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Volumn 36, Issue 1, 2010, Pages 25-32

Regulation of gene expression in osteoblasts

Author keywords

Atf4; HDAC; Lef1; miRs; NFATc; Osterix; Runx2; SMAD

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CALCINEURIN; HISTONE DEACETYLASE; LYMPHOID ENHANCER FACTOR 1; MICRORNA; SMAD PROTEIN; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR TWIST; ZINC FINGER PROTEIN;

EID: 77951116026     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.72     Document Type: Review
Times cited : (175)

References (99)
  • 1
    • 21644434750 scopus 로고    scopus 로고
    • The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription
    • Tapscott, S. J. (2005) The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription. Development 132, 2685-2695.
    • (2005) Development , vol.132 , pp. 2685-2695
    • Tapscott, S.J.1
  • 2
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PPARgamma
    • Tontonoz, P. and Spiegelman B. M. (2008) Fat and beyond: the diverse biology of PPARgamma. Annu. Rev. Biochem. 77, 289-312.
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 6
    • 0024371095 scopus 로고
    • Downregulation of cell growth and cell cycle regulated genes during chick osteoblast differentiation with the reciprocal expression of histone gene variants
    • Shalhoub, V., Gerstenfeld, L. C., Collart, D., Lian, J. B., and Stein, G. S. (1989) Downregulation of cell growth and cell cycle regulated genes during chick osteoblast differentiation with the reciprocal expression of histone gene variants. Biochemistry 28, 5318-5322. (Pubitemid 19175738)
    • (1989) Biochemistry , vol.28 , Issue.13 , pp. 5318-5322
    • Shalhoub, V.1    Gerstenfeld, L.C.2    Collart, D.3    Lian, J.B.4    Stein, G.S.5
  • 7
  • 8
    • 2942548981 scopus 로고    scopus 로고
    • Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
    • DOI 10.1038/sj.onc.1207676
    • Stein, G. S., Lian, J. B., van Wijnen, A. J., Stein, J. L., Montecino, M., Javed, A., Zaidi, S. K., Young, D. W., Choi, J. Y., and Pockwinse, S. M. (2004) Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene 23, 4315-4329. (Pubitemid 38758597)
    • (2004) Oncogene , vol.23 , Issue.24 , pp. 4315-4329
    • Stein, G.S.1    Lian, J.B.2    Van Wijnen, A.J.3    Stein, J.L.4    Montecino, M.5    Javed, A.6    Zaidi, S.K.7    Young, D.W.8    Choi, J.-Y.9    Pockwinse, S.M.10
  • 10
    • 34249994607 scopus 로고    scopus 로고
    • Histone deacetylase co-repressor complex control of Runx2 and bone formation
    • Jensen, E. D., Nair, A. K., and Westendorf, J. J. (2007) Histone deacetylase co-repressor complex control of Runx2 and bone formation. Crit. Rev. Eukaryot. Gene Expr. 17, 187-196.
    • (2007) Crit. Rev. Eukaryot. Gene Expr. , vol.17 , pp. 187-196
    • Jensen, E.D.1    Nair, A.K.2    Westendorf, J.J.3
  • 11
    • 26844574658 scopus 로고    scopus 로고
    • Runx2: A master organizer of gene transcription in developing and maturing osteoblasts
    • Schroeder, T. M., Jensen, E. D., and Westendorf, J. J. (2005) Runx2: a master organizer of gene transcription in developing and maturing osteoblasts. Birth Defects Res. C Embryo Today 75, 213-225.
    • (2005) Birth Defects Res. C Embryo Today , vol.75 , pp. 213-225
    • Schroeder, T.M.1    Jensen, E.D.2    Westendorf, J.J.3
  • 12
    • 0037129340 scopus 로고    scopus 로고
    • MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2
    • DOI 10.1038/sj.onc.1205367
    • Pelletier, N., Champagne, N., Stifani, S., and Yang, X. J. (2002) MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. Oncogene 21, 2729-2740. (Pubitemid 34478331)
    • (2002) Oncogene , vol.21 , Issue.17 , pp. 2729-2740
    • Pelletier, N.1    Champagne, N.2    Stifani, S.3    Yang, X.-J.4
  • 15
    • 39749130325 scopus 로고    scopus 로고
    • Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner
    • Jensen, E. D., Schroeder, T. M., Bailey, J., Gopalakrishnan, R., and Westendorf, J. J. (2008) Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation- independent manner. J. Bone Miner. Res. 23, 361-372.
