Recent advances in micro/nanoscale biomedical implants

Journal of Controlled Release

Volumn 189, Issue , 2014, Pages 25-45

  Arsiwala, Ammar ^a   Desai, Preshita ^a   Patravale, Vandana ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Biomedical implants; Bone; Micro; Nano; Neural; Stents

Indexed keywords

BIOMEDICAL EQUIPMENT; BONE; DENTAL PROSTHESES; RESEARCH; STENTS;

BIOMEDICAL IMPLANTS; CARDIOVASCULAR IMPLANTS; FUTURE PERSPECTIVES; IMPLANTABLE MEDICAL DEVICES; MEDICAL DEVICE INDUSTRY; MICRO; NANO; NEURAL;

IMPLANTS (SURGICAL);

NANOCARRIER; BIOMATERIAL;

BARE METAL STENT; BIOCOMPATIBILITY; BIOMEDICAL ENGINEERING; BIOMOLECULAR ELECTRONICS; BIOPHYSICS; BIORESORBABLE SCAFFOLD; BLOOD VESSEL GRAFT; BONE IMPLANT; CARDIOVASCULAR IMPLANT; CARDIOVASCULAR PROSTHESIS AND IMPLANT; CARDIOVASCULAR STENT; COCHLEA PROSTHESIS; CORONARY STENT; DEFIBRILLATOR; DRUG ELUTING STENT; HEART VALVE PROSTHESIS; HUMAN; IMPLANT; INSTRUMENT STERILIZATION; METAL STENT; MICROTECHNOLOGY; NANOBIOTECHNOLOGY; NEUROLOGICAL IMPLANT; NEUROPROSTHESIS; NONHUMAN; ORTHOPEDIC FIXATION DEVICE; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY BALLOON; PRIORITY JOURNAL; RETINAL IMPLANT; REVIEW; SURFACE PROPERTY; TOOTH IMPLANT; ANIMAL; NANOTECHNOLOGY; PROSTHESES AND ORTHOSES;

ANIMALS; BIOCOMPATIBLE MATERIALS; HUMANS; NANOTECHNOLOGY; PROSTHESES AND IMPLANTS;

EID: 84903954123     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.06.021     Document Type: Review

References (220)

1. Medical Bionic Implant (Artificial Organs) Market-trends and Global Forecasts to 2017 2012 Markets and Markets
2. D. Lloyd-Jones, R.J. Adams, T.M. Brown, M. Carnethon, S. Dai, G. De Simone, T.B. Ferguson, E. Ford, K. Furie, C. Gillespie, A. Go, K. Greenlund, N. Haase, S. Hailpern, P.M. Ho, V. Howard, B. Kissela, S. Kittner, D. Lackland, L. Lisabeth, A. Marelli, M.M. McDermott, J. Meigs, D. Mozaffarian, M. Mussolino, G. Nichol, V.L. Roger, W. Rosamond, R. Sacco, P. Sorlie, V.L. Roger, T. Thom, S. Wasserthiel-Smoller, N.D. Wong, and J. Wylie-Rosett American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Heart Disease and Stroke Statistics - 2010 update: a report from the American Heart Association Circulation 121 2010 46 215
3. V.L. Roger, A.S. Go, D.M. Lloyd-Jones, E.J. Benjamin, J.D. Berry, W.B. Borden, D.M. Bravata, S. Dai, E.S. Ford, C.S. Fox, H.J. Fullerton, C. Gillespie, S.M. Hailpern, J.A. Heit, V.J. Howard, B.M. Kissela, S.J. Kittner, D.T. Lackland, J.H. Lichtman, L.D. Lisabeth, D.M. Makuc, G.M. Marcus, A. Marelli, D.B. Matchar, C.S. Moy, D. Mozaffarian, M.E. Mussolino, G. Nichol, N.P. Paynter, E.Z. Soliman, P.D. Sorlie, N. Sotoodehnia, T.N. Turan, S.S. Virani, N.D. Wong, D. Woo, and M.B. Turner American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Heart Disease and Stroke Statistics - 2012 update: a report from the American Heart Association Circulation 125 2012 2 220
4. S. Allender, P. Scarborough, V. Peto, and M. Rayner European Cardiovascular Disease Statistics: 2008 Edition 2008 European Heart Network
5. A.M. Arsiwala, A.J. Raval, and V.B. Patravale Nanocoatings on implantable medical devices Pharm. Pat. Anal. 2 2013 499 512
6. P. Qi, M.F. Maitz, and N. Huang Surface modification of cardiovascular materials and implants Surf. Coat. Technol. 233 2013 80 90
