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Volumn 30, Issue 6, 2012, Pages 647-660

Cancer genomics: technology, discovery, and translation

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; CANCER GENETICS; CANCER THERAPY; DNA METHYLATION; EPIGENETICS; EXOME; FEASIBILITY STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE SEQUENCE; GENETIC TRANSCRIPTION AND TRANSLATION; GENOTYPE; GENOTYPING TECHNIQUE; HUMAN; MEDICAL ETHICS; PATIENT CARE; PERSONALIZED MEDICINE; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; WHOLE GENOME SEQUENCING;

EID: 84863393678     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2011.39.2316     Document Type: Review
Times cited : (162)

References (129)
  • 2
    • 84863416147 scopus 로고    scopus 로고
    • Office of Cancer Genomics
    • National Cancer Institute: Office of Cancer Genomics. http://ocg.cancer.gov/
  • 4
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies: The next generation
    • Metzker ML: Sequencing technologies: The next generation. Nat Rev Genet 11:31-46, 2009
    • (2009) Nat Rev Genet , vol.11 , pp. 31-46
    • Metzker, M.L.1
  • 5
    • 53649106195 scopus 로고    scopus 로고
    • Next-generation DNA sequencing
    • Shendure J, Ji H: Next-generation DNA sequencing. Nat Biotechnol 26:1135-1145, 2009
    • (2009) Nat Biotechnol , vol.26 , pp. 1135-1145
    • Shendure, J.1    Ji, H.2
  • 6
    • 7244245762 scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Consortium
    • International Human Genome Consortium: Finishing the euchromatic sequence of the human genome. Nature 431:931-945, 1992
    • (1992) Nature , vol.431 , pp. 931-945
  • 7
    • 77957252585 scopus 로고    scopus 로고
    • Application of second-generation sequencing to cancer genomics
    • Robison K: Application of second-generation sequencing to cancer genomics. Brief Bioinform 11:524-534, 2010
    • (2010) Brief Bioinform , vol.11 , pp. 524-534
    • Robison, K.1
  • 8
    • 44249090038 scopus 로고    scopus 로고
    • Molecular profiling in the age of cancer genomics
    • DOI 10.1586/14737159.8.3.263
    • Lin J, Li M: Molecular profiling in the age of cancer genomics. Exp Rev Mol Diagn 8:263-276, 2008 (Pubitemid 351724706)
    • (2008) Expert Review of Molecular Diagnostics , vol.8 , Issue.3 , pp. 263-276
    • Lin, J.1    Li, M.2
  • 9
    • 80051732262 scopus 로고    scopus 로고
    • Accurate and comprehensive sequencing of personal genomes
    • Ajay SS, Parker SC, Abaan HO, et al: Accurate and comprehensive sequencing of personal genomes. Genome Res 21:1498-1505, 2011
    • (2011) Genome Res , vol.21 , pp. 1498-1505
    • Ajay, S.S.1    Parker, S.C.2    Abaan, H.O.3
  • 10
    • 79551651006 scopus 로고    scopus 로고
    • Advances in whole genome sequencing technology
    • Zhao J, Grant SF: Advances in whole genome sequencing technology. Curr Pharm Biotechnol 12:293-305, 2011
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 293-305
    • Zhao, J.1    Grant, S.F.2
  • 11
    • 58149234737 scopus 로고    scopus 로고
    • Real-time DNA sequencing from single polymerase molecules
    • Eid J, Fehr A, Gray J, et al: Real-time DNA sequencing from single polymerase molecules. Science 323:133-138, 2009
    • (2009) Science , vol.323 , pp. 133-138
    • Eid, J.1    Fehr, A.2    Gray, J.3
  • 12
    • 80052173621 scopus 로고    scopus 로고
    • Open-source genomic analysis of shiga-toxin-producing E. coli O104:H4
    • Rohde H, Qin J, Cui Y, et al: Open-source genomic analysis of shiga-toxin-producing E. coli O104:H4. N Engl J Med 365:718-724, 2011
    • (2011) N Engl J Med , vol.365 , pp. 718-724
    • Rohde, H.1    Qin, J.2    Cui, Y.3
  • 13
    • 0037236218 scopus 로고    scopus 로고
    • Techniques patents for SNP genotyping
    • DOI 10.1517/phgs.4.1.67.22582
    • Twyman RM, Primrose SB: Techniques patents for SNP genotyping. Pharmacogenomics 4:67-79, 2003 (Pubitemid 36104657)
    • (2003) Pharmacogenomics , vol.4 , Issue.1 , pp. 67-79
    • Twyman, R.M.1    Primrose, S.B.2
  • 14
    • 34247100296 scopus 로고    scopus 로고
    • Analytical validation of genotyping assays in the biomarker laboratory
    • DOI 10.2217/14622416.8.4.353
    • Isler JA, Vesterqvist OE, Burczynski ME: Analytical validation of genotyping assays in the biomarker laboratory. Pharmacogenomics 8:353-368, 2007 (Pubitemid 46585498)
    • (2007) Pharmacogenomics , vol.8 , Issue.4 , pp. 353-368
    • Isler, J.A.1    Vesterqvist, O.E.2    Burczynski, M.E.3
  • 15
    • 78649321882 scopus 로고    scopus 로고
    • New technologies in the genetic approach to sudden cardiac death in the young
    • Brion M, Quintela I, Sobrino B, et al: New technologies in the genetic approach to sudden cardiac death in the young. Forensic Sci Int 203:15-24, 2010
