메뉴 건너뛰기




Volumn 4 JUL, Issue , 2014, Pages

Genomic analysis as the first step toward personalized treatment in renal cell carcinoma

Author keywords

Genome wide analysis; Genomics; High throughput techniques; Personalized treatment; Prognostic and predictive biomarkers; Renal cell carcinoma; Translational research; Tumor heterogeneity

Indexed keywords

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; BETA TUBULIN; BIOLOGICAL MARKER; BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; CD31 ANTIGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR; INTERLEUKIN 2; INTERLEUKIN 8; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; OSTEOPONTIN; PROTEIN SERINE THREONINE KINASE; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR; SCATTER FACTOR; SMALL INTERFERING RNA;

EID: 84904660221     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00194     Document Type: Article
Times cited : (23)

References (150)
  • 1
    • 67650760958 scopus 로고    scopus 로고
    • Epidemiology of kidney cancer
    • Pascual D, Borque A. Epidemiology of kidney cancer. Adv Urol 2008: 782381
    • (2008) Adv Urol , pp. 782381
    • Pascual, D.1    Borque, A.2
  • 2
    • 67749113811 scopus 로고    scopus 로고
    • CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
    • Epub 2009/06/06
    • McRonald FE, Morris MR, Gentle D et al. CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma. Mol Cancer 2009; 8:31. Epub 2009/06/06
    • (2009) Mol Cancer , vol.8 , pp. 31
    • McRonald, F.E.1    Morris, M.R.2    Gentle, D.3
  • 3
    • 0023865666 scopus 로고
    • Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma
    • Seizinger BR, Rouleau GA, Ozelius LJ et al. Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 1988; 332(6161):268-9
    • (1988) Nature , vol.332 , Issue.6161 , pp. 268-269
    • Seizinger, B.R.1    Rouleau, G.A.2    Ozelius, L.J.3
  • 4
    • 6344243850 scopus 로고    scopus 로고
    • WHO-World Health Organization: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
    • Eble JN, Sauter G, Epstein JI, Sesterhenn IA. WHO-World Health Organization: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Iarc Press 2004;7:359
    • (2004) Iarc Press , vol.7 , pp. 359
    • Eble, J.N.1    Sauter, G.2    Epstein, J.I.3    Sesterhenn, I.A.4
  • 5
    • 34347163881 scopus 로고
    • Ueber eine sehr seltene Erkrankung der Netzhaut
    • Von Hippel E (1904). "Ueber eine sehr seltene Erkrankung der Netzhaut". Albrecht von Graefes Arch Ophthal 59: 83-106.
    • (1904) Albrecht von Graefes Arch Ophthal , vol.59 , pp. 83-106
    • Von Hippel, E.1
  • 8
    • 0021329537 scopus 로고
    • Segregation and linkage analyses of von Hippel Lindau disease among 220 descendants from one kindred
    • Go RC, Lamiell JM, Hsia YE et al. Segregation and linkage analyses of von Hippel Lindau disease among 220 descendants from one kindred. Am J Hum Genet 1984;36(1): 131-42
    • (1984) Am J Hum Genet , vol.36 , Issue.1 , pp. 131-142
    • Go, R.C.1    Lamiell, J.M.2    Hsia, Y.E.3
  • 9
    • 0025666942 scopus 로고
    • Localization of the von Hippel-Lindau disease gene to a small region of chromosome 3
    • Hosoe S, Brauch H, Latif F et al. Localization of the von Hippel-Lindau disease gene to a small region of chromosome 3. Genomics 1990;8(4):634-40
    • (1990) Genomics , vol.8 , Issue.4 , pp. 634-640
    • Hosoe, S.1    Brauch, H.2    Latif, F.3
  • 10
    • 0027240519 scopus 로고
    • Identification of the von Hippel-Lindau disease tumor suppressor gene
    • Latif F, Tory K, Gnarra J et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993;260(5112):1317-20
    • (1993) Science , vol.260 , Issue.5112 , pp. 1317-1320
    • Latif, F.1    Tory, K.2    Gnarra, J.3
  • 11
    • 17444390822 scopus 로고    scopus 로고
    • Molecular genetics of familial renal cell carcinoma syndromes
    • Cohen D, Zhou M. Molecular genetics of familial renal cell carcinoma syndromes. Clin Lab Med. 2005;25(2): 259-77
    • (2005) Clin Lab Med. , vol.25 , Issue.2 , pp. 259-277
    • Cohen, D.1    Zhou, M.2
  • 12
    • 0000177603 scopus 로고
    • VHL gene mutation and clear-cell renal carcinomas
    • Knudson AG. VHL gene mutation and clear-cell renal carcinomas. Cancer J Sci Am 1995; 1(3): 180-1
    • (1995) Cancer J Sci Am , vol.1 , Issue.3 , pp. 180-181
    • Knudson, A.G.1
  • 13
    • 0027954044 scopus 로고
    • Mutations of the VHL tumor suppressor gene in renal cell carcinoma
    • Gnarra JR, Tory K, Weng Y et al. Mutations of the VHL tumor suppressor gene in renal cell carcinoma. Nat Genet 1994(7):85-90
    • (1994) Nat Genet , Issue.7 , pp. 85-90
    • Gnarra, J.R.1    Tory, K.2    Weng, Y.3
  • 14
    • 0033587146 scopus 로고    scopus 로고
    • The tumor suppressor protein VHL targets hypoxiainducible factors for oxygen-dependent proteolysis
    • Maxwell PH1, Wiesener MS, Chang GW et al. The tumor suppressor protein VHL targets hypoxiainducible factors for oxygen-dependent proteolysis. Nature 1999;399:271-5
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.L.1    Wiesener, M.S.2    Chang, G.W.3
  • 15
    • 84873084354 scopus 로고    scopus 로고
    • Genomics and epigenomics of renal cell carcinoma
    • Maher ER. Genomics and epigenomics of renal cell carcinoma. Semin Cancer Biol 2013; 23(1): 10-7
    • (2013) Semin Cancer Biol , vol.23 , Issue.1 , pp. 10-17
    • Maher, E.R.1
  • 16
    • 84887184397 scopus 로고    scopus 로고
    • Genomics and epigenomics of clear cell renal cell carcinoma: recent developments and potential applications
    • Rydzanicz M, Wrzesinski T, Bluyssen HA, Wesoly J. Genomics and epigenomics of clear cell renal cell carcinoma: recent developments and potential applications. Cancer Lett 2013;341(2):111-26
    • (2013) Cancer Lett , vol.341 , Issue.2 , pp. 111-126
    • Rydzanicz, M.1    Wrzesinski, T.2    Bluyssen, H.A.3    Wesoly, J.4
  • 17
    • 64949201827 scopus 로고    scopus 로고
    • From bench to bedside: current and future applications of molecular profiling in renal cell carcinoma
    • Arsanious A, Bjarnason GA, Yousef GM. From bench to bedside: current and future applications of molecular profiling in renal cell carcinoma. Mol Cancer 2009;8:20
    • (2009) Mol Cancer , vol.8 , pp. 20
    • Arsanious, A.1    Bjarnason, G.A.2    Yousef, G.M.3
  • 18
    • 84858294880 scopus 로고    scopus 로고
    • Epigenetic regulation in RCC: opportunities for therapeutic intervention?
    • Larkin J, Goh XY, Vetter M, Pickering L, Swanton C. Epigenetic regulation in RCC: opportunities for therapeutic intervention? Nat Rev Urol 2012;9(3):147-55
    • (2012) Nat Rev Urol , vol.9 , Issue.3 , pp. 147-155
    • Larkin, J.1    Goh, X.Y.2    Vetter, M.3    Pickering, L.4    Swanton, C.5
  • 19
    • 84899480870 scopus 로고    scopus 로고
    • Renal cell carcinoma: molecular biology and targeted therapy
    • Su D, Stamatakis L, Singer EA, Srinivasan R. Renal cell carcinoma: molecular biology and targeted therapy. Curr Opin Oncol 2014;26(3): 321-7
    • (2014) Curr Opin Oncol , vol.26 , Issue.3 , pp. 321-327
    • Su, D.1    Stamatakis, L.2    Singer, E.A.3    Srinivasan, R.4
  • 20
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    • Varela I, Tarpey P, Raine K et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 2011;469(7331): 539-42
    • (2011) Nature , vol.469 , Issue.7331 , pp. 539-542
    • Varela, I.1    Tarpey, P.2    Raine, K.3
  • 21
    • 84876037266 scopus 로고    scopus 로고
    • Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma
    • Hakimi AA, Chen YB, Wren J et al. Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma. Eur Urol 2013;63(5): 848-54
    • (2013) Eur Urol , vol.63 , Issue.5 , pp. 848-854
    • Hakimi, A.A.1    Chen, Y.B.2    Wren, J.3
  • 22
    • 84879890360 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of clear cell renal cell carcinoma
    • Cancer Genome Atlas Research Network.
    • Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 2013;499(7456): 43-9
    • (2013) Nature , vol.499 , Issue.7456 , pp. 43-49
  • 23
    • 84873081430 scopus 로고    scopus 로고
    • Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation
    • Kapur P, Peña-Llopis S, Christie A et al. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation. Lancet Oncol 2013;14(2): 159-67
    • (2013) Lancet Oncol , vol.14 , Issue.2 , pp. 159-167
    • Kapur, P.1    Peña-Llopis, S.2    Christie, A.3
  • 24
    • 84890129812 scopus 로고    scopus 로고
    • Renal cancer biomarkers: the promise of personalized care
    • Vasudev NS, Selby PJ, Banks RE. Renal cancer biomarkers: the promise of personalized care. BMC medicine 2012;10:112
    • (2012) BMC medicine , vol.10 , pp. 112
    • Vasudev, N.S.1    Selby, P.J.2    Banks, R.E.3
  • 25
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia--a key regulatory factor in tumour growth
    • Harris AL. Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2(1):38-47
    • (2002) Nat Rev Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 26
    • 78349292982 scopus 로고    scopus 로고
    • A Comprehensive Study of Progressive Cytogenetic Alterations in Clear Cell Renal Cell Carcinoma and a New Model for ccRCC Tumorigenesis and Progression
    • Zhang Z, Wondergem B, Dykema K. A Comprehensive Study of Progressive Cytogenetic Alterations in Clear Cell Renal Cell Carcinoma and a New Model for ccRCC Tumorigenesis and Progression. Adv Bioinformatics 2010; 2010: 428325
    • (2010) Adv Bioinformatics , vol.2010 , pp. 428325
    • Zhang, Z.1    Wondergem, B.2    Dykema, K.3
  • 27
    • 77953195346 scopus 로고    scopus 로고
    • Combined Classical Cytogenetics and Microarray-based Genomic Copy Number Analysis Reveal Frequent 3;5 Rearrangements in Clear Cell Renal Cell Carcinoma
    • Pei J, Feder MM, Al-Saleem T et al. Combined Classical Cytogenetics and Microarray-based Genomic Copy Number Analysis Reveal Frequent 3;5 Rearrangements in Clear Cell Renal Cell Carcinoma. Genes Chromosomes Cancer 2010; 49(7): 610-619
    • (2010) Genes Chromosomes Cancer , vol.49 , Issue.7 , pp. 610-619
    • Pei, J.1    Feder, M.M.2    Al-Saleem, T.3
  • 28
    • 17344381429 scopus 로고    scopus 로고
    • Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
    • Schmidt L, Duh FM, Chen F et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet 1997;16(1): 68-73
    • (1997) Nat Genet , vol.16 , Issue.1 , pp. 68-73
    • Schmidt, L.1    Duh, F.M.2    Chen, F.3
  • 29
    • 0033535530 scopus 로고    scopus 로고
    • Novel mutations of the MET proto-oncogene in papillary renal carcinomas
    • Schmidt L, Junker K, Nakaigawa N et al. Novel mutations of the MET proto-oncogene in papillary renal carcinomas. Oncogene. 1999;18(14): 2343-50
    • (1999) Oncogene. , vol.18 , Issue.14 , pp. 2343-2350
    • Schmidt, L.1    Junker, K.2    Nakaigawa, N.3
  • 30
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science. 1956(123): 309-14
    • (1956) Science , Issue.123 , pp. 309-314
    • Warburg, O.1
  • 31
    • 34547215963 scopus 로고    scopus 로고
    • Identification and Characterization of Renal Cell Carcinoma Gene Markers
    • Dalgin GS, Holloway DT, Liou LS, DeLisi C. Identification and Characterization of Renal Cell Carcinoma Gene Markers. Cancer Informatics 2007;(3):65-92
    • (2007) Cancer Informatics , Issue.3 , pp. 65-92
    • Dalgin, G.S.1    Holloway, D.T.2    Liou, L.S.3    DeLisi, C.4
  • 32
    • 21444432561 scopus 로고    scopus 로고
    • High frequency of somatic frameshift BHD gene mutation in Birt-Hogg-Dubé-associated renal tumors
    • Vocke CD, Yang Y, Pavlovich CP et al. High frequency of somatic frameshift BHD gene mutation in Birt-Hogg-Dubé-associated renal tumors. J Natl Cancer Inst 2005;(97): 931-5
    • (2005) J Natl Cancer Inst , Issue.97 , pp. 931-935
    • Vocke, C.D.1    Yang, Y.2    Pavlovich, C.P.3
  • 33
    • 80052265588 scopus 로고    scopus 로고
    • Prognostic factors and predictive models in renal cell carcinoma: a contemporary review
    • Epub 2011/07/12
    • Sun M, Shariat SF, Cheng C et al. Prognostic factors and predictive models in renal cell carcinoma: a contemporary review. European urology 2011;60(4):644-61. Epub 2011/07/12
    • (2011) European urology , vol.60 , Issue.4 , pp. 644-661
    • Sun, M.1    Shariat, S.F.2    Cheng, C.3
  • 34
    • 33750293584 scopus 로고    scopus 로고
    • Folliculin encoded by the BHD gene interacts with a binding protein FNIP1 and AMPK and is involved in AMPK and mTOR signalling
    • Baba M, Hong SB, Sharma N et al. Folliculin encoded by the BHD gene interacts with a binding protein FNIP1 and AMPK and is involved in AMPK and mTOR signalling. Proceedings of the National Academy of Sciences of the United States of America 2008(103): 15552-7
    • (2008) Proceedings of the National Academy of Sciences of the United States of America , Issue.103 , pp. 15552-15557
    • Baba, M.1    Hong, S.B.2    Sharma, N.3
  • 35
    • 84875722133 scopus 로고    scopus 로고
    • DNA methylation profiling distinguishes histological subtypes of renal cell carcinoma
    • Slater AA, Alokail M, Gentle D et al. DNA methylation profiling distinguishes histological subtypes of renal cell carcinoma. Epigenetics 2013;8(3):252-67
    • (2013) Epigenetics , vol.8 , Issue.3 , pp. 252-267
    • Slater, A.A.1    Alokail, M.2    Gentle, D.3
  • 36
    • 0035184764 scopus 로고    scopus 로고
    • Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array
    • Boer JM, Huber WK, Sültmann H et al. Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array. Genome Res 2001;11(11): 1861-70
    • (2001) Genome Res , vol.11 , Issue.11 , pp. 1861-1870
    • Boer, J.M.1    Huber, W.K.2    Sültmann, H.3
  • 37
    • 0035012170 scopus 로고    scopus 로고
    • Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers
    • Young AN, Amin MB, Moreno CS et al. Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers. Am J Pathol 2001;158(5): 1639-51
    • (2001) Am J Pathol , vol.158 , Issue.5 , pp. 1639-1651
    • Young, A.N.1    Amin, M.B.2    Moreno, C.S.3
  • 38
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • 199
    • Golub TR, Slonim DK, Tamayo P et al. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring. Science 199;286: 531-537
    • Science , vol.286 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3
  • 39
    • 0035984141 scopus 로고    scopus 로고
    • Differential gene expression in renal-cell cancer
    • Skubitz KM, Skubitz AP. Differential gene expression in renal-cell cancer. J Lab Clin Med 2002;140(1): 52-64
    • (2002) J Lab Clin Med , vol.140 , Issue.1 , pp. 52-64
    • Skubitz, K.M.1    Skubitz, A.P.2
  • 40
    • 0344127560 scopus 로고    scopus 로고
    • Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray
    • Higgins JP, Shinghal R, Gill H et al. Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol 2003;162(3): 925-32
    • (2003) Am J Pathol , vol.162 , Issue.3 , pp. 925-932
    • Higgins, J.P.1    Shinghal, R.2    Gill, H.3
  • 41
    • 0242521464 scopus 로고    scopus 로고
    • Molecular subclassification of kidney tumors and the discovery of new diagnostic markers
    • Takahashi M, Yang XJ, Sugimura J et al. Molecular subclassification of kidney tumors and the discovery of new diagnostic markers. Oncogene 2003;22(43): 6810-8
    • (2003) Oncogene , vol.22 , Issue.43 , pp. 6810-6818
    • Takahashi, M.1    Yang, X.J.2    Sugimura, J.3
  • 42
    • 54249156858 scopus 로고    scopus 로고
    • Combining differential expression, chromosomal and pathway analyses for the molecular characterization of renal cell carcinoma
    • Furge KA, Dykema K, Petillo D et al. Combining differential expression, chromosomal and pathway analyses for the molecular characterization of renal cell carcinoma. Can Urol Assoc J. 2007;1(2 Suppl): S21-7.
