FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 52, 2010, Pages 22659-22664

  Garré, Juan M ^a,b   Retamal, Mauricio A ^c,d   Cassina, Patricia ^a   Barbeito, Luis ^e   Bukauskas, Feliksas F ^b   Sáez, Juan C ^c,d,e   Bennett, Michael V L ^b   Abudara, Verónica ^a  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^d Núcleo Milenio de Inmunología e Inmunoterapia   (Chile)

^e INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

Author keywords

Astroglia; Connexon; Growth factor; Neurodegeneration; Pannexon

Indexed keywords

ADENOSINE TRIPHOSPHATE; APYRASE; BOTULINUM TOXIN A; CONNEXIN 43; FIBROBLAST GROWTH FACTOR 1; MEMBRANE PROTEIN; PANNEXIN 1; PROTEIN INHIBITOR; PURINERGIC P2X RECEPTOR; PURINERGIC P2X RECEPTOR ANTAGONIST; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; AUTOCRINE EFFECT; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL PROTECTION; CELL VACUOLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; EXTRACELLULAR SPACE; GAP JUNCTION; INFLAMMATION; INVERTEBRATE; MAMMAL; NERVE CELL; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SPINAL CORD INJURY; SPINE;

INVERTEBRATA; MAMMALIA; MUS;

EID: 78651081496     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1013793107     Document Type: Article

References (49)

