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Volumn 32, Issue 3, 2014, Pages 221-231

MicroRNAs regulate bone metabolism

Author keywords

miRNAs; Osteoblasts; Osteoclasts; Osteoporosis

Indexed keywords

MICRORNA; NOTCH RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

EID: 84904694111     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-013-0537-7     Document Type: Review
Times cited : (73)

References (118)
  • 1
    • 0037129560 scopus 로고    scopus 로고
    • Epidemiology and outcomes of osteoporotic fractures
    • Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761-1767
    • (2002) Lancet , vol.359 , pp. 1761-1767
    • Cummings, S.R.1    Melton, L.J.2
  • 2
    • 0035208925 scopus 로고    scopus 로고
    • Epidemiology of fractures in England and Wales
    • DOI 10.1016/S8756-3282(01)00614-7, PII S8756328201006147
    • Van Staa TP, Dennison EM, Leufkens HG, Cooper C (2001) Epidemiology of fractures in England and Wales. Bone 29:517-522 (Pubitemid 33124293)
    • (2001) Bone , vol.29 , Issue.6 , pp. 517-522
    • Van Staa, T.P.1    Dennison, E.M.2    Leufkens, H.G.M.3    Cooper, C.4
  • 6
    • 33750209491 scopus 로고    scopus 로고
    • An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    • DOI 10.1007/s00198-006-0172-4
    • Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726-1733 (Pubitemid 44607392)
    • (2006) Osteoporosis International , vol.17 , Issue.12 , pp. 1726-1733
    • Johnell, O.1    Kanis, J.A.2
  • 7
  • 8
    • 0037673933 scopus 로고    scopus 로고
    • Control of osteoblast function and regulation of bone mass
    • DOI 10.1038/nature01660
    • Harada S, Rodan GA (2003) Control of osteoblast function and regulation of bone mass. Nature 423:349-355 (Pubitemid 40852710)
    • (2003) Nature , vol.423 , Issue.6937 , pp. 349-355
    • Harada, S.-I.1    Rodan, G.A.2
  • 9
    • 33751197049 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation by transcription factors
    • Komori T (2006) Regulation of osteoblast differentiation by transcription factors. J Cell Biochem 99:1233-1239
    • (2006) J Cell Biochem , vol.99 , pp. 1233-1239
    • Komori, T.1
  • 10
    • 0042204967 scopus 로고    scopus 로고
    • Transcriptional mechanisms in osteoblast differentiation and bone formation
    • DOI 10.1016/S0168-9525(03)00176-8
    • Nakashima K, de Crombrugghe B (2003) Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet 19:458-466 (Pubitemid 36930029)
    • (2003) Trends in Genetics , vol.19 , Issue.8 , pp. 458-466
    • Nakashima, K.1    De Crombrugghe, B.2
  • 11
    • 70350441264 scopus 로고    scopus 로고
    • Growth factor control of bone mass
    • Canalis E (2009) Growth factor control of bone mass. J Cell Biochem 108:769-777
    • (2009) J Cell Biochem , vol.108 , pp. 769-777
    • Canalis, E.1
  • 12
    • 12344291865 scopus 로고    scopus 로고
    • Bone morphogenetic proteins
    • DOI 10.1080/08977190412331279890
    • Chen D, Zhao M, Mundy GR (2004) Bone morphogenetic proteins. Growth Factors 22:233-241 (Pubitemid 40136452)
    • (2004) Growth Factors , vol.22 , Issue.4 , pp. 233-241
    • Chen, D.1    Zhao, M.2    Mundy, G.R.3
  • 13
    • 13444302715 scopus 로고    scopus 로고
    • Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    • DOI 10.1242/dev.01564
    • Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132:49-60 (Pubitemid 40207966)
    • (2005) Development , vol.132 , Issue.1 , pp. 49-60
    • Hu, H.1    Hilton, M.J.2    Tu, X.3    Yu, K.4    Ornitz, D.M.5    Long, F.6
  • 15
    • 4444246433 scopus 로고    scopus 로고
    • Coordinated activation of Notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis: Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity
    • DOI 10.1074/jbc.M403813200
