Synchronous fluorescence spectroscopy as a novel tool to enable PAT applications in bioprocesses

Biotechnology and Bioengineering

Volumn 108, Issue 8, 2011, Pages 1852-1861

  Teixeira, Ana P ^a,b   Duarte, Tiago M ^a   Carrondo, M J T ^a,b   Alves, Paula M ^a,b  

^a IBET   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

Animal cell cultures; Chemometric methods; Monoclonal antibodies; PAT; Synchronous fluorescence spectroscopy

Indexed keywords

ANTIBODY TITERS; BIOPROCESS MONITORING; BIOPROCESSES; BIOREACTOR CULTURES; CELL DENSITY; CHEMOMETRIC METHOD; CHO CELL; CULTURE TIME; DATA SETS; DATA TYPE; FLUORESCENCE SIGNALS; FLUORESCENT COMPOUNDS; IN-SITU; MODEL PREDICTION; PARTIAL LEAST SQUARES REGRESSION; PAT; PEAK RESOLUTION; PROCESS CONTROL STRATEGIES; REAL TIME MONITORING; SPECTRAL FEATURE; SYNCHRONOUS FLUORESCENCE SPECTROSCOPY; SYNCHRONOUS SPECTRA; VIABLE CELLS; WAVELENGTH DIFFERENCE;

ANIMAL CELL CULTURE; ANIMALS; CELLS; FLUORESCENCE SPECTROSCOPY; FLUOROMETERS; MONITORING; MONOCLONAL ANTIBODIES; PRINCIPAL COMPONENT ANALYSIS; REGRESSION ANALYSIS; SURFACE PLASMON RESONANCE;

FLUORESCENCE;

MONOCLONAL ANTIBODY;

ANALYTIC METHOD; ANTIBODY TITER; ARTICLE; BIOPROCESS; CELL CULTURE; CELL DENSITY; CHO CELL; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; FLUORESCENCE SPECTROSCOPY; FLUOROMETRY; INFORMATION PROCESSING; MONITORING; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PROCESS ANALYTICAL TECHNOLOGY; SYNCHRONOUS FLUORESCENCE SPECTROSCOPY; TWO DIMENSIONAL FLUOROMETRY;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; FERMENTATION; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE;

ANIMALIA; SANDFLY FEVER SICILIAN VIRUS;

EID: 79959238152     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23131     Document Type: Article

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