    • (2010) Forensic Sci Int , vol.203 , pp. 15-24
    • Brion, M.1    Quintela, I.2    Sobrino, B.3
  • 16
    • 0036360439 scopus 로고    scopus 로고
    • Progress in high throughput SNP genotyping methods
    • DOI 10.1038/sj.tpj.6500094
    • Tsuchihashi Z, Dracopoli N: Progress in high throughput SNP genotyping methods. Biosystems 2:103-110, 2002 (Pubitemid 34982213)
    • (2002) Pharmacogenomics Journal , vol.2 , Issue.2 , pp. 103-110
    • Tsuchihashi, Z.1    Dracopoli, N.C.2
  • 17
    • 3242673452 scopus 로고    scopus 로고
    • A comparison between SNaPshot, pyrosequencing, and biplex invader SNP genotyping methods: Accuracy, cost, and throughput
    • DOI 10.1016/j.jbbm.2003.11.005, PII S0165022X03002148
    • Pati N, Schowinsky V, Kokanovic O, et al: A comparison between SNaPshot, pyrosequencing, and biplex invader SNP genotyping methods: Accuracy, cost, and throughput. J Biochem Biophys Methods 60:1-12, 2004 (Pubitemid 38952847)
    • (2004) Journal of Biochemical and Biophysical Methods , vol.60 , Issue.1 , pp. 1-12
    • Pati, N.1    Schowinsky, V.2    Kokanovic, O.3    Magnuson, V.4    Ghosh, S.5
  • 18
    • 4344584076 scopus 로고    scopus 로고
    • Evaluation and validation of the ABI 3700, ABI 3100, and the MegaBACE 1000 capillary array electrophoresis instruments for use with short tandem repeat microsatellite typing in a forensic environment
    • DOI 10.1002/elps.200305976
    • Koumi P, Green HE, Hartley S, et al: Evaluation and validation of the ABI 3700, ABI 3100, and the MegaBACE 1000 capillary array electrophoresis instruments for use with short tandem repeat microsatellite typing in a forensic environment. Electrophoresis 25:2227-2241, 2004 (Pubitemid 39136345)
    • (2004) Electrophoresis , vol.25 , Issue.14 , pp. 2227-2241
    • Koumi, P.1    Green, H.E.2    Hartley, S.3    Jordan, D.4    Lahec, S.5    Livett, R.J.6    Tsang, K.W.7    Ward, D.M.8
  • 19
    • 73449095762 scopus 로고    scopus 로고
    • The pitfalls of platform comparison: DNA copy number array technologies assessed
    • Curtis C, Lynch AG, Dunning MJ, et al: The pitfalls of platform comparison: DNA copy number array technologies assessed. BMC Genomics 10: 588, 2009
    • (2009) BMC Genomics , vol.10 , pp. 588
    • Curtis, C.1    Lynch, A.G.2    Dunning, M.J.3
  • 20
    • 62549112118 scopus 로고    scopus 로고
    • Basic principles and technologies for deciphering the genetic map of cancer
    • Voidonikolas G, Kreml SS, Chen C, et al: Basic principles and technologies for deciphering the genetic map of cancer. World J Surg 33:615-629, 2009
    • (2009) World J Surg , vol.33 , pp. 615-629
    • Voidonikolas, G.1    Kreml, S.S.2    Chen, C.3
  • 21
    • 79952198057 scopus 로고    scopus 로고
    • Exome sequencing: The sweet spot before whole genomes
    • Teer JK, Mullikin JC: Exome sequencing: The sweet spot before whole genomes. Hum Mol Genet 19:145-151, 2010
    • (2010) Hum Mol Genet , vol.19 , pp. 145-151
    • Teer, J.K.1    Mullikin, J.C.2
  • 23
    • 77954566882 scopus 로고    scopus 로고
    • Rapid targeted mutational analysis of human tumours: A clinical platform to guide personalized cancer medicine
    • Dias-Santagata D, Akhavanfard S, David SS, et al: Rapid targeted mutational analysis of human tumours: A clinical platform to guide personalized cancer medicine. EMBO Mol Med 2:146-158, 2010
    • (2010) EMBO Mol Med , vol.2 , pp. 146-158
    • Dias-Santagata, D.1    Akhavanfard, S.2    David, S.S.3
  • 24
    • 70849116358 scopus 로고    scopus 로고
    • Profiling critical cancer gene mutations in clinical tumor samples
    • MacConaill LE, Campbell CD, Kehoe SM, et al: Profiling critical cancer gene mutations in clinical tumor samples. PloS One 4:e7887, 2009
    • (2009) PloS One , vol.4
    • MacConaill, L.E.1    Campbell, C.D.2    Kehoe, S.M.3
  • 25
    • 62449090881 scopus 로고    scopus 로고
    • Guidelines for human epidermal growth factor receptor 2 testing: Biologic and methodologic considerations
    • Sauter G, Lee J, Bartlett JM, et al: Guidelines for human epidermal growth factor receptor 2 testing: Biologic and methodologic considerations. J Clin Oncol 27:1323-1333, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 1323-1333
    • Sauter, G.1    Lee, J.2    Bartlett, J.M.3
  • 27
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet 376:687-697, 2010
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 28
    • 23444459574 scopus 로고    scopus 로고
    • Array CGH technologies and their applications to cancer genomes
    • Davies JJ, Wilson IM, Lam WL: Array CGH technologies and their applications to cancer genomes. Chromosome Res 13:237-248, 2005
    • (2005) Chromosome Res , vol.13 , pp. 237-248
