vega-Avelaira D, Moss A, Fitzgerald M. Age-related changes in the spinal cord microglial and astrocytic response profile to nerve injury. Brain Behav Immun 2007; 21: 617-23. (Pubitemid 46829770)
    • (2007) Brain, Behavior, and Immunity , vol.21 , Issue.5 , pp. 617-623
    • Vega-Avelaira, D.1    Moss, A.2    Fitzgerald, M.3
  • 61
    • 33748783123 scopus 로고    scopus 로고
    • P2 purinergic receptors signal to STAT3 in astrocytes: Difference in STAT3 responses to P2Y and P2X receptor activation
    • DOI 10.1016/j.neuroscience.2006.06.034, PII S0306452206008694
    • Washburn KB, Neary JT. P2 purinergic receptors signal to STAT3 in astrocytes: difference in STAT3 responses to P2Y and P2X receptor activation. Neuroscience 2006; 142: 411-23. (Pubitemid 44415340)
    • (2006) Neuroscience , vol.142 , Issue.2 , pp. 411-423
    • Washburn, K.B.1    Neary, J.T.2
  • 62
    • 0035426434 scopus 로고    scopus 로고
    • Glial activation: A driving force for pathological pain
    • DOI 10.1016/S0166-2236(00)01854-3, PII S0166223600018543
    • Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends Neurosci 2001; 24: 450-5. (Pubitemid 32695356)
    • (2001) Trends in Neurosciences , vol.24 , Issue.8 , pp. 450-455
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 63
    • 0033526651 scopus 로고    scopus 로고
    • Neuropathic pain: Aetiology, symptoms, mechanisms, and management
    • Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 1999; 353: 1959-64.
    • (1999) Lancet , vol.353 , pp. 1959-64
    • Woolf, C.J.1    Mannion, R.J.2
  • 64
    • 0034625770 scopus 로고    scopus 로고
    • Neuronal plasticity: Increasing the gain in pain
    • Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science 2000; 288: 1765-9.
    • (2000) Science , vol.288 , pp. 1765-9
    • Woolf, C.J.1    Salter, M.W.2
  • 65
    • 2442685645 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
    • DOI 10.1038/sj.onc.1207383
    • Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, et al. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004; 23: 3550-60. (Pubitemid 38658421)
    • (2004) Oncogene , vol.23 , Issue.20 , pp. 3550-3560
    • Xie, T.-X.1    Wei, D.2    Liu, M.3    Gao, A.C.4    Ali-Osman, F.5    Sawaya, R.6    Huang, S.7
  • 66
    • 33847795830 scopus 로고    scopus 로고
    • Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by κ opioid activation of p38 mitogen-activated protein kinase
    • DOI 10.1523/JNEUROSCI.3728-06.2007
    • Xu M, Bruchas MR, Ippolito DL, Gendron L, Chavkin C. Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. J Neurosci 2007; 27: 2570-81. (Pubitemid 46393593)
    • (2007) Journal of Neuroscience , vol.27 , Issue.10 , pp. 2570-2581
    • Xu, M.1    Bruchas, M.R.2    Ippolito, D.L.3    Gendron, L.4    Chavkin, C.5
  • 67
    • 33847749886 scopus 로고    scopus 로고
    • Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo
    • DOI 10.1002/glia.20476
    • Zhu Z, Zhang Q, Yu Z, Zhang L, Tian D, Zhu S, et al. Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. Glia 2007; 55: 546-58. (Pubitemid 46383184)
    • (2007) GLIA , vol.55 , Issue.5 , pp. 546-558
    • Zhu, Z.1    Zhang, Q.2    Yu, Z.3    Zhang, L.4    Tian, D.5    Zhu, S.6    Bu, B.7    Xie, M.8    Wang, W.9
  • 68
    • 14044252008 scopus 로고    scopus 로고
    • ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    • DOI 10.1016/j.pain.2004.12.022
    • Zhuang ZY, Gerner P, Woolf CJ, Ji RR. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 2005; 114: 149-59. (Pubitemid 40279096)
    • (2005) Pain , vol.114 , Issue.1-2 , pp. 149-159
    • Zhuang, Z.-Y.1    Gerner, P.2    Woolf, C.J.3    Ji, R.-R.4
  • 69
    • 33645460235 scopus 로고    scopus 로고
    • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: Respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    • Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR, et al. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J Neurosci 2006; 26: 3551-60.
    • (2006) J Neurosci , vol.26 , pp. 3551-60
    • Zhuang, Z.Y.1    Wen, Y.R.2    Zhang, D.R.3    Borsello, T.4    Bonny, C.5    Strichartz, G.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.