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Volumn 20, Issue 8, 2014, Pages 2060-2071

Molecular biomarkers in advanced renal cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANGIOGENIC FACTOR; CARBONATE DEHYDRATASE IX; EVEROLIMUS; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; PAZOPANIB; PLACEBO; PROTEIN KINASE B; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TUMOR MARKER; VASCULOTROPIN A; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; VON HIPPEL LINDAU PROTEIN; VASCULOTROPIN RECEPTOR;

EID: 84898958636     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-1351     Document Type: Article
Times cited : (56)

References (79)
  • 2
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase iii trial
    • Escudier B, Pluzanska A, Koralewski P, Ravaud A, Bracarda S, Szczylik C, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007;370:2103-11.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3    Ravaud, A.4    Bracarda, S.5    Szczylik, C.6
  • 3
  • 4
    • 49249087039 scopus 로고    scopus 로고
    • Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
    • Rini BI, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, StadlerWM,et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 2008;26:3743-8.
    • (2008) J Clin Oncol , vol.26 , pp. 3743-3748
    • Rini, B.I.1    Michaelson, M.D.2    Rosenberg, J.E.3    Bukowski, R.M.4    Sosman, J.A.5    Stadler, W.M.6
  • 5
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009;27:3584-90.
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Oudard, S.6
  • 6
    • 77956227464 scopus 로고    scopus 로고
    • Phase 3 trial of everolimus for metastatic renal cell carcinoma: Final results and analysis of prognostic factors
    • Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 2010;116: 4256-65.
    • (2010) Cancer , vol.116 , pp. 4256-4265
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 7
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (axis): A randomised phase 3 trial
    • Rini BI, Escudier B, Tomczak P, Karin A, Szczylik C, Hutson TE, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 2011;378:1931-9.
    • (2011) Lancet , vol.378 , pp. 1931-1939
    • Rini, B.I.1    Escudier, B.2    Tomczak, P.3    Karin, A.4    Szczylik, C.5    Hutson, T.E.6
  • 8
    • 79551597099 scopus 로고    scopus 로고
    • Challenges and opportunities for converting renal cell carcinoma into a chronic disease with targeted therapies
    • Gore ME, Larkin JMG. Challenges and opportunities for converting renal cell carcinoma into a chronic disease with targeted therapies. Br J Cancer 2011;104:399-406.
    • (2011) Br J Cancer , vol.104 , pp. 399-406
    • Gore, M.E.1    Larkin, J.M.G.2
  • 9
    • 77949667760 scopus 로고    scopus 로고
    • Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents
    • Dancey JE, Dobbin KK, Groshen S, Jessup JM, Hruszkewycz AH, Koehler M, et al. Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents. Clin Cancer Res 2010;16:1745-55.
    • (2010) Clin Cancer Res , vol.16 , pp. 1745-1755
    • Dancey, J.E.1    Dobbin, K.K.2    Groshen, S.3    Jessup, J.M.4    Hruszkewycz, A.H.5    Koehler, M.6
  • 10
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase iii treatment approaches in renal cancer global evaluation trial
    • Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Staehler M, et al. Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009;27:3312-8.
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3    Szczylik, C.4    Oudard, S.5    Staehler, M.6
  • 11
    • 84883440578 scopus 로고    scopus 로고
    • Circulating protein biomarkers of sunitinib and interferon-A efficacy in treatment-naive patients with metastatic renal cell carcinoma
    • abstr 10525
    • Harmon CS, Figlin RA, Hutson TE, Michaelson MD, Negrier S, Kim ST, et al. Circulating protein biomarkers of sunitinib and interferon-A efficacy in treatment-naive patients with metastatic renal cell carcinoma. J Clin Oncol 29:2011 (suppl; abstr 10525).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Harmon, C.S.1    Figlin, R.A.2    Hutson, T.E.3    Michaelson, M.D.4    Negrier, S.5    Kim, S.T.6
  • 12
    • 34547779489 scopus 로고    scopus 로고
    • Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: Modulation of vegf and vegf-related proteins
    • DePrimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, Rini BI, et al. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med 2007;5:32.
