-
1
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 1994; 7: 85-90.
-
(1994)
Nat Genet
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
2
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
3
-
-
51049084870
-
Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
-
Nickerson ML, Jaeger E, Shi Y et al. Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin Cancer Res 2008; 14: 4726-4734.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4726-4734
-
-
Nickerson, M.L.1
Jaeger, E.2
Shi, Y.3
-
4
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356: 125-134.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
5
-
-
70249097380
-
Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
-
Escudier B, Eisen T, Stadler WM et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009; 27: 3312-3318.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3312-3318
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
6
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-124.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
7
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 3584-3590.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
8
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
-
Escudier B, Pluzanska A, Koralewski P et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370: 2103-2111.
-
(2007)
Lancet
, vol.370
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
9
-
-
56749161699
-
Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008; 26: 5422-5428.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5422-5428
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
10
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial
-
Sternberg CN, Davis ID, Mardiak J et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010; 28: 1061-1068.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
-
11
-
-
0031409282
-
Are angiogenic factors, cytokines, and soluble adhesion molecules prognostic factors in patients with renal cell carcinoma?
-
Dosquet C, Coudert MC, Lepage E et al. Are angiogenic factors, cytokines, and soluble adhesion molecules prognostic factors in patients with renal cell carcinoma? Clin Cancer Res 1997; 3: 2451-2458.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 2451-2458
-
-
Dosquet, C.1
Coudert, M.C.2
Lepage, E.3
-
12
-
-
0033992036
-
Vascular endothelial growth factor as prognostic factor in renal cell carcinoma
-
Jacobsen J, Rasmuson T, Grankvist K, Ljungberg B. Vascular endothelial growth factor as prognostic factor in renal cell carcinoma. J Urol 2000; 163: 343-347.
-
(2000)
J Urol
, vol.163
, pp. 343-347
-
-
Jacobsen, J.1
Rasmuson, T.2
Grankvist, K.3
Ljungberg, B.4
-
13
-
-
2942756034
-
Interleukin-6, interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: prognostic value of interleukin-6-from the Groupe Francais d'Immunotherapie
-
Negrier S, Perol D, Menetrier-Caux C et al. Interleukin-6, interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: prognostic value of interleukin-6-from the Groupe Francais d'Immunotherapie. J Clin Oncol 2004; 22: 2371-2378.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2371-2378
-
-
Negrier, S.1
Perol, D.2
Menetrier-Caux, C.3
-
14
-
-
39149121748
-
Serum level of vascular endothelial growth factor (VEGF) as an independent prognostic factor in metastatic renal cell carcinoma (MRCC)
-
Negrier S, Chabaud S, Escudier B et al. Serum level of vascular endothelial growth factor (VEGF) as an independent prognostic factor in metastatic renal cell carcinoma (MRCC). J Clin Oncol 2007; 25: 5044.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5044
-
-
Negrier, S.1
Chabaud, S.2
Escudier, B.3
-
15
-
-
77957570088
-
Biomarkers predicting outcome in patients with advanced renal cell carcinoma: results from sorafenib phase III Treatment Approaches in Renal Cancer Global Evaluation Trial
-
Pena C, Lathia C, Shan M et al. Biomarkers predicting outcome in patients with advanced renal cell carcinoma: results from sorafenib phase III Treatment Approaches in Renal Cancer Global Evaluation Trial. Clin Cancer Res 2010; 16: 4853-4863.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4853-4863
-
-
Pena, C.1
Lathia, C.2
Shan, M.3
-
16
-
-
64049084146
-
Update on AVOREN trial in metastatic renal cell carcinoma (mRCC): efficacy and safety in subgroups of patients (pts) and pharmacokinetic (PK) analysis
-
(Abstr 5025)
-
Escudier BJ, Ravaud A, Négrier S et al. Update on AVOREN trial in metastatic renal cell carcinoma (mRCC): efficacy and safety in subgroups of patients (pts) and pharmacokinetic (PK) analysis. J Clin Oncol 2008; 26: 15S (Abstr 5025).
-
(2008)
J Clin Oncol
, vol.26
-
-
Escudier, B.J.1
Ravaud, A.2
Négrier, S.3
-
17
-
-
65949083992
-
Circulating biomarkers for vascular endothelial growth factor inhibitors in renal cell carcinoma
-
Zurita AJ, Jonasch E, Wu HK et al. Circulating biomarkers for vascular endothelial growth factor inhibitors in renal cell carcinoma. Cancer 2009; 115: 2346-2354.
-
(2009)
Cancer
, vol.115
, pp. 2346-2354
-
-
Zurita, A.J.1
Jonasch, E.2
Wu, H.K.3
-
18
-
-
74949090109
-
Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer
-
Hanrahan EO, Lin HY, Kim ES et al. Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. J Clin Oncol 2010; 28: 193-201.
-
(2010)
J Clin Oncol
, vol.28
, pp. 193-201
-
-
Hanrahan, E.O.1
Lin, H.Y.2
Kim, E.S.3
-
19
-
-
74549209552
-
Upfront, randomized, phase 2 trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma: clinical and biomarker analysis
-
Jonasch E, Corn P, Pagliaro LC et al. Upfront, randomized, phase 2 trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma: clinical and biomarker analysis. Cancer 2010; 116: 57-65.
-
(2010)
Cancer
, vol.116
, pp. 57-65
-
-
Jonasch, E.1
Corn, P.2
Pagliaro, L.C.3
-
20
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008; 8: 592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
21
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009; 15: 232-239.
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
-
22
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15: 220-231.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
23
-
-
44649088833
-
Systemic endocrine instigation of indolent tumor growth requires osteopontin
-
McAllister SS, Gifford AM, Greiner AL et al. Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 2008; 133: 994-1005.
