Advanced online monitoring of cell culture off-gas using proton transfer reaction mass spectrometry

Biotechnology Progress

Volumn 30, Issue 2, 2014, Pages 496-504

  Schmidberger, Timo ^a,b   Gutmann, Rene ^c   Bayer, Karl ^b   Kronthaler, Jennifer ^a   Huber, Robert ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^c IONICON Analytik GmbH   (Austria)

Author keywords

Bioprocess monitoring; CHO cell culture; Proton transfer reaction mass spectrometry (PTR MS); Volatile organic compound

Indexed keywords

CARBON DIOXIDE; CULTIVATION; IONIZATION OF GASES; MASS SPECTROMETRY; METABOLISM; PROTON TRANSFER; STATISTICAL METHODS; VOLATILE ORGANIC COMPOUNDS;

BIOPROCESS MONITORING; CHO CELL CULTURES; CULTIVATION CONDITIONS; IN-PROCESS MONITORING; MAMMALIAN CELL CULTURE; MEASURABLE PARAMETERS; PARTIAL LEAST SQUARE REGRESSION; PROTON-TRANSFER REACTION MASS SPECTROMETRIES;

CELL CULTURE;

ANIMALIA; MAMMALIA;

LACTIC ACID; VOLATILE ORGANIC COMPOUND;

ANIMAL; BIOREACTOR; CHO CELL LINE; CRICETULUS; CULTURE TECHNIQUE; FERMENTATION; HAMSTER; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; PROCEDURES;

ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; FERMENTATION; LACTIC ACID; MASS SPECTROMETRY; VOLATILE ORGANIC COMPOUNDS;

EID: 84898546926     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1853     Document Type: Article

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