7. S. Satzl, C. Henn, P. Christoph, P. Kurz, U. Stampfl, S. Stampfl, F. Thomas, B. Radeleff, I. Berger, M. Grunze, and G.M. Richter The efficacy of nanoscale poly[bis(trifluoroethoxy) phosphazene] (PTFEP) coatings in reducing thrombogenicity and late in-stent stenosis in a porcine coronary artery model Investig. Radiol. 42 2007 303 311 (Pubitemid 46558090)
8. F.C. Tanner, Z.Y. Yang, E. Duckers, D. Gordon, G.J. Nabel, and E.G. Nabel Expression of cyclin-dependent kinase inhibitors in vascular disease Circ. Res. 82 1998 396 403 (Pubitemid 28101197)
9. G. Nakazawa Stent thrombosis of drug eluting stent: pathological perspective J. Cardiol. 58 2011 84 91
10. C. Chaabane, F. Otsuka, R. Virmani, and M.-L. Bochaton-Piallat Biological responses in stented arteries Cardiovasc. Res. 99 2013 353 363
11. G.A. Ferns, and T.Y. Avades The mechanisms of coronary restenosis: insights from experimental models Int. J. Exp. Pathol. 81 2000 63 88 (Pubitemid 30253349)
12. A.P. Mc Guigan, and M.V. Sefton The influence of biomaterials on endothelial cell thrombogenicity Biomaterials 28 2007 2547 2571 (Pubitemid 46371460)
13. A. de Mel, F. Murad, and A.M. Seifalian Nitric oxide: a guardian for vascular grafts? Chem. Rev. 111 2011 5742 5767
14. V. Karagkiozaki, P.G. Karagiannidis, N. Kalfagiannis, P. Kavatzikidou, P. Patsalas, D. Georgiu, and S. Logothetidis Novel nanostructured biomaterials: implications for coronary stent thrombosis Int. J. Nanomedicine 7 2012 6063 6076
15. R. Gallo, A. Padurean, T. Jayaraman, S. Marx, M. Roque, S. Adelman, J. Chesebro, J. Fallon, V. Fuster, A. Marks, and J.J. Badimon Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle Circulation 99 1999 2164 2170 (Pubitemid 29196802)
16. M.R. Bennett, and M. O'Sullivan Mechanisms of angioplasty and stent restenosis: implications for design of rational therapy Pharmacol. Ther. 91 2001 149 166 (Pubitemid 33139799)
17. H.C. Lowe, S.N. Oesterle, and L.M. Khachigian Coronary in-stent restenosis: current status and future strategies J. Am. Coll. Cardiol. 39 2002 183 193 (Pubitemid 34084620)
18. S. Garg, and P.W. Serruys Coronary stents: current status J. Am. Coll. Cardiol. 56 2010 S1 S42
19. A.S. Puranik, E.R. Dawson, and N.A. Peppas Recent advances in drug eluting stents Int. J. Pharm. 441 2013 665 679
20. A.T. Ong, and P.W. Serruys Technology insight: an overview of research in drug-eluting stents Nat. Clin. Pract. Cardiovasc. Med. 2 2005 647 658 (Pubitemid 43012602)
21. S. Silber When are drug-eluting stents effective? A critical analysis of the presently available data Z. Kardiol. 93 2004 649 663 (Pubitemid 39304389)
22. M. Joner, A.V. Finn, A. Farb, E.K. Mont, F.D. Kolodgie, E. Ladich, R. Kutys, K. Skorija, H.K. Gold, and R. Virmani Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk J. Am. Coll. Cardiol. 48 2006 193 202 (Pubitemid 43929240)
23. T.F. Luscher, J. Steffel, F.R. Eberli, M. Joner, G. Nakazawa, F.C. Tanner, and R. Virmani Drug eluting stent and coronary thrombosis: biological mechanisms and clinical implications Circulation 115 2007 1051 1058 (Pubitemid 46328299)
24. G.W. Stone, J.W. Moses, S.G. Ellis, J. Schofer, K.D. Dawkins, M.C. Morice, A. Colombo, E. Schampaert, E. Grube, A.J. Kirtane, D.E. Cutlip, M. Fahy, S.J. Pocock, R. Mehran, and M.B. Leon Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents N. Engl. J. Med. 356 2007 998 1008 (Pubitemid 46376800)