    • (2007) J Transl Med , vol.5 , pp. 32
    • DePrimo, S.E.1    Bello, C.L.2    Smeraglia, J.3    Baum, C.M.4    Spinella, D.5    Rini, B.I.6
  • 13
    • 78650666731 scopus 로고    scopus 로고
    • Circulating endothelial cells are an early predictor in renal cell carcinoma for tumor response to sunitinib
    • Gruenwald V, Beutel G, Schuch-Jantsch S, Reuter C, Ivanyi P, Ganser A, et al. Circulating endothelial cells are an early predictor in renal cell carcinoma for tumor response to sunitinib. BMC Cancer 2010;10:695.
    • (2010) BMC Cancer , vol.10 , pp. 695
    • Gruenwald, V.1    Beutel, G.2    Schuch-Jantsch, S.3    Reuter, C.4    Ivanyi, P.5    Ganser, A.6
  • 14
    • 63849092341 scopus 로고    scopus 로고
    • Sunitinib treatment for patientswith clear-cell metastatic renal cell carcinoma: Clinical outcomes and plasma angiogenesis markers
    • Kontovinis LF, Papazisis KT, Touplikioti P, Andreadis C, Mouratidou D, Kortsaris AH. Sunitinib treatment for patientswith clear-cell metastatic renal cell carcinoma: clinical outcomes and plasma angiogenesis markers. BMC Cancer 2009;9:82.
    • (2009) BMC Cancer , vol.9 , pp. 82
    • Kontovinis, L.F.1    Papazisis, K.T.2    Touplikioti, P.3    Andreadis, C.4    Mouratidou, D.5    Kortsaris, A.H.6
  • 15
    • 84870793390 scopus 로고    scopus 로고
    • Plasma cytokine and angiogenic factors (cafs) predictive of clinical benefit and prognosis in patients (pts) with advanced or metastatic renal cell cancer (mrcc) treated in phase iii trials of pazopanib (pazo
    • abstr 334
    • Liu G, Tran HT, Lin Y, Martin A, Zurita AJ, Sternberg CN, et al. Plasma cytokine and angiogenic factors (CAFs) predictive of clinical benefit and prognosis in patients (pts) with advanced or metastatic renal cell cancer (mRCC) treated in phase III trials of pazopanib (PAZO). J Clin Oncol 29: 2011 (suppl 7; abstr 334).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 7
    • Liu, G.1    Tran, H.T.2    Lin, Y.3    Martin, A.4    Zurita, A.J.5    Sternberg, C.N.6
  • 16
    • 84866761624 scopus 로고    scopus 로고
    • Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin
    • Armstrong AJ, George DJ, Halabi S. Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin. J Clin Oncol 2012;30:3402-7.
    • (2012) J Clin Oncol , vol.30 , pp. 3402-3407
    • Armstrong, A.J.1    George, D.J.2    Halabi, S.3
  • 17
    • 48649098245 scopus 로고    scopus 로고
    • Von hippel-lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
    • Choueiri TK, Vaziri SA, Jaeger E, Elson P, Wood L, Bhalla IP, et al. von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 2008;180:860-6.
    • (2008) J Urol , vol.180 , pp. 860-8606
    • Choueiri, T.K.1    Vaziri, S.A.2    Jaeger, E.3    Elson, P.4    Wood, L.5    Bhalla, I.P.6
  • 18
    • 56849096837 scopus 로고    scopus 로고
    • Hif-A effects on c-myc distinguish two subtypes of sporadic vhl-deficient clear cell renal carcinoma
    • Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, et al. HIF-A effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 2008;14: 435-46.
    • (2008) Cancer Cell , vol.14 , pp. 435-446
    • Gordan, J.D.1    Lal, P.2    Dondeti, V.R.3    Letrero, R.4    Parekh, K.N.5    Oquendo, C.E.6
  • 19
    • 84958574469 scopus 로고    scopus 로고
    • C-myc as a new predictive biomarker for sunitinib in metastatic renal clear cell carcinoma
    • abstr 832P
    • Maroto P, Esteban E, Fernandez-Parra E, Mendez-Vidal MJ, Domenech M, Leon L, et al. C-myc as a new predictive biomarker for sunitinib in metastatic renal clear cell carcinoma. Ann Oncol 23:2012 (suppl 9; abstr 832P).
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Maroto, P.1    Esteban, E.2    Fernandez-Parra, E.3    Mendez-Vidal, M.J.4    Domenech, M.5    Leon, L.6
  • 20
    • 35348858663 scopus 로고    scopus 로고
    • Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma
    • Cho D, Signoretti S, Dabora S, Regan M, Seeley A, Mariotti M, et al. Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma. Clin Genitourin Cancer 2007;5:379-85.
