-
1
-
-
84928580276
-
Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
-
Huggins C., and Hodges C.V. Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1 (1941) 293-297
-
(1941)
Cancer Res
, vol.1
, pp. 293-297
-
-
Huggins, C.1
Hodges, C.V.2
-
2
-
-
0033952191
-
Clinical states in prostate cancer: toward a dynamic model of disease progression
-
Scher H.I., and Heller G. Clinical states in prostate cancer: toward a dynamic model of disease progression. Urology 55 (2000) 323-327
-
(2000)
Urology
, vol.55
, pp. 323-327
-
-
Scher, H.I.1
Heller, G.2
-
3
-
-
0028805834
-
Hormone-refractory (D3) prostate cancer: refining the concept
-
Scher H.I., Steineck G., and Kelly W.K. Hormone-refractory (D3) prostate cancer: refining the concept. Urology 46 (1995) 142-148
-
(1995)
Urology
, vol.46
, pp. 142-148
-
-
Scher, H.I.1
Steineck, G.2
Kelly, W.K.3
-
4
-
-
0026544312
-
Androgen resistance-the clinical and molecular spectrum
-
Griffin J.E. Androgen resistance-the clinical and molecular spectrum. N Engl J Med 326 (1992) 611-618
-
(1992)
N Engl J Med
, vol.326
, pp. 611-618
-
-
Griffin, J.E.1
-
5
-
-
4744337716
-
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
-
Petrylak D.P., Tangen C.M., Hussain M.H., et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 351 (2004) 1513-1520
-
(2004)
N Engl J Med
, vol.351
, pp. 1513-1520
-
-
Petrylak, D.P.1
Tangen, C.M.2
Hussain, M.H.3
-
6
-
-
4744366279
-
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
-
Tannock I.F., de Wit R., Berry W.R., et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 351 (2004) 1502-1512
-
(2004)
N Engl J Med
, vol.351
, pp. 1502-1512
-
-
Tannock, I.F.1
de Wit, R.2
Berry, W.R.3
-
7
-
-
0042978480
-
Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer
-
Edwards J., Krishna N.S., Grigor K.M., and Bartlett J.M. Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer. Br J Cancer 89 (2003) 552-556
-
(2003)
Br J Cancer
, vol.89
, pp. 552-556
-
-
Edwards, J.1
Krishna, N.S.2
Grigor, K.M.3
Bartlett, J.M.4
-
8
-
-
1542574202
-
Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance
-
Holzbeierlein J., Lal P., LaTulippe E., et al. Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am J Pathol 164 (2004) 217-227
-
(2004)
Am J Pathol
, vol.164
, pp. 217-227
-
-
Holzbeierlein, J.1
Lal, P.2
LaTulippe, E.3
-
9
-
-
1842612441
-
Molecular determinants of resistance to antiandrogen therapy
-
Chen C.D., Welsbie D.S., Tran C., et al. Molecular determinants of resistance to antiandrogen therapy. Nat Med 10 (2004) 33-39
-
(2004)
Nat Med
, vol.10
, pp. 33-39
-
-
Chen, C.D.1
Welsbie, D.S.2
Tran, C.3
-
10
-
-
0042130389
-
Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663
-
Taplin M.E., Rajeshkumar B., Halabi S., et al. Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. J Clin Oncol 21 (2003) 2673-2678
-
(2003)
J Clin Oncol
, vol.21
, pp. 2673-2678
-
-
Taplin, M.E.1
Rajeshkumar, B.2
Halabi, S.3
-
11
-
-
0037226103
-
Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome
-
Hara T., Miyazaki J., Araki H., et al. Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome. Cancer Res 63 (2003) 149-153
-
(2003)
Cancer Res
, vol.63
, pp. 149-153
-
-
Hara, T.1
Miyazaki, J.2
Araki, H.3
-
12
-
-
27544485276
-
Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient
-
Yoshida T., Kinoshita H., Segawa T., et al. Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient. Cancer Res 65 (2005) 9611-9616
-
(2005)
Cancer Res
, vol.65
, pp. 9611-9616
