메뉴 건너뛰기




Volumn 26, Issue 30, 2007, Pages 4428-4434

In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma

Author keywords

Haploinsufficiency; KLF6; Kruppel like factor; p21; Tumor suppressor gene

Indexed keywords

CYCLINE; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 6; MESSENGER RNA; PROTEIN P21; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 34347358573     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210223     Document Type: Article
Times cited : (71)

References (36)
  • 2
    • 2542628097 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor proteinthrough interactionwith cyclin D1
    • Benzeno S, Narla G, Allina J, Cheng GZ, Reeves HL, Banck MS et al. (2004). Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor proteinthrough interactionwith cyclin D1. Cancer Res 64: 3885-3891.
    • (2004) Cancer Res , vol.64 , pp. 3885-3891
    • Benzeno, S.1    Narla, G.2    Allina, J.3    Cheng, G.Z.4    Reeves, H.L.5    Banck, M.S.6
  • 3
    • 0035860820 scopus 로고    scopus 로고
    • Kruppel-like factors: Three fingers in many pies
    • Bieker JJ. (2001). Kruppel-like factors: three fingers in many pies. J Biol Chem 276: 34355-34358.
    • (2001) J Biol Chem , vol.276 , pp. 34355-34358
    • Bieker, J.J.1
  • 4
    • 0019226759 scopus 로고
    • Phenotypic stability of adult rat hepatocytes inprimary monolayer culture
    • Bissell DM, Guzelian PS. (1980). Phenotypic stability of adult rat hepatocytes inprimary monolayer culture. Ann N Y Acad Sci 349: 85-98.
    • (1980) Ann N Y Acad Sci , vol.349 , pp. 85-98
    • Bissell, D.M.1    Guzelian, P.S.2
  • 5
    • 0036893431 scopus 로고    scopus 로고
    • Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between sp1 and KLF6: Their potential role in the response to vascular injury
    • Botella LM, Sanchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M et al. (2002). Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between sp1 and KLF6: their potential role in the response to vascular injury. Blood 100: 4001-4010.
    • (2002) Blood , vol.100 , pp. 4001-4010
    • Botella, L.M.1    Sanchez-Elsner, T.2    Sanz-Rodriguez, F.3    Kojima, S.4    Shimada, J.5    Guerrero-Esteo, M.6
  • 6
    • 14244254888 scopus 로고    scopus 로고
    • Absence of KLF6 gene mutation in 71 hepatocellular carcinomas
    • author reply 682-683
    • Boyault S, Herault A, Balabaud C, Zucman-Rossi J. (2005). Absence of KLF6 gene mutation in 71 hepatocellular carcinomas. Hepatology 41: 681-682 author reply 682-683.
    • (2005) Hepatology , vol.41 , pp. 681-682
    • Boyault, S.1    Herault, A.2    Balabaud, C.3    Zucman-Rossi, J.4
  • 8
    • 0036824877 scopus 로고    scopus 로고
    • Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas
    • Chen HK, Liu XQ, Lin J, Chen TY, Feng QS, Zeng YX. (2002). Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas. Ai Zheng 21: 1047-1050.
    • (2002) Ai Zheng , vol.21 , pp. 1047-1050
    • Chen, H.K.1    Liu, X.Q.2    Lin, J.3    Chen, T.Y.4    Feng, Q.S.5    Zeng, Y.X.6
  • 11
    • 33745725772 scopus 로고    scopus 로고
    • Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination
    • DiFeo A, Narla G, Hirshfeld J, Camacho-Vanegas O, Narla J, Rose SL et al. (2006). Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination. Clin Cancer Res 12: 3730-3739.
    • (2006) Clin Cancer Res , vol.12 , pp. 3730-3739
    • DiFeo, A.1    Narla, G.2    Hirshfeld, J.3    Camacho-Vanegas, O.4    Narla, J.5    Rose, S.L.6
  • 14
    • 2542521484 scopus 로고    scopus 로고
    • Kruppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells
    • Ito G, Uchiyama M., Kondo M, Mori S, Usami N, Maeda O et al. (2004). Kruppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells. Cancer Res 64: 3838-3843.
    • (2004) Cancer Res , vol.64 , pp. 3838-3843
    • Ito, G.1    Uchiyama, M.2    Kondo, M.3    Mori, S.4    Usami, N.5    Maeda, O.6
  • 15
    • 0038174752 scopus 로고    scopus 로고
    • KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas
    • Jeng YM, Hsu HC. (2003). KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas. Int J Cancer 105: 625-629.
    • (2003) Int J Cancer , vol.105 , pp. 625-629
    • Jeng, Y.M.1    Hsu, H.C.2
  • 16
    • 10744224693 scopus 로고    scopus 로고
    • Differentially expressed genes in nonsmall cell lung cancer: Expression profiling of cancer-related genes in squamous cell lung cancer
    • Kettunen E, Anttila S, Seppanen JK, Karjalainen A, Edgren H, Lindstrom I et al. (2004). Differentially expressed genes in nonsmall cell lung cancer: Expression profiling of cancer-related genes in squamous cell lung cancer. Cancer Genet Cytogenet 149: 98-106.
    • (2004) Cancer Genet Cytogenet , vol.149 , pp. 98-106
    • Kettunen, E.1    Anttila, S.2    Seppanen, J.K.3    Karjalainen, A.4    Edgren, H.5    Lindstrom, I.6
  • 17
    • 0032509217 scopus 로고    scopus 로고
    • Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury
    • Kim Y, Ratziu V, Choi SG, Lalazar A, Theiss G, Dang Q et al. (1998). Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury. J Biol Chem 273: 33750-33758.
    • (1998) J Biol Chem , vol.273 , pp. 33750-33758
    • Kim, Y.1    Ratziu, V.2    Choi, S.G.3    Lalazar, A.4    Theiss, G.5    Dang, Q.6
  • 18
    • 3042784094 scopus 로고    scopus 로고
    • Suppressionof glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6
    • Kimmelman AC, Qiao RF, Narla G, Banno A, Lau N, Bos PD et al. (2004). Suppressionof glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6. Oncogene 23: 5077-5083.
    • (2004) Oncogene , vol.23 , pp. 5077-5083
    • Kimmelman, A.C.1    Qiao, R.F.2    Narla, G.3    Banno, A.4    Lau, N.5    Bos, P.D.6
  • 19
    • 34347355610 scopus 로고    scopus 로고
    • Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation
    • Nov 27 [Epub ahead of print
    • Kremer-Tal S, Narla G, ChenY, Hod E, DiFeo A, Yea S et al. (2006). Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. J Hepatol Nov 27 [Epub ahead of print].
    • (2006) J Hepatol
    • Kremer-Tal, S.1    Narla, G.2    Chen, Y.3    Hod, E.4    DiFeo, A.5    Yea, S.6
  • 20
    • 7044246221 scopus 로고    scopus 로고
    • Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) inhepatocellular carcinoma
    • Kremer-Tal S, Reeves HL, Narla G, Thung SN, Schwartz M, Difeo A et al. (2004). Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) inhepatocellular carcinoma. Hepatology 40: 1047-1052.
    • (2004) Hepatology , vol.40 , pp. 1047-1052
    • Kremer-Tal, S.1    Reeves, H.L.2    Narla, G.3    Thung, S.N.4    Schwartz, M.5    Difeo, A.6
  • 22
    • 4544273428 scopus 로고    scopus 로고
    • Classificationan d prediction of survival inhepatocellular carcinoma by gene expression profiling
    • Lee JS, Chu IS, Heo J, Calvisi DF, SunZ, Roskams T et al. (2004). Classificationan d prediction of survival inhepatocellular carcinoma by gene expression profiling. Hepatology 40: 667-676.
    • (2004) Hepatology , vol.40 , pp. 667-676
    • Lee, J.S.1    Chu, I.S.2    Heo, J.3    Calvisi, D.F.4    Sun, Z.5    Roskams, T.6
  • 23
    • 32644441129 scopus 로고    scopus 로고
    • Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6
    • Matsumoto N, Kubo A, Liu H, Akita K, Laub F, Ramirez F et al. (2006). Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood 107: 1357-1365.
    • (2006) Blood , vol.107 , pp. 1357-1365
    • Matsumoto, N.1    Kubo, A.2    Liu, H.3    Akita, K.4    Laub, F.5    Ramirez, F.6
  • 24
    • 13944252065 scopus 로고    scopus 로고
    • A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk
    • Narla G, Difeo A, Reeves HL, Schaid DJ, Hirshfeld J, Hod E et al. (2005). A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. Cancer Res 65: 1213-1222.
    • (2005) Cancer Res , vol.65 , pp. 1213-1222
    • Narla, G.1    Difeo, A.2    Reeves, H.L.3    Schaid, D.J.4    Hirshfeld, J.5    Hod, E.6
  • 25
    • 0037377699 scopus 로고    scopus 로고
    • Kruppel cripples prostate cancer: KLF6 progress and prospects
