메뉴 건너뛰기




Volumn 73, Issue 15, 2013, Pages 4599-4605

A road map to comprehensive androgen receptor axis targeting for castration-resistant prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

ABIRATERONE; ANDROGEN; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ANTAGONIST; ANTINEOPLASTIC AGENT; ARN 509; DUTASTERIDE; ENZALUTAMIDE; GALETERONE; GLUCOCORTICOID; GONADORELIN DERIVATIVE; HYDROCORTISONE; KETOCONAZOLE; ORTERONEL; UNCLASSIFIED DRUG;

EID: 84881403991     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-4414     Document Type: Review
Times cited : (81)

References (49)
  • 1
    • 84870325099 scopus 로고    scopus 로고
    • The AR axis as a pathogenetic mechanism and therapeutic target throughout the clinical states of prostate cancer: Opportunities for second-line hormonal manipulations in castration-resistant prostate cancer
    • Scardino PT, Linehan WM, Zelefsky MJ, editors. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins
    • Mitsiades N, Chen Y, Scher HI. The AR axis as a pathogenetic mechanism and therapeutic target throughout the clinical states of prostate cancer: Opportunities for second-line hormonal manipulations in castration-resistant prostate cancer. In: Scardino PT, Linehan WM, Zelefsky MJ, editors. Comprehensive textbook of genitourinary oncology. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2011. p. 262-73.
    • (2011) Comprehensive Textbook of Genitourinary Oncology , pp. 262-273
    • Mitsiades, N.1    Chen, Y.2    Scher, H.I.3
  • 2
    • 84928580276 scopus 로고
    • Studies on prostatic cancer: I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins C, Hodges CV. Studies on prostatic cancer: I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1941;1: 293-7.
    • (1941) Cancer Res , vol.1 , pp. 293-297
    • Huggins, C.1    Hodges, C.V.2
  • 5
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res 2006;66:2815-25.
    • (2006) Cancer Res , vol.66 , pp. 2815-2825
    • Stanbrough, M.1    Bubley, G.J.2    Ross, K.3    Golub, T.R.4    Rubin, M.A.5    Penning, T.M.6
  • 6
    • 0021220507 scopus 로고
    • Comparison of prostatic cancer tissue dihydrotestosterone levels at the time of relapse following orchiectomy or estrogen therapy
    • Geller J, Albert JD, Nachtsheim DA, Loza D. Comparison of prostatic cancer tissue dihydrotestosterone levels at the time of relapse following orchiectomy or estrogen therapy. J Urol 1984;132:693-6.
    • (1984) J Urol , vol.132 , pp. 693-696
    • Geller, J.1    Albert, J.D.2    Nachtsheim, D.A.3    Loza, D.4
  • 8
    • 0035300409 scopus 로고    scopus 로고
    • Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen
    • Gregory CW, Johnson RT Jr, Mohler JL, French FS, Wilson EM. Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen. Cancer Res 2001;61: 2892-8.
    • (2001) Cancer Res , vol.61 , pp. 2892-2898
    • Gregory, C.W.1    Johnson Jr., R.T.2    Mohler, J.L.3    French, F.S.4    Wilson, E.M.5
  • 9
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    • Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 2008;68:4447-54.
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5    Higano, C.S.6
  • 10
    • 1542574202 scopus 로고    scopus 로고
    • Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance
    • Holzbeierlein J, Lal P, LaTulippe E, Smith A, Satagopan J, Zhang L, et al. Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am J Pathol 2004;164: 217-27.
    • (2004) Am J Pathol , vol.164 , pp. 217-227
    • Holzbeierlein, J.1    Lal, P.2    Latulippe, E.3    Smith, A.4    Satagopan, J.5    Zhang, L.6
  • 11
    • 84870336847 scopus 로고    scopus 로고
    • Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors
    • Mitsiades N, Sung CC, Schultz N, Danila DC, He B, Eedunuri VK, et al. Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors. Cancer Res 2012;72:6142-52.
    • (2012) Cancer Res , vol.72 , pp. 6142-6152
    • Mitsiades, N.1    Sung, C.C.2    Schultz, N.3    Danila, D.C.4    He, B.5    Eedunuri, V.K.6
  • 12
  • 13
    • 0028944138 scopus 로고
    • In vivo amplification of the androgen receptor gene and progression of human prostate cancer
    • Visakorpi T, Hyytinen E, Koivisto P, Tanner M, Keinanen R, Palmberg C, et al. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet 1995; 9:401-6.