-
-
Yoshida, T.1
Kinoshita, H.2
Segawa, T.3
-
13
-
-
66249135684
-
Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy
-
Steinkamp M.P., O'Mahony O.A., Brogley M., et al. Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy. Cancer Res 69 (2009) 4434-4442
-
(2009)
Cancer Res
, vol.69
, pp. 4434-4442
-
-
Steinkamp, M.P.1
O'Mahony, O.A.2
Brogley, M.3
-
14
-
-
7944234374
-
HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability
-
Mellinghoff I.K., Vivanco I., Kwon A., Tran C., Wongvipat J., and Sawyers C.L. HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability. Cancer Cell 6 (2004) 517-527
-
(2004)
Cancer Cell
, vol.6
, pp. 517-527
-
-
Mellinghoff, I.K.1
Vivanco, I.2
Kwon, A.3
Tran, C.4
Wongvipat, J.5
Sawyers, C.L.6
-
15
-
-
34347263425
-
Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation
-
Mahajan N.P., Liu Y., Majumder S., et al. Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Proc Natl Acad Sci USA 104 (2007) 8438-8443
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8438-8443
-
-
Mahajan, N.P.1
Liu, Y.2
Majumder, S.3
-
16
-
-
33749445413
-
Regulation of androgen receptor activity by tyrosine phosphorylation
-
Guo Z., Dai B., Jiang T., et al. Regulation of androgen receptor activity by tyrosine phosphorylation. Cancer Cell 10 (2006) 309-319
-
(2006)
Cancer Cell
, vol.10
, pp. 309-319
-
-
Guo, Z.1
Dai, B.2
Jiang, T.3
-
17
-
-
30944461586
-
PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer
-
Mulholland D.J., Dedhar S., Wu H., and Nelson C.C. PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene 25 (2006) 329-337
-
(2006)
Oncogene
, vol.25
, pp. 329-337
-
-
Mulholland, D.J.1
Dedhar, S.2
Wu, H.3
Nelson, C.C.4
-
18
-
-
0035361340
-
A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
-
Gregory C.W., He B., Johnson R.T., et al. A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy. Cancer Res 61 (2001) 4315-4319
-
(2001)
Cancer Res
, vol.61
, pp. 4315-4319
-
-
Gregory, C.W.1
He, B.2
Johnson, R.T.3
-
19
-
-
0037222317
-
The transcriptional co-activator cAMP response element-binding protein-binding protein is expressed in prostate cancer and enhances androgen- and anti-androgen-induced androgen receptor function
-
Comuzzi B., Lambrinidis L., Rogatsch H., et al. The transcriptional co-activator cAMP response element-binding protein-binding protein is expressed in prostate cancer and enhances androgen- and anti-androgen-induced androgen receptor function. Am J Pathol 162 (2003) 233-241
-
(2003)
Am J Pathol
, vol.162
, pp. 233-241
-
-
Comuzzi, B.1
Lambrinidis, L.2
Rogatsch, H.3
-
20
-
-
34548310506
-
A 90 kDa fragment of filamin A promotes casodex-induced growth inhibition in casodex-resistant androgen receptor positive C4-2 prostate cancer cells
-
Wang Y., Kreisberg J.I., Bedolla R.G., Mikhailova M., deVere White R.W., and Ghosh P.M. A 90 kDa fragment of filamin A promotes casodex-induced growth inhibition in casodex-resistant androgen receptor positive C4-2 prostate cancer cells. Oncogene 26 (2007) 6061-6070
-
(2007)
Oncogene
, vol.26
, pp. 6061-6070
-
-
Wang, Y.1
Kreisberg, J.I.2
Bedolla, R.G.3
Mikhailova, M.4
deVere White, R.W.5
Ghosh, P.M.6
-
21
-
-
33645056171
-
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
-
Stanbrough M., Bubley G.J., Ross K., et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res 66 (2006) 2815-2825
-
(2006)
Cancer Res
, vol.66
, pp. 2815-2825
-
-
Stanbrough, M.1
Bubley, G.J.2
Ross, K.3
-
22
-
-
49249119358
-