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 361-372
    • Jensen, E.D.1    Schroeder, T.M.2    Bailey, J.3    Gopalakrishnan, R.4    Westendorf, J.J.5
  • 17
    • 4744349390 scopus 로고    scopus 로고
    • Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation
    • Schroeder, T. M., Kahler, R. A., Li, X., and Westendorf, J. J. (2004) Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J. Biol. Chem. 279, 41998-42007.
    • (2004) J. Biol. Chem. , vol.279 , pp. 41998-42007
    • Schroeder, T.M.1    Kahler, R.A.2    Li, X.3    Westendorf, J.J.4
  • 19
    • 68049105392 scopus 로고    scopus 로고
    • NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation
    • Choo, M. K., Yeo, H., and Zayzafoon, M. (2009) NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation. Bone 45, 579-589.
    • (2009) Bone , vol.45 , pp. 579-589
    • Choo, M.K.1    Yeo, H.2    Zayzafoon, M.3
  • 20
    • 37549003675 scopus 로고    scopus 로고
    • Runx2- And histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression
    • Lamour, V., Detry, C., Sanchez, C., Henrotin, Y., Castronovo, V., and Bellahcene, A. (2007) Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. J. Biol. Chem. 282, 36240-36249.
    • (2007) J. Biol. Chem. , vol.282 , pp. 36240-36249
    • Lamour, V.1    Detry, C.2    Sanchez, C.3    Henrotin, Y.4    Castronovo, V.5    Bellahcene, A.6
  • 21
    • 28144448363 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors promote osteoblast maturation
    • Schroeder, T. M. and Westendorf, J. J. (2005) Histone deacetylase inhibitors promote osteoblast maturation. J. Bone Miner. Res. 20, 2254-2263.
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 2254-2263
    • Schroeder, T.M.1    Westendorf, J.J.2
  • 22
    • 27144453009 scopus 로고    scopus 로고
    • Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors
    • Cho, H. H., Park, H. T., Kim, Y. J., Bae, Y. C., Suh, K. T., and Jung, J. S. (2005) Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. J. Cell. Biochem. 96, 533-542.
    • (2005) J. Cell. Biochem. , vol.96 , pp. 533-542
    • Cho, H.H.1    Park, H.T.2    Kim, Y.J.3    Bae, Y.C.4    Suh, K.T.5    Jung, J.S.6
  • 23
    • 33749353184 scopus 로고    scopus 로고
    • Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation
    • Lee, H. W., Suh, J. H., Kim, A. Y., Lee, Y. S., Park, S. Y., and Kim, J. B. (2006) Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation. Mol. Endocrinol. 20, 2432-2443.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 2432-2443
    • Lee, H.W.1    Suh, J.H.2    Kim, A.Y.3    Lee, Y.S.4    Park, S.Y.5    Kim, J.B.6
  • 24
    • 0032849244 scopus 로고    scopus 로고
    • Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation
    • Tintut, Y., Parhami, F., Le, V., Karsenty, G., and Demer, L. L. (1999) Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation. J. Biol. Chem. 274, 28875-28879.
    • (1999) J. Biol. Chem. , vol.274 , pp. 28875-28879
    • Tintut, Y.1    Parhami, F.2    Le, V.3    Karsenty, G.4    Demer, L.L.5
  • 25
    • 0041845297 scopus 로고    scopus 로고
    • E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    • Zhao, M., Qiao, M., Oyajobi, B. O., Mundy, G. R., and D. Chen (2003) E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. J. Biol. Chem. 278, 27939-27944.
    • (2003) J. Biol. Chem. , vol.278 , pp. 27939-27944
    • Zhao, M.1    Qiao, M.2    Oyajobi, B.O.3    Mundy, G.R.4    Chen, D.5
  • 26
    • 38449109035 scopus 로고    scopus 로고
    • Schnurri-3: A key regulator of postnatal skeletal remodeling
    • Jones, D. C., Wein, M. N., and Glimcher, L. H. (2007) Schnurri-3: a key regulator of postnatal skeletal remodeling. Adv. Exp. Med. Biol. 602, 1-13.
