Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 6, 2012, Pages

  Egea, Virginia ^a   Zahler, Stefan ^a   Rieth, Nicole ^b   Neth, Peter ^a   Popp, Tanja ^a   Kehe, Kai ^c   Jochum, Marianne ^a   Ries, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Canonical Wnt signaling; Osteogenesis; Plasticity

Indexed keywords

AXIN 2; BETA CATENIN; CD63 ANTIGEN; INHIBITOR PROTEIN; LET 7F MICRORNA; MATRIX METALLOPROTEINASE; MICRORNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL METABOLISM; CELL NUCLEUS; CELL PROLIFERATION; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MESENCHYMAL STEM CELL; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; REGULATORY MECHANISM; UPREGULATION;

ANTIGENS, CD63; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MESENCHYMAL STEM CELLS; MICRORNAS; OSTEOGENESIS; PROTEIN BINDING; TISSUE INHIBITOR OF METALLOPROTEINASE-1; WNT SIGNALING PATHWAY;

EID: 84857126923     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1115083109     Document Type: Article

References (44)

1. Brew K, Nagase H (2010) The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity. Biochim Biophys Acta 1803:55-71.
2. Avalos BR, et al. (1988) K562 cells produce and respond to human erythroidpotentiating activity. Blood 71:1720-1725.
3. Stetler-Stevenson WG (2008) Tissue inhibitors of metalloproteinases in cell signaling: Metalloproteinase-independent biological activities. Sci Signal 1:re6.
4. Jung KK, Liu XW, Chirco R, Fridman R, Kim HR (2006) Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J 25: 3934-3942. (Pubitemid 44338736)
5. Ries C, et al. (2007) MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: Differential regulation by inflammatory cytokines. Blood 109:4055-4063. (Pubitemid 46641761)
6. Pittenger MF, et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147. (Pubitemid 29282067)
7. Jiang Y, et al. (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41-49. (Pubitemid 34742565)
8. Egea V, et al. (2011) TNF-α respecifies human mesenchymal stem cells to a neural fate and promotes migration toward experimental glioma. Cell Death Differ 18:853-863.
9. Prockop DJ, Kota DJ, Bazhanov N, Reger RL (2010) Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). J Cell Mol Med 14:2190-2199.
10. Martinez EC, Kofidis T (2011) Adult stem cells for cardiac tissue engineering. J Mol Cell Cardiol 50:312-319.
11. Joyce N, et al. (2010) Mesenchymal stem cells for the treatment of neurodegenerative disease. Regen Med 5:933-946.
12. Singer NG, Caplan AI (2011) Mesenchymal stem cells: Mechanisms of inflammation. Annu Rev Pathol 6:457-478.
13. Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127:469-480.
14. MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell 17:9-26.
15. Shtutman M, et al. (1999) The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 96:5522-5527. (Pubitemid 29234650)
16. Takahashi M, Tsunoda T, Seiki M, Nakamura Y, Furukawa Y (2002) Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene 21:5861-5867. (Pubitemid 35007236)
17. Bartel DP (2009) MicroRNAs: Target recognition and regulatory functions. Cell 136:215-233.
18. Yi R, Fuchs E (2011) MicroRNAs and their roles in mammalian stem cells. J Cell Sci 124:1775-1783.
19. Ivey KN, Srivastava D (2010) MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell 7:36-41.
20. Guo L, Zhao RC, Wu Y (2011) The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp Hematol 39:608-616.
21. Wingfield PT, et al. (1999) Biophysical and functional characterization of full-length, recombinant human tissue inhibitor of metalloproteinases-2 (TIMP-2) produced in Escherichia coli. Comparison of wild type and amino-terminal alanine appended variant with implications for the mechanism of TIMP functions. J Biol Chem 274:21362-21368.
22. Behrens J, et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280:596-599.
23. Fata JE, Leco KJ, Moorehead RA, Martin DC, Khokha R (1999) Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development. Dev Biol 211:238-254. (Pubitemid 29343279)
24. Schiltz C, Marty C, de Vernejoul MC, Geoffroy V (2008) Inhibition of osteoblastic metalloproteinases in mice prevents bone loss induced by oestrogen deficiency. J Cell Biochem 104:1803-1817.
25. Guedez L, et al. (2001) Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis. Blood 97:1796-1802. (Pubitemid 32217248)
26. Guedez L, et al. (2005) Tissue inhibitor of metalloproteinase 1 (TIMP-1) promotes plasmablastic differentiation of a Burkitt lymphoma cell line: Implications in the pathogenesis of plasmacytic/plasmablastic tumors. Blood 105:1660-1668. (Pubitemid 40223688)
27. Dassé E, et al. (2007) Tissue inhibitor of metalloproteinase-1 promotes hematopoietic differentiation via caspase-3 upstream the MEKK1/MEK6/p38alpha pathway. Leukemia 21:595-603. (Pubitemid 46444540)
28. Day TF, Guo X, Garrett-Beal L, Yang Y (2005) Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8:739-750. (Pubitemid 40585296)
29. Qiang YW, et al. (2009) Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling. Blood 113:4319-4330.
30. Taube ME, Liu XW, Fridman R, Kim HR (2006) TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27(KIP1) protein. Oncogene 25:3041-3048. (Pubitemid 43780468)
31. Liu XW, Bernardo MM, Fridman R, Kim HR (2003) Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway. J Biol Chem 278:40364-40372. (Pubitemid 37248605)
32. Liu XW, et al. (2005) Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: A potential oncogenic activity of tissue inhibitor of metalloproteinase-1. Cancer Res 65:898-906.
33. Chirco R, Liu XW, Jung KK, Kim HR (2006) Novel functions of TIMPs in cell signaling. Cancer Metastasis Rev 25:99-113. (Pubitemid 43723986)
34. Huang K, et al. (2010) MicroRNA roles in beta-catenin pathway. Mol Cancer 9:252.
35. Peter ME (2009) Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression. Cell Cycle 8:843-852.
36. Viswanathan SR, Daley GQ, Gregory RI (2008) Selective blockade of microRNA processing by Lin28. Science 320:97-100. (Pubitemid 351490762)
37. Oskowitz AZ, et al. (2008) Human multipotent stromal cells from bone marrow and microRNA: Regulation of differentiation and leukemia inhibitory factor expression. Proc Natl Acad Sci USA 105:18372-18377.
38. Goff LA, et al. (2008) Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: Prediction of microRNA regulation by PDGF during osteogenesis. Exp Hematol 36:1354-1369.
39. Jho EH, et al. (2002) Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 22:1172-1183.
40. Neth P, et al. (2006) Wnt signaling regulates the invasion capacity of human mesenchymal stem cells. Stem Cells 24:1892-1903. (Pubitemid 44478764)
41. Reynolds A, et al. (2004) Rational siRNA design for RNA interference. Nat Biotechnol 22:326-330. (Pubitemid 38295766)
42. John B, et al. (2004) Human MicroRNA targets. PLoS Biol 2:e363.
43. Huang Y, et al. (2010) A study of miRNAs targets prediction and experimental validation. Protein Cell 1:979-986.
44. Biechele TL, Adams AM, Moon RT (2009) Transcription-based reporters of Wnt/beta-catenin signaling. Cold Spring Harb Protoc 2009(6): pdb.prot5233.