25. C.D. Rogers Optimal stent design for drug delivery Rev. Cardiovasc. Med. 5 2004 S9 S15
26. R. Virmani, F. Liistro, G. Stankovic, C.D. Mario, M. Montormano, A. Farb, F.D. Colodgie, and A. Colombo Mechanism of late in-stent restenosis after implantation of a paclitaxel derivate-eluting polymer stent system in humans Circulation 106 2002 2649 2651 (Pubitemid 35364917)
27. M.C. Morice, P.W. Serruys, J.E. Sousa, J. Fajadet, E.B. Hayashi, M. Perin, A. Colombo, G. Schuler, P. Barragan, G. Guagliumi, F. Molnar, and R. Falotico A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization N. Engl. J. Med. 346 2002 1773 1780 (Pubitemid 34586912)
28. J. Mehilli, A. Dibra, A. Kastrati, J. Pache, J. Dirshinger, and A. Schomig Randomized trial of paclitaxel- and sirolimus-eluting stents in small coronary vessels Eur. Heart J. 27 2006 260 266 (Pubitemid 43100018)
29. S. Venkatraman, and F. Boey Release profiles in drug-eluting stents: issues and uncertainties J. Control. Release 120 2007 149 160 (Pubitemid 47058640)
30. A.E. Rodriguez Are drug-eluting stents superior to bare metal stents when compared to coronary artery bypass surgery? Show me the data Cardiovasc. Revasc. Med. 14 2013 90 92
31. L. Mei, H. Sun, X. Jin, D. Zhu, R. Sun, M. Zhang, and C. Song Modified paclitaxel-loaded nanoparticles for inhibition of hyperplasia in a rabbit arterial balloon injury model Pharm. Res. 24 2007 955 962 (Pubitemid 46675396)
32. A. de Mel, C. Bolvin, M. Edirisinghe, G. Hamilton, and A.M. Seifailan Development of cardiovascular bypass grafts: endothelialization and applications of nanotechnology Expert. Rev. Cardiovasc. Ther. 6 2008 1259 1277
33. M.S. Sacks, W.D. Merryman, and D.E. Schmidt On the biomechanics of heart valve functions J. Biomech. 42 2009 1804 1824
34. C.X. Song, V. Labhsetwar, H. Murphy, X. Qu, W.R. Humphrey, R.J. Shebuski, and R.J. Levy Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery J. Control. Release 43 1997 197 212 (Pubitemid 26390968)
35. W.R. Humphrey, L.A. Erickson, C.A. Simmons, J.L. Northrup, D.G. Wishka, J. Morris, V. Labhasetwar, C. Song, R.J. Levy, and R.J. Shebuski The effect of intramural delivery of polymeric nanoparticles loaded with antiproliferative 2-aminochrome U-86983 on neointimal hyperplasia development in balloon-injured porcine coronary artery Adv. Drug Deliv. Rev. 24 1997 87 108 (Pubitemid 27062763)
36. C. Song, V. Labhsetwar, X. Cui, T. Underwood, and R.J. Levy Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: results with an acute dog model J. Control. Release 54 1998 201 211 (Pubitemid 28342699)
37. J. Davda, and V. Labhsetwar Characterization of nanoparticle uptake by endothelial cells Int. J. Pharm. 233 2002 51 59 (Pubitemid 34230418)
38. S. Prabha, W.-Z. Zhou, J. Panyam, and V. Labhasetwar Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles Int. J. Pharm. 244 2002 105 115 (Pubitemid 35245451)
39. D. Deshpande, H. Devalapally, and M. Amiji Enhancement in anti-proliferative effects of paclitaxel in aortic smooth muscle cells upon co-administration with ceramide using biodegradable polymeric nanoparticles Pharm. Res. 25 2008 1936 1947