    • (2007) Can Urol Assoc J. , vol.1 , Issue.2 SUPPL.
    • Furge, K.A.1    Dykema, K.2    Petillo, D.3
  • 43
    • 20844437574 scopus 로고    scopus 로고
    • Molecular classification of renal tumors by gene expression profiling
    • Schuetz AN, Yin-Goen Q, Amin MB et al. Molecular classification of renal tumors by gene expression profiling. J Mol Diagn 2005;7(2): 206-18
    • (2005) J Mol Diagn , vol.7 , Issue.2 , pp. 206-218
    • Schuetz, A.N.1    Yin-Goen, Q.2    Amin, M.B.3
  • 44
    • 47249164780 scopus 로고    scopus 로고
    • A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma
    • Yao M, Huang Y, Shioi K et al. A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma. Int J Cancer 2008;123(5): 1126-32
    • (2008) Int J Cancer , vol.123 , Issue.5 , pp. 1126-1132
    • Yao, M.1    Huang, Y.2    Shioi, K.3
  • 45
    • 29844454948 scopus 로고    scopus 로고
    • Advances in molecular classification of renal neoplasms
    • Yin-Goen Q, Dale J, Yang WL et al. Advances in molecular classification of renal neoplasms. Histol Histopathol 2006;21(3): 325-39
    • (2006) Histol Histopathol , vol.21 , Issue.3 , pp. 325-339
    • Yin-Goen, Q.1    Dale, J.2    Yang, W.L.3
  • 46
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group.
    • Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001;69(3): 89-95
    • (2001) Clin Pharmacol Ther , vol.69 , Issue.3 , pp. 89-95
  • 47
    • 84897095116 scopus 로고    scopus 로고
    • Biomarkers of renal cell carcinoma
    • Ngo TC, Wood CG, Karam JA. Biomarkers of renal cell carcinoma. Urol Oncol 2014;32(3): 243-51
    • (2014) Urol Oncol , vol.32 , Issue.3 , pp. 243-251
    • Ngo, T.C.1    Wood, C.G.2    Karam, J.A.3
  • 48
    • 84896726545 scopus 로고    scopus 로고
    • A systematic review of predictive and prognostic biomarkers for VEGF-targeted therapy in renal cell carcinoma
    • Funakoshi T, Lee CH, Hsieh JJ. A systematic review of predictive and prognostic biomarkers for VEGF-targeted therapy in renal cell carcinoma. Cancer Treat Rev 2014;40(4): 533-47
    • (2014) Cancer Treat Rev , vol.40 , Issue.4 , pp. 533-547
    • Funakoshi, T.1    Lee, C.H.2    Hsieh, J.J.3
  • 49
  • 50
    • 39649084890 scopus 로고    scopus 로고
    • Molecular markers for predicting prognosis of renal cell carcinoma
    • Nogueira M, Kim HL. Molecular markers for predicting prognosis of renal cell carcinoma. Urol Oncol 2008;26(2): 113-24
    • (2008) Urol Oncol , vol.26 , Issue.2 , pp. 113-124
    • Nogueira, M.1    Kim, H.L.2
  • 51
    • 84875758730 scopus 로고    scopus 로고
    • Lessons from the cancer genome
    • Garraway LA, Lander ES. Lessons from the cancer genome. Cell 2013;153(1): 17-37
    • (2013) Cell , vol.153 , Issue.1 , pp. 17-37
    • Garraway, L.A.1    Lander, E.S.2
  • 52
    • 78651257523 scopus 로고    scopus 로고
    • Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
    • Purdue MP, Johansson M, Zelenika D et al. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nature genetics 2011;43(1): 60-5
    • (2011) Nature genetics , vol.43 , Issue.1 , pp. 60-65
    • Purdue, M.P.1    Johansson, M.2    Zelenika, D.3
  • 53
    • 84855377024 scopus 로고    scopus 로고
    • A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23
    • Wu X, Scelo G, Purdue MP et al. A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Human molecular genetics 2012;21(2): 456-62
    • (2012) Human molecular genetics , vol.21 , Issue.2 , pp. 456-462
    • Wu, X.1    Scelo, G.2    Purdue, M.P.3
  • 54
    • 83955161686 scopus 로고    scopus 로고
    • Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology
    • Brannon AR, Haake SM, Hacker KE et al. Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology. European urology 2012;61(2): 258-68
    • (2012) European urology , vol.61 , Issue.2 , pp. 258-268
    • Brannon, A.R.1    Haake, S.M.2    Hacker, K.E.3
  • 55
    • 84855393367 scopus 로고    scopus 로고
    • Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets
    • Dondeti VR, Wubbenhorst B, Lal P et al. Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets. Cancer research 2012;72(1): 112-21
    • (2012) Cancer research , vol.72 , Issue.1 , pp. 112-121
    • Dondeti, V.R.1    Wubbenhorst, B.2    Lal, P.3
  • 56
    • 84891713377 scopus 로고    scopus 로고
    • Urine screening by Seldi-Tof, followed by biomarker identification, in a Brazilian cohort of patients with renal cell carcinoma (RCC)
    • Epub 2013/05/21
    • Alves G, Pereira DA, Sandim V et al. Urine screening by Seldi-Tof, followed by biomarker identification, in a Brazilian cohort of patients with renal cell carcinoma (RCC). International Braz J Urol 2013;39(2): 228-39. Epub 2013/05/21
    • (2013) International Braz J Urol , vol.39 , Issue.2 , pp. 228-239
    • Alves, G.1    Pereira, D.A.2    Sandim, V.3
  • 58
  • 59
    • 79958289707 scopus 로고    scopus 로고
    • A specific gene expression signature characterises metastatic potential in clear cell renal cell carcinoma
    • Sanjmyatav J, Steiner T, Wunderlich H, Diegmann J, Gajda M, Junker K. A specific gene expression signature characterises metastatic potential in clear cell renal cell carcinoma. The Journal of urology 2011(186): 289-94
    • (2011) The Journal of urology , Issue.186 , pp. 289-294
    • Sanjmyatav, J.1    Steiner, T.2    Wunderlich, H.3    Diegmann, J.4    Gajda, M.5    Junker, K.6
  • 60
    • 66349100709 scopus 로고    scopus 로고
    • Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney
    • Beroukhim R, Brunet JP, Di Napoli A et al. Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer research 2009;69(11): 4674-81
    • (2009) Cancer research , vol.69 , Issue.11 , pp. 4674-4681
    • Beroukhim, R.1    Brunet, J.P.2    Di Napoli, A.3
  • 61
    • 84867542519 scopus 로고    scopus 로고
    • Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma
    • Girgis AH, Iakovlev VV, Beheshti B et al. Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma. Cancer research 2012;72(20): 5273-84
    • (2012) Cancer research , vol.72 , Issue.20 , pp. 5273-5284
    • Girgis, A.H.1    Iakovlev, V.V.2    Beheshti, B.3
  • 62
    • 84876147277 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule is an independent prognostic marker in clear cell renal carcinoma
    • Eichelberg C, Chun FK, Bedke J et al. Epithelial cell adhesion molecule is an independent prognostic marker in clear cell renal carcinoma. Int J Cancer 2013;132(12): 2948-55
    • (2013) Int J Cancer , vol.132 , Issue.12 , pp. 2948-2955
    • Eichelberg, C.1    Chun, F.K.2    Bedke, J.3
  • 63
    • 79960758585 scopus 로고    scopus 로고
    • Molecular sub-classification of renal epithelial tumors using meta-analysis of gene expression microarrays
    • Sanford T, Chung PH, Reinish A et al. Molecular sub-classification of renal epithelial tumors using meta-analysis of gene expression microarrays. PloS one 2011;6(7): e21260
    • (2011) PloS one , vol.6 , Issue.7