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
-
Montgomery R.B., Mostaghel E.A., Vessella R., et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 68 (2008) 4447-4454
-
(2008)
Cancer Res
, vol.68
, pp. 4447-4454
-
-
Montgomery, R.B.1
Mostaghel, E.A.2
Vessella, R.3
-
23
-
-
51449087794
-
Targeting the androgen receptor pathway in prostate cancer
-
Chen Y., Sawyers C.L., and Scher H.I. Targeting the androgen receptor pathway in prostate cancer. Curr Opin Pharmacol 8 (2008) 440-448
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 440-448
-
-
Chen, Y.1
Sawyers, C.L.2
Scher, H.I.3
-
24
-
-
0034728828
-
Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials
-
Prostate Cancer Trialists' Collaborative Group
-
Prostate Cancer Trialists' Collaborative Group. Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials. Lancet 355 (2000) 1491-1498
-
(2000)
Lancet
, vol.355
, pp. 1491-1498
-
-
-
25
-
-
41849084513
-
A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones
-
Taplin M.E., Manola J., Oh W.K., et al. A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones. BJU Int 101 (2008) 1084-1089
-
(2008)
BJU Int
, vol.101
, pp. 1084-1089
-
-
Taplin, M.E.1
Manola, J.2
Oh, W.K.3
-
26
-
-
0343708486
-
Analysis of the androgenic activity of synthetic "progestins" currently used for the treatment of prostate cancer
-
Labrie C., Cusan L., Plante M., Lapointe S., and Labrie F. Analysis of the androgenic activity of synthetic "progestins" currently used for the treatment of prostate cancer. J Steroid Biochem 28 (1987) 379-384
-
(1987)
J Steroid Biochem
, vol.28
, pp. 379-384
-
-
Labrie, C.1
Cusan, L.2
Plante, M.3
Lapointe, S.4
Labrie, F.5
-
27
-
-
0021072579
-
New approach in the treatment of prostate cancer: Complete instead of partial withdrawal of androgen
-
Labrie F., Dupont A., and Bellanger A. New approach in the treatment of prostate cancer: Complete instead of partial withdrawal of androgen. Prostate 4 (1983) 579-584
-
(1983)
Prostate
, vol.4
, pp. 579-584
-
-
Labrie, F.1
Dupont, A.2
Bellanger, A.3
-
28
-
-
0024324367
-
A controlled trial of leuprolide with and without flutamide in prostatic carcinoma
-
Crawford E.D., Eisenberger M.A., McLeod D.G., et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med 321 (1989) 419-424
-
(1989)
N Engl J Med
, vol.321
, pp. 419-424
-
-
Crawford, E.D.1
Eisenberger, M.A.2
McLeod, D.G.3
-
29
-
-
0032497522
-
Bilateral orchiectomy with or without flutamide for metastatic prostate cancer
-
Eisenberger M.A., Blumenstein B.A., Crawford E.D., et al. Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl J Med 339 (1998) 1036-1042
-
(1998)
N Engl J Med
, vol.339
, pp. 1036-1042
-
-
Eisenberger, M.A.1
Blumenstein, B.A.2
Crawford, E.D.3
-
30
-
-
0030915668
-
Long-term efficacy and safety of nilutamide plus castration in advanced prostate cancer, and the significance of early prostate specific antigen normalization. International Anandron Study Group
-
Dijkman G.A., Janknegt R.A., De Reijke T.M., and Debruyne F.M. Long-term efficacy and safety of nilutamide plus castration in advanced prostate cancer, and the significance of early prostate specific antigen normalization. International Anandron Study Group. J Urol 158 (1997) 160-163
-
(1997)
J Urol
, vol.158
, pp. 160-163
-
-
Dijkman, G.A.1
Janknegt, R.A.2
De Reijke, T.M.3
Debruyne, F.M.4
-
31
-
-
0030824059
-