40. F. Luderer, M. Lobler, H.W. Rohm, G. Gocke, K. Kunna, K. Kock, H.K. Kroemer, W. Weitschies, K.-P. Schimitz, and K. Sternberg Biodegradable sirolimus-loaded poly(lactide) nanoparticles as drug delivery system for the prevention of in-stent restenosis in coronary stent application J. Biomater. Appl. 25 2011 851 875
41. D.C. Drummond, C.O. Noble, M.E. Hayes, J.W. Park, and D.B. Kirpotin Pharma-cokinetics and in vivo drug release rates in liposomal nanocarrier development J. Pharm. Sci. 97 2008 4696 4740
42. A. Haeri, S. Sadeghian, S. Rabbani, M.S. Anvari, A. Lavasanifar, M. Amini, and S. Dadashzadeh Sirolimus-loaded stealth colloidal systems attenuate neointimal hyperplasia after balloon injury: a comparison of phospholipid micelles and liposomes Int. J. Pharm. 455 2013 320 330
43. U. Westedt, L. Barbu-Tudoran, A.K. Schaper, M. Kalinowski, H. Alfke, and T. Kissel Effects of different application parameters on penetration characteristics and arterial vessel wall integrity after local nanoparticle delivery using a porous balloon catheter Eur. J. Pharm. Biopharm. 58 2004 161 168 (Pubitemid 38781017)
44. K. Nakano, K. Egashira, S. Masuda, K. Funakoshi, G. Zhao, S. Kimura, T. Matoba, K. Sueishi, Y. Endo, Y. Kawashima, K. Hara, H. Tsujimoto, R. Tominaga, and K. Sunagawa Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology JACC Cardiovasc. Interv. 2 2009 277 283
45. J. Joo, H.Y. Nam, S.H. Nam, I. Baek, and J.-S. Park A novel deposition method of PLGA nanoparticles on coronary stents Bull. Korean Chem. Soc. 30 2009 1085 1087
46. P.A. Lemos, V. Farooq, C.K. Takimura, P.S. Gutierrez, R. Virmani, F. Kolodgie, U. Christians, A. Kharlamov, M. Doshi, P. Sojitra, H.M.M. van Beusekom, and P.W. Serruys Emerging technologies: polymer-free phospholipid encapsulated sirolimus nanocarriers for the controlled release of drug from a stent-plus-balloon or a stand-alone balloon catheter EuroIntervention 9 2013 148 156
47. S. Garg, and P.W. Serruys Coronary stents: looking forward J. Am. Coll. Cardiol. 56 2010 S43 S78
48. A.N. Lukyanov, W.C. Hartner, and V.P. Torchilin Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits J. Control. Release 94 2004 187 193 (Pubitemid 37542388)
49. V. Weissig, K.R. Whiteman, and V.P. Torchilin Accumulation of protein-loaded long-circulating micelles and liposomes in subcutaneous lewis lung carcinomain mice Pharm. Res. 15 1998 1552 1556 (Pubitemid 28465741)
50. X. Li, M. Kong, A. Dong, J. Qian, and D. Jiang Polymer-based delivering of shRNA to rabbit aortic smooth muscle cells suppressed the expression of IGF-1R in vitro and in vivo Acta Biochim. Biophys. Sin. (Shanghai) 46 2014 141 148
51. M.C. Scimia, A.M. Gumpert, and W.J. Koch Cardiovascular gene therapy for myocardial infarction Expert. Opin. Biol. Ther. 14 2013 183 195
52. N. Choe, J.S. Kwon, J.R. Kim, G.H. Eom, Y. Kim, K.I. Nam, Y. Ahn, H.J. Kee, and H. Kook The microRNA miR-132 targets Lrrfip1 to block vascular smooth muscle cell proliferation and neointimal hyperplasia Atherosclerosis 229 2013 348 355
53. L. Indolfi, F. Causa, C. Giovino, F. Ungaro, F. Quaglia, and P.A. Netti Microsphere integrated drug-eluting stents: PLGA microsphere integration in hydrogel coating for local and prolonged delivery of hydrophilic antirestenosis agents J. Biomed. Mater. Res. A 97A 2011 201 211