    • (2007) Adv. Exp. Med. Biol. , vol.602 , pp. 1-13
    • Jones, D.C.1    Wein, M.N.2    Glimcher, L.H.3
  • 27
    • 33744454653 scopus 로고    scopus 로고
    • Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3
    • DOI 10.1126/science.1126313
    • Jones, D. C., Wein, M. N., Oukka, M., Hofstaetter, J. G., Glimcher, M. J., and Glimcher, L. H. (2006) Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science 312, 1223-1227. (Pubitemid 43801150)
    • (2006) Science , vol.312 , Issue.5777 , pp. 1223-1227
    • Jones, D.C.1    Wein, M.N.2    Oukka, M.3    Hofstaetter, J.G.4    Glimcher, M.J.5    Glimcher, L.H.6
  • 28
    • 37248998857 scopus 로고    scopus 로고
    • Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3
    • Glimcher, L. H., Jones, D. C., and Wein, M. N. (2007) Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3. Ann. N Y Acad. Sci. 1116, 174-181.
    • (2007) Ann. N Y Acad. Sci. , vol.1116 , pp. 174-181
    • Glimcher, L.H.1    Jones, D.C.2    Wein, M.N.3
  • 29
    • 10744231292 scopus 로고    scopus 로고
    • Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. a putative explanation for why intermittent administration is needed for bone anabolism
    • Bellido, T., Ali, A. A., Plotkin, L. I., Fu, Q., Gubrij, I., Roberson, P. K., Weinstein, R. S., O'Brien, C. A., Manolagas, S. C., and Jilka, R. L. (2003) Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J. Biol. Chem. 278, 50259-50272.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50259-50272
    • Bellido, T.1    Ali, A.A.2    Plotkin, L.I.3    Fu, Q.4    Gubrij, I.5    Roberson, P.K.6    Weinstein, R.S.7    O'Brien, C.A.8    Manolagas, S.C.9    Jilka, R.L.10
  • 30
    • 67649831233 scopus 로고    scopus 로고
    • The orphan nuclear receptor estrogen receptor-related receptor gamma negatively regulates BMP2-induced osteoblast differentiation and bone formation
    • Jeong, B. C., Lee, Y. S., Park, Y. Y., Bae, I. H., Kim, D. K., Koo, S. H., Choi, H. R., Kim, S. H., Franceschi, R. T., Koh, J. T., and Choi, H. S. (2009) The orphan nuclear receptor estrogen receptor-related receptor gamma negatively regulates BMP2-induced osteoblast differentiation and bone formation. J. Biol. Chem. 284, 14211-14218.
    • (2009) J. Biol. Chem. , vol.284 , pp. 14211-14218
    • Jeong, B.C.1    Lee, Y.S.2    Park, Y.Y.3    Bae, I.H.4    Kim, D.K.5    Koo, S.H.6    Choi, H.R.7    Kim, S.H.8    Franceschi, R.T.9    Koh, J.T.10    Choi, H.S.11
  • 31
    • 59049104478 scopus 로고    scopus 로고
    • Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2
    • Jensen, E. D., Gopalakrishnan, R., and Westendorf, J. J. (2009) Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2. J. Biol. Chem. 284, 2225-2234.
    • (2009) J. Biol. Chem. , vol.284 , pp. 2225-2234
    • Jensen, E.D.1    Gopalakrishnan, R.2    Westendorf, J.J.3
  • 32
    • 0033590648 scopus 로고    scopus 로고
    • Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone
    • DOI 10.1038/sj.onc.1202333
    • Porte, D., Tuckermann, J., Becker, M., Baumann, B., Teurich, S., Higgins, T., Owen, M. J., Schorpp-Kistner, M., and P. Angel (1999) Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene 18, 667-678. (Pubitemid 29080324)
    • (1999) Oncogene , vol.18 , Issue.3 , pp. 667-678
    • Porte, D.1    Tuckermann, J.2    Becker, M.3    Baumann, B.4    Teurich, S.5    Higgins, T.6    Owen, M.J.7    Schorpp-Kistner, M.8    Angel, P.9
  • 33
    • 0034725717 scopus 로고    scopus 로고
    • Developmental regulation of collagenase-3 mRNA in normal, differentiating osteoblasts through the activator protein-1 and the runt domain binding sites
    • Winchester, S. K., Selvamurugan, N., D'Alonzo, R. C., and Partridge, N. C. (2000) Developmental regulation of collagenase-3 mRNA in normal, differentiating osteoblasts through the activator protein-1 and the runt domain binding sites. J. Biol. Chem. 275, 23310-23318.