Clinical benefits of bicalutamide compared with flutamide in combined androgen blockade for patients with advanced prostatic carcinoma: final report of a double-blind, randomized, multicenter trial. Casodex Combination Study Group
-
Schellhammer P.F., Sharifi R., Block N.L., et al. Clinical benefits of bicalutamide compared with flutamide in combined androgen blockade for patients with advanced prostatic carcinoma: final report of a double-blind, randomized, multicenter trial. Casodex Combination Study Group. Urology 50 (1997) 330-336
-
(1997)
Urology
, vol.50
, pp. 330-336
-
-
Schellhammer, P.F.1
Sharifi, R.2
Block, N.L.3
-
32
-
-
0033782359
-
Bicalutamide monotherapy compared with castration in patients with nonmetastatic locally advanced prostate cancer: 6.3 years of follow up
-
Iversen P., Tyrrell C.J., Kaisary A.V., et al. Bicalutamide monotherapy compared with castration in patients with nonmetastatic locally advanced prostate cancer: 6.3 years of follow up. J Urol 164 (2000) 1579-1582
-
(2000)
J Urol
, vol.164
, pp. 1579-1582
-
-
Iversen, P.1
Tyrrell, C.J.2
Kaisary, A.V.3
-
33
-
-
0029561445
-
A controlled trial of bicalutamide versus castration in patients with advanced prostate cancer
-
Bales G.T., and Chodak G.W. A controlled trial of bicalutamide versus castration in patients with advanced prostate cancer. Urology 47 1A suppl (1996) 38-43
-
(1996)
Urology
, vol.47
, Issue.1 A SUPPL
, pp. 38-43
-
-
Bales, G.T.1
Chodak, G.W.2
-
34
-
-
0031798627
-
A randomised comparison of 'casodex' (bicalutamide) 150 mg monotherapy versus castration in the treatment of metastatic and locally advanced prostate cancer
-
Tyrrell C.J., Kaisary A.V., Iversen P., et al. A randomised comparison of 'casodex' (bicalutamide) 150 mg monotherapy versus castration in the treatment of metastatic and locally advanced prostate cancer. Eur Urol 33 (1998) 447-456
-
(1998)
Eur Urol
, vol.33
, pp. 447-456
-
-
Tyrrell, C.J.1
Kaisary, A.V.2
Iversen, P.3
-
35
-
-
0027477695
-
Prostate specific antigen decline after antiandrogen withdrawal: the flutamide withdrawal syndrome
-
Kelly W.K., and Scher H.I. Prostate specific antigen decline after antiandrogen withdrawal: the flutamide withdrawal syndrome. J Urol 149 (1993) 607-609
-
(1993)
J Urol
, vol.149
, pp. 607-609
-
-
Kelly, W.K.1
Scher, H.I.2
-
36
-
-
0031001274
-
Prostate specific antigen decreases after withdrawal of antiandrogen therapy with bicalutamide or flutamide in patients receiving combined androgen blockade
-
Schellhammer P.F., Venner P., Haas G.P., et al. Prostate specific antigen decreases after withdrawal of antiandrogen therapy with bicalutamide or flutamide in patients receiving combined androgen blockade. J Urol 157 (1997) 1731-1735
-
(1997)
J Urol
, vol.157
, pp. 1731-1735
-
-
Schellhammer, P.F.1
Venner, P.2
Haas, G.P.3
-
37
-
-
0034714276
-
Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations
-
Matias P.M., Donner P., Coelho R., et al. Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations. J Biol Chem 275 (2000) 26164-26171
-
(2000)
J Biol Chem
, vol.275
, pp. 26164-26171
-
-
Matias, P.M.1
Donner, P.2
Coelho, R.3
-
38
-
-
0035942197
-
Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone
-
Sack J.S., Kish K.F., Wang C., et al. Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone. Proc Natl Acad Sci USA 98 (2001) 4904-4909
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4904-4909
-
-
Sack, J.S.1
Kish, K.F.2
Wang, C.3
-
39
-
-
8344226282
-
Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
-