    • Sanford, T.1    Chung, P.H.2    Reinish, A.3
  • 64
    • 67349203626 scopus 로고    scopus 로고
    • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    • van Haaften G, Dalgliesh GL, Davies H et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 2009;41(5): 521-3
    • (2009) Nat Genet , vol.41 , Issue.5 , pp. 521-523
    • van Haaften, G.1    Dalgliesh, G.L.2    Davies, H.3
  • 65
    • 36749049879 scopus 로고    scopus 로고
    • High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma
    • Epub 2007/10/09
    • Yoshimoto T, Matsuura K, Karnan S et al. High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma. J Pathol 2007;213(4): 392-401. Epub 2007/10/09
    • (2007) J Pathol , vol.213 , Issue.4 , pp. 392-401
    • Yoshimoto, T.1    Matsuura, K.2    Karnan, S.3
  • 66
    • 84655176646 scopus 로고    scopus 로고
    • Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
    • Guo G, Gui Y, Gao S et al. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet 2012;44(1): 17-9
    • (2012) Nat Genet , vol.44 , Issue.1 , pp. 17-19
    • Guo, G.1    Gui, Y.2    Gao, S.3
  • 67
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010;463(7279): 360-3
    • (2010) Nature , vol.463 , Issue.7279 , pp. 360-363
    • Dalgliesh, G.L.1    Furge, K.2    Greenman, C.3    Chen, L.4    Bignell, G.5    Butler, A.6
  • 68
    • 84868309625 scopus 로고    scopus 로고
    • Genetic basis of kidney cancer: role of genomics for the development of diseasebased therapeutics
    • Linehan WM. Genetic basis of kidney cancer: role of genomics for the development of diseasebased therapeutics. Genome Res 2012;22(11): 2089-100
    • (2012) Genome Res , vol.22 , Issue.11 , pp. 2089-2100
    • Linehan, W.M.1
  • 69
    • 84856404470 scopus 로고    scopus 로고
    • Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production
    • Fitzgerald JP, Nayak B, Shanmugasundaram K et al. Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production. PLoS One. 2012;7(1): e30712
    • (2012) PLoS One. , vol.7 , Issue.1
    • Fitzgerald, J.P.1    Nayak, B.2    Shanmugasundaram, K.3
  • 70
    • 84890790069 scopus 로고    scopus 로고
    • Precision medicine for metastatic renal cell carcinoma
    • Sonpavde G, Choueiri TK. Precision medicine for metastatic renal cell carcinoma. Urol Oncol 2014;32(1): 5-15
    • (2014) Urol Oncol , vol.32 , Issue.1 , pp. 5-15
    • Sonpavde, G.1    Choueiri, T.K.2
  • 71
    • 84887947864 scopus 로고    scopus 로고
    • A study exploring critical pathways in clear cell renal cell carcinoma
    • Zeng Z, Que T, Zhang J, Hu Y. A study exploring critical pathways in clear cell renal cell carcinoma. Experimental and therapeutic medicine 2014;7(1): 121-30
    • (2014) Experimental and therapeutic medicine , vol.7 , Issue.1 , pp. 121-130
    • Zeng, Z.1    Que, T.2    Zhang, J.3    Hu, Y.4
  • 72
    • 0037204953 scopus 로고    scopus 로고
    • A road map for those who know JAK-STAT
    • Aaronson DS, Horvath CM. A road map for those who know JAK-STAT. Science 2002(296): 1653-5
    • (2002) Science , Issue.296 , pp. 1653-1655
    • Aaronson, D.S.1    Horvath, C.M.2
  • 73
    • 84903273678 scopus 로고    scopus 로고
    • Evodiamine inhibition of TGF-beta1-induced epithelial-mesenchymal transition in NRK52E cells via Smad and PPAR-gamma pathway
    • doi: 10.1002/cbin.10270.
    • Wei J, Li Z, Yuan F. Evodiamine inhibition of TGF-beta1-induced epithelial-mesenchymal transition in NRK52E cells via Smad and PPAR-gamma pathway. Cell Biol Int 2014. doi: 10.1002/cbin.10270
    • (2014) Cell Biol Int
    • Wei, J.1    Li, Z.2    Yuan, F.3
  • 74
    • 84875540660 scopus 로고    scopus 로고
    • Identifying resistance mechanisms against five tyrosine kinase inhibitors targeting the ERBB/RAS pathway in 45 cancer cell lines
    • Penzvalto Z, Tegze B, Szasz AM et al. Identifying resistance mechanisms against five tyrosine kinase inhibitors targeting the ERBB/RAS pathway in 45 cancer cell lines. PloS One 2013;8(3): e59503
    • (2013) PloS One , vol.8 , Issue.3
    • Penzvalto, Z.1    Tegze, B.2    Szasz, A.M.3
  • 75
    • 54249156858 scopus 로고    scopus 로고
    • Combining differential expression, chromosomal and pathway analyses for the molecular characterization of renal cell carcinoma
    • Furge KA, Dykema K, Petillo D et al. Combining differential expression, chromosomal and pathway analyses for the molecular characterization of renal cell carcinoma. Canadian Urological Association Journal 2007;1(2 Suppl): S21-7
    • (2007) Canadian Urological Association Journal , vol.1 , Issue.2 SUPPL.
    • Furge, K.A.1    Dykema, K.2    Petillo, D.3
  • 76
    • 84896266290 scopus 로고    scopus 로고
    • Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity
    • Nabti I, Marangos P, Bormann J, Kudo NR, Carroll J. Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity. The Journal of Cell Biology 2014;204(6): 891-900
    • (2014) The Journal of Cell Biology , vol.204 , Issue.6 , pp. 891-900
    • Nabti, I.1    Marangos, P.2    Bormann, J.3    Kudo, N.R.4    Carroll, J.5
  • 77
    • 84875364330 scopus 로고    scopus 로고
    • Cumulative number of altered biomarkers in mammalian target of rapamycin pathway is an independent predictor of outcome in patients with clear cell renal cell carcinoma
    • Darwish OM1, Kapur P, Youssef RF et al. Cumulative number of altered biomarkers in mammalian target of rapamycin pathway is an independent predictor of outcome in patients with clear cell renal cell carcinoma. Urology 2013;81(3):581-6
    • (2013) Urology , vol.81 , Issue.3 , pp. 581-586
    • Darwish, O.M.L.1    Kapur, P.2    Youssef, R.F.3
  • 78
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004;18(16): 1926-45
    • (2004) Genes Dev , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 79
    • 84926222122 scopus 로고    scopus 로고
    • Understanding Pathologic Variants of Renal Cell Carcinoma: Distilling Therapeutic Opportunities from Biologic Complexity
    • doi: 10.1016/ j.eururo. 2014.04.029.
    • Shuch B, Amin A, Armstrong AJ et al. Understanding Pathologic Variants of Renal Cell Carcinoma: Distilling Therapeutic Opportunities from Biologic Complexity. Eur Urol. 2014; doi: 10.1016/ j.eururo. 2014.04.029.
    • (2014) Eur Urol.
    • Shuch, B.1    Amin, A.2    Armstrong, A.J.3
  • 80
    • 84895865038 scopus 로고    scopus 로고
    • Intratumoral heterogeneity in kidney cancer
    • Ricketts CJ, Linehan WM. Intratumoral heterogeneity in kidney cancer. Nat Genet. 2014 ;46(3): 214-5
    • (2014) Nat Genet. , vol.46 , Issue.3 , pp. 214-215
    • Ricketts, C.J.1    Linehan, W.M.2
  • 81
    • 84864014138 scopus 로고    scopus 로고
    • Immunological heterogeneity of the RCC microenvironment: do targeted therapies influence immune response?
    • Jun
    • Bex A, Etto T, Vyth-Dreese F, Blank C, Griffioen AW. Immunological heterogeneity of the RCC microenvironment: do targeted therapies influence immune response? Curr Oncol Rep 2012 Jun;14(3): 230-9.