    • (2007) Clin Genitourin Cancer , vol.5 , pp. 379-385
    • Cho, D.1    Signoretti, S.2    Dabora, S.3    Regan, M.4    Seeley, A.5    Mariotti, M.6
  • 21
    • 74549209552 scopus 로고    scopus 로고
    • Upfront, randomized, phase 2 trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma: Clinical and biomarker analysis
    • Jonasch E, Corn P, Pagliaro LC, Warneke CL, JohnsonMM,Tamboli P, et al. Upfront, randomized, phase 2 trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma: clinical and biomarker analysis. Cancer 2010;116:57-65.
    • (2010) Cancer , vol.116 , pp. 57-65
    • Jonasch, E.1    Corn, P.2    Pagliaro, L.C.3    Warneke, C.L.4    Johnson, M.M.5    Tamboli, P.6
  • 22
    • 79551701442 scopus 로고    scopus 로고
    • Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib
    • van der Veldt AA, Eechoute K, Gelderblom H, Gietema J, Guchelaar HJ, van Erp NP, et al. Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib. Clin Cancer Res 2011;17:620-9.
    • (2011) Clin Cancer Res , vol.17 , pp. 620-629
    • Van Der Veldt, A.A.1    Eechoute, K.2    Gelderblom, H.3    Gietema, J.4    Guchelaar, H.J.5    Van Erp, N.P.6
  • 23
    • 84898963011 scopus 로고    scopus 로고
    • Prospective exploratory analysis of the association between genetic polymorphisms and sunitinib toxicity and efficacy in metastatic renal-cell carcinoma
    • abstr 4620
    • Farfan CA, Sepulveda J, Benitez J, de Velasco G, Villacampa F, de la Rosa F, et al. Prospective exploratory analysis of the association between genetic polymorphisms and sunitinib toxicity and efficacy in metastatic renal-cell carcinoma. J Clin Oncol 30:2012 (suppl; abstr 4620).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Farfan, C.A.1    Sepulveda, J.2    Benitez, J.3    De Velasco, G.4    Villacampa, F.5    De La Rosa, F.6
  • 24
    • 79959316184 scopus 로고    scopus 로고
    • Pazopanib efficacy in renal cell carcinoma: Evidence for predictive genetic markers in angiogenesis-related and exposure-related genes
    • Xu CF, Bing NX, Ball HA, Rajagopalan D, Sternberg CN, Hutson TE, et al. Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes. J Clin Oncol 2011;29:2557-64.
    • (2011) J Clin Oncol , vol.29 , pp. 2557-2564
    • Xu, C.F.1    Bing, N.X.2    Ball, H.A.3    Rajagopalan, D.4    Sternberg, C.N.5    Hutson, T.E.6
  • 25
    • 81255160848 scopus 로고    scopus 로고
    • Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renalcell carcinoma treated with first-line sunitinib: A multicentre, observational, prospective study
    • Garcia-Donas J, Esteban E, Leandro-Garcia LJ, Castellano DE, Del Alba AG, Climent MA, et al. Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renalcell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study. Lancet Oncol 2011;12:1143-50.
    • (2011) Lancet Oncol , vol.12 , pp. 1143-1150
    • Garcia-Donas, J.1    Esteban, E.2    Leandro-Garcia, L.J.3    Castellano, D.E.4    Del Alba, A.G.5    Climent, M.A.6
  • 28
    • 84863338437 scopus 로고    scopus 로고
    • Association of vegf and vegfr2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib
    • Kim JJ, Vaziri SA, Rini BI, Elson P, Garcia JA, Wirka R, et al. Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib. Cancer 2012;118:1946-54.
    • (2012) Cancer , vol.118 , pp. 1946-1954
    • Kim, J.J.1    Vaziri, S.A.2    Rini, B.I.3    Elson, P.4    Garcia, J.A.5    Wirka, R.6
  • 29
    • 79957925832 scopus 로고    scopus 로고
    • Vascular endothelial growth factors and receptors: Anti-angiogenic therapy in the treatment of cancer
    • Tugues S, Koch S, Gualandi L, Li X, Claesson-Welsh L. Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer. Mol Aspects Med 2011;32:88-111.