He B., Gampe Jr. R.T., Kole A.J., et al. Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance. Mol Cell 16 (2004) 425-438
-
(2004)
Mol Cell
, vol.16
, pp. 425-438
-
-
He, B.1
Gampe Jr., R.T.2
Kole, A.J.3
-
40
-
-
0036208492
-
Formation of the androgen receptor transcription complex
-
Shang Y., Myers M., and Brown M. Formation of the androgen receptor transcription complex. Mol Cell 9 (2002) 601-610
-
(2002)
Mol Cell
, vol.9
, pp. 601-610
-
-
Shang, Y.1
Myers, M.2
Brown, M.3
-
41
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau A.K., Barstad D., Loria P.M., et al. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95 (1998) 927-937
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
-
42
-
-
17844376217
-
Structural basis for antagonism and resistance of bicalutamide in prostate cancer
-
Bohl C.E., Gao W., Miller D.D., Bell C.E., and Dalton J.T. Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proc Natl Acad Sci USA 102 (2005) 6201-6206
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 6201-6206
-
-
Bohl, C.E.1
Gao, W.2
Miller, D.D.3
Bell, C.E.4
Dalton, J.T.5
-
43
-
-
0037135630
-
Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor
-
Masiello D., Cheng S., Bubley G.J., Lu M.L., and Balk S.P. Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. J Biol Chem 277 (2002) 26321-26326
-
(2002)
J Biol Chem
, vol.277
, pp. 26321-26326
-
-
Masiello, D.1
Cheng, S.2
Bubley, G.J.3
Lu, M.L.4
Balk, S.P.5
-
44
-
-
34548595236
-
Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors
-
Hodgson M.C., Astapova I., Hollenberg A.N., and Balk S.P. Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors. Cancer Res 67 (2007) 8388-8395
-
(2007)
Cancer Res
, vol.67
, pp. 8388-8395
-
-
Hodgson, M.C.1
Astapova, I.2
Hollenberg, A.N.3
Balk, S.P.4
-
45
-
-
59749095425
-
Pleiotropic functional properties of androgen receptor mutants in prostate cancer
-
Bergerat J.P., and Ceraline J. Pleiotropic functional properties of androgen receptor mutants in prostate cancer. Hum Mutat 30 (2009) 145-157
-
(2009)
Hum Mutat
, vol.30
, pp. 145-157
-
-
Bergerat, J.P.1
Ceraline, J.2
-
46
-
-
66449085018
-
Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2
-
Feng S., Tang Q., Sun M., Chun J.Y., Evans C.P., and Gao A.C. Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. Mol Cancer Ther 8 (2009) 665-671
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 665-671
-
-
Feng, S.1
Tang, Q.2
Sun, M.3
Chun, J.Y.4
Evans, C.P.5
Gao, A.C.6
-
47
-
-
65649090203
-
Development of a second-generation antiandrogen for treatment of advanced prostate cancer
-
Tran C., Ouk S., Clegg N.J., et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324 (2009) 787-790
-
(2009)
Science
, vol.324
, pp. 787-790
-
-
Tran, C.1
Ouk, S.2
Clegg, N.J.3
-
48
-
-
47349122948
-
4-(Anilino)pyrrole-2-carboxamides: novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor
-
Wakabayashi K., Imai K., Miyachi H., Hashimoto Y., and Tanatani A. 4-(Anilino)pyrrole-2-carboxamides: novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor. Bioorg Med Chem 16 (2008) 6799-6812
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 6799-6812
-
-
Wakabayashi, K.1
Imai, K.2
Miyachi, H.3
Hashimoto, Y.4
Tanatani, A.5
-
49
-
-
34247159601
-
Circumventing anti-androgen resistance by molecular design
-
McGinley P.L., and Koh J.T. Circumventing anti-androgen resistance by molecular design. J Am Chem Soc 129 (2007) 3822-3823
-
(2007)
J Am Chem Soc
, vol.129
, pp. 3822-3823
-
-
McGinley, P.L.1
Koh, J.T.2
-
50
-