    • Davies, J.J.1    Wilson, I.M.2    Lam, W.L.3
  • 29
    • 77952499379 scopus 로고    scopus 로고
    • Multiplatform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number
    • Andrews J, Kennette W, Pilon J, et al: Multiplatform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number. PloS One 5:e8665, 2010
    • (2010) PloS One , vol.5
    • Andrews, J.1    Kennette, W.2    Pilon, J.3
  • 30
    • 39649084637 scopus 로고    scopus 로고
    • Bioinformatics challenges of new sequencing technology
    • Pop M, Salzberg SL: Bioinformatics challenges of new sequencing technology. Trends Genet 24:142-149, 2008
    • (2008) Trends Genet , vol.24 , pp. 142-149
    • Pop, M.1    Salzberg, S.L.2
  • 31
    • 33745699558 scopus 로고    scopus 로고
    • Current bioinformatics tools in genomic biomedical research
    • Teufel A, Krupp M, Weinmann A, et al: Current bioinformatics tools in genomic biomedical research. Int J Mol Med 17:967-973, 2006
    • (2006) Int J Mol Med , vol.17 , pp. 967-973
    • Teufel, A.1    Krupp, M.2    Weinmann, A.3
  • 32
    • 35748932917 scopus 로고    scopus 로고
    • A review of feature selection techniques in bioinformatics
    • DOI 10.1093/bioinformatics/btm344
    • Saeys Y, Inza I, Larrañaga P: A review of feature selection techniques in bioinformatics. Bioinformatics 23:2507-2517, 2007 (Pubitemid 350048351)
    • (2007) Bioinformatics , vol.23 , Issue.19 , pp. 2507-2517
    • Saeys, Y.1    Inza, I.2    Larranaga, P.3
  • 33
    • 37549024563 scopus 로고    scopus 로고
    • A bioinformatic filter for improved base-call accuracy and polymorphism detection using the Affymetrix GeneChip whole-genome resequencing platform
    • Pandya GA, Holmes MH, Sunkara S, et al: A bioinformatic filter for improved base-call accuracy and polymorphism detection using the Affymetrix GeneChip whole-genome resequencing platform. Nucleic Acids Res 35:e148, 2007
    • (2007) Nucleic Acids Res , vol.35
    • Pandya, G.A.1    Holmes, M.H.2    Sunkara, S.3
  • 34
    • 77951139631 scopus 로고    scopus 로고
    • Genome remodelling in a basal-like breast cancer metastasis and xenograft
    • Ding L, Ellis MJ, Li S, et al: Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464:999-1005, 2010
    • (2010) Nature , vol.464 , pp. 999-1005
    • Ding, L.1    Ellis, M.J.2    Li, S.3
  • 35
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al: Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 361:1058-1066, 2009
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 36
    • 74449085934 scopus 로고    scopus 로고
    • A small-cell lung cancer genome with complex signatures of tobacco exposure
    • Pleasance ED, Stephens PJ, O'Meara S, et al: A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 463:184-190, 2010
    • (2010) Nature , vol.463 , pp. 184-190
    • Pleasance, E.D.1    Stephens, P.J.2    O'Meara, S.3
  • 37
    • 74449093973 scopus 로고    scopus 로고
    • A comprehensive catalogue of somatic mutations from a human cancer genome
    • Pleasance ED, Cheetham RK, Stephens PJ, et al: A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463: 191-196, 2010
    • (2010) Nature , vol.463 , pp. 191-196
    • Pleasance, E.D.1    Cheetham, R.K.2    Stephens, P.J.3
  • 38
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network: Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068, 2008
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 39
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al: An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-1812, 2008
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 40
    • 79951497419 scopus 로고    scopus 로고
    • The genomic complexity of primary human prostate cancer
    • Berger MF, Lawrence MS, Demichelis F, et al: The genomic complexity of primary human prostate cancer. Nature 470:214-220, 2011
    • (2011) Nature , vol.470 , pp. 214-220
    • Berger, M.F.1    Lawrence, M.S.2    Demichelis, F.3
  • 41
    • 55549101623 scopus 로고    scopus 로고
    • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
    • Ley TJ, Mardis ER, Ding L, et al: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 456:66-72, 2008
    • (2008) Nature , vol.456 , pp. 66-72
    • Ley, T.J.1    Mardis, E.R.2    Ding, L.3
  • 43
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • International Cancer Genome Consortium
    • International Cancer Genome Consortium: International network of cancer genome projects. Nature 464:993-998, 2010
    • (2010) Nature , vol.464 , pp. 993-998
  • 44
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • DOI 10.1038/nrg1521
