Loop interactions during catalysis by dihydrofolate reductase from Moritella profunda

Biochemistry

Volumn 53, Issue 29, 2014, Pages 4769-4774

  Behiry, Enas M ^a   Evans, Rhiannon M ^a,b   Guo, Jiannan ^a   Loveridge, E Joel ^a   Allemann, Rudolf K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; ESCHERICHIA COLI;

CATALYTIC CYCLES; DIFFERENT EFFECTS; DIHYDROFOLATE REDUCTASE; LOOP INTERACTION; MODEL SYSTEM; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATES; PROTEIN DYNAMICS; TURNOVER RATE;

CATALYSIS;

DIHYDROFOLATE REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; BACTERIAL PROTEIN; DIHYDROFOLIC ACID; FOLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ESCHERICHIA COLI; MORITELLA; MORITELLA PROFUNDA; MUTATION; NONHUMAN; PH; PRIORITY JOURNAL; STEADY STATE; TURNOVER TIME; ANALOGS AND DERIVATIVES; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; OXIDATION REDUCTION REACTION; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE;

BACTERIAL PROTEINS; BIOCATALYSIS; ESCHERICHIA COLI; FOLIC ACID; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MORITELLA; MUTAGENESIS, SITE-DIRECTED; NADP; OXIDATION-REDUCTION; PROTEIN CONFORMATION; SPECIES SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84904959826     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500508z     Document Type: Article

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