-
69249083981
-
Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signalling for the treatment of prostate cancer
-
Attar R.M., Jure-Kunkel M., Balog A., et al. Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signalling for the treatment of prostate cancer. Cancer Res 69 (2009) 6522-6530
-
(2009)
Cancer Res
, vol.69
, pp. 6522-6530
-
-
Attar, R.M.1
Jure-Kunkel, M.2
Balog, A.3
-
51
-
-
35648970526
-
Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12
-
Cantin L., Faucher F., Couture J.F., et al. Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12. J Biol Chem 282 (2007) 30910-30919
-
(2007)
J Biol Chem
, vol.282
, pp. 30910-30919
-
-
Cantin, L.1
Faucher, F.2
Couture, J.F.3
-
52
-
-
51649107127
-
Rational design of novel antiandrogens for neutralizing androgen receptor function in hormone refractory prostate cancer
-
Singh P., Hallur G., Anchoori R.K., et al. Rational design of novel antiandrogens for neutralizing androgen receptor function in hormone refractory prostate cancer. Prostate 68 (2008) 1570-1581
-
(2008)
Prostate
, vol.68
, pp. 1570-1581
-
-
Singh, P.1
Hallur, G.2
Anchoori, R.K.3
-
53
-
-
65249166947
-
AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization
-
Jones J.O., An W.F., and Diamond M.I. AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization. ACS Chem Biol 4 (2009) 191-197
-
(2009)
ACS Chem Biol
, vol.4
, pp. 191-197
-
-
Jones, J.O.1
An, W.F.2
Diamond, M.I.3
-
54
-
-
70349741668
-
Antitimor activity of MDV3100 in a phase 1/2 study of castration-resistant prostate cancer (CRPC)
-
Scher H.I., Beer T.M., Higano C.S., et al. Antitimor activity of MDV3100 in a phase 1/2 study of castration-resistant prostate cancer (CRPC). Proc Am Soc Clin Oncol 27 15 suppl (2009) 5011
-
(2009)
Proc Am Soc Clin Oncol
, vol.27
, Issue.15 SUPPL
, pp. 5011
-
-
Scher, H.I.1
Beer, T.M.2
Higano, C.S.3
-
55
-
-
53049092194
-
Anti-tumor activity of abiraterone acetate (AA), a CYP17 inhibitor of androgen synthesis, in chemotherapy naive and docetaxel pre-treated castration resistant prostate cancer (CRPC)
-
De Bono J.S., Attard G., Reid A.H., et al. Anti-tumor activity of abiraterone acetate (AA), a CYP17 inhibitor of androgen synthesis, in chemotherapy naive and docetaxel pre-treated castration resistant prostate cancer (CRPC). Proc Am Soc Clin Oncol 26 15 suppl (2008) 5005
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, Issue.15 SUPPL
, pp. 5005
-
-
De Bono, J.S.1
Attard, G.2
Reid, A.H.3
-
56
-
-
58149165081
-
Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer
-
de Bono J.S., Scher H.I., Montgomery R.B., et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res 14 (2008) 6302-6309
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6302-6309
-
-
de Bono, J.S.1
Scher, H.I.2
Montgomery, R.B.3
-
57
-
-
48549089747
-
Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
-
Dehm S.M., Schmidt L.J., Heemers H.V., Vessella R.L., and Tindall D.J. Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res 68 (2008) 5469-5477
-
(2008)
Cancer Res
, vol.68
, pp. 5469-5477
-
-
Dehm, S.M.1
Schmidt, L.J.2
Heemers, H.V.3
Vessella, R.L.4
Tindall, D.J.5
-
58
-
-
58249110391
-
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
-
Hu R., Dunn T.A., Wei S., et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 69 (2009) 16-22
-
(2009)
Cancer Res
, vol.69
, pp. 16-22
-
-
Hu, R.1
Dunn, T.A.2
Wei, S.3
-
59
-
-
55949134647
-
Hypophysectomy for prostate cancer: a revival of old knowledge?
