메뉴 건너뛰기




Volumn 20, Issue 7, 2014, Pages 1955-1964

Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy

Author keywords

[No Author keywords available]

Indexed keywords

EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; TEMSIROLIMUS; INDOLE DERIVATIVE; MTOR PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; SUNITINIB; TARGET OF RAPAMYCIN KINASE; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 84898732516     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-2345     Document Type: Article
Times cited : (181)

References (37)
  • 3
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449-56.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 4
    • 67651056360 scopus 로고    scopus 로고
    • Effect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologies
    • Dutcher JP, de Souza P, McDermott D, Figlin RA, Berkenblit A, Thiele A, et al. Effect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologies. Med Oncol 2009;26:202-9.
    • (2009) Med Oncol , vol.26 , pp. 202-209
    • Dutcher, J.P.1    De Souza, P.2    McDermott, D.3    Figlin, R.A.4    Berkenblit, A.5    Thiele, A.6
  • 5
    • 77956227464 scopus 로고    scopus 로고
    • Phase 3 trial of everolimus for metastatic renal cell carcinoma: Final results and analysis of prognostic factors
    • Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 2010;116:4256-65.
    • (2010) Cancer , vol.116 , pp. 4256-4265
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 8
    • 66649133114 scopus 로고    scopus 로고
    • A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer
    • Amato RJ, Jac J, Giessinger S, Saxena S, Willis JP. A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer. Cancer 2009;115:2438-46.
    • (2009) Cancer , vol.115 , pp. 2438-2446
    • Amato, R.J.1    Jac, J.2    Giessinger, S.3    Saxena, S.4    Willis, J.P.5
  • 10
    • 84655176768 scopus 로고    scopus 로고
    • Long-term response with everolimus for metastatic renal cell carcinoma refractory to sunitinib
    • Molina AM, Ginsberg MS, Motzer RJ. Long-term response with everolimus for metastatic renal cell carcinoma refractory to sunitinib. Med Oncol 2010;28:1527-9.
    • (2010) Med Oncol , vol.28 , pp. 1527-1529
    • Molina, A.M.1    Ginsberg, M.S.2    Motzer, R.J.3
  • 11
    • 59849113821 scopus 로고    scopus 로고
    • Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing
    • Gnirke A, Melnikov A, Maguire J, Rogov P, LeProust EM, Brockman W, et al. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nat Biotechnol 2009;27:182-9.
    • (2009) Nat Biotechnol , vol.27 , pp. 182-189
    • Gnirke, A.1    Melnikov, A.2    Maguire, J.3    Rogov, P.4    LeProust, E.M.5    Brockman, W.6
  • 12
    • 84865833740 scopus 로고    scopus 로고
    • High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
    • Wagle N, Berger MF, Davis MJ, Blumenstiel B, Defelice M, Pochanard P, et al. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discov 2012;2:82-93.
    • (2012) Cancer Discov , vol.2 , pp. 82-93
    • Wagle, N.1    Berger, M.F.2    Davis, M.J.3    Blumenstiel, B.4    Defelice, M.5    Pochanard, P.6
  • 14
    • 68549092780 scopus 로고    scopus 로고
    • Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha
    • Figlin RA, de Souza P, McDermott D, Dutcher JP, Berkenblit A, Thiele A, et al. Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha. Cancer 2009;115:3651-60.
    • (2009) Cancer , vol.115 , pp. 3651-3660
    • Figlin, R.A.1    De Souza, P.2    McDermott, D.3    Dutcher, J.P.4    Berkenblit, A.5    Thiele, A.6
  • 16
    • 78650003580 scopus 로고    scopus 로고
    • The GIST paradigm: Lessons for other kinase-driven cancers
    • Antonescu CR. The GIST paradigm: lessons for other kinase-driven cancers. J Pathol 2011;223:251-61.
    • (2011) J Pathol , vol.223 , pp. 251-261
    • Antonescu, C.R.1
  • 18
    • 84879635389 scopus 로고    scopus 로고
    • Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology
    • Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, et al. Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. Arch Pathol Lab Med 2013;137:828-60.
    • (2013) Arch Pathol Lab Med , vol.137 , pp. 828-860
    • Lindeman, N.I.1    Cagle, P.T.2    Beasley, M.B.3    Chitale, D.A.4    Dacic, S.5    Giaccone, G.6
  • 19
    • 77955288855 scopus 로고    scopus 로고
    • Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