    • (1995) Nat Genet , vol.9 , pp. 401-406
    • Visakorpi, T.1    Hyytinen, E.2    Koivisto, P.3    Tanner, M.4    Keinanen, R.5    Palmberg, C.6
  • 17
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm SM, Schmidt LJ, Heemers HV, Vessella RL, Tindall DJ. Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res 2008;68:5469-77.
    • (2008) Cancer Res , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 18
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, Humphreys E, et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 2009;69:16-22.
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1    Dunn, T.A.2    Wei, S.3    Isharwal, S.4    Veltri, R.W.5    Humphreys, E.6
  • 19
    • 33751304953 scopus 로고    scopus 로고
    • Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    • Agoulnik IU, Vaid A, Nakka M, Alvarado M, Bingman WE III, Erdem H, et al. Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. Cancer Res 2006;66:10594-602.
    • (2006) Cancer Res , vol.66 , pp. 10594-10602
    • Agoulnik, I.U.1    Vaid, A.2    Nakka, M.3    Alvarado, M.4    Bingman III, W.E.5    Erdem, H.6
  • 20
    • 24744442616 scopus 로고    scopus 로고
    • Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression
    • Agoulnik IU, Vaid A, Bingman WE III, Erdeme H, Frolov A, Smith CL, et al. Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression. Cancer Res 2005;65:7959-67.
    • (2005) Cancer Res , vol.65 , pp. 7959-7967
    • Agoulnik, I.U.1    Vaid, A.2    Bingman III, W.E.3    Erdeme, H.4    Frolov, A.5    Smith, C.L.6
  • 21
    • 69249110003 scopus 로고    scopus 로고
    • Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
    • Xu J,WuRC, O'Malley BW. Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer 2009;9:615-30.
    • (2009) Nat Rev Cancer , vol.9 , pp. 615-630
    • Xu, J.1    Wu, R.C.2    O'Malley, B.W.3
  • 23
    • 7944234374 scopus 로고    scopus 로고
    • HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability
    • Mellinghoff IK, Vivanco I, Kwon A, Tran C, Wongvipat J, Sawyers CL. HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability. Cancer Cell 2004;6:517-27.
    • (2004) Cancer Cell , vol.6 , pp. 517-527
    • Mellinghoff, I.K.1    Vivanco, I.2    Kwon, A.3    Tran, C.4    Wongvipat, J.5    Sawyers, C.L.6
  • 24
    • 0033545848 scopus 로고    scopus 로고
    • From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    • Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C. From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proc Natl Acad Sci U S A 1999;96:5458-63.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5458-5463
    • Yeh, S.1    Lin, H.K.2    Kang, H.Y.3    Thin, T.H.4    Lin, M.F.5    Chang, C.6
  • 25
    • 34347263425 scopus 로고    scopus 로고
    • Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation
    • Mahajan NP, Liu Y, Majumder S, Warren MR, Parker CE, Mohler JL, et al. Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Proc Natl Acad Sci U S A 2007;104:8438-43.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 8438-8443
    • Mahajan, N.P.1    Liu, Y.2    Majumder, S.3    Warren, M.R.4    Parker, C.E.5    Mohler, J.L.6
  • 26
    • 77953229511 scopus 로고    scopus 로고
    • Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
    • Liu Y, Karaca M, Zhang Z, Gioeli D, Earp HS, Whang YE. Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases. Oncogene 2010;29:3208-16.
    • (2010) Oncogene , vol.29 , pp. 3208-3216
    • Liu, Y.1    Karaca, M.2    Zhang, Z.3    Gioeli, D.4    Earp, H.S.5    Whang, Y.E.6
  • 27
    • 84866758890 scopus 로고    scopus 로고
    • Interim analysis (IA) results of COU-AA-302, a randomized, phase III study of abiraterone acetate (AA) in chemotherapy-naive patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)
    • abstr LBA4518
    • Ryan CJ, Smith MR, De Bono JS, Molina A, Logothetis C, De Souza PL, et al. Interim analysis (IA) results of COU-AA-302, a randomized, phase III study of abiraterone acetate (AA) in chemotherapy-naive patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol 30, 2012 (suppl; abstr LBA4518).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Ryan, C.J.1    Smith, M.R.2    De Bono, J.S.3    Molina, A.4    Logothetis, C.5    De Souza, P.L.6
  • 28
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009;324:787-90.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3    Chen, Y.4    Watson, P.A.5    Arora, V.6
  • 30
    • 80054761058 scopus 로고    scopus 로고
    • Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1
    • Cai C, He HH, Chen S, Coleman I, Wang H, Fang Z, et al. Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1. Cancer Cell 2011;20:457-71.