    • Narla G, FriedmanSL, Martignetti JA. (2003). Kruppel cripples prostate cancer: KLF6 progress and prospects. Am J Pathol 162: 1047-1052.
    • (2003) Am J Pathol , vol.162 , pp. 1047-1052
    • Narla, G.1    Friedman, S.L.2    Martignetti, J.A.3
  • 26
  • 27
    • 34347337761 scopus 로고    scopus 로고
    • Inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) by mutationor decreased expressionin hepatocellular carcinomas
    • Pan XC, Chen Z, Chen F, Chen XH, Jin HY, Xu XY. (2006). Inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) by mutationor decreased expressionin hepatocellular carcinomas. J Zhejiang Univ Sci B 7: 830-836.
    • (2006) J Zhejiang Univ Sci B , vol.7 , pp. 830-836
    • Pan, X.C.1    Chen, Z.2    Chen, F.3    Chen, X.H.4    Jin, H.Y.5    Xu, X.Y.6
  • 28
    • 11144357280 scopus 로고    scopus 로고
    • Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer
    • Reeves HL, Narla G, Ogunbiyi O, Haq AI, Katz A, Benzeno S et al. (2004). Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. Gastroenterology 126: 1090-1103.
    • (2004) Gastroenterology , vol.126 , pp. 1090-1103
    • Reeves, H.L.1    Narla, G.2    Ogunbiyi, O.3    Haq, A.I.4    Katz, A.5    Benzeno, S.6
  • 30
    • 8844286089 scopus 로고    scopus 로고
    • A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-jun proto-oncoprotein function
    • Slavin DA, Koritschoner NP, Prieto CC, Lopez-Diaz FJ, ChattonB, Bocco JL. (2004). A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-jun proto-oncoprotein function. Oncogene 23: 8196-8205.
    • (2004) Oncogene , vol.23 , pp. 8196-8205
    • Slavin, D.A.1    Koritschoner, N.P.2    Prieto, C.C.3    Lopez-Diaz, F.J.4    Chatton, B.5    Bocco, J.L.6
  • 31
    • 33745855527 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations of the KLF6 gene inhepatocellular carcinoma
    • Song J, Kim CJ, Cho YG, Kim SY, Nam SW, Lee SH et al. (2006). Genetic and epigenetic alterations of the KLF6 gene inhepatocellular carcinoma. J Gastroenterol Hepatol 21: 1286-1289.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 1286-1289
    • Song, J.1    Kim, C.J.2    Cho, Y.G.3    Kim, S.Y.4    Nam, S.W.5    Lee, S.H.6
  • 32
    • 26444575972 scopus 로고    scopus 로고
    • Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenity testing
    • Venkatachalam S, Tyner SD, Pickering CR, Boley S, Recio L, French JE et al. (2001). Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenity testing. Toxicol Pathol 29(Suppl): 147-154.
    • (2001) Toxicol Pathol , vol.29 , Issue.SUPPL. , pp. 147-154
    • Venkatachalam, S.1    Tyner, S.D.2    Pickering, C.R.3    Boley, S.4    Recio, L.5    French, J.E.6
  • 34
    • 27144454089 scopus 로고    scopus 로고
    • A candidate tumor suppressor gene mutated in primary hepatocellular carcinoma: Kruppel-like factor 6
    • Wang SP, Chen XP, Qiu FZ. (2004). A candidate tumor suppressor gene mutated in primary hepatocellular carcinoma: Kruppel-like factor 6. Zhonghua Wai Ke Za Zhi 42: 1258-1261.
    • (2004) Zhonghua Wai Ke Za Zhi , vol.42 , pp. 1258-1261
    • Wang, S.P.1    Chen, X.P.2    Qiu, F.Z.3
  • 35
    • 0038351924 scopus 로고    scopus 로고
    • Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6
    • Warke VG, Nambiar MP, Krishnan S, Tenbrock K, Geller DA, Koritschoner NP et al. (2003). Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6. J Biol Chem 278: 14812-14819.
    • (2003) J Biol Chem , vol.278 , pp. 14812-14819
    • Warke, V.G.1    Nambiar, M.P.2    Krishnan, S.3    Tenbrock, K.4    Geller, D.A.5    Koritschoner, N.P.6
  • 36
    • 0030067581 scopus 로고    scopus 로고
    • Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration
    • Wu H, Wade M, Krall L, Grisham J, Xiong Y, Van Dyke T. (1996). Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration. Genes Dev 10: 245-260.
    • (1996) Genes Dev , vol.10 , pp. 245-260
    • Wu, H.1    Wade, M.2    Krall, L.3    Grisham, J.4    Xiong, Y.5    Van Dyke, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.