    • Hirschhorn JN, Daly MJ: Genome-wide association studies for common diseases and complex traits. Nature Rev Genet 6:95-108, 2005 (Pubitemid 40179532)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.2 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 45
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network: Integrated genomic analyses of ovarian carcinoma. Nature 474:609-615, 2011
    • (2011) Nature , vol.474 , pp. 609-615
  • 46
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Pinyol M, Quesada V, et al: Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475:101-105, 2011
    • (2011) Nature , vol.475 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3
  • 47
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, et al: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806, 2008
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 48
    • 79951494668 scopus 로고    scopus 로고
    • Initial genome sequencing and analysis of multiple myeloma
    • Chapman MA, Lawrence MS, Keats JJ, et al: Initial genome sequencing and analysis of multiple myeloma. Nature 471:467-472, 2011
    • (2011) Nature , vol.471 , pp. 467-472
    • Chapman, M.A.1    Lawrence, M.S.2    Keats, J.J.3
  • 49
    • 85027927831 scopus 로고    scopus 로고
    • High-resolution characterization of a hepatocellular carcinoma genome
    • Totoki Y, Tatsuno K, Yamamoto S, et al: High-resolution characterization of a hepatocellular carcinoma genome. Nat Genet 43:464-469, 2011
    • (2011) Nat Genet , vol.43 , pp. 464-469
    • Totoki, Y.1    Tatsuno, K.2    Yamamoto, S.3
  • 50
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M: Epigenetics in cancer. N Engl J Med 358:1148-1159, 2008
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 51
    • 77955654135 scopus 로고    scopus 로고
    • Expectations, validity, and reality in gene expression profiling
    • Kim K, Zakharkin SO, Allison DB: Expectations, validity, and reality in gene expression profiling. J Clin Epidemiol 63:950-959, 2010
    • (2010) J Clin Epidemiol , vol.63 , pp. 950-959
    • Kim, K.1    Zakharkin, S.O.2    Allison, D.B.3
  • 52
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sørlie T, Eisen MB, et al: Molecular portraits of human breast tumours. Nature 406:747-752, 2000
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sørlie, T.2    Eisen, M.B.3
  • 55
    • 20544442173 scopus 로고    scopus 로고
    • Gene profiling of immune responses against tumors
    • DOI 10.1016/j.coi.2005.05.007, PII S0952791505000786
    • Wang E, Panelli MC, Marincola FM: Gene profiling of immune responses against tumors. Cur Opin Immunol 17:423-427, 2005 (Pubitemid 40848546)
    • (2005) Current Opinion in Immunology , vol.17 , Issue.4 SPEC. ISS. , pp. 423-427
    • Wang, E.1    Panelli, M.C.2    Marincola, F.M.3
  • 56
    • 0036548986 scopus 로고    scopus 로고
    • Spinning molecular immunology into successful immunotherapy
    • Pardoll DM: Spinning molecular immunology into successful immunotherapy. Nature Rev Immunol 2:227-238, 2002
    • (2002) Nature Rev Immunol , vol.2 , pp. 227-238
    • Pardoll, D.M.1
  • 58
    • 77953233668 scopus 로고    scopus 로고
    • Gene-expression profiling in vaccine therapy and immunotherapy for cancer
    • Bedognetti D, Wang E, Sertoli MR, et al: Gene-expression profiling in vaccine therapy and immunotherapy for cancer. Exp Rev Vaccines 9:555-565, 2010
    • (2010) Exp Rev Vaccines , vol.9 , pp. 555-565
    • Bedognetti, D.1    Wang, E.2    Sertoli, M.R.3
  • 59
    • 80052512017 scopus 로고    scopus 로고
    • Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling
    • Coppola D, Nebozhyn M, Khalil F, et al: Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling. Am J Path 179:37-45, 2011
    • (2011) Am J Path , vol.179 , pp. 37-45
    • Coppola, D.1    Nebozhyn, M.2    Khalil, F.3
  • 60
    • 77955976922 scopus 로고    scopus 로고
    • The grand challenge to decipher the cancer proteome
    • Hanash S, Taguchi A: The grand challenge to decipher the cancer proteome. Nature Rev Cancer 10:652-660, 2010
    • (2010) Nature Rev Cancer , vol.10 , pp. 652-660
    • Hanash, S.1    Taguchi, A.2
  • 61
    • 77950448106 scopus 로고    scopus 로고
    • Point: Hypotheses first
    • Weinberg R: Point: Hypotheses first. Nature 464:678, 2010
    • (2010) Nature , vol.464 , pp. 678
    • Weinberg, R.1
  • 62
    • 34547641984 scopus 로고    scopus 로고
    • Cancer genome sequencing: The challenges ahead
    • Heng HH: Cancer genome sequencing: The challenges ahead. Bioessays 29:783-794, 2007
    • (2007) Bioessays , vol.29 , pp. 783-794
    • Heng, H.H.1
  • 63
    • 70249111091 scopus 로고    scopus 로고
    • Targeted capture and massively parallel sequencing of 12 human exomes
    • Ng SB, Turner EH, Robertson PD, et al: Targeted capture and massively parallel sequencing of 12 human exomes. Nature 461:272-276, 2009