    • (2011) Mol Aspects Med , vol.32 , pp. 88-111
    • Tugues, S.1    Koch, S.2    Gualandi, L.3    Li, X.4    Claesson-Welsh, L.5
  • 30
    • 1342288873 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor protein in human renal cell carcinoma
    • Jacobsen J, Grankvist K, Rasmuson T, Bergh A, Landberg G, Ljungberg B. Expression of vascular endothelial growth factor protein in human renal cell carcinoma. BJU Int 2004;93:297-302.
    • (2004) BJU Int , vol.93 , pp. 297-302
    • Jacobsen, J.1    Grankvist, K.2    Rasmuson, T.3    Bergh, A.4    Landberg, G.5    Ljungberg, B.6
  • 32
    • 77957570088 scopus 로고    scopus 로고
    • Biomarkers predicting outcome in patients with advanced renal cell carcinoma: Results from sorafenib phase iii treatment approaches in renal cancer global evaluation trial
    • Pena C, Lathia C, Shan M, Escudier B, Bukowski RM. Biomarkers predicting outcome in patients with advanced renal cell carcinoma: Results from sorafenib phase III Treatment Approaches in Renal Cancer Global Evaluation Trial. Clin Cancer Res 2010;16:4853-63.
    • (2010) Clin Cancer Res , vol.16 , pp. 4853-4863
    • Pena, C.1    Lathia, C.2    Shan, M.3    Escudier, B.4    Bukowski, R.M.5
  • 33
    • 36749052895 scopus 로고    scopus 로고
    • Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
    • Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci U S A 2007;104:17069-74.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 17069-17074
    • Ebos, J.M.1    Lee, C.R.2    Christensen, J.G.3    Mutsaers, A.J.4    Kerbel, R.S.5
  • 35
    • 0035253739 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M, Sledge GW Jr, Holmgren E, Benjamin R, et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001;19:843-50.
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3    Sledge Jr., G.W.4    Holmgren, E.5    Benjamin, R.6
  • 36
    • 34249100236 scopus 로고    scopus 로고
    • Vascular endothelial growth factor levels in immunodepleted plasma of cancer patients as a possible pharmacodynamic marker for bevacizumab activity
    • Loupakis F, Falcone A, Masi G, Fioravanti A, Kerbel RS, Del Tacca M, et al. Vascular endothelial growth factor levels in immunodepleted plasma of cancer patients as a possible pharmacodynamic marker for bevacizumab activity. J Clin Oncol 2007;25:1816-8.
    • (2007) J Clin Oncol , vol.25 , pp. 1816-1818
    • Loupakis, F.1    Falcone, A.2    Masi, G.3    Fioravanti, A.4    Kerbel, R.S.5    Del Tacca, M.6
  • 38
    • 84855173597 scopus 로고    scopus 로고
    • A cytokine and angiogenic factor (caf) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma
    • Zurita AJ, Jonasch E, Wang X, Khajavi M, Yan S, Du DZ, et al. A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma. Ann Oncol 2012;23:46-52.
    • (2012) Ann Oncol , vol.23 , pp. 46-52
    • Zurita, A.J.1    Jonasch, E.2    Wang, X.3    Khajavi, M.4    Yan, S.5    Du, D.Z.6
  • 39
    • 84864333467 scopus 로고    scopus 로고
    • Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: A retrospective analysis of phase 2 and phase 3 trials
    • Tran HT, Liu Y, Zurita AJ, Lin Y, Baker-Neblett KL, Martin AM, et al. Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials. Lancet Oncol 2012;13:827-37.