    • (2000) J. Biol. Chem. , vol.275 , pp. 23310-23318
    • Winchester, S.K.1    Selvamurugan, N.2    D'Alonzo, R.C.3    Partridge, N.C.4
  • 34
    • 67749122133 scopus 로고    scopus 로고
    • Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene
    • Boumah, C. E., Lee, M., Selvamurugan, N., Shimizu, E., and Partridge, N. C. (2009) Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene. Mol. Endocrinol. 23, 1255-1263.
    • (2009) Mol. Endocrinol. , vol.23 , pp. 1255-1263
    • Boumah, C.E.1    Lee, M.2    Selvamurugan, N.3    Shimizu, E.4    Partridge, N.C.5
  • 35
    • 0034681454 scopus 로고    scopus 로고
    • Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1
    • Selvamurugan, N., Pulumati, M. R., Tyson, D. R., and Partridge, N. C. (2000) Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1. J. Biol. Chem. 275, 5037-5042.
    • (2000) J. Biol. Chem. , vol.275 , pp. 5037-5042
    • Selvamurugan, N.1    Pulumati, M.R.2    Tyson, D.R.3    Partridge, N.C.4
  • 36
    • 0037016730 scopus 로고    scopus 로고
    • Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation
    • D'Alonzo, R. C., Selvamurugan, N., Karsenty, G., and Partridge, N. C. (2002) Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J. Biol. Chem. 277, 816-822.
    • (2002) J. Biol. Chem. , vol.277 , pp. 816-822
    • D'Alonzo, R.C.1    Selvamurugan, N.2    Karsenty, G.3    Partridge, N.C.4
  • 37
    • 33748940904 scopus 로고    scopus 로고
    • Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/ RD/Cbfa sites alters bone remodeling in vivo
    • Selvamurugan, N., Jefcoat, S. C., Kwok, S., Kowalewski, R., Tamasi, J. A., and Partridge, N. C. (2006) Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/ RD/Cbfa sites alters bone remodeling in vivo. J. Cell. Biochem. 99, 545-557.
    • (2006) J. Cell. Biochem. , vol.99 , pp. 545-557
    • Selvamurugan, N.1    Jefcoat, S.C.2    Kwok, S.3    Kowalewski, R.4    Tamasi, J.A.5    Partridge, N.C.6
  • 38
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation
    • DOI 10.1016/S0092-8674(01)00622-5
    • Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., and de Crombrugghe, B. (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29. (Pubitemid 34137009)
    • (2002) Cell , vol.108 , Issue.1 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 39
    • 33646050013 scopus 로고    scopus 로고
    • Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene
    • Nishio, Y., Dong, Y., Paris, M., O'Keefe, R. J., Schwarz, E. M., and Drissi, H. (2006) Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene 372, 62-70.
    • (2006) Gene , vol.372 , pp. 62-70
    • Nishio, Y.1    Dong, Y.2    Paris, M.3    O'Keefe, R.J.4    Schwarz, E.M.5    Drissi, H.6
  • 42
  • 43
    • 8744224520 scopus 로고    scopus 로고
    • ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells
    • Yang, X. and Karsenty, G. (2004) ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells. J. Biol. Chem. 279, 47109-47114.
    • (2004) J. Biol. Chem. , vol.279 , pp. 47109-47114
    • Yang, X.1    Karsenty, G.2
  • 44
    • 24744458827 scopus 로고    scopus 로고
    • Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression
    • Xiao, G., Jiang, D., Ge, C., Zhao, Z., Lai, Y., Boules, H., Phimphilai, M., Yang, X., Karsenty, G., and Franceschi, R. T. (2005) Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J. Biol. Chem. 280, 30689-30696.