-
(2008)
Cell
, vol.133
, pp. 994-1005
-
-
McAllister, S.S.1
Gifford, A.M.2
Greiner, A.L.3
-
24
-
-
33750532947
-
Improved tolerability and quality of life with maintained efficacy using twice-daily low-dose interferon-alpha-2b: results of a randomized phase II trial of low-dose versus intermediate-dose interferonalpha-2b in patients with metastatic renal cell carcinoma
-
Tannir NM, Cohen L, Wang X et al. Improved tolerability and quality of life with maintained efficacy using twice-daily low-dose interferon-alpha-2b: results of a randomized phase II trial of low-dose versus intermediate-dose interferonalpha-2b in patients with metastatic renal cell carcinoma. Cancer 2006; 107: 2254-2261.
-
(2006)
Cancer
, vol.107
, pp. 2254-2261
-
-
Tannir, N.M.1
Cohen, L.2
Wang, X.3
-
25
-
-
48749092867
-
First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma
-
Melichar B, Koralewski P, Ravaud A et al. First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma. Ann Oncol 2008; 19: 1470-1476.
-
(2008)
Ann Oncol
, vol.19
, pp. 1470-1476
-
-
Melichar, B.1
Koralewski, P.2
Ravaud, A.3
-
26
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427-434.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
27
-
-
49249087039
-
Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
-
Rini BI, Michaelson MD, Rosenberg JE et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 2008; 26: 3743-3748.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
-
28
-
-
66149188254
-
Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in nonsmall cell lung cancer
-
Hanrahan EO, Ryan AJ, Mann H et al. Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in nonsmall cell lung cancer. Clin Cancer Res 2009; 15: 3600-3609.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3600-3609
-
-
Hanrahan, E.O.1
Ryan, A.J.2
Mann, H.3
-
29
-
-
34548315347
-
Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis
-
(Abstr 5023)
-
Bukowski RM, Eisen T, Szczylik C et al. Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis. J Clin Oncol 2007; 25: 18S (Abstr 5023).
-
(2007)
J Clin Oncol
, vol.25
-
-
Bukowski, R.M.1
Eisen, T.2
Szczylik, C.3
-
30
-
-
34547779489
-
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins
-
Deprimo SE, Bello CL, Smeraglia J et al. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med 2007; 5: 32.
-
(2007)
J Transl Med
, vol.5
, pp. 32
-
-
Deprimo, S.E.1
Bello, C.L.2
Smeraglia, J.3
-
31
-
-
55349124241
-
Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor
-
(Abstr 5046)
-
Hutson TE, Davis ID, Machiels JH et al. Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor. J Clin Oncol 2008; 26: 15S (Abstr 5046).
-
(2008)
J Clin Oncol
, vol.26
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.H.3
-
32
-
-
33646684668
-
Surrogate markers of activity of AG-013736, a multi-target tyrosine kinase receptor inhibitor, in metastatic renal cell cancer (RCC)
-
(Abstr 3003)
-
Rixe O, Meric J, Bloch J et al. Surrogate markers of activity of AG-013736, a multi-target tyrosine kinase receptor inhibitor, in metastatic renal cell cancer (RCC). J Clin Oncol 2005; 23: 16S (Abstr 3003).
-
(2005)
J Clin Oncol
, vol.23
-
-
Rixe, O.1
Meric, J.2
Bloch, J.3
-
33
-
-
41149083841
-
Evaluation of AZD2171, an oral, highly potent and selective VEGFR signaling inhibitor, in renal cell carcinoma (RCC): combined results from two phase I studies
-
(Abstr 3560)
-
van Herpen C, Drevs J, van Cruijsen H et al. Evaluation of AZD2171, an oral, highly potent and selective VEGFR signaling inhibitor, in renal cell carcinoma (RCC): combined results from two phase I studies. J Clin Oncol 2007; 25: 18S (Abstr 3560).
-
(2007)
J Clin Oncol
, vol.25
-
-
van Herpen, C.1
Drevs, J.2
van Cruijsen, H.3
-
34
-
-
70349642288
-
Cytokines and angiogenic factors in patients with metastatic renal cell carcinoma treated with interferonalpha: association of pretreatment serum levels with survival
-
Montero AJ, Diaz-Montero CM, Millikan RE et al. Cytokines and angiogenic factors in patients with metastatic renal cell carcinoma treated with interferonalpha: association of pretreatment serum levels with survival. Ann Oncol 2009; 20: 1682-1687.
-
(2009)
Ann Oncol
, vol.20
, pp. 1682-1687
-
-
Montero, A.J.1
Diaz-Montero, C.M.2
Millikan, R.E.3
-
35
-
-
70649112122
-
Identification of TNF-alpha and MMP-9 as potential baseline predictive serum markers of sunitinib activity in patients with renal cell carcinoma using a human cytokine array
-
Perez-Gracia JL, Prior C, Guillen-Grima F et al. Identification of TNF-alpha and MMP-9 as potential baseline predictive serum markers of sunitinib activity in patients with renal cell carcinoma using a human cytokine array. Br J Cancer 2009; 101: 1876-1883.
-
(2009)
Br J Cancer
, vol.101
, pp. 1876-1883
-
-
Perez-Gracia, J.L.1
Prior, C.2
Guillen-Grima, F.3
-
36
-
-
76249133170
-
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
-
Huang D, Ding Y, Zhou M et al. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res 2010; 70: 1063-1071.
-
(2010)
Cancer Res
, vol.70
, pp. 1063-1071
-
-
Huang, D.1
Ding, Y.2
Zhou, M.3
|