    • (2012) Lancet Oncol , vol.13 , pp. 827-837
    • Tran, H.T.1    Liu, Y.2    Zurita, A.J.3    Lin, Y.4    Baker-Neblett, K.L.5    Martin, A.M.6
  • 40
    • 80455151555 scopus 로고    scopus 로고
    • Circulating baseline plasma cytokines and angiogenic factors (caf) as markers of tumor burden and therapeutic response in a phase iii study of pazopanib for metastatic renal cell carcinoma (mrcc
    • abstr 4553
    • Liu Y, Tran HT, Lin Y, Martin A, Zurita AJ, Sternberg CN, et al. Circulating baseline plasma cytokines and angiogenic factors (CAF) as markers of tumor burden and therapeutic response in a phase III study of pazopanib for metastatic renal cell carcinoma (mRCC). J Clin Oncol 29:2011 (suppl; abstr 4553).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Liu, Y.1    Tran, H.T.2    Lin, Y.3    Martin, A.4    Zurita, A.J.5    Sternberg, C.N.6
  • 41
    • 84898933099 scopus 로고    scopus 로고
    • Multivariate analysis of cytokines and angiogenic factors (cafs) and established prognostic parameters in metastatic renal cell carcinoma (mrcc) patients receiving pazopanib or placebo
    • abstr 791PD
    • Zurita-Saavedra A, Liu Y, Lin Y, Tran HT, Pandite LN, Heymach JV. Multivariate analysis of cytokines and angiogenic factors (CAFs) and established prognostic parameters in metastatic renal cell carcinoma (mRCC) patients receiving pazopanib or placebo. Ann Oncol 23:2012 (suppl 9; abstr 791PD).
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Zurita-Saavedra, A.1    Liu, Y.2    Lin, Y.3    Tran, H.T.4    Pandite, L.N.5    Heymach, J.V.6
  • 42
    • 33750286135 scopus 로고    scopus 로고
    • The multifaceted circulating endothelial cell in cancer: Towards marker and target identification
    • Bertolini F, Shaked Y, Mancuso P, Kerbel RS. The multifaceted circulating endothelial cell in cancer: towards marker and target identification. Nat Rev Cancer 2006;6:835-45.
    • (2006) Nat Rev Cancer , vol.6 , pp. 835-845
    • Bertolini, F.1    Shaked, Y.2    Mancuso, P.3    Kerbel, R.S.4
  • 43
    • 79959737234 scopus 로고    scopus 로고
    • Increased mobilisation of circulating endothelial progenitors in von hippel-lindau disease and renal cell carcinoma
    • Bhatt RS, Zurita AJ, O'Neill A, Norden-Zfoni A, Zhang L, Wu HK, et al. Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma. Br J Cancer 2011; 105:112-7.
    • (2011) Br J Cancer , vol.105 , pp. 112-117
    • Bhatt, R.S.1    Zurita, A.J.2    O'Neill, A.3    Norden-Zfoni, A.4    Zhang, L.5    Wu, H.K.6
  • 44
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002;20:289-96.
    • (2002) J Clin Oncol , vol.20 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3    Russo, P.4    Mazumdar, M.5
  • 45
    • 76749161366 scopus 로고    scopus 로고
    • Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13c magnetic resonance spectroscopy
    • Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, et al. Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer Res 2010;70: 1296-305.
    • (2010) Cancer Res , vol.70 , pp. 1296-1305
    • Ward, C.S.1    Venkatesh, H.S.2    Chaumeil, M.M.3    Brandes, A.H.4    Vancriekinge, M.5    Dafni, H.6
  • 46
    • 79251574372 scopus 로고    scopus 로고
    • Prognostic factors for progression-free and overall survival with sunitinib targeted therapy and with cytokine as first-line therapy in patients with metastatic renal cell carcinoma
    • Patil S, Figlin RA, Hutson TE, Michaelson MD, Negrier S, Kim ST, et al. Prognostic factors for progression-free and overall survival with sunitinib targeted therapy and with cytokine as first-line therapy in patients with metastatic renal cell carcinoma. Ann Oncol 2011;22:295-300.
    • (2011) Ann Oncol , vol.22 , pp. 295-300
    • Patil, S.1    Figlin, R.A.2    Hutson, T.E.3    Michaelson, M.D.4    Negrier, S.5    Kim, S.T.6
  • 47
    • 84876739783 scopus 로고    scopus 로고
    • Expression level of vascular endothelial growth factor receptor-2 in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with sunitinib
    • Terakawa T, Miyake H, Kusuda Y, Fujisawa M. Expression level of vascular endothelial growth factor receptor-2 in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with sunitinib. Urol Oncol 2013;31:493-8.
    • (2013) Urol Oncol , vol.31 , pp. 493-498
    • Terakawa, T.1    Miyake, H.2    Kusuda, Y.3    Fujisawa, M.4
  • 48
    • 77956270281 scopus 로고    scopus 로고
    • Soluble isoforms of vascular endothelial growth factor are predictors of response to sunitinib in metastatic renal cell carcinomas
    • Paule B, Bastien L, Deslandes E, Cussenot O, Podgorniak MP, Allory Y, et al. Soluble isoforms of vascular endothelial growth factor are predictors of response to sunitinib in metastatic renal cell carcinomas. PLoS ONE 2010;5:e10715.