    • (2011) Cancer Cell , vol.20 , pp. 457-471
    • Cai, C.1    He, H.H.2    Chen, S.3    Coleman, I.4    Wang, H.5    Fang, Z.6
  • 31
    • 34250331066 scopus 로고    scopus 로고
    • Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer
    • Mostaghel EA, Page ST, Lin DW, Fazli L, Coleman IM, True LD, et al. Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res 2007;67:5033-41.
    • (2007) Cancer Res , vol.67 , pp. 5033-5041
    • Mostaghel, E.A.1    Page, S.T.2    Lin, D.W.3    Fazli, L.4    Coleman, I.M.5    True, L.D.6
  • 32
    • 8444231965 scopus 로고    scopus 로고
    • The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer
    • Nishiyama T, Hashimoto Y, Takahashi K. The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer. Clin Cancer Res 2004;10: 7121-6.
    • (2004) Clin Cancer Res , vol.10 , pp. 7121-7126
    • Nishiyama, T.1    Hashimoto, Y.2    Takahashi, K.3
  • 33
    • 13544277666 scopus 로고    scopus 로고
    • Cell proliferation and apoptosis in prostate tumors and adjacent non-malignant prostate tissue in patients at different time-points after castration treatment
    • Ohlson N, Wikstrom P, Stattin P, Bergh A. Cell proliferation and apoptosis in prostate tumors and adjacent non-malignant prostate tissue in patients at different time-points after castration treatment. Prostate 2005;62:307-15.
    • (2005) Prostate , vol.62 , pp. 307-315
    • Ohlson, N.1    Wikstrom, P.2    Stattin, P.3    Bergh, A.4
  • 34
    • 0034939517 scopus 로고    scopus 로고
    • Randomized comparative study of 3 versus 8-month neoadjuvant hormonal therapy before radical prostatectomy: Biochemical and pathological effects
    • Gleave ME, Goldenberg SL, Chin JL, Warner J, Saad F, Klotz LH, et al. Randomized comparative study of 3 versus 8-month neoadjuvant hormonal therapy before radical prostatectomy: biochemical and pathological effects. J Urol 2001;166:500-6.
    • (2001) J Urol , vol.166 , pp. 500-506
    • Gleave, M.E.1    Goldenberg, S.L.2    Chin, J.L.3    Warner, J.4    Saad, F.5    Klotz, L.H.6
  • 35
    • 0020595290 scopus 로고
    • New hormonal therapy in prostate cancer: Combined use of a pure antiandrogen and an LHRH agonist
    • Labrie F, Dupont A, Belanger A, Lefebvre FA, Cusan L, Raynaud JP, et al. New hormonal therapy in prostate cancer: combined use of a pure antiandrogen and an LHRH agonist. Horm Res 1983;18: 18-27.
    • (1983) Horm Res , vol.18 , pp. 18-27
    • Labrie, F.1    Dupont, A.2    Belanger, A.3    Lefebvre, F.A.4    Cusan, L.5    Raynaud, J.P.6
  • 36
    • 0034728828 scopus 로고    scopus 로고
    • Maximum androgen blockade in advanced prostate cancer: An overview of the randomised trials
    • Prostate Cancer Trialists' Collaborative Group
    • Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials. Prostate Cancer Trialists' Collaborative Group. Lancet 2000;355:1491-8.
    • (2000) Lancet , vol.355 , pp. 1491-1498
  • 37
    • 72549108829 scopus 로고    scopus 로고
    • Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer
    • Taplin ME, Regan MM, Ko YJ, Bubley GJ, Duggan SE, Werner L, et al. Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer. Clin Cancer Res 2009;15:7099-105.
    • (2009) Clin Cancer Res , vol.15 , pp. 7099-7105
    • Taplin, M.E.1    Regan, M.M.2    Ko, Y.J.3    Bubley, G.J.4    Duggan, S.E.5    Werner, L.6
  • 38
    • 0042203576 scopus 로고    scopus 로고
    • Pathological effects of neoadjuvant hormonal therapy help predict progression of prostate cancer after radical prostatectomy
    • Kitagawa Y, Koshida K, Mizokami A, Komatsu K, Nakashima S, Misaki T, et al. Pathological effects of neoadjuvant hormonal therapy help predict progression of prostate cancer after radical prostatectomy. Int J Urol 2003;10:377-82.