    • (2009) Nature , vol.461 , pp. 272-276
    • Ng, S.B.1    Turner, E.H.2    Robertson, P.D.3
  • 64
    • 66149092582 scopus 로고    scopus 로고
    • Exome sequencing takes centre stage in cancer profiling
    • Maher B: Exome sequencing takes centre stage in cancer profiling. Nature 459:146-147, 2009
    • (2009) Nature , vol.459 , pp. 146-147
    • Maher, B.1
  • 65
    • 77952718611 scopus 로고    scopus 로고
    • Screening the human exome: A comparison of whole genome and whole transcriptome sequencing
    • Cirulli ET, Singh A, Shianna KV, et al: Screening the human exome: A comparison of whole genome and whole transcriptome sequencing. Genome Biol 11:R57, 2010
    • (2010) Genome Biol , vol.11
    • Cirulli, E.T.1    Singh, A.2    Shianna, K.V.3
  • 67
    • 75549085403 scopus 로고    scopus 로고
    • Whole-genome cancer analysis as an approach to deeper understanding of tumour biology
    • Strausberg RL, Simpson AJ: Whole-genome cancer analysis as an approach to deeper understanding of tumour biology. Br J Cancer 102:243-248, 2010
    • (2010) Br J Cancer , vol.102 , pp. 243-248
    • Strausberg, R.L.1    Simpson, A.J.2
  • 68
    • 50849127837 scopus 로고    scopus 로고
    • Genetic variation in an individual human exome
    • Ng PC, Levy S, Huang J, et al: Genetic variation in an individual human exome. PLoS Genet 4:e1000160, 2008
    • (2008) PLoS Genet , vol.4
    • Ng, P.C.1    Levy, S.2    Huang, J.3
  • 69
    • 72449209239 scopus 로고    scopus 로고
    • Next-generation sequencing of cancer genomes: Back to the future
    • Walter MJ, Graubert TA, Dipersio JF, et al: Next-generation sequencing of cancer genomes: Back to the future. Per Med 6:653, 2009
    • (2009) Per Med , vol.6 , pp. 653
    • Walter, M.J.1    Graubert, T.A.2    Dipersio, J.F.3
  • 70
    • 73949109877 scopus 로고    scopus 로고
    • Our changing view of the genomic landscape of cancer
    • Bell DW: Our changing view of the genomic landscape of cancer. J Path 220:231-243, 2010
    • (2010) J Path , vol.220 , pp. 231-243
    • Bell, D.W.1
  • 71
    • 79958817037 scopus 로고    scopus 로고
    • Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer
    • epub ahead of print on March 31, 2011
    • Tran B, Kopetz S, Tie J, et al: Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer [epub ahead of print on March 31, 2011]
    • Cancer
    • Tran, B.1    Kopetz, S.2    Tie, J.3
  • 72
    • 75749096130 scopus 로고    scopus 로고
    • Cancer genome sequencing: A review
    • Mardis ER, Wilson RK: Cancer genome sequencing: A review. Hum Mol Genet 18:R163-R168, 2009
    • (2009) Hum Mol Genet , vol.18
    • Mardis, E.R.1    Wilson, R.K.2
  • 73
    • 67649500009 scopus 로고    scopus 로고
    • GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer
    • Scott KL, Kabbarah O, Liang MC, et al: GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature 459:1085-1090, 2009
    • (2009) Nature , vol.459 , pp. 1085-1090
    • Scott, K.L.1    Kabbarah, O.2    Liang, M.C.3
  • 74
    • 0038745614 scopus 로고    scopus 로고
    • Integrating biological databases
    • Stein LD: Integrating biological databases. Nat Rev Genet 4:337-345, 2003
    • (2003) Nat Rev Genet , vol.4 , pp. 337-345
    • Stein, L.D.1
  • 76
    • 3042562270 scopus 로고    scopus 로고
    • Genomics, prior probability, and statistical tests of multiple hypotheses
    • DOI 10.1101/gr.2156804
    • Manly KF, Nettleton D, Hwang JT: Genomics, prior probability, and statistical tests of multiple hypotheses. Genome Res 14:997-1001, 2004 (Pubitemid 38811535)
    • (2004) Genome Research , vol.14 , Issue.6 , pp. 997-1001
    • Manly, K.F.1    Nettleton, D.2    Gene, H.J.T.3
  • 77
    • 0036574916 scopus 로고    scopus 로고
    • Statistical issues with microarrays: Processing and analysis
    • DOI 10.1016/S0168-9525(02)02665-3, PII S0168952502026653
    • Nadon R, Shoemaker J: Statistical issues with microarrays: Processing and analysis. Trends Genet 18:265-271, 2002 (Pubitemid 34607142)
    • (2002) Trends in Genetics , vol.18 , Issue.5 , pp. 265-271
    • Nadon, R.1    Shoemaker, J.2
  • 78
    • 38049040796 scopus 로고    scopus 로고
    • Multiple testing in the genomics era: Findings from Genetic Analysis Workshop 15, Group 15
    • Martin LJ, Woo JG, Avery CL, et al: Multiple testing in the genomics era: Findings from Genetic Analysis Workshop 15, Group 15. Genet Epidemiol 31:124-131, 2007
    • (2007) Genet Epidemiol , vol.31 , pp. 124-131
    • Martin, L.J.1    Woo, J.G.2    Avery, C.L.3
  • 81
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361:947-957, 2011
    • (2011) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 82