    • (2012) Curr Oncol Rep , vol.14 , Issue.3 , pp. 230-239
    • Bex, A.1    Etto, T.2    Vyth-Dreese, F.3    Blank, C.4    Griffioen, A.W.5
  • 83
    • 84871968042 scopus 로고    scopus 로고
    • Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization
    • Sottoriva A, Spiteri I, Shibata D, Curtis C, Tavaré S. Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization. Cancer Res 2013 1;73(1): 41-9
    • (2013) Cancer Res , vol.73 , Issue.1 , pp. 41-49
    • Sottoriva, A.1    Spiteri, I.2    Shibata, D.3    Curtis, C.4    Tavaré, S.5
  • 84
    • 70349969478 scopus 로고    scopus 로고
    • Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
    • 8
    • Shah SP, Morin RD, Khattra J et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 2009;8;461(7265): 809-13
    • (2009) Nature , vol.461 , Issue.7265 , pp. 809-813
    • Shah, S.P.1    Morin, R.D.2    Khattra, J.3
  • 85
    • 84861541343 scopus 로고    scopus 로고
    • Mutational processes molding the genomes of 21 breast cancers
    • 25
    • Nik-Zainal S, Alexandrov LB, Wedge DC et al. Mutational processes molding the genomes of 21 breast cancers. Cell 2012; 25;149(5):979-93
    • (2012) Cell , vol.149 , Issue.5 , pp. 979-993
    • Nik-Zainal, S.1    Alexandrov, L.B.2    Wedge, D.C.3
  • 86
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Epub 2012/03/09
    • Gerlinger M, Rowan AJ, Horswell S et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. The New England Journal of Medicine. 2012;366(10): 883-92. Epub 2012/03/09
    • (2012) The New England Journal of Medicine. , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 87
    • 84873084388 scopus 로고    scopus 로고
    • Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
    • Kreso A1, O'Brien CA, van Galen P et al. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science 2013 1;339(6119):543-8
    • (2013) Science , vol.339 , Issue.6119 , pp. 543-548
    • Kreso, A.L.1    O'Brien, C.A.2    van Galen, P.3
  • 89
    • 78751693800 scopus 로고    scopus 로고
    • Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets
    • Epub 2010/08/13
    • Swanton C, Larkin JM, Gerlinger Met al. Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets. Genome medicine 2010; 2(8): 53. Epub 2010/08/13
    • (2010) Genome medicine , vol.2 , Issue.8 , pp. 53
    • Swanton, C.1    Larkin, J.M.2    Gerlinger, M.3
  • 90
    • 58149197550 scopus 로고    scopus 로고
    • Differential expression in clear cell renal cell carcinoma identified by gene expression profiling
    • Epub 2008/12/20
    • Lane BR, Li J, Zhou M et al. Differential expression in clear cell renal cell carcinoma identified by gene expression profiling. The Journal of Urology 2009;181(2): 849-60. Epub 2008/12/20
    • (2009) The Journal of Urology , vol.181 , Issue.2 , pp. 849-860
    • Lane, B.R.1    Li, J.2    Zhou, M.3
  • 91
    • 84863218985 scopus 로고    scopus 로고
    • CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases
    • Epub 2012/01/04
    • Wuttig D, Zastrow S, Fussel S et al. CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases. Int J Cancer 2012;131(5): E693-704. Epub 2012/01/04
    • (2012) Int J Cancer , vol.131 , Issue.5
    • Wuttig, D.1    Zastrow, S.2    Fussel, S.3
  • 92
    • 84902073050 scopus 로고    scopus 로고
    • ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma
    • Epub 2014/03/13.
    • Brooks SA, Brannon AR, Parker JS et al. ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma. European Urology 2014. Epub 2014/03/13
    • (2014) European Urology
    • Brooks, S.A.1    Brannon, A.R.2    Parker, J.S.3
  • 93
    • 84874607534 scopus 로고    scopus 로고
    • Integrative genome-wide gene expression profiling of clear cell renal cell carcinoma in Czech Republic and in the United States
    • Epub 2013/03/26
    • Wozniak MB, Le Calvez-Kelm F, Abedi-Ardekani B et al. Integrative genome-wide gene expression profiling of clear cell renal cell carcinoma in Czech Republic and in the United States. PloS One. 2013;8(3): e57886. Epub 2013/03/26
    • (2013) PloS One. , vol.8 , Issue.3
    • Wozniak, M.B.1    Le Calvez-Kelm, F.2    Abedi-Ardekani, B.3
  • 94
    • 22344432541 scopus 로고    scopus 로고
    • Clear cell renal cell carcinoma: gene expression analyses identify a potential signature for tumor aggressiveness
    • Epub 2005/07/22
    • Kosari F, Parker AS, Kube DM et al. Clear cell renal cell carcinoma: gene expression analyses identify a potential signature for tumor aggressiveness. Clin Cancer Res 2005;11(14): 5128-39. Epub 2005/07/22
    • (2005) Clin Cancer Res , vol.11 , Issue.14 , pp. 5128-5139
    • Kosari, F.1    Parker, A.S.2    Kube, D.M.3
  • 95
    • 80053961000 scopus 로고    scopus 로고
    • Role of inflammatory related gene expression in clear cell renal cell carcinoma development and clinical outcomes
    • Epub 2011/09/29
    • Tan W, Hildebrandt MA, Pu X et al. Role of inflammatory related gene expression in clear cell renal cell carcinoma development and clinical outcomes. The Journal of Urology. 2011;186(5): 2071-7. Epub 2011/09/29
    • (2011) The Journal of Urology. , vol.186 , Issue.5 , pp. 2071-2077
    • Tan, W.1    Hildebrandt, M.A.2    Pu, X.3
  • 96
    • 78049280665 scopus 로고    scopus 로고
    • Identification of a set of genes associated with response to interleukin-2 and interferon-alpha combination therapy for renal cell carcinoma through genome-wide gene expression profiling
    • Epub 2010/11/01
    • Mizumori O, Zembutsu H, Kato Y et al. Identification of a set of genes associated with response to interleukin-2 and interferon-alpha combination therapy for renal cell carcinoma through genome-wide gene expression profiling. Experimental and therapeutic medicine 2010;1(6): 955-61. Epub 2010/11/01
    • (2010) Experimental and therapeutic medicine , vol.1 , Issue.6 , pp. 955-961
    • Mizumori, O.1    Zembutsu, H.2    Kato, Y.3
  • 97
    • 84898732516 scopus 로고    scopus 로고
    • Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy
    • Epub 2014/03/14
    • Voss MH, Hakimi AA, Pham CG et al. Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy. Clin Cancer Res 2014;20(7): 1955-64. Epub 2014/03/14
    • (2014) Clin Cancer Res , vol.20 , Issue.7 , pp. 1955-1964
    • Voss, M.H.1    Hakimi, A.A.2    Pham, C.G.3
  • 98
    • 84871530565 scopus 로고    scopus 로고
    • MicroRNA expression profiling of peripheral blood samples predicts resistance to first-line sunitinib in advanced renal cell carcinoma patients
    • Epub 2013/01/12
    • Gamez-Pozo A, Anton-Aparicio LM, Bayona C et al. MicroRNA expression profiling of peripheral blood samples predicts resistance to first-line sunitinib in advanced renal cell carcinoma patients. Neoplasia 2012;14(12): 1144-52. Epub 2013/01/12
    • (2012) Neoplasia , vol.14 , Issue.12 , pp. 1144-1152
    • Gamez-Pozo, A.1    Anton-Aparicio, L.M.2    Bayona, C.3
  • 99
    • 84875917518 scopus 로고    scopus 로고
    • Differential expression of prognostic proteomic markers in primary tumour, venous tumour thrombus and metastatic renal cell cancer tissue and correlation with patient outcome
    • Laird A, O'Mahony FC, Nanda J et al. Differential expression of prognostic proteomic markers in primary tumour, venous tumour thrombus and metastatic renal cell cancer tissue and correlation with patient outcome. PloS One 2013;8(4): e60483
    • (2013) PloS One , vol.8 , Issue.4
    • Laird, A.1    O'Mahony, F.C.2    Nanda, J.3
  • 100
    • 84865554296 scopus 로고    scopus 로고
    • Emerging immunotherapies for renal cell carcinom
    • doi: 10.1093/annonc/mds261
    • Escudier B. Emerging immunotherapies for renal cell carcinoma. Annals of Oncology 23 (Supplement 8), 2012; 35-40, doi:10.1093/annonc/mds261
    • (2012) Annals of Oncology , vol.23 , Issue.SUPPL. 8 , pp. 35-40
    • Escudier, B.1
  • 102
    • 33644853617 scopus 로고    scopus 로고
    • Significance of gene expression analysis of renal cell carcinoma
    • Leppert JT, Pantuck AJ. Significance of gene expression analysis of renal cell carcinoma. Expert Rev Anticancer Ther 2006;6(2): 293-9
    • (2006) Expert Rev Anticancer Ther , vol.6 , Issue.2 , pp. 293-299
    • Leppert, J.T.1    Pantuck, A.J.2
  • 103
    • 84898602164 scopus 로고    scopus 로고
    • Towards defining biomarkers indicating resistances to targeted therapies
    • Stehle F, Schulz K, Seliger B. Towards defining biomarkers indicating resistances to targeted therapies. Biochimica et Biophysica Acta. 2013; 1844(5): 909-16
    • (2013) Biochimica et Biophysica Acta. , vol.1844 , Issue.5 , pp. 909-916
    • Stehle, F.1    Schulz, K.2    Seliger, B.3
  • 104
    • 33846878502 scopus 로고    scopus 로고
    • Genomics of renal cell cancer: the biology behind and the therapy ahead
    • Jones J, Libermann TA. Genomics of renal cell cancer: the biology behind and the therapy ahead. Clin Cancer Res 2007;13(2 Pt 2): 685s-92s
    • (2007) Clin Cancer Res , vol.13 , Issue.2 PART 2
    • Jones, J.1    Libermann, T.A.2
  • 105
    • 84904693583 scopus 로고    scopus 로고
    • Incidence and risk of treatment-related mortality in patients with renal cell cancer (RCC) and non-RCC treated with mammalian target of rapamycin (mTOR) inhibitors.
