Comprehensive proteomic analysis of the human spliceosome

Nature

Volumn 419, Issue 6903, 2002, Pages 182-185

  Zhou, Zhaolan ^a   Licklider, Lawrence J ^a   Gygi, Steven P ^a   Reed, Robin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RNA;

HUMAN SPLICESOME;

PROTEINS;

SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEAR RNA;

GENOME; RNA;

ARTICLE; DNA SPLICING; GENE EXPRESSION REGULATION; HUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; SPLICEOSOME;

AMINO ACID MOTIFS; CARRIER PROTEINS; CHROMATOGRAPHY, AFFINITY; GENETIC COMPLEMENTATION TEST; HUMANS; INTRONS; MACROMOLECULAR SUBSTANCES; MASS SPECTROMETRY; PROTEIN SUBUNITS; PROTEOME; RECOMBINANT FUSION PROTEINS; RNA PRECURSORS; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS; SPLICEOSOMES;

METAZOA;

EID: 0037068447     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01031     Document Type: Article

References (30)

1. Spliceosomal UsnRNP biogenesis, structure and function
2. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex
3. Protein components specifically associated with prespliceosome and spliceosome complexes
4. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
5. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E
6. Automation of nanoscale microcapillary liquid chromatography-tandem mass spectrometry with a vented column
7. Mechanical devices of the spliceosome: Motors, clocks, springs, and things
8. Pre-mRNA splicing in the new millennium
9. Differential binding of heterogeneous nuclear ribonudeoproteins to mRNA precursors prior to spliceosome assembly in vitro
10. The superfamily of arginine/serine-rich splicing factors
11. Determinants of SR protein specificity
12. Sorting out the complexity of SR protein functions
13. Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step 11 of pre-mRNA splicing
14. A conserved mRNA export machinery coupled to pre-mRNA splicing
15. A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11)
16. Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6·U5 tri-snRNP formation and pre-mRNA splicing
17. Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa
18. Mutations in the pre-mRNA splicing factor gene PRPC8 in autosomal dominant retinitis pigmentosa (RP13)
19. Identification of WTAP, a novel Wilms' tumour 1-associating protein
20. A cyclophilin functions in pre-mRNA splicing
21. Directed proteomic analysis of the human nucleolus
22. Composition and functional characterization of the yeast spliceosomal penta-snRNP
23. Listening to silence and understanding nonsense: Exonic mutations that affect splicing
24. Coupling RNA polymerase II transcription with pre-mRNA processing
25. RNA polymemse II and the integration of nuclear events
26. An extensive network of coupling among gene expression machines
27. Stimulatory effect of splicing factors on transcriptional elongation
28. TREX is a conserved complex coupling transcription with messenger RNA export
29. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database