54. S. Banai, M. Chorny, S.D. Gertz, I. Fishbein, J. Gao, L. Perez, G. Lazarovichi, A. Gazit, A. Levitzki, and G. Golomb Locally delivered nanoencapsulated tyrphostin (AGL-2043) reduces neointima formation in balloon-injured rat carotid and stented porcine coronary arteries Biomaterials 26 2005 451 461 (Pubitemid 38951112)
55. A.J. Carter, J.R. Laird, W.M. Kufs, L. Bailey, T.G. Hoopes, T. Reeves, A. Farb, and R. Virmani Coronary stenting with a novel stainless steel balloon expandable stent: determinants of neointimal formation and changes in arterial geometry after placement in an atherosclerotic model J. Am. Coll. Cardiol. 27 1996 1270 1277 (Pubitemid 26117725)
56. A. Farb, G. Sangiorgi, A.J. Carter, V.M. Walley, W.D. Edwards, R.S. Schwartz, and R. Virmani Pathology of acute and chronic coronary stenting in humans Circulation 99 1996 44 52
57. A. Farb, D.K. Weber, F.D. Kolodgie, A.P. Burke, and R. Virmani Morphological predictors of restenosis after coronary stenting in humans Circulation 105 2002 2974 2980 (Pubitemid 34693829)
58. F. Ribichini, M. Joner, V. Ferrero, A.V. Finn, J. Crimins, G. Nakazawa, E. Acampado, F.D. Kolodgie, C. Vassanelli, and R. Virmani Effects of oral prednisone after stenting in a rabbit model of established atherosclerosis J. Am. Coll. Cardiol. 50 2007 176 185 (Pubitemid 47002181)
59. M. Joner, K. Morimoto, H. Kasukawa, K. Steigerwald, S. Merl, G. Nakazawa, M.C. John, A.V. Finn, E. Acampado, F.D. Kolodgie, H.K. Gold, and R. Virmani Site-specific targeting of nanoparticle prednisolone reduces in-stent restenosis in a rabbit model of established atheroma Arterioscler. Thromb. Vasc. Biol. 28 2008 1960 1966
60. F.D. Kolodgie, M. John, C. Khurana, A. Farb, P. Wilson, E. Acampado, N. Desai, P. Soon-Shiong, and R. Virmani Sustained reduction of in-stent neointimal growth with the use of a novel systemic nanoparticle paclitaxel Circulation 106 2002 1195 1198 (Pubitemid 34988635)
61. W.V. Oeveren Polyethylene and silicon carbide coated steel promote less complement activation and platelet or leukocyte adhesion than medical steel and silicone rubber material Prog. Biomed. Res. 6 2001 195 201
62. H. Hara, M. Nakamura, J.C. Palmaz, and R.S. Schwartz Role of stent design and coatings on restenosis and thrombosis Adv. Drug Deliv. Rev. 58 2006 377 386 (Pubitemid 43816740)
63. F. Variola, J. Brunski, G. Orsini, P. Tambasco de Oliveira, R. Wazen, and A. Nanci Nanoscale surface modifications of medically-relevant metals: state-of-the art and perspectives Nanoscale 3 2011 335 353
64. M.L. Reed, C. Wu, J. Kneller, S. Watkins, D.A. Vorp, A. Nadeem, L.E. Weiss, K. Rebello, M. Mescher, J.C. Smith, W. Rosenblum, and M.D. Feldman Micomechanical devices for intravascular drug delivery J. Pharm. Sci. 87 1998 1387 1394 (Pubitemid 28514146)
65. Y. Wang, W. Zhang, J. Zhang, W. Sun, R. Zhang, and H. Gu Fabrication of a novel polymer-free nanostructured drug-eluting coating for cardiovascular stents ACS Appl. Mater. Interfaces 5 2013 10337 10345
66. J. Daemen, P. Wenaweser, K. Tsuchida, L. Abrecht, S. Vaina, C. Morger, N. Kukreja, P. Juni, R.T. van Domburg, O.M. Hess, E. Boersma, B. Meier, S. Windecker, and P.W. Serruys Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study Lancet 369 2007 667 678 (Pubitemid 46281313)
67. X. Ma, T. Wu, and M.P. Robich Drug eluting stent coatings Interv. Cardiol. 4 2012 73 83