    • (2005) J. Biol. Chem. , vol.280 , pp. 30689-30696
    • Xiao, G.1    Jiang, D.2    Ge, C.3    Zhao, Z.4    Lai, Y.5    Boules, H.6    Phimphilai, M.7    Yang, X.8    Karsenty, G.9    Franceschi, R.T.10
  • 45
    • 41549122869 scopus 로고    scopus 로고
    • Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: Requirement for Osteocalcin gene expression
    • DOI 10.1210/en.2007-1573
    • Yu, S., Franceschi, R. T., Luo, M., Zhang, X., Jiang, D., Lai, Y., Jiang, Y., Zhang, J., and Xiao, G. (2008) Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology 149, 1960-1968. (Pubitemid 351468354)
    • (2008) Endocrinology , vol.149 , Issue.4 , pp. 1960-1968
    • Yu, S.1    Franceschi, R.T.2    Luo, M.3    Zhang, X.4    Jiang, D.5    Lai, Y.6    Jiang, Y.7    Zhang, J.8    Xiao, G.9
  • 47
    • 41949123120 scopus 로고    scopus 로고
    • General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    • Yu, S., Jiang, Y., Galson, D. L., Luo, M., Lai, Y., Lu, Y., Ouyang, H. J., Zhang, J., and Xiao, G. (2008) General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J. Biol. Chem. 283, 5542-5553.
    • (2008) J. Biol. Chem. , vol.283 , pp. 5542-5553
    • Yu, S.1    Jiang, Y.2    Galson, D.L.3    Luo, M.4    Lai, Y.5    Lu, Y.6    Ouyang, H.J.7    Zhang, J.8    Xiao, G.9
  • 50
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • Lee, K. S., Kim, H. J., Li, Q. L., Chi, X. Z., Ueta, C., Komori, T., Wozney, J. M., Kim, E. G., Choi, J. Y., Ryoo, H. M., and Bae, S. C. (2000) Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol. Cell Biol. 20, 8783-8792.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 8783-8792
    • Lee, K.S.1    Kim, H.J.2    Li, Q.L.3    Chi, X.Z.4    Ueta, C.5    Komori, T.6    Wozney, J.M.7    Kim, E.G.8    Choi, J.Y.9    Ryoo, H.M.10    Bae, S.C.11
  • 51
    • 33846436417 scopus 로고    scopus 로고
    • Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation
    • Bae, J. S., Gutierrez, S., Narla, R., Pratap, J., Devados, R., van Wijnen, A. J., Stein, J. L., Stein, G. S., Lian, J. B., and Javed, A. (2007) Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation. J. Cell. Biochem. 100, 434-449.
    • (2007) J. Cell. Biochem. , vol.100 , pp. 434-449
    • Bae, J.S.1    Gutierrez, S.2    Narla, R.3    Pratap, J.4    Devados, R.5    Van Wijnen, A.J.6    Stein, J.L.7    Stein, G.S.8    Lian, J.B.9    Javed, A.10
  • 55
    • 20144365699 scopus 로고    scopus 로고
    • Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription
    • DOI 10.1002/jcp.20258
    • Afzal, F., Pratap, J., Ito, K., Ito, Y., Stein, J. L., van Wijnen, A. J., Stein, G. S., Lian, J. B., and Javed, A. (2005) Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J. Cell Physiol. 204, 63-72. (Pubitemid 40776807)
    • (2005) Journal of Cellular Physiology , vol.204 , Issue.1 , pp. 63-72
    • Afzal, F.1    Pratap, J.2    Ito, K.3    Ito, Y.4    Stein, J.L.5    Van Wijnen, A.J.6    Stein, G.S.7    Lian, J.B.8    Javed, A.9
  • 56
    • 34249846564 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2
    • Wang, Q., Wei, X., Zhu, T., Zhang, M., Shen, R., Xing, L., R.J. O'Keefe, and Chen, D. (2007) Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. J. Biol. Chem. 282, 10742-10748.
    • (2007) J. Biol. Chem. , vol.282 , pp. 10742-10748
    • Wang, Q.1    Wei, X.2    Zhu, T.3    Zhang, M.4    Shen, R.5    Xing, L.6    O'Keefe, R.J.7    Chen, D.8
  • 57
    • 33645647676 scopus 로고    scopus 로고
    • Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation
    • Shen, R., Chen, M., Wang, Y. J., Kaneki, H., Xing, L., O'Keefe R. J., and Chen, D. (2006) Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. J. Biol. Chem. 281, 3569-3576.
