Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma

Nature Genetics

Volumn 44, Issue 1, 2012, Pages 17-19

  Guo, Guangwu ^a   Gui, Yaoting ^b   Gao, Shengjie ^a   Tang, Aifa ^b,c   Hu, Xueda ^a   Huang, Yi ^b,c   Jia, Wenlong ^a   Li, Zesong ^b,c   He, Minghui ^a   Sun, Liang ^b   Song, Pengfei ^a   Sun, Xiaojuan ^c   Zhao, Xiaokun ^d   Yang, Sangming ^a   Liang, Chaozhao ^e   Wan, Shengqing ^a   Zhou, Fangjian ^f   Chen, Chao ^a   Zhu, Jialou ^a,g   Li, Xianxin ^b   Jian, Minghan ^a   Zhou, Liang ^b   Ye, Rui ^a   Huang, Peide ^a   Chen, Jing ^b   Jiang, Tao ^a   Liu, Xiao ^a   Wang, Yong ^b   Zou, Jing ^a   Jiang, Zhimao ^b   Wu, Renhua ^a   Wu, Song ^b   Fan, Fan ^a   Zhang, Zhongfu ^b   Liu, Lin ^a   Yang, Ruilin ^b   Liu, Xingwang ^a   Wu, Haibo ^a   Yin, Weihua ^b   Zhao, Xia ^a   Liu, Yuchen ^b   Peng, Huanhuan ^a   Jiang, Binghua ^b   Feng, Qingxin ^b   Li, Cailing ^b   Xie, Jun ^b   Lu, Jingxiao ^b   Kristiansen, Karsten ^a,h   Li, Yingrui ^a   Zhang, Xiuqing ^a   Li, Songgang ^a   Wang, Jian ^a   Yang, Huanming ^a   Cai, Zhiming ^b,c   Wang, Jun ^a,h,i   more..

^a BGI SHENZHEN   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^d CENTRAL SOUTH UNIVERSITY   (China)

^e ANHUI MEDICAL UNIVERSITY   (China)

^f SUN YAT SEN UNIVERSITY   (China)

^g WUHAN UNIVERSITY   (China)

^h UNIVERSITY OF COPENHAGEN   (Denmark)

ⁱ Capital Region   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; UBIQUITIN;

ARTICLE; CARCINOGENESIS; CLEAR CELL CARCINOMA; CONTROLLED STUDY; EXOME; GENE FREQUENCY; GENE IDENTIFICATION; GENE MUTATION; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SOMATIC MUTATION; UBIQUITIN MEDIATED PROTEOLYSIS PATHWAY;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, RENAL CELL; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY NEOPLASMS; MUTATION; MUTATION RATE; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 84655176646     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.1014     Document Type: Article

References (14)

1. Rini, B.I., Campbell, S.C. & Escudier, B. Lancet 373, 1119-1132 (2009).
2. van Haaften, G. et al. Nat. Genet. 41, 521-523 (2009).
3. Dalgliesh, G.L. et al. Nature 463, 360-363 (2010).
4. Varela, I. et al. Nature 469, 539-542 (2011).
5. Gui, Y. et al. Nat. Genet. 43, 875-878 (2011).
6. Forbes, S.A. et al. Curr. Protoc. Hum. Genet. Chapter 10, Unit 10.11 (Wiley, 2008).
7. Getz, G. et al. Science 317, 1500 (2007).
8. Szymanska, K. et al. Cancer Lett. 293, 92-98 (2010).
9. Banks, R.E. et al. Cancer Res. 66, 2000-2011 (2006).
10. Harbour, J.W. et al. Science 330, 1410-1413 (2010).
11. Lamb, R.F. et al. Nat. Cell Biol. 2, 281-287 (2000).
12. Ding, L. et al. Nature 455, 1069-1075 (2008).
13. Sonoda, I. et al. Cancer Res. 64, 3741-3747 (2004).
14. Linehan, W.M. et al. Annu. Rev. Med. 61, 329-343 (2010).