    • (abstr 347).
    • Choueiri TK, Ye J, Sonpavde G et al. Incidence and risk of treatment-related mortality in patients with renal cell cancer (RCC) and non-RCC treated with mammalian target of rapamycin (mTOR) inhibitors. J Clin Oncol 31, 2013 (suppl 6; abstr 347)
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL. 6
    • Choueiri, T.K.1    Ye, J.2    Sonpavde, G.3
  • 106
    • 84904620513 scopus 로고    scopus 로고
    • Professional practice gaps and barriers to optimal care of renal cell carcinoma (RCC) among oncologists in the United States
    • (abstr 404).
    • Rini BI, Bowser A, Lazure P et al. Professional practice gaps and barriers to optimal care of renal cell carcinoma (RCC) among oncologists in the United States. J Clin Oncol 32, 2014 (suppl 4; abstr 404)
    • (2014) J Clin Oncol , vol.32 , Issue.SUPPL. 4
    • Rini, B.I.1    Bowser, A.2    Lazure, P.3
  • 107
    • 84898958636 scopus 로고    scopus 로고
    • Molecular biomarkers in advanced renal cell carcinoma
    • Apr 15
    • Maroto P, Rini B. Molecular biomarkers in advanced renal cell carcinoma. Clin Cancer Res. 2014 Apr 15;20(8):2060-71
    • (2014) Clin Cancer Res. , vol.20 , Issue.8 , pp. 2060-2071
    • Maroto, P.1    Rini, B.2
  • 108
    • 84908574875 scopus 로고    scopus 로고
    • Fas/Fas Ligand Mediates Keratinocyte Death in Sunitinib- Induced Hand-Foot Skin Reaction
    • May 6. doi: 10.1038/jid.2014.218.
    • Yeh CN, Chung WH, Su SC et al. Fas/Fas Ligand Mediates Keratinocyte Death in Sunitinib- Induced Hand-Foot Skin Reaction. J Invest Dermatol. 2014 May 6. doi: 10.1038/jid.2014.218
    • (2014) J Invest Dermatol
    • Yeh, C.N.1    Chung, W.H.2    Su, S.C.3
  • 109
    • 84916603095 scopus 로고    scopus 로고
    • Biomarker analysis from a phase III trial (GOLD) of dovitinib (Dov) versus sorafenib (Sor) in patients with metastatic renal cell carcinoma after one prior VEGF pathway-targeted therapy and one prior mTOR inhibitor therapy.
    • (abstr 473).
    • Escudier BJ, Porta C, Squires M, Szczylik C et al. Biomarker analysis from a phase III trial (GOLD) of dovitinib (Dov) versus sorafenib (Sor) in patients with metastatic renal cell carcinoma after one prior VEGF pathway-targeted therapy and one prior mTOR inhibitor therapy. J Clin Oncol 32, 2014 (suppl 4; abstr 473)
    • (2014) J Clin Oncol , vol.32 , Issue.SUPPL. 4
    • Escudier, B.J.1    Porta, C.2    Squires, M.3    Szczylik, C.4
  • 110
    • 84904617830 scopus 로고    scopus 로고
    • Correlation of PDL1 tumor expression and treatment outcomes in patients with renal cell carcinoma (RCC) receiving tyrosine kinase inhibitors: COMPARZ study analysis
    • (abstr 416).
    • Choueiri TK, Figueroa DJ, Liu Y et al. Correlation of PDL1 tumor expression and treatment outcomes in patients with renal cell carcinoma (RCC) receiving tyrosine kinase inhibitors: COMPARZ study analysis. J Clin Oncol 32, 2014 (suppl 4; abstr 416)
    • (2014) J Clin Oncol , vol.32 , Issue.SUPPL. 4
    • Choueiri, T.K.1    Figueroa, D.J.2    Liu, Y.3
  • 111
    • 84904626302 scopus 로고    scopus 로고
    • Dysregulation of the beta-catenin complex as an independent predictor of oncological outcomes in patients with ccRCC
    • (abstr 493).
    • Krabbe L-M, Westerman ME et al. Dysregulation of the beta-catenin complex as an independent predictor of oncological outcomes in patients with ccRCC. J Clin Oncol 32, 2014 (suppl 4; abstr 493)
    • (2014) J Clin Oncol , vol.32 , Issue.SUPPL. 4
    • Krabbe, L-M.1    Westerman, M.E.2
  • 112
    • 80053515901 scopus 로고    scopus 로고
    • Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century
    • Oct
    • Khoury MJ, Clauser SB, Freedman AN et al. Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century. Cancer Epidemiol Biomarkers Prev 2011 Oct;20(10): 2105-14
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , Issue.10 , pp. 2105-2114
    • Khoury, M.J.1    Clauser, S.B.2    Freedman, A.N.3
  • 113
    • 84877278637 scopus 로고    scopus 로고
    • Implementing personalized cancer genomics in clinical trials
    • May
    • Simon R, Roychowdhury S. Implementing personalized cancer genomics in clinical trials. Nat Rev Drug Discov 2013 May;12(5): 358-69
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.5 , pp. 358-369
    • Simon, R.1    Roychowdhury, S.2
  • 114
    • 79851493086 scopus 로고    scopus 로고
    • Effect of direct-to-consumer genomewide profiling to assess disease risk
    • Feb 10
    • Bloss CS, Schork NJ, Topol EJ. Effect of direct-to-consumer genomewide profiling to assess disease risk. N Engl J Med 2011 Feb 10;364(6): 524-34
    • (2011) N Engl J Med , vol.364 , Issue.6 , pp. 524-534
    • Bloss, C.S.1    Schork, N.J.2    Topol, E.J.3
  • 115
    • 79951581670 scopus 로고    scopus 로고
    • Horizon scanning for new genomic tests
    • Fb
    • Gwinn M, Grossniklaus DA, Yu W et al. Horizon scanning for new genomic tests. Genet Med. 2011 Fb;13(2): 161-5
    • (2011) Genet Med. , vol.13 , Issue.2 , pp. 161-165
    • Gwinn, M.1    Grossniklaus, D.A.2    Yu, W.3
  • 116
    • 77956326790 scopus 로고    scopus 로고
    • Genome-wide association studies of cancer predisposition
    • Oct
    • Stadler ZK, Vijai J, Thom P. Genome-wide association studies of cancer predisposition. Hematol Oncol Clin North Am 2010 Oct;24(5): 973-96
    • (2010) Hematol Oncol Clin North Am , vol.24 , Issue.5 , pp. 973-996
    • Stadler, Z.K.1    Vijai, J.2    Thom, P.3
  • 117
    • 33846325824 scopus 로고    scopus 로고
    • Educating health-care professionals about genetics and genomics
    • Feb
    • Guttmacher AE, Porteous ME, McInerney JD. Educating health-care professionals about genetics and genomics. Nat Rev Genet 2007 Feb;8(2): 151-7
    • (2007) Nat Rev Genet , vol.8 , Issue.2 , pp. 151-157
    • Guttmacher, A.E.1    Porteous, M.E.2    McInerney, J.D.3
  • 118
    • 84856544369 scopus 로고    scopus 로고
    • Translational genomics: the challenge of developing cancer biomarkers
    • Feb
    • Brooks JD. Translational genomics: the challenge of developing cancer biomarkers. Genome Res 2012 Feb;22(2): 183-7
    • (2012) Genome Res , vol.22 , Issue.2 , pp. 183-187
    • Brooks, J.D.1
  • 119
    • 84863393678 scopus 로고    scopus 로고
    • Cancer genomics: technology, discovery, and translation
    • Feb 20