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • Kim E, Hirsh V, Mok T, et al: Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial. Lancet 372:1809-1818, 2008
    • (2008) Lancet , vol.372 , pp. 1809-1818
    • Kim, E.1    Hirsh, V.2    Mok, T.3
  • 83
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al: Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507-2516, 2011
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 85
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al: Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711-723, 2010
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 86
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al: Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 363:411-422, 2010
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 87
    • 77954938591 scopus 로고    scopus 로고
    • Future of personalized medicine in oncology: A systems biology approach
    • Gonzalez-Angulo AM, Hennessy BT, Mills GB: Future of personalized medicine in oncology: A systems biology approach. J Clin Oncol 28:2777-2783, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 2777-2783
    • Gonzalez-Angulo, A.M.1    Hennessy, B.T.2    Mills, G.B.3
  • 88
    • 79951865370 scopus 로고    scopus 로고
    • Clinical implications of the cancer genome
    • Macconaill LE, Garraway LA: Clinical implications of the cancer genome. J Clin Oncol 28:5219-5228, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 5219-5228
    • Macconaill, L.E.1    Garraway, L.A.2
  • 89
    • 77949667760 scopus 로고    scopus 로고
    • Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents
    • Dancey JE, Dobbin KK, Groshen S, et al: Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents. Clin Cancer Res 16:1745-1755, 2010
    • (2010) Clin Cancer Res , vol.16 , pp. 1745-1755
    • Dancey, J.E.1    Dobbin, K.K.2    Groshen, S.3
  • 90
    • 79951897927 scopus 로고    scopus 로고
    • Selecting systemic cancer therapy one patient at a time: Is there a role for molecular profiling of individual patients with advanced solid tumors?
    • Doroshow JH: Selecting systemic cancer therapy one patient at a time: Is there a role for molecular profiling of individual patients with advanced solid tumors? J Clin Oncol 28:4869-4871, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 4869-4871
    • Doroshow, J.H.1
  • 91
    • 79951906119 scopus 로고    scopus 로고
    • Pilot study using molecular profiling of patients tumors to find potential targets and select treatments for their refractory cancers
    • Von Hoff DD, Stephenson JJ Jr, Rosen P, et al: Pilot study using molecular profiling of patients tumors to find potential targets and select treatments for their refractory cancers. J Clin Oncol 28:4877-4883, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 4877-4883
    • Von Hoff, D.D.1    Stephenson Jr., J.J.2    Rosen, P.3
  • 92
    • 84855558810 scopus 로고    scopus 로고
    • Personalized medicine in a phase I clinical trials program: The M. D. Anderson Cancer Center initiative
    • suppl; abstr CRC2500
    • Tsimberidou AM, Iskander NG, Hong DS, et al: Personalized medicine in a phase I clinical trials program: The M. D. Anderson Cancer Center initiative. J Clin Oncol 29:18s, 2011 (suppl; abstr CRC2500)
    • (2011) J Clin Oncol , vol.29
    • Tsimberidou, A.M.1    Iskander, N.G.2    Hong, D.S.3
  • 93
    • 79957857433 scopus 로고    scopus 로고
    • The BATTLE Trial: Personalizing Therapy for Lung Cancer
    • Kim ES, Herbst RS, Wistuba II, et al: The BATTLE Trial: Personalizing Therapy for Lung Cancer. Cancer Discov 1:44-53, 2011
    • (2011) Cancer Discov , vol.1 , pp. 44-53
    • Kim, E.S.1    Herbst, R.S.2    Wistuba, I.I.3
  • 94
    • 70649113052 scopus 로고    scopus 로고
    • Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy
    • Ross CJ, Katzov-Eckert H, Dubé MP, et al: Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. Nature Genet 41:1345-1349, 2009
    • (2009) Nature Genet , vol.41 , pp. 1345-1349
    • Ross, C.J.1    Katzov-Eckert, H.2    Dubé, M.P.3
  • 95
    • 42949174211 scopus 로고    scopus 로고
    • Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer
    • de Haas EC, Zwart N, Meijer C, et al: Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. J Clin Oncol 26:1817-1823, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1817-1823
    • De Haas, E.C.1    Zwart, N.2    Meijer, C.3
  • 96
    • 33750583902 scopus 로고    scopus 로고
    • Uridine diphosphate glucuronosyltransferase (UGT) 1A1 and irinotecan: Practical pharmacogenomics arrives in cancer therapy
    • DOI 10.1200/JCO.2006.07.3031