68. B. O'Brien, and W. Carroll The evolution of cardiovascular stent materials and surfaces in response to clinical drivers: a review Acta Biomater. 5 2009 945 958
69. S. Choudhary, M. Berhe, K.M. Haberstroh, and T. Webster Increased endothelial and vascular smooth muscle cell adhesion on nanostructured titanium and CoCrMo Int. J. Nanomedicine 1 2006 41 49
70. E. Fine, L. Zhang, H. Fenniri, and T.J. Webster Enhanced endothelial cell functions on rosette nanotube-coated titanium vascular stents Int. J. Nanomedicine 4 2009 91 97
71. 2 nanotube surfaces Nano Lett. 8 2008 786 793
72. I. Iakovou, T. Schmidt, E. Bonizzoni, L. Ge, G.M. Sangiorgi, G. Stankovic, F. Airoldi, A. Chieffo, M. Montorfano, M. Carlino, I. Michev, N. Corvaja, C. Briguori, U. Gerckens, E. Grube, and A. Colombo Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents J. Am. Med. Assoc. 293 2005 2126 2130 (Pubitemid 40617065)
73. M. Shuchman Trading restenosis for thrombosis? New questions about drug-eluting stents N. Engl. J. Med. 355 2006 1949 1952 (Pubitemid 44708012)
74. G.J. Bakeine, J. Ban, G. Grenci, A. Pozzato, S.D. Zilio, M. Prasciolu, L. Businaro, M. Tormen, and M.E. Ruaro Design, fabrication and evaluation of nanoscale surface topography as a tool in directing differentiation and organisation of embryonic stem-cell-derived neural precursors Microelectron. Eng. 86 2009 1435 1438
75. G.J. Picha Tissue Response to Peritoneal Implants, NASA CR, 159817 1980
76. 2 nanotubes J. Biomed. Mater. Res. A 78 2006 97 103 (Pubitemid 44032531)
77. M.C. Loya, E. Park, L.H. Chen, K.S. Brammer, and S. Jin Radially arrayed nanopillar formation on metallic stent wire surface via radio-frequency plasma Acta Biomater. 6 2010 1671 1677
78. W. Maisel Unanswered questions - drug-eluting stents and the risk of late thrombosis N. Engl. J. Med. 356 2007 981 984 (Pubitemid 46376797)
79. M.C. Loya, K.S. Brammer, C. Choi, L.H. Chen, and S. Jin Plasma-induced nanopillars on bare metallic coronary stent surface for enhanced endothelialization Acta Biomater. 6 2010 4589 4595
80. I. Tsujino, J. Ako, Y. Honda, and P.J. Fitzgerald Drug delivery via nano-, micro and macroporous coronary stent surfaces Expert Opin. Drug Deliv. 4 2007 287 295 (Pubitemid 46767628)
81. E.W. Davie A brief historical review of the waterfall/cascade of blood coagulation J. Biol. Chem. 278 2003 50819 50832 (Pubitemid 38020312)
82. N. Mackman Triggers, targets and treatments for thrombosis Nature 451 2008 914 918 (Pubitemid 351301746)
83. P. Lu, H. Fan, Y. Liu, L. Cao, X. Wu, and X. Xu Controllable biodegradability, drug release behavior and hemocompatibility of PTX-eluting magnesium stents Colloids Surf. B: Biointerfaces 83 2011 23 28
84. V. Karagkiozaki, S. Logothetidis, and G. Giannoglou Advances in stent coating technology via nanotechnology tools and process Eur. J. Nanomedicine 1 2008 24 28
85. V. Karagkiozaki, S. Logothetidis, A. Laskarakis, G. Giannoglou, and S. Lousinian AFM study of the thrombogenicity of carbon-based coatings for cardiovascular applications Mater. Sci. Eng. B 152 2008 16 21
86. V. Karagkiozaki, S. Logothetidis, S. Kassavetis, and S. Lousinian Nanoscale characterization of biological and mechanical profile of carbon stent nanocoatings Eur. J. Nanomedicine 2 2009 14 21