    • Tran B, Dancey JE, Kamel-Reid S et al. Cancer genomics: technology, discovery, and translation. J Clin Oncol 2012 Feb 20;30(6): 647-60
    • (2012) J Clin Oncol , vol.30 , Issue.6 , pp. 647-660
    • Tran, B.1    Dancey, J.E.2    Kamel-Reid, S.3
  • 120
    • 84870664207 scopus 로고    scopus 로고
    • Comparative effectiveness research, genomics-enabled personalized medicine, and rapid learning health care: a common bond
    • Dec
    • Ginsburg GS, Kuderer NM. Comparative effectiveness research, genomics-enabled personalized medicine, and rapid learning health care: a common bond. J Clin Oncol 2012 Dec 1;30(34): 4233-42
    • (2012) J Clin Oncol , vol.30 , Issue.34 , pp. 4233-4242
    • Ginsburg, G.S.1    Kuderer, N.M.2
  • 121
    • 56249126012 scopus 로고    scopus 로고
    • Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms
    • Cheng L, Zhang S, MacLennan GT. Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms. Hum Pathol 2009;40(1): 10-29
    • (2009) Hum Pathol , vol.40 , Issue.1 , pp. 10-29
    • Cheng, L.1    Zhang, S.2    MacLennan, G.T.3
  • 122
    • 84904671779 scopus 로고    scopus 로고
    • MicroRNA as novel blood-based biomarkers in clear cell renal cell carcinoma.
    • (abstr 375).
    • Hakimi AA, Jacobsen A, Mikkilineni N et al. MicroRNA as novel blood-based biomarkers in clear cell renal cell carcinoma. J Clin Oncol 31, 2013 (suppl 6; abstr 375)
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL. 6
    • Hakimi, A.A.1    Jacobsen, A.2    Mikkilineni, N.3
  • 123
    • 84904598006 scopus 로고    scopus 로고
    • Molecular expression profiling and pathway analysis of formalin-fixed paraffin-embedded primary renal tumor specimens
    • (abstr 448).
    • Aparicio LMA, Villaamil VM, Gallego GA et al. Molecular expression profiling and pathway analysis of formalin-fixed paraffin-embedded primary renal tumor specimens. J Clin Oncol 31, 2013 (suppl 6; abstr 448)
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL. 6
    • Aparicio, L.M.A.1    Villaamil, V.M.2    Gallego, G.A.3
  • 124
    • 84904650373 scopus 로고    scopus 로고
    • Association of mutations in chromatin modifiers with poor survival in clear cell renal cell carcinoma: Analysis of the Cancer Genome Atlas Project
    • (abstr 360).
    • Hakimi AA, Ostrovnaya I, Voss MH et al. Association of mutations in chromatin modifiers with poor survival in clear cell renal cell carcinoma: Analysis of the Cancer Genome Atlas Project. J Clin Oncol 31, 2013 (suppl 6; abstr 360)
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL. 6
    • Hakimi, A.A.1    Ostrovnaya, I.2    Voss, M.H.3
  • 125
    • 84899480870 scopus 로고    scopus 로고
    • Renal cell carcinoma: molecular biology and targeted therapy
    • Su D, Stamatakis L, Singer EA, Srinivasan R. Renal cell carcinoma: molecular biology and targeted therapy. Curr Opin Oncol 2014;26(3): 321-7
    • (2014) Curr Opin Oncol , vol.26 , Issue.3 , pp. 321-327
    • Su, D.1    Stamatakis, L.2    Singer, E.A.3    Srinivasan, R.4
  • 126
    • 84893031630 scopus 로고    scopus 로고
    • Molecular marker for predicting treatment response in advanced renal cell carcinoma: does the promise fulfill clinical need?
    • Garcia-Roig M, Ortiz N, Lokeshwar V. Molecular marker for predicting treatment response in advanced renal cell carcinoma: does the promise fulfill clinical need? Curr Urol Rep 2014;15(1): 375
    • (2014) Curr Urol Rep , vol.15 , Issue.1 , pp. 375
    • Garcia-Roig, M.1    Ortiz, N.2    Lokeshwar, V.3
  • 127
    • 84903522671 scopus 로고    scopus 로고
    • Implementing personalized cancer care
    • doi: 10.1038/nrclinonc.2014.54
    • Schilsky RL. Implementing personalized cancer care. Nat Rev Clin Oncol 2014; doi: 10.1038/nrclinonc.2014.54
    • (2014) Nat Rev Clin Oncol
    • Schilsky, R.L.1
  • 128
    • 84901840263 scopus 로고    scopus 로고
    • Revealing pathway maps of renal cell carcinoma by gene expression change
    • doi: 10.1016/j.compbiomed.2014.04.023
    • Hung FH, Chiu HW, Chang YC. Revealing pathway maps of renal cell carcinoma by gene expression change. Comput Biol Med 2014;51C:111-121. doi: 10.1016/j.compbiomed.2014.04.023
    • (2014) Comput Biol Med , vol.51 C , pp. 111-121
    • Hung, F.H.1    Chiu, H.W.2    Chang, Y.C.3
  • 129
    • 84909987964 scopus 로고    scopus 로고
    • Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies.
    • Jun 7 [Epub ahead of print].
    • Zhao DP, Yang CL, Zhou X, Ding JA, Jiang GN. Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies. Mol Genet Genomics 2014 Jun 7 [Epub ahead of print]
    • (2014) Mol Genet Genomics
    • Zhao, D.P.1    Yang, C.L.2    Zhou, X.3    Ding, J.A.4    Jiang, G.N.5
  • 130
    • 84904649019 scopus 로고    scopus 로고
    • An inducible hepatocellular carcinoma model for preclinical evaluation of anti-angiogenic therapy in adult mice
    • Jun 6. pii: canres.2311.2013.
    • Runge A, Hu J, Wieland M et al. An inducible hepatocellular carcinoma model for preclinical evaluation of anti-angiogenic therapy in adult mice. Cancer Res 2014 Jun 6. pii: canres.2311.2013
    • (2014) Cancer Res
    • Runge, A.1    Hu, J.2    Wieland, M.3
  • 131
    • 84903898814 scopus 로고    scopus 로고
    • An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-beta in human breast cancer
    • 2 Jun R57 [Epub ahead of print]
    • Sato M, Kadota M, Tang B et al. An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-beta in human breast cancer. Breast Cancer Res 2014 Jun 2;16(3):R57 [Epub ahead of print]
    • (2014) Breast Cancer Res , vol.16 , Issue.3
    • Sato, M.1    Kadota, M.2    Tang, B.3
  • 132
    • 84904602423 scopus 로고    scopus 로고
    • A Monotonic and Prognostic Genomic Signature from Fibroblasts for Colorectal Cancer Initiation, Progression and Metastasis
    • May 14. pii: molcanres.0121.2014.
    • Berdiel-Acer M, Cuadras D, Guillen Diaz-Maroto N et al. A Monotonic and Prognostic Genomic Signature from Fibroblasts for Colorectal Cancer Initiation, Progression and Metastasis. Mol Cancer Res 2014 May 14. pii: molcanres.0121.2014
    • (2014) Mol Cancer Res
    • Berdiel-Acer, M.1    Cuadras, D.2    Guillen Diaz-Maroto, N.3
  • 133
    • 84904703755 scopus 로고    scopus 로고
    • Genome-wide genotyping of acute myeloid leukemia with translocation t(9;11)(p22;q23) reveals novel recurrent genomic alterations
    • May 23. pii: haematol.2014.105544].