1. Söhl G, Willecke K (2004) Gap junctions and the connexin protein family. Cardiovasc Res 62:228-232.
2. Bennett MVL, Zukin RS (2004) Electrical coupling and neuronal synchronization in the mammalian brain. Neuron 41:495-511.
3. Bennett MVL, Contreras JE, Bukauskas FF, Sáez JC (2003) Gating and regulation of connexin 43 (Cx43) hemichannels. Trends Neurosci 26:610-617.
4. Orellana JA, et al. (2009) Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal 11:369-399.
5. Huang Y, Grinspan JB, Abrams CK, Scherer SS (2007) Pannexin1 is expressed by neurons and glia but does not form functional gap junctions. Glia 55:46-56.
6. Bruzzone R, Hormuzdi SG, Barbe MT, Herb A, Monyer H (2003) Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci USA 100:13644-13649.
7. MacVicar BA, Thompson RJ (2010) Non-junction functions of pannexin-1 channels. Trends Neurosci 33:93-102.
8. Ma W, Hui H, Pelegrin P, Surprenant A (2009) Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J Pharmacol Exp Ther 328:409-418.
9. Lai CP, et al. (2007) Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Cancer Res 67:1545-1554.
10. 7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J Neurosci 26:1378-1385.
11. North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067.
12. Locovei S, Bao L, Dahl G (2006) Pannexin 1 in erythrocytes: Function without a gap. Proc Natl Acad Sci USA 103:7655-7659.
13. 7 receptor-operated single-channel currents. Biophys J 93:846-858.
14. Yan Z, et al. (2010) Experimental characterization and mathematical modeling of P2X7 receptor channel gating. J Neurosci 30:14213-14224.
15. De Vuyst E, et al. (2007) Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor. Mol Biol Cell 18:34-46.
16. Retamal MA, et al. (2007) Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci 27:13781-13792.
17. Wang X, et al. (2004) P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med 10:821-827.
18. Lin JH, et al. (2008) A central role of connexin 43 in hypoxic preconditioning. J Neurosci 28:681-695.
19. Koshinaga M, Sanon HR, Whittemore SR (1993) Altered acidic and basic fibroblast growth factor expression following spinal cord injury. Exp Neurol 120:32-48.
20. Reuss B, von Bohlen und Halbach O (2003) Fibroblast growth factors and their receptors in the central nervous system. Cell Tissue Res 313:139-157.
21. Cassina P, et al. (2005) Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: Implications for amyotrophic lateral sclerosis. J Neurochem 93:38-46.
22. MarchettoMC, et al. (2008)Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3:649-657.
23. Tardieu M, Gamby C, Avramoglou T, Jozefonvicz J, Barritault D (1992) Derivatized dextrans mimic heparin as stabilizers, potentiators, and protectors of acidic or basic FGF. J Cell Physiol 150:194-203.
24. Garré JM (2005) Connexins Hemichannels: Regulation by FGF-1 and ATP. Master's thesis [Programa para el Desarrollo de la Ciencias Basicas (PEDECIBA), Universidad de la Republica Oriental del Uruguay, Montevideo].
25. Contreras JE, et al. (2002) Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci USA 99:495-500.
26. 7) receptor death complex. FEBS Lett 581:483-488.
27. Bansal R, Magge S, Winkler S (2003) Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells. J Neurosci Res 74:486-493.
28. Reaume AG, et al. (1995) Cardiac malformation in neonatal mice lacking connexin43. Science 267:1831-1834.
29. Iglesias R, Dahl G, Qiu F, Spray DC, Scemes E (2009) Pannexin 1: The molecular substrate of astrocyte "hemichannels". J Neurosci 29:7092-7097.
30. Dolly JO, Aoki KR (2006) The structure and mode of action of different botulinum toxins. Eur J Neurol 13(Suppl 4):1-9.
31. Tay S, et al. (2010) Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature 466:267-271.
32. Zhang Y, Barres BA (2010) Astrocyte heterogeneity: An underappreciated topic in neurobiology. Curr Opin Neurobiol 20:588-594.
33. Simon J, Webb TE, King BF, Burnstock G, Barnard EA (1995) Characterisation of a recombinant P2Y purinoceptor. Eur J Pharmacol 291:281-289.
34. Tuluc F, Bültmann R, Glänzel M, Frahm AW, Starke K (1998) P2-receptor antagonists: IV. Blockade of P2-receptor subtypes and ecto-nucleotidases by compounds related to reactive blue 2. Naunyn Schmiedebergs Arch Pharmacol 357:111-120.
35. Reuss B, Dermietzel R, Unsicker K (1998) Fibroblast growth factor 2 (FGF-2) differentially regulates connexin (cx) 43 expression and function in astroglial cells from distinct brain regions. Glia 22:19-30.
36. Munaron L (2002) Calcium signalling and control of cell proliferation by tyrosine kinase receptors (review). Int J Mol Med 10:671-676.
37. Roberts JA, et al. (2006) Molecular properties of P2X receptors. Pflugers Arch 452: 486-500.
38. Schalper KA, et al. (2008) Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Mol Biol Cell 19:3501-3513.
39. Katz S, Boland R, Santillán G (2006) Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: Involvement of mechanical stress-activated calcium influx, PKC and Src activation. Int J Biochem Cell Biol 38:2082-2091.
40. 7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho. J Leukoc Biol 75:1173-1182.
41. Warn-Cramer BJ, Lau AF (2004) Regulation of gap junctions by tyrosine protein kinases. Biochim Biophys Acta 1662:81-95.
42. Gaietta G, et al. (2002) Multicolor and electron microscopic imaging of connexin trafficking. Science 296:503-507.
43. Giaume C, McCarthy KD (1996) Control of gap-junctional communication in astrocytic networks. Trends Neurosci 19:319-325.
44. Ye ZC, Wyeth MS, Baltan-Tekkok S, Ransom BR (2003) Functional hemichannels in astrocytes: A novel mechanism of glutamate release. J Neurosci 23:3588-3596.
45. Ilieva H, Polymenidou M, Cleveland DW (2009) Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol 187:761-772.
46. Peng W, et al. (2009) Systemic administration of anantagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc Natl Acad Sci USA 106:12489-12493.
47. Giaume C, Marin P, Cordier J, Glowinski J, Premont J (1991) Adrenergic regulation of intercellular communications between cultured striatal astrocytes from the mouse. Proc Natl Acad Sci USA 88:5577-5581.
48. Brañes MC, Contreras JE, Sáez JC (2002) Activation of human polymorphonuclear cells induces formation of functional gap junctions and expression of connexins. Med Sci Monit 8:BR313-BR323.
49. Retamal MA, Cortés CJ, Reuss L, Bennett MVL, Sáez JC (2006) S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents. Proc Natl Acad Sci USA 103:4475-4480.