    • (2010) PLoS ONE , vol.5
    • Paule, B.1    Bastien, L.2    Deslandes, E.3    Cussenot, O.4    Podgorniak, M.P.5    Allory, Y.6
  • 49
    • 60349101704 scopus 로고    scopus 로고
    • Vhl gene mutations in renal cell carcinoma: Role as a biomarker of disease outcome and drug efficacy
    • Cowey CL, Rathmell WK. VHL gene mutations in renal cell carcinoma: role as a biomarker of disease outcome and drug efficacy. Curr Oncol Rep 2009;11:94-101.
    • (2009) Curr Oncol Rep , vol.11 , pp. 94-101
    • Cowey, C.L.1    Rathmell, W.K.2
  • 50
    • 16744366213 scopus 로고    scopus 로고
    • Vhl alterations in human clear cell renal cell carcinoma: Association with advanced tumor stage and a novel hot spot mutation
    • Brauch H, Weirich G, Brieger J, Glavac D, Rodl H, Eichinger M, et al. VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation. Cancer Res 2000;60:1942-8.
    • (2000) Cancer Res , vol.60 , pp. 1942-1948
    • Brauch, H.1    Weirich, G.2    Brieger, J.3    Glavac, D.4    Rodl, H.5    Eichinger, M.6
  • 51
    • 18344396226 scopus 로고    scopus 로고
    • Comprehensive mutational analysis of the vhl gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters
    • Kondo K, Yao M, Yoshida M, Kishida T, Shuin T, Miura T, et al. Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters. Genes Chromosomes Cancer 2002;34:58-68.
    • (2002) Genes Chromosomes Cancer , vol.34 , pp. 58-68
    • Kondo, K.1    Yao, M.2    Yoshida, M.3    Kishida, T.4    Shuin, T.5    Miura, T.6
  • 54
    • 55349124241 scopus 로고    scopus 로고
    • Biomarker analysis and final efficacy and safety results of a phase ii renal cell carcinoma trial with pazopanib (gw786034), a multi-kinase angiogenesis inhibitor
    • abstr 5046
    • Hutson TE, Davis ID, Machiels JP, De Souza P, Baker KL, Bordogna W, et al. Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor. J Clin Oncol 26:2008 (suppl; abstr 5046).
    • (2008) J Clin Oncol 26 , Issue.SUPPL.
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.P.3    De Souza, P.4    Baker, K.L.5    Bordogna, W.6
  • 58
    • 84899012778 scopus 로고    scopus 로고
    • The Cancer Genome Atlas (TCGA) Data Portal [Cited 2013, September 5]. Available from
    • The Cancer Genome Atlas (TCGA) Data Portal. Kidney renal clear cell carcinoma. [Cited 2013, September 5]. Available from: https://tcgadata. nci.nih.gov/tcga/.
    • Kidney Renal Clear Cell Carcinoma
  • 59
    • 84873081430 scopus 로고    scopus 로고
    • Effects on survival of bap1 and pbrm1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation
    • Kapur P, Pena-Llopis S, Christie A, Zhrebker L, Pavía-Jimenez A, Rathmell WK, et al. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation. Lancet Oncol 2013;14: 159-67.
    • (2013) Lancet Oncol , vol.14 , pp. 159-167
    • Kapur, P.1    Pena-Llopis, S.2    Christie, A.3    Zhrebker, L.4    Pavía-Jimenez, A.5    Rathmell, W.K.6
  • 60
    • 77956198463 scopus 로고    scopus 로고
    • Carbonic anhydrase ix and pathological features as predictors of outcome in patients with metastatic clear-cell renal cell carcinoma receiving vascular endothelial growth factor-targeted therapy
    • Choueiri TK, ReganMM,Rosenberg JE,OhWK, Clement J, AmatoAM, et al. Carbonic anhydrase IX and pathological features as predictors of outcome in patients with metastatic clear-cell renal cell carcinoma receiving vascular endothelial growth factor-targeted therapy. BJU Int 2010;106:772-8.