    • Zamurovic N, Cappellen D, Rohner D, Susa M (2004) Coordinated activation of notch, Wnt, and transforming growth factorbeta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity. J Biol Chem 279:37704-37715 (Pubitemid 39195484)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.36 , pp. 37704-37715
    • Zamurovic, N.1    Cappellen, D.2    Rohner, D.3    Susa, M.4
  • 16
    • 84860331458 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    • Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL et al (2012) Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet 44:491-501
    • (2012) Nat Genet , vol.44 , pp. 491-501
    • Estrada, K.1    Styrkarsdottir, U.2    Evangelou, E.3    Hsu, Y.H.4    Duncan, E.L.5
  • 17
    • 20344363684 scopus 로고    scopus 로고
    • Cell Signalling: Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation
    • DOI 10.1126/science.1107627
    • Kratchmarova I, Blagoev B, Haack-Sorensen M, Kassem M, Mann M (2005) Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science 308:1472-1477 (Pubitemid 40791302)
    • (2005) Science , vol.308 , Issue.5727 , pp. 1472-1477
    • Kratchmarova, I.1    Blagoev, B.2    Haack-Sorensen, M.3    Kassem, M.4    Mann, M.5
  • 18
    • 82155163802 scopus 로고    scopus 로고
    • MicroRNA biogenesis and regulation of bone remodeling
    • Kapinas K, Delany AM (2011) MicroRNA biogenesis and regulation of bone remodeling. Arthritis Res Ther 13:220
    • (2011) Arthritis Res Ther , vol.13 , pp. 220
    • Kapinas, K.1    Delany, A.M.2
  • 19
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • DOI 10.1016/0092-8674(93)90529-Y
    • Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronicgene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843-854 (Pubitemid 24014542)
    • (1993) Cell , vol.75 , Issue.5 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 20
    • 84857978205 scopus 로고    scopus 로고
    • Mechanisms in endocrinology: Micro-RNAs: Targets for enhancing osteoblast differentiation and bone formation
    • Taipaleenmäki H, Bjerre Hokland L, Chen L, Kauppinen S, Kassem M (2012) Mechanisms in endocrinology: micro-RNAs: targets for enhancing osteoblast differentiation and bone formation. Eur J Endocrinol 166:359-371
    • (2012) Eur J Endocrinol , vol.166 , pp. 359-371
    • Taipaleenmäki, H.1    Bjerre Hokland, L.2    Chen, L.3    Kauppinen, S.4    Kassem, M.5
  • 21
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • DOI 10.1126/science.1065062
    • Lau NC, Lim LP, Weinstein EG, Bartel DP (2001) An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294:858-862 (Pubitemid 33032104)
    • (2001) Science , vol.294 , Issue.5543 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 22
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • DOI 10.1126/science.1065329
    • Lee RC, Ambros V (2001) An extensive class of small RNAs in Caenorhabditis elegans. Science 294:862-864 (Pubitemid 33032105)
    • (2001) Science , vol.294 , Issue.5543 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 23
    • 77951919333 scopus 로고    scopus 로고
    • MicroRNA regulatory networks in cardiovascular development
    • Liu N, Olson EN (2009) MicroRNA regulatory networks in cardiovascular development. Dev Cell 18:510-525
    • (2009) Dev Cell , vol.18 , pp. 510-525
    • Liu, N.1    Olson, E.N.2
  • 24
    • 77951499826 scopus 로고    scopus 로고
    • Roles of small regulatory RNAs in determining neuronal identity
    • Li X, Jin P (2010) Roles of small regulatory RNAs in determining neuronal identity. Nat Rev Neurosci 11:329-338
    • (2010) Nat Rev Neurosci , vol.11 , pp. 329-338
    • Li, X.1    Jin, P.2
  • 25
    • 79952126479 scopus 로고    scopus 로고
    • Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment
    • Zhang L, Stokes N, Polak L, Fuchs E (2011) Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment. Cell Stem Cell 8:294-308