    • (2006) J. Biol. Chem. , vol.281 , pp. 3569-3576
    • Shen, R.1    Chen, M.2    Wang, Y.J.3    Kaneki, H.4    Xing, L.5    O'Keefe, R.J.6    Chen, D.7
  • 58
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • DOI 10.1101/gad.1102703
    • Hogan, P. G., Chen, L., Nardone, J., and Rao, A. (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 17, 2205-2232. (Pubitemid 37128637)
    • (2003) Genes and Development , vol.17 , Issue.18 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 59
    • 0031832127 scopus 로고    scopus 로고
    • The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome
    • Bourgeois, P., Bolcato-Bellemin, A. L., Danse, J. M., Bloch-Zupan, A., Yoshiba, K., Stoetzel, C., and Perrin-Schmitt, F. (1998) The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome. Hum. Mol. Genet. 7, 945-957.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 945-957
    • Bourgeois, P.1    Bolcato-Bellemin, A.L.2    Danse, J.M.3    Bloch-Zupan, A.4    Yoshiba, K.5    Stoetzel, C.6    Perrin-Schmitt, F.7
  • 64
    • 0029783822 scopus 로고    scopus 로고
    • Developmental expression and activities of specific Fos and Jun proteins are functionally related to osteoblast maturation: Role of Fra-2 and Jun D during differentiation
    • DOI 10.1210/en.137.10.4398
    • McCabe, L. R., Banerjee, C., Kundu, R., Harrison, R. J., Dobner, P. R., Stein, J. L., Lian, J. B., and Stein, G. S. (1996) Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation: role of Fra-2 and Jun D during differentiation. Endocrinology 137, 4398-4408. (Pubitemid 26321890)
    • (1996) Endocrinology , vol.137 , Issue.10 , pp. 4398-4408
    • Mccabe, L.R.1    Banerjee, C.2    Kundu, R.3    Harrison, R.J.4    Dobner, P.R.5    Stein, J.L.6    Lian, J.B.7    Stein, G.S.8
  • 65
    • 0028173214 scopus 로고
    • C-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling
    • Grigoriadis, A. E., Wang, Z. Q., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., and Wagner, E. F. (1994) c-Fos: a key regulator of osteoclast- macrophage lineage determination and bone remodeling. Science 266, 443-448. (Pubitemid 2146943)
    • (1994) Science , vol.266 , Issue.5184 , pp. 443-448
    • Grigoriadis, A.E.1    Wang Zhao, Q.2    Cecchini, M.G.3    Hofstetter, W.4    Felix, R.5    Fleisch, H.A.6    Wagner, E.F.7
  • 66
    • 0027236534 scopus 로고
    • Osteoblasts are target cells for transformation in c-fos transgenic mice
    • Grigoriadis, A. E., Schellander, K., Wang, Z. Q., and Wagner, E. F. (1993) Osteoblasts are target cells for transformation in c-fos transgenic mice. J. Cell Biol. 122, 685-701. (Pubitemid 23226685)
    • (1993) Journal of Cell Biology , vol.122 , Issue.3 , pp. 685-701
    • Grigoriadis, A.E.1    Schellander, K.2    Wang, Z.-Q.3    Wagner, E.F.4
  • 67
    • 0033835880 scopus 로고    scopus 로고
    • Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1
    • Jochum, W., David, J. P., Elliott, C., Wutz, A., Plenk, H., Jr., Matsuo, K., and Wagner, E. F. (2000) Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med 6, 980-984.
    • (2000) Nat Med , vol.6 , pp. 980-984
    • Jochum, W.1    David, J.P.2    Elliott, C.3    Wutz, A.4    Plenk Jr., H.5    Matsuo, K.6    Wagner, E.F.7
  • 71
    • 0025599438 scopus 로고
    • Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: Model for phenotype suppression of transcription
    • Owen, T. A., Bortell, R., Yocum, S. A., Smock, S. L., Zhang, M., Abate, C., Shalhoub, V., Aronin, N., Wright, K. L., van Wijnen, A. J., et al. (1990) Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription. Proc. Natl. Acad. Sci. USA 87, 9990-9994.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 9990-9994
    • Owen, T.A.1    Bortell, R.2    Yocum, S.A.3    Smock, S.L.4    Zhang, M.5    Abate, C.6    Shalhoub, V.7    Aronin, N.8    Wright, K.L.9    Van Wijnen, A.J.10
  • 72
    • 42449144295 scopus 로고    scopus 로고
    • Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity
    • Sabatakos, G., Rowe, G. C., Kveiborg, M., Wu, M., Neff, L., Chiusaroli, R., Philbrick, W. M., and Baron, R. (2008) Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity. J. Bone Miner. Res. 23, 584-595.
