Gene expression profiling of 49 human tumor xenografts from in vitro culture through multiple in vivo passages - strategies for data mining in support of therapeutic studies

BMC Genomics

Volumn 15, Issue 1, 2014, Pages

  Hollingshead, Melinda G ^a   Stockwin, Luke H ^b   Alcoser, Sergio Y ^a   Newton, Dianne L ^b   Orsburn, Benjamin C ^c   Bonomi, Carrie A ^b   Borgel, Suzanne D ^b   Divelbiss, Raymond ^b   Dougherty, Kelly M ^b   Hager, Elizabeth J ^a   Holbeck, Susan L ^d   Kaur, Gurmeet ^a   Kimmel, David J ^b   Kunkel, Mark W ^d   Millione, Angelena ^b   Mullendore, Michael E ^b   Stotler, Howard ^b   Collins, Jerry ^d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c Thermo Fisher Scientific   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Affymetrix HG U133 Plus 2.0 array; cDNA microarray; in vitro to in vivo transition; NCI 60 cell line screen; Transcriptomic expression; Transcriptomic stability; Xenograft models

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; COMPLEMENTARY DNA; IMATINIB; MK 1775; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; PLACEBO; PROTEIN P53; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; PROSTAGLANDIN E RECEPTOR 2; PTGER2 PROTEIN, HUMAN;

ANALYTICAL EQUIPMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MONITORING; CANCER CHEMOTHERAPY; CANCER GENETICS; CANCER MODEL; CANCER RESISTANCE; CELL STRAIN; CELL STRAIN A549; CELL STRAIN HCT 15; CHEMOSENSITIVITY; COHORT ANALYSIS; COLON CANCER; CONTROLLED STUDY; CROSS HYBRIDIZATION; DATA MINING; DNA MICROARRAY; DNA TRANSCRIPTION; DRUG EFFICACY; FEMALE; GENE EXPRESSION PROFILING; GENE MUTATION; GENETIC DATABASE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR PROBE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROSTATE TUMOR; PROTEIN EXPRESSION; SUBCUTANEOUS TISSUE TUMOR; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; ANIMAL; C57BL MOUSE; CLUSTER ANALYSIS; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASMS; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; XENOGRAFT;

ANIMALIA; MURINAE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; CLUSTER ANALYSIS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED C57BL; MICE, NUDE; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PACLITAXEL; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; TRANSPLANTATION, HETEROLOGOUS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901588884     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-15-393     Document Type: Article

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