    • (2011) Cell Stem Cell , vol.8 , pp. 294-308
    • Zhang, L.1    Stokes, N.2    Polak, L.3    Fuchs, E.4
  • 29
    • 33645321647 scopus 로고    scopus 로고
    • MicroRNAs in cell proliferation, cell death, and tumorigenesis
    • Hwang HW, Mendell JT (2006) MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 94:776-780
    • (2006) Br J Cancer , vol.94 , pp. 776-780
    • Hwang, H.W.1    Mendell, J.T.2
  • 30
    • 79954532462 scopus 로고    scopus 로고
    • MicroRNAs in adipogenesis and as therapeutic targets for obesity
    • Alexander R, Lodish H, Sun L (2011) MicroRNAs in adipogenesis and as therapeutic targets for obesity. Expert Opin Ther Targets 15:623-636
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 623-636
    • Alexander, R.1    Lodish, H.2    Sun, L.3
  • 31
    • 77955316898 scopus 로고    scopus 로고
    • Biomarkers: MicroRNAs under the spotlight in inflammatory arthritis
    • Buckland J (2010) Biomarkers: microRNAs under the spotlight in inflammatory arthritis. Nat Rev Rheumatol 6:436
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 436
    • Buckland, J.1
  • 32
    • 77953286512 scopus 로고    scopus 로고
    • Roles of small RNAs in tumor formation
    • Di Leva G, Croce CM (2010) Roles of small RNAs in tumor formation. Trends Mol Med 16:257-267
    • (2010) Trends Mol Med , vol.16 , pp. 257-267
    • Di Leva, G.1    Croce, C.M.2
  • 36
    • 33745813856 scopus 로고    scopus 로고
    • The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells
    • DOI 10.1016/j.febslet.2006.06.080, PII S0014579306007988
    • Tuddenham L, Wheeler G, Ntounia-Fousara S, Waters J, Hajihosseini MK, Clark I, Dalmay T (2006) The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett 580:4214-4217 (Pubitemid 44037596)
    • (2006) FEBS Letters , vol.580 , Issue.17 , pp. 4214-4217
    • Tuddenham, L.1    Wheeler, G.2    Ntounia-Fousara, S.3    Waters, J.4    Hajihosseini, M.K.5    Clark, I.6    Dalmay, T.7
  • 39
    • 72849121740 scopus 로고    scopus 로고
    • A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans
    • Li H, Xie H, Liu W, Hu R, Huang B, Tan YF, Xu K, Sheng ZF, Zhou HD, Wu XP, Luo XH (2009) A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest 119:3666-3677
    • (2009) J Clin Invest , vol.119 , pp. 3666-3677
    • Li, H.1    Xie, H.2    Liu, W.3    Hu, R.4    Huang, B.5    Tan, Y.F.6    Xu, K.7    Sheng, Z.F.8    Zhou, H.D.9    Wu, X.P.10    Luo, X.H.11
  • 45
    • 28544443670 scopus 로고    scopus 로고
    • 3 and macrophage colony-stimulating factor: Partners in osteoclast biology
    • Ross FP, Teitelbaum SL (2005) avb3 and macrophage colonystimulating factor: partners in osteoclast biology. Immunol Rev 208:88-105 (Pubitemid 41746387)
    • (2005) Immunological Reviews , vol.208 , pp. 88-105
    • Ross, F.P.1    Teitelbaum, S.L.2
  • 46
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • DOI 10.1016/S1534-5807(02)00157-0
    • Karsenty G, Wagner EF (2002) Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2:389-406 (Pubitemid 34436569)
    • (2002) Developmental Cell , vol.2 , Issue.4 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 47
    • 28544452658 scopus 로고    scopus 로고
    • Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system
    • Tanaka S, Nakamura K, Takahasi N, Suda T (2005) Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol Rev 208:30-49 (Pubitemid 41746383)
    • (2005) Immunological Reviews , vol.208 , pp. 30-49
    • Tanaka, S.1    Nakamura, K.2    Takahasi, N.3    Suda, T.4
  • 48
    • 84255194192 scopus 로고    scopus 로고
    • MicroRNAs and their roles in osteoclast differentiation
    • Xia Z, Chen C, Chen P, Xie H, Luo X (2011) MicroRNAs and their roles in osteoclast differentiation. Front Med 5:414-419
    • (2011) Front Med , vol.5 , pp. 414-419