    • Kühn MW, Bullinger L, Gröschel S et al. Genome-wide genotyping of acute myeloid leukemia with translocation t(9;11)(p22;q23) reveals novel recurrent genomic alterations. Haematologica 2014 May 23. pii: haematol.2014.105544]
    • (2014) Haematologica
    • Kühn, M.W.1    Bullinger, L.2    Gröschel, S.3
  • 134
    • 84904701929 scopus 로고    scopus 로고
    • Low grade prostate cancer diverges early from high grade and metastatic disease.
    • May 31. doi: 10.1111/cas.12460.
    • VanderWeele DJ, Brown CD, Taxy JB et al. Low grade prostate cancer diverges early from high grade and metastatic disease. Cancer Sci 2014 May 31. doi: 10.1111/cas.12460
    • (2014) Cancer Sci
    • VanderWeele, D.J.1    Brown, C.D.2    Taxy, J.B.3
  • 135
    • 84901588884 scopus 로고    scopus 로고
    • Gene expression profiling of 49 human tumor xenografts from in vitro culture through multiple in vivo passages-strategies for data mining in support of therapeutic studies
    • doi: 10.1186/1471-2164-15-393
    • Hollingshead MG, Stockwin LH, Alcoser SY et al. Gene expression profiling of 49 human tumor xenografts from in vitro culture through multiple in vivo passages-strategies for data mining in support of therapeutic studies. BMC Genomics 2014;15:393. doi: 10.1186/1471-2164-15-393
    • (2014) BMC Genomics , vol.15 , pp. 393
    • Hollingshead, M.G.1    Stockwin, L.H.2    Alcoser, S.Y.3
  • 136
    • 84904611547 scopus 로고    scopus 로고
    • Multi-marker Solid Tumor Panels Using Next-generation Sequencing to Direct Molecularly Targeted Therapies
    • doi: 10.1371/currents.eogt.aa5415d435fc886145bd7137a280a971
    • Marrone M, Filipski KK, Gillanders EM, Schully SD, Freedman AN. Multi-marker Solid Tumor Panels Using Next-generation Sequencing to Direct Molecularly Targeted Therapies. PLoS Curr 2014;27;6. doi: 10.1371/currents.eogt.aa5415d435fc886145bd7137a280a971
    • (2014) PLoS Curr , vol.27 , pp. 6
    • Marrone, M.1    Filipski, K.K.2    Gillanders, E.M.3    Schully, S.D.4    Freedman, A.N.5
  • 137
    • 84904672670 scopus 로고    scopus 로고
    • From genome to cancer-why the time is right.
    • Scientific American In: Collins FS, Barker D.
    • Dulbecco R. From genome to cancer-why the time is right. In: Collins FS, Barker D. Mapping the Cancer Genome. Scientific American 2007.
    • (2007) Mapping the Cancer Genome
    • Dulbecco, R.1
  • 138
  • 139
    • 84882646524 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of renal cell carcinoma
    • Xu J, Guo Z, Zhang J et al. Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of renal cell carcinoma. Sci Rep 2013;3: 2408
    • (2013) Sci Rep , vol.3 , pp. 2408
    • Xu, J.1    Guo, Z.2    Zhang, J.3
  • 140
    • 84884583240 scopus 로고    scopus 로고
    • The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma
    • Choueiri TK, Fay AP, Gagnon R et al. The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma. Clin Cancer Res 2013;19(18): 5218-26
    • (2013) Clin Cancer Res , vol.19 , Issue.18 , pp. 5218-5226
    • Choueiri, T.K.1    Fay, A.P.2    Gagnon, R.3
  • 141
    • 84855173597 scopus 로고    scopus 로고
    • A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma
    • Zurita AJ, Jonasch E, Wang X et al. A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma. Ann Oncol 2012;23(1):46-52
    • (2012) Ann Oncol , vol.23 , Issue.1 , pp. 46-52
    • Zurita, A.J.1    Jonasch, E.2    Wang, X.3
  • 142
    • 84903843228 scopus 로고    scopus 로고
    • MET is a potential target across all Papillary Renal Cell Carcinomas. Result from a large molecular study of pRCC with CGHa and matching Gene Expression array
    • [Epub ahead of print].
    • Albiges L, Guegan J, Le Formal A. MET is a potential target across all Papillary Renal Cell Carcinomas. Result from a large molecular study of pRCC with CGHa and matching Gene Expression array. Clin Cancer Res 2014 [Epub ahead of print]
    • (2014) Clin Cancer Res
    • Albiges, L.1    Guegan, J.2    Le Formal, A.3
  • 143
    • 84860292632 scopus 로고    scopus 로고
    • CXCR7: a novel tumor endothelial marker in renal cell carcinoma
    • Maishi N, Ohga N, Hida Y. CXCR7: a novel tumor endothelial marker in renal cell carcinoma. Pathol Int 2012;62(5): 309-17
    • (2012) Pathol Int , vol.62 , Issue.5 , pp. 309-317
    • Maishi, N.1    Ohga, N.2    Hida, Y.3
  • 144
    • 84883279733 scopus 로고    scopus 로고
    • PD-0332991, a potent and selective inhibitor of cyclindependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity
    • Logan JE, Mostofizadeh N, Desai AJ. PD-0332991, a potent and selective inhibitor of cyclindependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity. Anticancer Res. 2013;33(8): 2997-3004
    • (2013) Anticancer Res. , vol.33 , Issue.8 , pp. 2997-3004
    • Logan, J.E.1    Mostofizadeh, N.2    Desai, A.J.3
  • 145
    • 84901752563 scopus 로고    scopus 로고
    • The miR21/10b ratio as a prognostic marker in clear cell renal cell carcinoma
    • pii: S0959-8049(14)00563-2.
    • Fritz HK, Lindgren D, Ljungberg B, Axelson H, Dahlbäck B. The miR21/10b ratio as a prognostic marker in clear cell renal cell carcinoma. Eur J Cancer 2014. pii: S0959-8049(14)00563-2
    • (2014) Eur J Cancer
    • Fritz, H.K.1    Lindgren, D.2    Ljungberg, B.3    Axelson, H.4    Dahlbäck, B.5
  • 146
    • 84860299780 scopus 로고    scopus 로고
    • Prognostic and diagnostic relevance of hypermethylated in cancer 1 (HIC1) CpG island methylation in renal cell carcinoma
    • Eggers H, Steffens S, Grosshennig A et al. Prognostic and diagnostic relevance of hypermethylated in cancer 1 (HIC1) CpG island methylation in renal cell carcinoma. Int J Oncol 2012;40(5): 1650-8
    • (2012) Int J Oncol , vol.40 , Issue.5 , pp. 1650-1658
    • Eggers, H.1    Steffens, S.2    Grosshennig, A.3
  • 147
    • 84896512807 scopus 로고    scopus 로고
    • FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway
    • Lin A, Piao HL, Zhuang L et al. FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway. Cancer Res 2014;74(6): 1682-93
    • (2014) Cancer Res , vol.74 , Issue.6 , pp. 1682-1693
    • Lin, A.1    Piao, H.L.2    Zhuang, L.3
  • 148
    • 0033615538 scopus 로고    scopus 로고
    • Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
    • Lee JO, Yang H, Georgescu MM et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 1999; 99(3):323-34
    • (1999) Cell , vol.99 , Issue.3 , pp. 323-334
    • Lee, J.O.1    Yang, H.2    Georgescu, M.M.3
  • 149
    • 0037623417 scopus 로고    scopus 로고
    • GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
    • Kim DH, Sarbassov DD, Ali SM et al. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003;11(4): 895- 904.
    • (2003) Mol Cell , vol.11 , Issue.4 , pp. 895-904
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3
  • 150
    • 80052837898 scopus 로고    scopus 로고
    • Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma
    • Kucejova B, Peña-Llopis S, Yamasaki T et al. Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma. Mol Cancer Res 2011;9(9): 1255-65
    • (2011) Mol Cancer Res , vol.9 , Issue.9 , pp. 1255-1265
    • Kucejova, B.1    Peña-Llopis, S.2    Yamasaki, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.