    • (2003) Int J Urol , vol.10 , pp. 377-382
    • Kitagawa, Y.1    Koshida, K.2    Mizokami, A.3    Komatsu, K.4    Nakashima, S.5    Misaki, T.6
  • 39
    • 33750366075 scopus 로고    scopus 로고
    • Persistent prostate-specific antigen expression after neoadjuvant androgen depletion: An early predictor of relapse or incomplete androgen suppression
    • Ryan CJ, Smith A, Lal P, Satagopan J, Reuter V, Scardino P, et al. Persistent prostate-specific antigen expression after neoadjuvant androgen depletion: an early predictor of relapse or incomplete androgen suppression. Urology 2006;68:834-9.
    • (2006) Urology , vol.68 , pp. 834-839
    • Ryan, C.J.1    Smith, A.2    Lal, P.3    Satagopan, J.4    Reuter, V.5    Scardino, P.6
  • 40
    • 68049131467 scopus 로고    scopus 로고
    • Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castrationresistant prostate cancer
    • Cai C, Wang H, Xu Y, Chen S, Balk SP. Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castrationresistant prostate cancer. Cancer Res 2009;69:6027-32.
    • (2009) Cancer Res , vol.69 , pp. 6027-6032
    • Cai, C.1    Wang, H.2    Xu, Y.3    Chen, S.4    Balk, S.P.5
  • 42
    • 61649103983 scopus 로고    scopus 로고
    • Steroid hormone transforming aldo-keto reductases and cancer
    • Penning TM, Byrns MC. Steroid hormone transforming aldo-keto reductases and cancer. Ann N Y Acad Sci 2009;1155:33-42.
    • (2009) Ann N y Acad Sci , vol.1155 , pp. 33-42
    • Penning, T.M.1    Byrns, M.C.2
  • 43
    • 37349047898 scopus 로고    scopus 로고
    • An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies
    • Byrns MC, Steckelbroeck S, Penning TM. An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies. Biochem Pharmacol 2008;75:484-93.
    • (2008) Biochem Pharmacol , vol.75 , pp. 484-493
    • Byrns, M.C.1    Steckelbroeck, S.2    Penning, T.M.3
  • 44
    • 79957722662 scopus 로고    scopus 로고
    • Inhibitors of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3): Overview and structural insights
    • Byrns MC, Jin Y, Penning TM. Inhibitors of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights. J Steroid Biochem Mol Biol 2011;125:95-104.
    • (2011) J Steroid Biochem Mol Biol , vol.125 , pp. 95-104
    • Byrns, M.C.1    Jin, Y.2    Penning, T.M.3
  • 45
    • 84863230589 scopus 로고    scopus 로고
    • Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17beta-hydroxysteroid dehydrogenase) based on Nphenyl- aminobenzoates and their structure-activity relationships
    • Adeniji AO, Twenter BM, Byrns MC, Jin Y, Chen M, Winkler JD, et al. Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17beta-hydroxysteroid dehydrogenase) based on Nphenyl- aminobenzoates and their structure-activity relationships. J Med Chem 2012;55:2311-23.
    • (2012) J Med Chem , vol.55 , pp. 2311-2323
    • Adeniji, A.O.1    Twenter, B.M.2    Byrns, M.C.3    Jin, Y.4    Chen, M.5    Winkler, J.D.6
  • 46
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 2011;19:575-86.
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1    Chapinski, C.2    Wongvipat, J.3    Hieronymus, H.4    Chen, Y.5    Chandarlapaty, S.6
  • 47
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
    • Mostaghel EA, Marck BT, Plymate SR, Vessella RL, Balk S, Matsumoto AM, et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 2011;17: 5913-25.
    • (2011) Clin Cancer Res , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1    Marck, B.T.2    Plymate, S.R.3    Vessella, R.L.4    Balk, S.5    Matsumoto, A.M.6
  • 48
    • 80054021222 scopus 로고    scopus 로고
    • Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    • Cai C, Chen S, Ng P, Bubley GJ, Nelson PS, Mostaghel EA, et al. Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res 2011;71:6503-13.
    • (2011) Cancer Res , vol.71 , pp. 6503-6513
    • Cai, C.1    Chen, S.2    Ng, P.3    Bubley, G.J.4    Nelson, P.S.5    Mostaghel, E.A.6
  • 49
    • 84872534568 scopus 로고    scopus 로고
    • Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
    • Li Y, Chan SC, Brand LJ, Hwang TH, Silverstein KA, Dehm SM. Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res 2013;73: 483-9.
    • (2013) Cancer Res , vol.73 , pp. 483-489
    • Li, Y.1    Chan, S.C.2    Brand, L.J.3    Hwang, T.H.4    Silverstein, K.A.5    Dehm, S.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.