    • O'Dwyer PJ, Catalano RB: Uridine diphosphate glucuronosyltransferase (UGT) 1A1 and irinotecan: Practical pharmacogenomics arrives in cancer therapy. J Clin Oncol 24:4534-4538, 2006 (Pubitemid 46630947)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.28 , pp. 4534-4538
    • O'Dwyer, P.J.1    Catalano, R.B.2
  • 98
    • 84863407177 scopus 로고    scopus 로고
    • Comparative genomic analysis of primary versus metastasis in colorectal carcinomas
    • suppl; abstr 10500
    • Vakiani E, Janakiraman M, Shen R, et al: Comparative genomic analysis of primary versus metastasis in colorectal carcinomas. J Clin Oncol 29:15s, 2011 (suppl; abstr 10500)
    • (2011) J Clin Oncol , vol.29
    • Vakiani, E.1    Janakiraman, M.2    Shen, R.3
  • 99
    • 79952463028 scopus 로고    scopus 로고
    • Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAFV600E mutation
    • Tie J, Gibbs P, Lipton L, et al: Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAFV600E mutation. Int J Cancer 128:2075-2084, 2010
    • (2010) Int J Cancer , vol.128 , pp. 2075-2084
    • Tie, J.1    Gibbs, P.2    Lipton, L.3
  • 100
    • 84857568955 scopus 로고    scopus 로고
    • Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer
    • Amir E, Miller N, Geddie W, et al: Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer. J Clin Oncol 30:587-592, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 587-592
    • Amir, E.1    Miller, N.2    Geddie, W.3
  • 101
    • 0027043081 scopus 로고
    • Outcome of patients hospitalized for complications after outpatient liver biopsy
    • Janes CH, Lindor KD: Outcome of patients hospitalized for complications after outpatient liver biopsy. Ann Intern Med 118:96-98, 1993
    • (1993) Ann Intern Med , vol.118 , pp. 96-98
    • Janes, C.H.1    Lindor, K.D.2
  • 102
    • 41649102043 scopus 로고    scopus 로고
    • The cancer biomarker problem
    • Sawyers CL: The cancer biomarker problem. Nature 452:548-552, 2008
    • (2008) Nature , vol.452 , pp. 548-552
    • Sawyers, C.L.1
  • 103
    • 78649325247 scopus 로고    scopus 로고
    • Tumor heterogeneity in neoplasms of breast, colon, and skin
    • Li J, Wang K, Jensen TD, et al: Tumor heterogeneity in neoplasms of breast, colon, and skin. BMC Res Notes 3:321, 2010
    • (2010) BMC Res Notes , vol.3 , pp. 321
    • Li, J.1    Wang, K.2    Jensen, T.D.3
  • 104
    • 78649723255 scopus 로고    scopus 로고
    • PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors
    • suppl; abstr 3534
    • Kopetz S, Desai J, Chan E, et al: PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors. J Clin Oncol 28:15s, 2010 (suppl; abstr 3534)
    • (2010) J Clin Oncol , vol.28
    • Kopetz, S.1    Desai, J.2    Chan, E.3
  • 106
    • 0028174839 scopus 로고
    • Effects of ethanol and paraformaldehyde on RNA yield and quality
    • Klimecki WT, Futscher BW, Dalton WS: Effects of ethanol and paraformaldehyde on RNA yield and quality. BioTechniques 16:1021-1023, 1994
    • (1994) BioTechniques , vol.16 , pp. 1021-1023
    • Klimecki, W.T.1    Futscher, B.W.2    Dalton, W.S.3
  • 107
    • 0026029136 scopus 로고
    • Effect of fixation on the amplification of nucleic acids from paraffin-embedded material by the polymerase chain reaction
    • Ben-Ezra J, Johnson DA, Rossi J, et al: Effect of fixation on the amplification of nucleic acids from paraffin-embedded material by the polymerase chain reaction. J Histochem Cytochem 39:351-354, 1991
    • (1991) J Histochem Cytochem , vol.39 , pp. 351-354
    • Ben-Ezra, J.1    Johnson, D.A.2    Rossi, J.3
  • 108
    • 23444462084 scopus 로고    scopus 로고
    • An alternative protocol for DNA extraction from formalin fixed and paraffin wax embedded tissue
    • DOI 10.1136/jcp.2004.021352
    • Coura R, Prolla JC, Meurer L, et al: An alternative protocol for DNA extraction from formalin fixed and paraffin wax embedded tissue. J Clin Path 58:894-895, 2005 (Pubitemid 41113404)
    • (2005) Journal of Clinical Pathology , vol.58 , Issue.8 , pp. 894-895
    • Coura, R.1    Prolla, J.C.2    Meurer, L.3    Ashton-Prolla, P.4
  • 109
    • 0030726659 scopus 로고    scopus 로고
    • Laser capture microdissection: Molecular analysis of tissue
    • Bonner RF: Laser capture microdissection: Molecular analysis of tissue. Science 278:1481-1483, 1997
    • (1997) Science , vol.278 , pp. 1481-1483
    • Bonner, R.F.1
  • 111
    • 16544388740 scopus 로고    scopus 로고
    • Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH
    • Cardoso J, Molenaar L, de Menezes RX, et al: Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH. Nucleic Acids Res 32:e146, 2004
    • (2004) Nucleic Acids Res , vol.32
    • Cardoso, J.1    Molenaar, L.2    De Menezes, R.X.3
  • 112
    • 34147164024 scopus 로고    scopus 로고
    • Is molecular profiling ready for use in clinical decision making?