    • Xia, Z.1    Chen, C.2    Chen, P.3    Xie, H.4    Luo, X.5
  • 49
    • 79953686494 scopus 로고    scopus 로고
    • A microRNA expression signature of osteoclastogenesis
    • Sugatani T, Vacher J, Hruska KA (2011) A microRNA expression signature of osteoclastogenesis. Blood 117:3648-3657
    • (2011) Blood , vol.117 , pp. 3648-3657
    • Sugatani, T.1    Vacher, J.2    Hruska, K.A.3
  • 50
    • 84867233477 scopus 로고    scopus 로고
    • miR-21 expression is related to particle-induced osteolysis pathogenesis
    • Zhou Yingchuan, Liu Yi, Cheng Li (2012) miR-21 expression is related to particle-induced osteolysis pathogenesis. J Orthop Res 30:1837-1842
    • (2012) J Orthop Res , vol.30 , pp. 1837-1842
    • Yingchuan, Z.1    Yi, L.2    Li, C.3
  • 51
    • 34447262870 scopus 로고    scopus 로고
    • MicroRNA-223 is a key factor in osteoclast differentiation
    • DOI 10.1002/jcb.21335
    • Sugatani T, Hruska KA (2007) MicroRNA-223 is a key factor in osteoclast differentiation. J Cell Biochem 101:996-999 (Pubitemid 47040879)
    • (2007) Journal of Cellular Biochemistry , vol.101 , Issue.4 , pp. 996-999
    • Sugatani, T.1    Hruska, K.A.2
  • 52
    • 34247483919 scopus 로고    scopus 로고
    • An Evolutionarily Conserved Mechanism for MicroRNA-223 Expression Revealed by MicroRNA Gene Profiling
    • DOI 10.1016/j.cell.2007.02.048, PII S0092867407003947
    • Fukao T, Fukuda Y, Kiga K, Sharif J, Hino K, Enomoto Y, Kawamura A, Nakamura K, Takeuchi T, Tanabe M (2007) An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell 129:617-631 (Pubitemid 46660972)
    • (2007) Cell , vol.129 , Issue.3 , pp. 617-631
    • Fukao, T.1    Fukuda, Y.2    Kiga, K.3    Sharif, J.4    Hino, K.5    Enomoto, Y.6    Kawamura, A.7    Nakamura, K.8    Takeuchi, T.9    Tanabe, M.10
  • 53
    • 63249113375 scopus 로고    scopus 로고
    • Impaired micro-RNA pathways diminish osteoclast differentiation and function
    • Sugatani T, Hruska KA (2009) Impaired micro-RNA pathways diminish osteoclast differentiation and function. J Biol Chem 284:4667-4678
    • (2009) J Biol Chem , vol.284 , pp. 4667-4678
    • Sugatani, T.1    Hruska, K.A.2
  • 57
    • 52249094653 scopus 로고    scopus 로고
    • Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    • Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK (2008) Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther 10:R101
    • (2008) Arthritis Res Ther , vol.10
    • Pauley, K.M.1    Satoh, M.2    Chan, A.L.3    Bubb, M.R.4    Reeves, W.H.5    Chan, E.K.6
  • 58
    • 79958053053 scopus 로고    scopus 로고
    • The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis
    • Nakasa T, Shibuya H, Nagata Y, Niimoto T, Ochi M (2011) The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum 63:1582-1590
    • (2011) Arthritis Rheum , vol.63 , pp. 1582-1590
    • Nakasa, T.1    Shibuya, H.2    Nagata, Y.3    Niimoto, T.4    Ochi, M.5
  • 59
    • 84859595006 scopus 로고    scopus 로고
    • MiR-133a in human circulating monocytes: A potential biomarker associated with postmenopausal osteoporosis
    • Wang Y, Li L, Moore BT, Peng XH, Fang X, Lappe JM, Recker RR, Xiao P (2012) MiR-133a in human circulating monocytes: a potential biomarker associated with postmenopausal osteoporosis. PLoS One 7:e34641
    • (2012) PLoS One , vol.7
    • Wang, Y.1    Li, L.2    Moore, B.T.3    Peng, X.H.4    Fang, X.5    Lappe, J.M.6    Recker, R.R.7    Xiao, P.8
  • 60
    • 84255200563 scopus 로고    scopus 로고
    • Building strong bones: Molecular regulation of the osteoblast lineage
    • Long F (2011) Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol 13:27-38
    • (2011) Nat Rev Mol Cell Biol , vol.13 , pp. 27-38
    • Long, F.1
  • 61
    • 0041695485 scopus 로고    scopus 로고