-
Flitsch J., Bernreuther C., Hagel C., and Ludecke D.K. Hypophysectomy for prostate cancer: a revival of old knowledge?. J Neurosurg 109 (2008) 760-764
-
(2008)
J Neurosurg
, vol.109
, pp. 760-764
-
-
Flitsch, J.1
Bernreuther, C.2
Hagel, C.3
Ludecke, D.K.4
-
60
-
-
0024535895
-
Treatment of metastatic prostatic cancer with low-dose prednisone: evaluation of pain and quality of life as pragmatic indices of response
-
Tannock I., Gospodarowicz M., Meakin W., Panzarella T., Stewart L., and Rider W. Treatment of metastatic prostatic cancer with low-dose prednisone: evaluation of pain and quality of life as pragmatic indices of response. J Clin Oncol 7 (1989) 590-597
-
(1989)
J Clin Oncol
, vol.7
, pp. 590-597
-
-
Tannock, I.1
Gospodarowicz, M.2
Meakin, W.3
Panzarella, T.4
Stewart, L.5
Rider, W.6
-
61
-
-
0035148171
-
Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the European organization for research and treatment of cancer genitourinary group
-
Fossa S.D., Slee P.H., Brausi M., et al. Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the European organization for research and treatment of cancer genitourinary group. J Clin Oncol 19 (2001) 62-71
-
(2001)
J Clin Oncol
, vol.19
, pp. 62-71
-
-
Fossa, S.D.1
Slee, P.H.2
Brausi, M.3
-
62
-
-
0023126444
-
Androgen suppression by hydrocortisone without aminoglutethimide in orchiectomised men with prostatic cancer
-
Plowman P.N., Perry L.A., and Chard T. Androgen suppression by hydrocortisone without aminoglutethimide in orchiectomised men with prostatic cancer. Br J Urol 59 (1987) 255-257
-
(1987)
Br J Urol
, vol.59
, pp. 255-257
-
-
Plowman, P.N.1
Perry, L.A.2
Chard, T.3
-
63
-
-
0023278218
-
Adrenal steroid levels in castrated men with prostatic carcinoma treated with aminoglutethimide plus hydrocortisone
-
Ahmann F.R., Crawford E.D., Kreis W., and Levasseur Y. Adrenal steroid levels in castrated men with prostatic carcinoma treated with aminoglutethimide plus hydrocortisone. Cancer Res 47 (1987) 4736-4739
-
(1987)
Cancer Res
, vol.47
, pp. 4736-4739
-
-
Ahmann, F.R.1
Crawford, E.D.2
Kreis, W.3
Levasseur, Y.4
-
64
-
-
1842457650
-
Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583)
-
Small E.J., Halabi S., Dawson N.A., et al. Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583). J Clin Oncol 22 (2004) 1025-1033
-
(2004)
J Clin Oncol
, vol.22
, pp. 1025-1033
-
-
Small, E.J.1
Halabi, S.2
Dawson, N.A.3
-
65
-
-
0028031372
-
Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase)
-
Barrie S.E., Potter G.A., Goddard P.M., Haynes B.P., Dowsett M., and Jarman M. Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J Steroid Biochem Mol Biol 50 (1994) 267-273
-
(1994)
J Steroid Biochem Mol Biol
, vol.50
, pp. 267-273
-
-
Barrie, S.E.1
Potter, G.A.2
Goddard, P.M.3
Haynes, B.P.4
Dowsett, M.5
Jarman, M.6
-
66
-
-
3042784503
-
Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer
-
O'Donnell A., Judson I., Dowsett M., et al. Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. Br J Cancer 90 (2004) 2317-2325
-
(2004)
Br J Cancer
, vol.90
, pp. 2317-2325
-
-
O'Donnell, A.1
Judson, I.2
Dowsett, M.3
-
67
-
-
53749090666
-
Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
-
Attard G., Reid A.H., Yap T.A., et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol 26 (2008) 4563-4571
-
(2008)
J Clin Oncol
, vol.26
, pp. 4563-4571
-
-
Attard, G.1
Reid, A.H.2
Yap, T.A.3
-
68
-
-
58149170155
-
Abiraterone acetate and prednisone in patients (Pts) with progressive metastatic castration resistant prostate cancer (CRPC) after failure of docetaxel-based chemotherapy
-