    • (2010) BJU Int , vol.106 , pp. 772-778
    • Choueiri, T.K.1    Regan, M.M.2    Rosenberg, J.E.3    Oh, W.K.4    Clement, J.5    Amato, A.M.6
  • 61
    • 84886245708 scopus 로고    scopus 로고
    • Carbonic anhydrase ix as a potential biomarker of efficacy in metastatic clear-cell renal cell carcinoma patients receiving sorafenib or placebo: Analysis from the treatment approaches in renal cancer global evaluation trial (target
    • Choueiri TK, Cheng S, Qu AQ, Pastorek J, Atkins MB, Signoretti S. Carbonic anhydrase IX as a potential biomarker of efficacy in metastatic clear-cell renal cell carcinoma patients receiving sorafenib or placebo: Analysis from the treatment approaches in renal cancer global evaluation trial (TARGET). Urol Oncol 2013;31: 1788-93.
    • (2013) Urol Oncol , vol.31 , pp. 1788-1793
    • Choueiri, T.K.1    Cheng, S.2    Qu, A.Q.3    Pastorek, J.4    Atkins, M.B.5    Signoretti, S.6
  • 62
    • 77955288855 scopus 로고    scopus 로고
    • Deregulation of the pi3k and kras signaling pathways in human cancer cells determines their response to everolimus
    • Di Nicolantonio F, Arena S, Tabernero J, Grosso S, Molinari F, Macarulla T, et al. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J Clin Invest 2010;120:2858-66.
    • (2010) J Clin Invest , vol.120 , pp. 2858-2866
    • Di Nicolantonio, F.1    Arena, S.2    Tabernero, J.3    Grosso, S.4    Molinari, F.5    Macarulla, T.6
  • 63
    • 77953033291 scopus 로고    scopus 로고
    • Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: Results of a pharmacokinetic/pharmacodynamic meta-analysis
    • Houk BE, Bello CL, Poland B, Rosen LS, Demetri GD, Motzer RJ. Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis. Cancer Chemother Pharmacol 2010;66:357-71.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 357-371
    • Houk, B.E.1    Bello, C.L.2    Poland, B.3    Rosen, L.S.4    Demetri, G.D.5    Motzer, R.J.6
  • 64
    • 84898995939 scopus 로고    scopus 로고
    • Association of il8 polymorphisms with overall survival in patients with renal cell carcinoma in comparz (pazopanib versus sunitinib phase iii study
    • abstr 4519
    • Xu CF, Johnson T, Choueiri TK, Deen KC, Xue Z, Spraggs CF, et al. Association of IL8 polymorphisms with overall survival in patients with renal cell carcinoma in COMPARZ (pazopanib versus sunitinib phase III study). J Clin Oncol 31:2013 (suppl; abstr 4519).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Xu, C.F.1    Johnson, T.2    Choueiri, T.K.3    Deen, K.C.4    Xue, Z.5    Spraggs, C.F.6
  • 65
    • 53749093040 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: Ecog 2100
    • Schneider BP, Wang M, Radovich M, Sledge GW, Badve S, Thor A, et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 2008;26:4672-8.
    • (2008) J Clin Oncol , vol.26 , pp. 4672-4678
    • Schneider, B.P.1    Wang, M.2    Radovich, M.3    Sledge, G.W.4    Badve, S.5    Thor, A.6
  • 66
    • 79956146844 scopus 로고    scopus 로고
    • Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma
    • Xu CF, Reck BH, Goodman VL, Xue Z, Huang L, Barnes MR, et al. Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma. J Hepatol 2011;54: 1237-43.
    • (2011) J Hepatol , vol.54 , pp. 1237-1243
    • Xu, C.F.1    Reck, B.H.2    Goodman, V.L.3    Xue, Z.4    Huang, L.5    Barnes, M.R.6
  • 67
    • 77951666852 scopus 로고    scopus 로고
    • Pazopanibinduced hyperbilirubinemia is associated with gilbert's syndrome ugt1a1 polymorphism
    • Xu CF, Reck BH, Xue Z, Huang L, Baker KL, Chen M, et al. Pazopanibinduced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. Br J Cancer 2010;102:1371-7.
    • (2010) Br J Cancer , vol.102 , pp. 1371-1377
    • Xu, C.F.1    Reck, B.H.2    Xue, Z.3    Huang, L.4    Baker, K.L.5    Chen, M.6
  • 68
    • 69849108427 scopus 로고    scopus 로고
    • Clinical trial designs for predictive biomarker validation: Theoretical considerations and practical challenges
    • Mandrekar SJ, Sargent DJ. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J Clin Oncol 2009;27:4027-34.