    • A second canon: Functions and mechanisms of b-catenin-independent Wnt signaling
    • DOI 10.1016/S1534-5807(03)00266-1, PII S1534580703002661
    • Veeman MT, Axelrod JD, Moon RT (2003) A second canon. Functions and mechanisms of b-catenin-independent Wnt signaling. Dev Cell 5:367-377 (Pubitemid 37107667)
    • (2003) Developmental Cell , vol.5 , Issue.3 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 62
    • 79960633240 scopus 로고    scopus 로고
    • Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1
    • Zhang J, Tu Q, Bonewald LF, He X, Stein G, Lian J, Chen J (2011) Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1. J Bone Miner Res 26:1953-1963
    • (2011) J Bone Miner Res , vol.26 , pp. 1953-1963
    • Zhang, J.1    Tu, Q.2    Bonewald, L.F.3    He, X.4    Stein, G.5    Lian, J.6    Chen, J.7
  • 63
    • 77955492538 scopus 로고    scopus 로고
    • miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop
    • Kapinas K, Kessler C, Ricks T, Gronowicz G, Delany AM (2010) miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop. J Biol Chem 285:25221-25231
    • (2010) J Biol Chem , vol.285 , pp. 25221-25231
    • Kapinas, K.1    Kessler, C.2    Ricks, T.3    Gronowicz, G.4    Delany, A.M.5
  • 64
    • 69249143283 scopus 로고    scopus 로고
    • MiR-29 suppression of osteonectin in osteoblasts: Regulation during differentiation and by canonical Wnt signaling
    • Kapinas K, Kessler CB, Delany AM (2009) MiR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling. J Cell Biochem 108:216-224
    • (2009) J Cell Biochem , vol.108 , pp. 216-224
    • Kapinas, K.1    Kessler, C.B.2    Delany, A.M.3
  • 66
    • 84857126923 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/beta-catenin signaling
    • Egea V, Zahler S, Rieth N, Neth P, Popp T, Kehe K, Jochum M, Ries C (2012) Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/beta-catenin signaling. Proc Natl Acad Sci USA 109:E309- E316
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Egea, V.1    Zahler, S.2    Rieth, N.3    Neth, P.4    Popp, T.5    Kehe, K.6    Jochum, M.7    Ries, C.8
  • 67
    • 77958086896 scopus 로고    scopus 로고
    • miR-27 promotes osteoblast differentiation by modulating Wnt signaling
    • Wang T, Xu Z (2010) miR-27 promotes osteoblast differentiation by modulating Wnt signaling. Biochem Biophys Res Commun 402:186-189
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 186-189
    • Wang, T.1    Xu, Z.2
  • 68
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-β signaling through Smads
    • Feng XH, Derynck R (2005) Specificity and versatility in TGF-β signaling through Smads. Annu Rev Cell Dev Biol 21:659-693
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 69
    • 33845971522 scopus 로고    scopus 로고
    • Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    • Bandyopadhyay A, Tsuji K, Cox K, Harfe BD, Rosen V, Tabin CJ (2006) Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet 2:e216
    • (2006) PLoS Genet , vol.2
    • Bandyopadhyay, A.1    Tsuji, K.2    Cox, K.3    Harfe, B.D.4    Rosen, V.5    Tabin, C.J.6
  • 70
    • 84861972028 scopus 로고    scopus 로고
    • Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370
    • Itoh T, Ando M, Tsukamasa Y, Akao Y (2012) Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370. FEBS Lett 586:1693-1701
    • (2012) FEBS Lett , vol.586 , pp. 1693-1701
    • Itoh, T.1    Ando, M.2    Tsukamasa, Y.3    Akao, Y.4
  • 71
    • 47149109822 scopus 로고    scopus 로고
    • MicroRNAs in normal and malignant hematopoiesis
    • Garzon R, Croce CM (2008) MicroRNAs in normal and malignant hematopoiesis. Curr Opin Hematol 15:352-358
    • (2008) Curr Opin Hematol , vol.15 , pp. 352-358
    • Garzon, R.1    Croce, C.M.2
  • 72
    • 80054898958 scopus 로고    scopus 로고