Danila D.C., Rathkopf D.E., Morris M.J., et al. Abiraterone acetate and prednisone in patients (Pts) with progressive metastatic castration resistant prostate cancer (CRPC) after failure of docetaxel-based chemotherapy. Proc Am Soc Clin Oncol 26 15 suppl (2008) 5019
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, Issue.15 SUPPL
, pp. 5019
-
-
Danila, D.C.1
Rathkopf, D.E.2
Morris, M.J.3
-
69
-
-
58049208734
-
Impact of prior ketoconazole therapy on response proportion to abiraterone acetate, a 17-alpha hydroxylase C17,20-lyase inhibitor in castration resistant prostate cancer (CRPC)
-
Ryan C., Smith M.R., Rosenberg J.E., et al. Impact of prior ketoconazole therapy on response proportion to abiraterone acetate, a 17-alpha hydroxylase C17,20-lyase inhibitor in castration resistant prostate cancer (CRPC). Proc Am Soc Clin Oncol 26 15 suppl (2008) 5018
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, Issue.15 SUPPL
, pp. 5018
-
-
Ryan, C.1
Smith, M.R.2
Rosenberg, J.E.3
-
70
-
-
53349101498
-
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer
-
Vasaitis T., Belosay A., Schayowitz A., et al. Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer. Mol Cancer Ther 7 (2008) 2348-2357
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2348-2357
-
-
Vasaitis, T.1
Belosay, A.2
Schayowitz, A.3
-
71
-
-
67349083573
-
Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls
-
Hille U.E., Hu Q., Vock C., et al. Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls. Eur J Med Chem 44 (2009) 2765-2775
-
(2009)
Eur J Med Chem
, vol.44
, pp. 2765-2775
-
-
Hille, U.E.1
Hu, Q.2
Vock, C.3
-
72
-
-
37349107226
-
Type 1 and type 2 5alpha-reductase expression in the development and progression of prostate cancer
-
Thomas L.N., Douglas R.C., Lazier C.B., Too C.K., Rittmaster R.S., and Tindall D.J. Type 1 and type 2 5alpha-reductase expression in the development and progression of prostate cancer. Eur Urol 53 (2008) 244-252
-
(2008)
Eur Urol
, vol.53
, pp. 244-252
-
-
Thomas, L.N.1
Douglas, R.C.2
Lazier, C.B.3
Too, C.K.4
Rittmaster, R.S.5
Tindall, D.J.6
-
73
-
-
34548398124
-
Effects of dutasteride on prostate growth in the large probasin-large T antigen mouse model of prostate cancer
-
Shao T.C., Li H., Ittmann M., and Cunningham G.R. Effects of dutasteride on prostate growth in the large probasin-large T antigen mouse model of prostate cancer. J Urol 178 4 Pt 1 (2007) 1521-1527
-
(2007)
J Urol
, vol.178
, Issue.4 PART 1
, pp. 1521-1527
-
-
Shao, T.C.1
Li, H.2
Ittmann, M.3
Cunningham, G.R.4
-
74
-
-
33746047132
-
Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
-
Xu Y., Dalrymple S.L., Becker R.E., Denmeade S.R., and Isaacs J.T. Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Clin Cancer Res 12 (2006) 4072-4079
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4072-4079
-
-
Xu, Y.1
Dalrymple, S.L.2
Becker, R.E.3
Denmeade, S.R.4
Isaacs, J.T.5
-
75
-
-
58149203191
-
Phase 2 study of dutasteride for recurrent prostate cancer during androgen deprivation therapy
-
Shah S.K., Trump D.L., Sartor O., et al. Phase 2 study of dutasteride for recurrent prostate cancer during androgen deprivation therapy. J Urol 181 (2009) 621-626
-
(2009)
J Urol
, vol.181
, pp. 621-626
-
-
Shah, S.K.1
Trump, D.L.2
Sartor, O.3
-
76
-
-
67349242268
-
Phase II trial of ketoconazole, hydrocortisone, and dutasteride (KHAD) for castration resistant prostate cancer (CRPC)
-
Taplin M., Ko Y., Regan M.M., et al. Phase II trial of ketoconazole, hydrocortisone, and dutasteride (KHAD) for castration resistant prostate cancer (CRPC). Proc Am Soc Clin Oncol 26 15 suppl (2008) 5068
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, Issue.15 SUPPL
, pp. 5068
-
-
Taplin, M.1
Ko, Y.2
Regan, M.M.3
|