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 584-595
    • Sabatakos, G.1    Rowe, G.C.2    Kveiborg, M.3    Wu, M.4    Neff, L.5    Chiusaroli, R.6    Philbrick, W.M.7    Baron, R.8
  • 73
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of β-catenin with the transcription factor LEF- 1
    • DOI 10.1038/382638a0
    • Behrens, J., von Kries, J. P., Kuhl, M., Bruhn, L., Wedlich, D., Grosschedl, R., and Birchmeier, W. (1996) Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382, 638-642. (Pubitemid 26268958)
    • (1996) Nature , vol.382 , Issue.6592 , pp. 638-642
    • Behrens, J.1    Von Kries, J.P.2    Kuhl, M.3    Bruhn, L.4    Wedlich, D.5    Grosschedl, R.6    Birchmeier, W.7
  • 74
    • 0033817339 scopus 로고    scopus 로고
    • Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator
    • Billin, A. N., Thirlwell, H., and Ayer, D. E. (2000) Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator. Mol. Cell Biol. 20, 6882-6890.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 6882-6890
    • Billin, A.N.1    Thirlwell, H.2    Ayer, D.E.3
  • 75
    • 0033200392 scopus 로고    scopus 로고
    • A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development
    • DOI 10.1101/gad.13.17.2218
    • Chen, G., Fernandez, J., Mische, S., and Courey, A. J. (1999) A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev. 13, 2218-2230. (Pubitemid 29426727)
    • (1999) Genes and Development , vol.13 , Issue.17 , pp. 2218-2230
    • Chen, G.1    Fernandez, J.2    Mische, S.3    Courey, A.J.4
  • 76
    • 18744400798 scopus 로고    scopus 로고
    • Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
    • Daniels, D. L. and Weis, W. I. (2005) Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat. Struct. Mol. Biol. 12, 364-371.
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 364-371
    • Daniels, D.L.1    Weis, W.I.2
  • 77
    • 0034678610 scopus 로고    scopus 로고
    • The p300/CBP acetyltransferases function as transcriptional coactivators of β-catenin in vertebrates
    • Hecht, A., Vleminckx, K., Stemmler, M. P., van Roy, F., and Kemler, R. (2000) The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates. EMBO J. 19, 1839-1850. (Pubitemid 30204395)
    • (2000) EMBO Journal , vol.19 , Issue.8 , pp. 1839-1850
    • Hecht, A.1    Vleminckx, K.2    Stemmler, M.P.3    Van Roy, F.4    Kemler, R.5
  • 79
    • 0038485600 scopus 로고    scopus 로고
    • Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter
    • Kahler, R. A. and Westendorf, J. J. (2003) Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. J. Biol. Chem. 278, 11937-11944.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11937-11944
    • Kahler, R.A.1    Westendorf, J.J.2
  • 81
    • 0027945654 scopus 로고
    • Development of several organs that require inductive epithelial- Mesenchymal interactions is impaired in LEF-1-deficient mice
    • van Genderen, C., Okamura, R. M., Farinas, I., Quo, R. G., Parslow, T. G., Bruhn, L., and Grosschedl, R. (1994) Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 8, 2691-2703. (Pubitemid 24375419)
    • (1994) Genes and Development , vol.8 , Issue.22 , pp. 2691-2703
    • Van Genderen, C.1    Okamura, R.M.2    Farinas, I.3    Quo, R.-G.4    Parslow, T.G.5    Bruhn, L.6    Grosschedl, R.7
  • 83
    • 33645243606 scopus 로고    scopus 로고
    • Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts
    • Kahler, R. A., Galindo, M., Lian, J., Stein, G. S., van Wijnen, A. J., and Westendorf, J. J. (2006) Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts. J. Cell. Biochem. 97, 969-983.
    • (2006) J. Cell. Biochem. , vol.97 , pp. 969-983
    • Kahler, R.A.1    Galindo, M.2    Lian, J.3    Stein, G.S.4    Van Wijnen, A.J.5    Westendorf, J.J.6
  • 84
    • 70149125015 scopus 로고    scopus 로고
    • Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation
    • Hoeppner, L. H., Secreto, F., Jensen, E. D., Li, X., Kahler, R. A., and Westendorf, J. J. (2009) Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation. J. Cell Physiol. 221, 480-489.
    • (2009) J. Cell Physiol. , vol.221 , pp. 480-489
    • Hoeppner, L.H.1    Secreto, F.2    Jensen, E.D.3    Li, X.4    Kahler, R.A.5    Westendorf, J.J.6
  • 86
    • 0037474465 scopus 로고    scopus 로고
    • Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction
    • Bain, G., Muller, T., Wang, X., and Papkoff, J. (2003) Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem. Biophys. Res. Commun. 301, 84-91.