87. V.C. Karagkiozaki, S.D. Logothetidis, S.N. Kassavetis, and G.D. Giannoglou Nanomedicine for the reduction of the thrombogenicity of stent coatings Int. J. Nanomedicine 5 2010 239 248
88. H. Jia, H. Liu, J. Kong, J. Hou, J. Wu, M. Zhang, J. Tian, H. Liu, L. Ma, S. Hu, X. Huang, S. Zhang, S. Zhang, B. Yu, and I.-K. Jang A novel polymer-free paclitaxel-eluting stent with a nanoporous surface for rapid endothelialization and inhibition of intimal hyperplasia: comparison with a polymer-based sirolimus-eluting stent and bare metal stent in a porcine model J. Biomed. Mater. Res. A 98 2011 629 637
89. 2 nanotubes on endothelial function and smooth muscle proliferation Biomaterials 30 2009 1268 1272
90. M. Tanaka, A. Takayama, E. Ito, H. Sunami, S. Yamamoto, and M. Shimomura Effect of pore size of self-organized honeycomb-patterned polymer films on spreading, focal adhesion, proliferation, and function of endothelial cells J. Nanosci. Nanotechnol. 7 2007 763 772
91. J.L. McGrath, E.A. Osborn, Y.S. Tardy Jr., C.F. Dewey, and J.H. Hartwig Regulation of the actin cycle in vivo by actin filament severing Proc. Natl. Acad. Sci. U. S. A. 97 2000 6532 6537 (Pubitemid 30412748)
92. H. Wieneke, O. Dirsch, T. Sawitowski, Y.L. Gu, H. Brauer, U. Dahmen, A. Fischer, S. Wnendt, and R. Erbel Synergistic effects of a novel nanoporous stent coating and tacrolimus on intima proliferation in rabbits Catheter. Cardiovasc. Interv. 60 2003 399 407 (Pubitemid 37356512)
93. 3 surfaces for controlled vascular endothelial and smooth muscle cell adhesion and proliferation Mater. Sci. Eng. C 32 2012 1017 1024
94. Ang1 + Vegf nanoparticles Biomaterials 33 2012 7655 7664
95. F. Nazneen, M. Schmidt, E. McLoughlin, N. Petkov, G. Herzog, D.W. Arrigan, and P. Galvin Impact of surface nano-textured stainless steel prepared by focused ion beam on endothelial cell growth J. Nanosci. Nanotechnol. 13 2013 5283 5290
96. F. Nazneen, G. Herzog, D.W. Arrigan, N. Caplice, P. Benvenuto, P. Galvin, and M. Thompson Surface chemical and physical modification in stent technology for the treatment of coronary artery disease J. Biomed. Mater. Res. B Appl. Biomater. 100 2012 1989 2014
97. J. Lu, C. Yao, L. Yang, and T.J. Webster Decreased platelet adhesion and enhanced endothelial cell functions on nano and submicron-rough titanium stents Tissue Eng. A 18 2012 1389 1398
98. T. Muramatsu, Y. Onuma, Y.-J. Zhang, C.V. Bourantas, A. Kharlamov, R. Diletti, V. Farooq, B.D. Gogas, S. Garg, H.M. Garcia-Garcia, Y. Ozaki, and P.W. Serruys Progress in treatment by percutaneous coronary intervention: the stent of the future Rev. Esp. Cardiol. 66 2013 483 496
99. A.J. Halliday, S.E. Moulton, G.G. Wallace, and M.J. Cook Novel methods of antiepileptic drug delivery-polymer-based implants Adv. Drug Deliv. Rev. 64 2012 953 964
100. J.B. Wolinsky, Y.L. Colson, and M.W. Grinstaff Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers J. Control. Release 159 2012 14 26
101. D.Y. Lewitus, K.L. Smith, W. Shain, D. Bolikal, and J. Kohn The fate of ultrafast degrading polymeric implants in the brain Biomaterials 32 2011 5543 5550
102. S.H. Ranganath, and C.H. Wang Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma Biomaterials 29 2008 2996 3003