    • Ioannidis JP: Is molecular profiling ready for use in clinical decision making? Oncologist 12:301-311, 2007
    • (2007) Oncologist , vol.12 , pp. 301-311
    • Ioannidis, J.P.1
  • 115
    • 84860728924 scopus 로고    scopus 로고
    • US Food and Drug Administration: Device advice: Investigational device exemption (IDE). http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/ HowtoMarketYourDevice/InvestigationalDeviceExemptionIDE/default.htm
    • Device Advice: Investigational Device Exemption (IDE)
  • 116
    • 65449144325 scopus 로고    scopus 로고
    • Evaluation of next generation sequencing platforms for population targeted sequencing studies
    • Harismendy O, Ng PC, Strausberg RL, et al: Evaluation of next generation sequencing platforms for population targeted sequencing studies. Genome Biol 10:R32, 2009
    • (2009) Genome Biol , vol.10
    • Harismendy, O.1    Ng, P.C.2    Strausberg, R.L.3
  • 117
    • 70149098012 scopus 로고    scopus 로고
    • Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue
    • Bhagwat NR, Roginskaya VY, Acquafondata MB, et al: Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. Cancer Res 69:6831-6838, 2009
    • (2009) Cancer Res , vol.69 , pp. 6831-6838
    • Bhagwat, N.R.1    Roginskaya, V.Y.2    Acquafondata, M.B.3
  • 118
    • 35248874798 scopus 로고    scopus 로고
    • ERCC1-specific immunostaining in non-small-cell lung cancer [9]
    • DOI 10.1056/NEJMc072007
    • Olaussen KA, Fouret P, Kroemer G: ERCC1-specific immunostaining in non-small-cell lung cancer. N Engl J Med 357:1559-1561, 2007 (Pubitemid 47572656)
    • (2007) New England Journal of Medicine , vol.357 , Issue.15 , pp. 1559-1561
    • Olaussen, K.A.1    Fouret, P.2    Kroemer, G.3
  • 121
    • 38549085235 scopus 로고    scopus 로고
    • Research ethics and the challenge of whole-genome sequencing
    • DOI 10.1038/nrg2302, PII NRG2302
    • McGuire AL, Caulfield T, Cho MK: Research ethics and the challenge of whole-genome sequencing. Nat Rev Genet 9:152-156, 2008 (Pubitemid 351147709)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.2 , pp. 152-156
    • McGuire, A.L.1    Caulfield, T.2    Cho, M.K.3
  • 122
    • 79951863517 scopus 로고    scopus 로고
    • Ethical and practical guidelines for reporting genetic research results to study participants: Updated guidelines from a National Heart, Lung, and Blood Institute Working Group
    • Fabsitz RR, McGuire A, Sharp RR, et al: Ethical and practical guidelines for reporting genetic research results to study participants: Updated guidelines from a National Heart, Lung, and Blood Institute Working Group. Circ Cardiovasc Genet 3:574-580, 2010
    • (2010) Circ Cardiovasc Genet , vol.3 , pp. 574-580
    • Fabsitz, R.R.1    McGuire, A.2    Sharp, R.R.3
  • 123
    • 33646254125 scopus 로고    scopus 로고
    • Reporting genetic results in research studies: Summary and recommendations of an NHLBI working group
    • Bookman EB, Langehorne AA, Eckfeldt JH, et al: Reporting genetic results in research studies: Summary and recommendations of an NHLBI working group. Am J Med Genet 140:1033-1040, 2006
    • (2006) Am J Med Genet , vol.140 , pp. 1033-1040
    • Bookman, E.B.1    Langehorne, A.A.2    Eckfeldt, J.H.3
  • 124
    • 42649145667 scopus 로고    scopus 로고
    • Wildtype KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al: Wildtype KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26:1626-1634, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 125
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al: K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 359:1757-1765, 2008
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 126
    • 84863400088 scopus 로고    scopus 로고
    • The introduction of systematic genomic testing for patients with non-small cell lung cancer (NSCLC) at Dana-Farber Cancer Institute (DFCI)
    • suppl; abstr 7517
    • Ortiz TM, Joshi VA, Heon S, et al: The introduction of systematic genomic testing for patients with non-small cell lung cancer (NSCLC) at Dana-Farber Cancer Institute (DFCI). J Clin Oncol 29:15s, 2011 (suppl; abstr 7517)
    • (2011) J Clin Oncol , vol.29
    • Ortiz, T.M.1    Joshi, V.A.2    Heon, S.3
  • 127
    • 80053371003 scopus 로고    scopus 로고
    • SNaPshot genotyping of non-small cell lung cancers (NSCLC) in clinical practice
    • suppl; abstr 7518
    • Sequist LV, Heist RS, Shaw AT, et al: SNaPshot genotyping of non-small cell lung cancers (NSCLC) in clinical practice. J Clin Oncol 29:15s, 2011 (suppl; abstr 7518)
    • (2011) J Clin Oncol , vol.29
    • Sequist, L.V.1    Heist, R.S.2    Shaw, A.T.3
  • 128
    • 33748093767 scopus 로고    scopus 로고
    • Linking oncogenic pathways with therapeutic opportunities
    • DOI 10.1038/nrc1976, PII NRC1976
    • Bild AH, Potti A, Nevins JR: Linking oncogenic pathways with therapeutic opportunities. Nature Rev Cancer 6:735-741, 2006 (Pubitemid 44304232)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 735-741
    • Bild, A.H.1    Potti, A.2    Nevins, J.R.3


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