    • (2003) Biochem. Biophys. Res. Commun. , vol.301 , pp. 84-91
    • Bain, G.1    Muller, T.2    Wang, X.3    Papkoff, J.4
  • 87
    • 40849083276 scopus 로고    scopus 로고
    • Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    • Qiang, Y. W., Barlogie, B., Rudikoff, S., and Shaughnessy, J. D., Jr. (2008) Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone 42, 669-680.
    • (2008) Bone , vol.42 , pp. 669-680
    • Qiang, Y.W.1    Barlogie, B.2    Rudikoff, S.3    Shaughnessy Jr., J.D.4
  • 88
    • 0142241118 scopus 로고    scopus 로고
    • BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
    • Rawadi, G., Vayssiere, B., Dunn, F., Baron, R., and Roman-Roman S. (2003) BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J. Bone Miner. Res. 18, 1842-1853.
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 1842-1853
    • Rawadi, G.1    Vayssiere, B.2    Dunn, F.3    Baron, R.4    Roman-Roman, S.5
  • 89
    • 47949115772 scopus 로고    scopus 로고
    • Fibroblast growth factor signaling uses multiple mechanisms to inhibit Wnt-induced transcription in osteoblasts
    • Ambrosetti, D., Holmes, G., Mansukhani, A., and Basilico, C. (2008) Fibroblast growth factor signaling uses multiple mechanisms to inhibit Wnt-induced transcription in osteoblasts. Mol. Cell Biol. 28, 4759-4771.
    • (2008) Mol. Cell Biol. , vol.28 , pp. 4759-4771
    • Ambrosetti, D.1    Holmes, G.2    Mansukhani, A.3    Basilico, C.4
  • 91
    • 59149094516 scopus 로고    scopus 로고
    • Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats)
    • Zhang, Y., Hassan, M. Q., Xie, R. L., Hawse, J. R., Spelsberg, T. C., Montecino, M., Stein, J. L., Lian, J. B., van Wijnen, A. J., and Stein, G. S. (2009) Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats). J. Biol. Chem. 284, 3125-3135.
    • (2009) J. Biol. Chem. , vol.284 , pp. 3125-3135
    • Zhang, Y.1    Hassan, M.Q.2    Xie, R.L.3    Hawse, J.R.4    Spelsberg, T.C.5    Montecino, M.6    Stein, J.L.7    Lian, J.B.8    Van Wijnen, A.J.9    Stein, G.S.10
  • 92
    • 0034680856 scopus 로고    scopus 로고
    • Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling
    • Lai, C. F., Feng, X., Nishimura, R., Teitelbaum, S. L., Avioli, L. V., Ross, F. P., and Cheng, S. L. (2000) Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling. J. Biol. Chem. 275, 36400-36406.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36400-36406
    • Lai, C.F.1    Feng, X.2    Nishimura, R.3    Teitelbaum, S.L.4    Avioli, L.V.5    Ross, F.P.6    Cheng, S.L.7
  • 94
    • 52449115337 scopus 로고    scopus 로고
    • MicroRNAs in development and disease
    • Erson, A. E. and Petty, E. M. (2008) MicroRNAs in development and disease. Clin. Genet. 74, 296-306.
    • (2008) Clin. Genet. , vol.74 , pp. 296-306
    • Erson, A.E.1    Petty, E.M.2
  • 97
    • 67749145694 scopus 로고    scopus 로고
    • MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5
    • Itoh, T., Nozawa, Y., and Akao, Y. (2009) MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5. J. Biol. Chem. 284, 19272-19279.
    • (2009) J. Biol. Chem. , vol.284 , pp. 19272-19279
    • Itoh, T.1    Nozawa, Y.2    Akao, Y.3
  • 98
    • 69249143283 scopus 로고    scopus 로고
    • MiR-29 suppression of osteonectin in osteoblasts: Regulation during differentiation and by canonical Wnt signaling
    • Kapinas, K., Kessler, C. B., and Delany, A. M. (2009) miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling. J. Cell. Biochem. 108, 216-224.
    • (2009) J. Cell. Biochem. , vol.108 , pp. 216-224
    • Kapinas, K.1    Kessler, C.B.2    Delany, A.M.3


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