    • Di Nicolantonio F, Arena S, Tabernero J, Grosso S, Molinari F, Macarulla T, et al. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J Clin Invest 2010;120:2858-66.
    • (2010) J Clin Invest , vol.120 , pp. 2858-2866
    • Di Nicolantonio, F.1    Arena, S.2    Tabernero, J.3    Grosso, S.4    Molinari, F.5    Macarulla, T.6
  • 20
    • 58249120506 scopus 로고    scopus 로고
    • Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance
    • Ihle NT, Lemos R Jr., Wipf P, Yacoub A, Mitchell C, Siwak D, et al. Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res 2009;69:143-50.
    • (2009) Cancer Res , vol.69 , pp. 143-150
    • Ihle, N.T.1    Lemos Jr., R.2    Wipf, P.3    Yacoub, A.4    Mitchell, C.5    Siwak, D.6
  • 21
    • 79955983369 scopus 로고    scopus 로고
    • The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations
    • Tanaka H, Yoshida M, Tanimura H, Fujii T, Sakata K, Tachibana Y, et al. The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res 2011;17:3272-81.
    • (2011) Clin Cancer Res , vol.17 , pp. 3272-3281
    • Tanaka, H.1    Yoshida, M.2    Tanimura, H.3    Fujii, T.4    Sakata, K.5    Tachibana, Y.6
  • 23
    • 84863338519 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations
    • Janku F, Wheler JJ, Westin SN, Moulder SL, Naing A, Tsimberidou AM, et al. PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 2012;30:777-82.
    • (2012) J Clin Oncol , vol.30 , pp. 777-782
    • Janku, F.1    Wheler, J.J.2    Westin, S.N.3    Moulder, S.L.4    Naing, A.5    Tsimberidou, A.M.6
  • 26
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2012;2:401-4.
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3    Gross, B.E.4    Sumer, S.O.5    Aksoy, B.A.6
  • 27
    • 84879890360 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of clear cell renal cell carcinoma
    • Cancer Genome Atlas Research N
    • Cancer Genome Atlas Research N. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 2013;499:43-9.
    • (2013) Nature , vol.499 , pp. 43-49
  • 29
    • 84898744239 scopus 로고    scopus 로고
    • Everolimus therapy for angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: Final results from EXIST-2
    • abstr LB-PO3159
    • Bissler JJ, Kingswood C, Zonnenberg B, Frost M, Belousova E, Radzikowska E, et al. Everolimus therapy for angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: final results from EXIST-2. J Am Soc Nephrol 2011;22 (abstr LB-PO3159).
    • (2011) J Am Soc Nephrol , vol.22
    • Bissler, J.J.1    Kingswood, C.2    Zonnenberg, B.3    Frost, M.4    Belousova, E.5    Radzikowska, E.6
  • 30
    • 84863230091 scopus 로고    scopus 로고
    • Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor
    • Xu X, Hou Y, Yin X, Bao L, Tang A, Song L, et al. Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell 2012;148:886-95.
    • (2012) Cell , vol.148 , pp. 886-895
    • Xu, X.1    Hou, Y.2    Yin, X.3    Bao, L.4    Tang, A.5    Song, L.6
  • 31
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time
    • Swanton C. Intratumor heterogeneity: evolution through space and time. Cancer Res 2012;72:4875-82.
    • (2012) Cancer Res , vol.72 , pp. 4875-4882
    • Swanton, C.1
  • 32
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • DOI 10.1038/nm1087
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004;10:789-99. (Pubitemid 39070849)
    • (2004) Nature Medicine , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 33
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 35
    • 84876037266 scopus 로고    scopus 로고
    • Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma
    • Hakimi AA, Chen YB, Wren J, Gonen M, Abdel-Wahab O, Heguy A, et al. Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma. Eur Urol 2013;63:848-54.
    • (2013) Eur Urol , vol.63 , pp. 848-854
    • Hakimi, A.A.1    Chen, Y.B.2    Wren, J.3    Gonen, M.4    Abdel-Wahab, O.5    Heguy, A.6
  • 36
    • 84879466482 scopus 로고    scopus 로고
    • Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: A report by MSKCC and the KIRC TCGA research network
    • Hakimi AA, Ostrovnaya I, Reva BA, Schultz N, Chen YB, Gonen M, et al. Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network. Clin Cancer Res 2013;19:3259-67.
    • (2013) Clin Cancer Res , vol.19 , pp. 3259-3267
    • Hakimi, A.A.1    Ostrovnaya, I.2    Reva, B.A.3    Schultz, N.4    Chen, Y.B.5    Gonen, M.6
  • 37
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012;149:274-93.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.