Towards real-time monitoring of therapeutic protein quality in mammalian cell processes

Current Opinion in Biotechnology

Volumn 30, Issue , 2014, Pages 161-167

  Pais, Daniel A M ^a   Carrondo, Manuel JT ^a,b   Alves, Paula M ^a,b   Teixeira, Ana P ^a,b  

^a INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; MULTIVARIANT ANALYSIS; PROTEINS;

BIOPHARMACEUTICAL INDUSTRY; HIGH-THROUGHPUT TECHNIQUE; MANUFACTURING PROCESS; MULTIVARIATE DATA ANALYSIS; POST-TRANSLATIONAL MODIFICATIONS; PROCESS ANALYTICAL TECHNOLOGY; REAL TIME MONITORING; THERAPEUTIC PROTEIN; MAMMALIAN CELLS;

QUALITY CONTROL;

BIOSIMILAR AGENT; PROTEIN; RECOMBINANT PROTEIN;

BIOMICS; BIOTECHNOLOGY; DRUG APPROVAL; DRUG DESIGN; DRUG MANUFACTURE; DRUG MONITORING; DRUG QUALITY; MAMMAL CELL; NONHUMAN; ONLINE MONITORING; PRIORITY JOURNAL; PROCESS TECHNOLOGY; PROTEIN QUALITY; REVIEW; BIOPROCESS; CHEMICAL PARAMETERS; CHEMOMETRIC ANALYSIS; CRITICAL QUALITY ATTRIBUTE; DATA ANALYSIS; DEUTERIUM HYDROGEN EXCHANGE; DRUG INDUSTRY; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NEAR INFRARED SPECTROSCOPY; PROCESS ANALYTICAL TECHNOLOGY; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEOMICS; QUALITY BY DESIGN; RAMAN SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; CELL LINE; METABOLISM; PROCEDURES; QUALITY CONTROL; STANDARDS;

ANIMALS; CELL LINE; DRUG INDUSTRY; HUMANS; QUALITY CONTROL; RECOMBINANT PROTEINS;

EID: 84904341038     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2014.06.019     Document Type: Review

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