miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells

Journal of Biological Chemistry

Volumn 287, Issue 50, 2012, Pages 42084-42092

  Hassan, Mohammad Q ^a,c   Maeda, Yukiko ^a   Taipaleenmaki, Hanna ^a   Zhang, Weibing ^a   Jafferji, Mohammad ^a   Gordon, Jonathan A R ^a   Li, Zhaoyong ^a   Croce, Carlo M ^b   Van Wijnen, Andre J ^a,d   Stein, Janet L ^a,e   Stein, Gary S ^a,e   Lian, Jane B ^a,e  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c Univ of Alabama School of Dentistry   (United States)

^d MAYO CLINIC   (United States)

^e UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE FORMATION; BONE MARROW STROMAL CELLS; BREAST CANCER CELLS; FEED FORWARD; GROWTH OF CELLS; MAMMARY EPITHELIAL CELLS; METASTATIC CANCER CELLS; MICRORNAS; MULTIPLE TARGETS; OSTEOBLAST DIFFERENTIATION; OSTEOBLAST PHENOTYPE; OSTEOBLASTIC GENES; OSTEOGENESIS; OSTEOGENIC; POSITIVE FEEDBACK LOOP; SCLEROSTIN; TUMOR ACTIVITY; WNT PATHWAY; WNT SIGNALING;

BONE; ENZYME INHIBITION; GENES; OSTEOBLASTS; TRANSCRIPTION;

SIGNALING;

DICKKOPF 2 PROTEIN; GLYCOPROTEIN; MICRORNA; MICRORNA 218; PROTEIN INHIBITOR; SCLEROSTIN; SECRETED FRIZZLED RELATED PROTEIN 2; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL FUNCTIONS; BONE DEVELOPMENT; BONE MARROW; BONE METASTASIS; BREAST EPITHELIUM; BREAST METASTASIS; CANCER CELL; CANCER GROWTH; CELL ACTIVITY; CELL DIFFERENTIATION; CELL HOMING; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; METASTASIS POTENTIAL; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOMIMICRY; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; RNA ANALYSIS; STROMA CELL; UPREGULATION; WNT SIGNALING PATHWAY;

ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAMMARY NEOPLASMS, ANIMAL; MEMBRANE PROTEINS; MICE; MICRORNAS; NEOPLASM METASTASIS; OSTEOBLASTS; RNA, NEOPLASM; WNT SIGNALING PATHWAY;

EID: 84871345038     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.377515     Document Type: Article

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