    • (2009) J Clin Oncol , vol.27 , pp. 4027-40234
    • Mandrekar, S.J.1    Sargent, D.J.2
  • 69
    • 23844534811 scopus 로고    scopus 로고
    • On behalf of the statistics subcommittee of the nci-eortc working group on cancer diagnostics. Reporting recommendations for tumor marker prognostic studies (remark
    • McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM, on behalf of the Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics. Reporting recommendations for tumor marker prognostic studies (REMARK). J Natl Cancer Inst 2005;97: 1180-4.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1180-1184
    • McShane, L.M.1    Altman, D.G.2    Sauerbrei, W.3    Taube, S.E.4    Gion, M.5    Clark, G.M.6
  • 70
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in cyp3a promoters and characterization of the genetic basis of polymorphic cyp3a5 expression
    • Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 2001; 27:383-91.
    • (2001) Nat Genet , vol.27 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3    Lamba, J.4    Assem, M.5    Schuetz, J.6
  • 72
    • 20444450056 scopus 로고    scopus 로고
    • Molecular epidemiology biomarkers-sample collection and processing considerations
    • Holland NT, Pfleger L, Berger E, Ho A, Bastaki M. Molecular epidemiology biomarkers-sample collection and processing considerations. Toxicol Appl Pharmacol 2005;206:261-8.
    • (2005) Toxicol Appl Pharmacol , vol.206 , pp. 261-268
    • Holland, N.T.1    Pfleger, L.2    Berger, E.3    Ho, A.4    Bastaki, M.5
  • 74
    • 34250177269 scopus 로고    scopus 로고
    • Pd-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma
    • Thompson RH, Dong H, Lohse CM, Leibovich BC, Blute ML, Cheville JC, et al. PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma. Clin Cancer Res 2007;13:1757-61.
    • (2007) Clin Cancer Res , vol.13 , pp. 1757-1761
    • Thompson, R.H.1    Dong, H.2    Lohse, C.M.3    Leibovich, B.C.4    Blute, M.L.5    Cheville, J.C.6
  • 75
    • 33645736792 scopus 로고    scopus 로고
    • Tumor b7-h1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • Thompson RH, Kuntz SM, Leibovich BC, Dong H, Lohse CM, Webster WS, et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 2006;66: 3381-5.
    • (2006) Cancer Res , vol.66 , pp. 3381-3385
    • Thompson, R.H.1    Kuntz, S.M.2    Leibovich, B.C.3    Dong, H.4    Lohse, C.M.5    Webster, W.S.6
  • 77
    • 68949132736 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in peripheral blood of patients with renal cell carcinoma correlates with prognosis
    • Bluemke K, Bilkenroth U, Meye A, Fuessel S, Lautenschlaeger C, Goebel S, et al. Detection of circulating tumor cells in peripheral blood of patients with renal cell carcinoma correlates with prognosis. Cancer Epidemiol Biomarkers Prev 2009;18:2190-4.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 2190-2194
    • Bluemke, K.1    Bilkenroth, U.2    Meye, A.3    Fuessel, S.4    Lautenschlaeger, C.5    Goebel, S.6
  • 78
    • 78751693800 scopus 로고    scopus 로고
    • Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets
    • Swanton C, Larkin JM, Gerlinger M, Eklund AC, Howell M, Stamp G, et al. Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets. Genome Med 2010;2:53.
    • (2010) Genome Med , vol.2 , pp. 53
    • Swanton, C.1    Larkin, J.M.2    Gerlinger, M.3    Eklund, A.C.4    Howell, M.5    Stamp, G.6
  • 79
    • 84856159566 scopus 로고    scopus 로고
    • Targeted therapies for renal cell carcinoma: Review of adverse event management strategies
    • Eisen T, Sternberg CN, Robert C, Mulders P, Pyle L, Zbinden S, et al. Targeted therapies for renal cell carcinoma: review of adverse event management strategies. J Natl Cancer Inst 2012:104:93-113.
    • J Natl Cancer Inst , vol.2012 , Issue.104 , pp. 93-113
    • Eisen, T.1    Sternberg, C.N.2    Robert, C.3    Mulders, P.4    Pyle, L.5    Zbinden, S.6


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