    • MiR-17 modulates osteogenic differentiation through a coherent feedforward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis
    • Liu Y, Liu W, Hu C, Xue Z, Wang G, Ding B, Luo H, Tang L, Kong X, Chen X, Liu N, Ding Y, Ding Y, Jin Y (2011) MiR-17 modulates osteogenic differentiation through a coherent feedforward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis. Stem Cells 29:1804-1816
    • (2011) Stem Cells , vol.29 , pp. 1804-1816
    • Liu, Y.1    Liu, W.2    Hu, C.3    Xue, Z.4    Wang, G.5    Ding, B.6    Luo, H.7    Tang, L.8    Kong, X.9    Chen, X.10    Liu, N.11    Ding, Y.12    Ding, Y.13    Jin, Y.14
  • 73
    • 38549101581 scopus 로고    scopus 로고
    • Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor
    • DOI 10.1359/jbmr.071011
    • Luzi E, Marini F, Sala SC, Tognarini I, Galli G, Brandi ML (2008) Osteogenic differentiation of human adipose tissuederived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor. J Bone Miner Res 23:287-295 (Pubitemid 351160043)
    • (2008) Journal of Bone and Mineral Research , vol.23 , Issue.2 , pp. 287-295
    • Luzi, E.1    Marini, F.2    Sala, S.C.3    Tognarini, I.4    Galli, G.5    Brandi, M.L.6
  • 74
    • 80051587553 scopus 로고    scopus 로고
    • MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration
    • Duan Z, Choy E, Harmon D, Liu X, Susa M, Mankin H, Hornicek F (2011) MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. Mol Cancer Ther 10:1337-1345
    • (2011) Mol Cancer Ther , vol.10 , pp. 1337-1345
    • Duan, Z.1    Choy, E.2    Harmon, D.3    Liu, X.4    Susa, M.5    Mankin, H.6    Hornicek, F.7
  • 76
    • 0034669031 scopus 로고    scopus 로고
    • A common enzyme connects notch signaling and Alzheimer's disease
    • Kopan R, Goate A (2000) A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev 14:2799-2806
    • (2000) Genes Dev , vol.14 , pp. 2799-2806
    • Kopan, R.1    Goate, A.2
  • 77
    • 0032574993 scopus 로고    scopus 로고
    • Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
    • DOI 10.1038/30756
    • Schroeter EH, Kisslinger JA, Kopan R (1998) Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382-386 (Pubitemid 28269713)
    • (1998) Nature , vol.393 , Issue.6683 , pp. 382-386
    • Schroeter, E.H.1    Kisslinger, J.A.2    Kopan, R.3
  • 80
    • 84872701013 scopus 로고    scopus 로고
    • Osteoblast lineage-specific effects of notch activation in the skeleton
    • Canalis E, Parker K, Feng JQ, Zanotti S (2013) Osteoblast lineage-specific effects of notch activation in the skeleton. Endocrinology 154:623-634
    • (2013) Endocrinology , vol.154 , pp. 623-634
    • Canalis, E.1    Parker, K.2    Feng, J.Q.3    Zanotti, S.4
  • 82
    • 84863887333 scopus 로고    scopus 로고
    • Genetics of osteoporosis from genome-wide association studies: Advances and challenges
    • Richards JB, Zheng HF, Spector TD (2012) Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet 13:576-588
    • (2012) Nat Rev Genet , vol.13 , pp. 576-588
    • Richards, J.B.1    Zheng, H.F.2    Spector, T.D.3
  • 84
    • 84878609509 scopus 로고    scopus 로고
    • MicroRNA-29a protects against glucocorticoid-induced bone loss and fragility in rats by orchestrating bone acquisition and resorption
    • Wang FS, Chung PC, Lin CL, Chen MW, Ke HJ, Chang YH, Chen YS, Wu SL, Ko JY (2013) MicroRNA-29a protects against glucocorticoid-induced bone loss and fragility in rats by orchestrating bone acquisition and resorption. Arthritis Rheum 65:1530-1540
    • (2013) Arthritis Rheum , vol.65 , pp. 1530-1540
    • Wang, F.S.1    Chung, P.C.2    Lin, C.L.3    Chen, M.W.4    Ke, H.J.5    Chang, Y.H.6    Chen, Y.S.7    Wu, S.L.8    Ko, J.Y.9
  • 85
    • 84876012965 scopus 로고    scopus 로고
    • MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein
    • Kuo PL, Liao SH, Hung JY, Huang MS, Hsu YL (2013) MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein. Biochim Biophys Acta 1830:3756-3766
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 3756-3766
    • Kuo, P.L.1    Liao, S.H.2    Hung, J.Y.3    Huang, M.S.4    Hsu, Y.L.5
  • 87
    • 51249096975 scopus 로고    scopus 로고
    • Runx transcription factors in neuronal development
    • Inoue K, Shiga T, Ito Y (2008) Runx transcription factors in neuronal development. Neural Dev 3:20
    • (2008) Neural Dev , vol.3 , pp. 20
    • Inoue, K.1    Shiga, T.2    Ito, Y.3
  • 89
    • 79251631940 scopus 로고    scopus 로고
    • Inducible expression of Runx2 results in multiorgan abnormalities in mice
    • He N, Xiao Z, Yin T, Stubbs J, Li L, Quarles LD (2011) Inducible expression of Runx2 results in multiorgan abnormalities in mice. J Cell Biochem 112:653-665
    • (2011) J Cell Biochem , vol.112 , pp. 653-665
    • He, N.1    Xiao, Z.2    Yin, T.3    Stubbs, J.4    Li, L.5    Quarles, L.D.6
  • 91
    • 77149136767 scopus 로고    scopus 로고
    • MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation
    • Huang J, Zhao L, Xing L, Chen D (2010) MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells 28:357-364
    • (2010) Stem Cells , vol.28 , pp. 357-364
    • Huang, J.1    Zhao, L.2    Xing, L.3    Chen, D.4
  • 92
    • 84865308101 scopus 로고    scopus 로고
    • Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells
    • Okamoto H, Matsumi Y, Hoshikawa Y, Takubo K, Ryoke K, Shiota G (2012) Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells. PloS One 7:e43800
    • (2012) PloS One , vol.7
    • Okamoto, H.1    Matsumi, Y.2    Hoshikawa, Y.3    Takubo, K.4    Ryoke, K.5    Shiota, G.6
  • 93
    • 47049125858 scopus 로고    scopus 로고
    • Upregulation of miR-23a approximately 27a approximately 24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells
    • DOI 10.1002/ijc.23580
    • Huang S, He X, Ding J, Liang L, Zhao Y, Zhang Z, Yao X, Pan Z, Zhang P, Li J, Wan D, Gu J (2008) Upregulation of miR-23a approximately 27a approximately 24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells. Int J Cancer 123:972-978 (Pubitemid 352032429)
    • (2008) International Journal of Cancer , vol.123 , Issue.4 , pp. 972-978
    • Huang, S.1    He, X.2    Ding, J.3    Liang, L.4    Zhao, Y.5    Zhang, Z.6    Yao, X.7    Pan, Z.8    Zhang, P.9    Li, J.10    Wan, D.11    Gu, J.12
  • 94
    • 36349001297 scopus 로고    scopus 로고
    • 2-M checkpoint in MDA-MB-231 breast cancer cells
    • DOI 10.1158/0008-5472.CAN-07-2416
    • Mertens-Talcott SU, Chintharlapalli S, Li X, Safe S (2007) The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB- 231 breast cancer cells. Cancer Res 67:11001-11011 (Pubitemid 350145930)
    • (2007) Cancer Research , vol.67 , Issue.22 , pp. 11001-11011
    • Mertens-Talcott, S.U.1    Chintharlapalli, S.2    Li, X.3    Safe, S.4
  • 97
    • 78650946447 scopus 로고    scopus 로고
    • Polymorphisms in predicted miRNAs binding sites and osteoporosis
    • Lei SF, Papasian CJ, Deng HW (2011) Polymorphisms in predicted miRNAs binding sites and osteoporosis. J Bone Miner Res 26:72-78
    • (2011) J Bone Miner Res , vol.26 , pp. 72-78
    • Lei, S.F.1    Papasian, C.J.2    Deng, H.W.3
  • 99
    • 65949105697 scopus 로고    scopus 로고
    • MiR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue
    • Kim YJ, Bae SW, Yu SS, Bae YC, Jung JS (2009) MiR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue. J Bone Miner Res 24:816-825
    • (2009) J Bone Miner Res , vol.24 , pp. 816-825
    • Kim, Y.J.1    Bae, S.W.2    Yu, S.S.3    Bae, Y.C.4    Jung, J.S.5
  • 101
    • 84864281323 scopus 로고    scopus 로고
    • Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression
    • Huang S, Wang S, Bian C, Yang Z, Zhou H, Zeng Y, Li H, Han Q, Zhao RC (2012) Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression. Stem Cells Dev 21:2531-2540
    • (2012) Stem Cells Dev , vol.21 , pp. 2531-2540
    • Huang, S.1    Wang, S.2    Bian, C.3    Yang, Z.4    Zhou, H.5    Zeng, Y.6    Li, H.7    Han, Q.8    Zhao, R.C.9
  • 102
    • 84861320209 scopus 로고    scopus 로고
    • Identification of microRNAs inhibiting TGF-beta- induced IL-11 production in bone metastatic breast cancer cells
    • Pollari S, Leivonen SK, Perälä M, Fey V, Käkönen SM, Kallioniemi O (2012) Identification of microRNAs inhibiting TGF-beta- induced IL-11 production in bone metastatic breast cancer cells. PloS One 7:e37361
    • (2012) PloS One , vol.7
    • Pollari, S.1    Leivonen, S.K.2    Perälä, M.3    Fey, V.4    Käkönen, S.M.5    Kallioniemi, O.6
  • 104
    • 84864286762 scopus 로고    scopus 로고
    • MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2
    • Zeng Y, Qu X, Li H, Huang S, Wang S, Xu Q, Lin R, Han Q, Li J, Zhao RC (2012) MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2. FEBS Lett 586:2375-2381
    • (2012) FEBS Lett , vol.586 , pp. 2375-2381
    • Zeng, Y.1    Qu, X.2    Li, H.3    Huang, S.4    Wang, S.5    Xu, Q.6    Lin, R.7    Han, Q.8    Li, J.9    Zhao, R.C.10
  • 106
    • 67749145694 scopus 로고    scopus 로고
    • MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5
    • Itoh T, Nozawa Y, Akao Y (2009) MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5. J Biol Chem 284:19272-19279
    • (2009) J Biol Chem , vol.284 , pp. 19272-19279
    • Itoh, T.1    Nozawa, Y.2    Akao, Y.3
  • 110
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation
    • DOI 10.1016/S0092-8674(01)00622-5
    • Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29 (Pubitemid 34137009)
    • (2002) Cell , vol.108 , Issue.1 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 112
    • 84875988471 scopus 로고    scopus 로고
    • miR-145 and miR-143 regulate odontoblast differentiation through targeting Klf4 and Osx genes in a feedback loop
    • Liu H, Lin H, Zhang L, Sun Q, Yuan G, Zhang L, Chen S, Chen Z (2013) miR-145 and miR-143 regulate odontoblast differentiation through targeting Klf4 and Osx genes in a feedback loop. J Biol Chem 288:9261-9271
    • (2013) J Biol Chem , vol.288 , pp. 9261-9271
    • Liu, H.1    Lin, H.2    Zhang, L.3    Sun, Q.4    Yuan, G.5    Zhang, L.6    Chen, S.7    Chen, Z.8
  • 115
    • 38049021536 scopus 로고    scopus 로고
    • Total oxidative/anti-oxidative status and relation to bone mineral density in osteoporosis
    • Altindag O, Erel O, Soran N, Celik H, Selek S (2008) Total oxidative/anti-oxidative status and relation to bone mineral density in osteoporosis. Rheumatol Int 28:317-321
    • (2008) Rheumatol Int , vol.28 , pp. 317-321
    • Altindag, O.1    Erel, O.2    Soran, N.3    Celik, H.4    Selek, S.5
  • 116
    • 77957258122 scopus 로고    scopus 로고
    • Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis
    • Teixeira CC, Liu Y, Thant LM, Pang J, Palmer G, Alikhani M (2010) Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis. J Biol Chem 285:31055-31065
    • (2010) J Biol Chem , vol.285 , pp. 31055-31065
    • Teixeira, C.C.1    Liu, Y.2    Thant, L.M.3    Pang, J.4    Palmer, G.5    Alikhani, M.6
  • 117
    • 84864115273 scopus 로고    scopus 로고
    • miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1
    • Kim KM, Park SJ, Jung SH, Kim EJ, Jogeswar G, Ajita J, Rhee Y, Kim CH, Lim SK (2012) miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1. J Bone Miner Res 27:1669-1679
    • (2012) J Bone Miner Res , vol.27 , pp. 1669-1679
    • Kim, K.M.1    Park, S.J.2    Jung, S.H.3    Kim, E.J.4    Jogeswar, G.5    Ajita, J.6    Rhee, Y.7    Kim, C.H.8    Lim, S.K.9


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