Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse

Developmental Biology

Volumn 340, Issue 1, 2010, Pages 10-21

  Gaur, Tripti ^a   Hussain, Sadiq ^a   Mudhasani, Rajini ^a   Parulkar, Isha ^a   Colby, Jennifer L ^a   Frederick, Dana ^a   Kream, Barbara E ^b   van Wijnen, Andre J ^a   Stein, Janet L ^a   Stein, Gary S ^a   Jones, Stephen N ^a   Lian, Jane B ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Bone development; Bone formation; Col1a Cre; Dicer ablation; High bone mass; MicroRNAs; Osteoblast differentiation; Osteocalcin Cre

Indexed keywords

CELL MARKER; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA1; CRE RECOMBINASE; DICER; OSTEOCALCIN; RNA; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MASS; CELL AGING; CELL DIFFERENTIATION; CONTROLLED STUDY; CORTICAL BONE; DEVELOPMENTAL STAGE; EMBRYO; EX VIVO STUDY; EXTRACELLULAR MATRIX; FETUS; HISTOLOGY; LONG BONE; MESENCHYME CELL; MINERALIZATION; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; STEM CELL; SURVIVAL; VERTEBRA;

EID: 77649187445     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2010.01.008     Document Type: Article

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