103. P.P. Wang, J. Frazier, and H. Brem Local drug delivery to the brain Adv. Drug Deliv. Rev. 54 2002 987 1013
104. J. Xie, and C.H. Wang Electrospun micro- and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro Pharm. Res. 23 2006 1817 1826 (Pubitemid 44200545)
105. S.H. Ranganath, Y. Fu, D.Y. Arifin, I. Kee, L. Zheng, H.S. Lee, P.K. Chow, and C.H. Wang The use of submicron/nanoscale PLGA implants to deliver paclitaxel with enhanced pharmacokinetics and therapeutic efficacy in intracranial glioblastoma in mice Biomaterials 31 2010 5199 5207
106. W. Vogelhuber, T. Spruss, G. Bernhardt, A. Buschauer, and A. Göpferich Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts Int. J. Pharm. 238 2002 111 121 (Pubitemid 34457880)
107. P. Kumar Naraharisetti, B. Yung Sheng Ong, J. Wei Xie, T. Kam Yiu Lee, C.H. Wang, and N.V. Sahinidis In vivo performance of implantable biodegradable preparations delivering paclitaxel and etanidazole for the treatment of glioma Biomaterials 28 2007 886 894 (Pubitemid 44667027)
108. C. Buonerba, G. Di Lorenzo, A. Marinelli, P. Federico, G. Palmieri, M. Imbimbo, P. Conti, G. Peluso, S. De Placido, and J.H. Sampson A comprehensive outlook on intracerebral therapy of malignant gliomas Crit. Rev. Oncol. Hematol. 80 2011 54 68
109. P. Menei, L. Capelle, J. Guyotat, S. Fuentes, R. Assaker, B. Bataille, P. François, D. Dorwling-Carter, P. Paquis, L. Bauchet, F. Parker, J. Sabatier, N. Faisant, and J.P. Benoit Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of malignant glioma: a randomized phase II trial Neurosurgery 56 2005 242 248
110. V.G. Roullin, J.R. Deverre, L. Lemaire, F. Hindré, M.C. Venier-Julienne, R. Vienet, and J.P. Benoit Anti-cancer drug diffusion within rat brain tissue: an experimental study using [3H]-(6)-5-fluorouracil-loaded PLGA microspheres Eur. J. Pharm. Biopharm. 53 2002 293 299 (Pubitemid 34303292)
111. N. Qi, X. Tang, X. Lin, P. Gu, C. Cai, H. Xu, H. He, and Y. Zhang Sterilization stability of vesicular phospholipid gels loaded with cytarabine for brain implant Int. J. Pharm. 427 2012 234 241
112. A.J. Halliday, T.E. Campbell, T.S. Nelson, K.J. McLean, G.G. Wallace, and M.J. Cook Levetiracetam-loaded biodegradable polymer implants in the tetanus toxin model of temporal lobe epilepsy in rats J. Clin. Neurosci. 20 2013 148 152
113. J.E. Moran, S.M. Bowyer, A. Manoharan, K.M. Mason, N. Tepley, B.J. Smith, G.L. Barkley, D. Greene, and M. Morrell MEG coherence imaging compared to electrocortical recordings from NeuroPace implants to determine the location of ictal onset in epilepsy patients Int. Congr. Ser. 1300 2007 673 676
114. A. Wilz, E.M. Pritchard, T. Li, J.Q. Lan, D.L. Kaplan, and D. Boison Silk polymer-based adenosine release: therapeutic potential for epilepsy Biomaterials 29 2003 3609 3616
115. S. Pillay, V. Pillay, Y.E. Choonara, D. Naidoo, R.A. Khan, L.C. du Toit, V.M. Ndesendo, G. Modi, M.P. Danckwerts, and S.E. Iyuke Design, biometric simulation and optimization of a nano-enabled scaffold device for enhanced delivery of dopamine to the brain Int. J. Pharm. 382 2009 277 290
116. A. Morizane, D. Doi, T. Kikuchi, K. Okita, A. Hotta, T. Kawasaki, T. Hayashi, H. Onoe, T. Shiina, S. Yamanaka, and J. Takahashi Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a nonhuman primate Stem Cell Rep. 1 2013 283 292
117. P. Bergonzoa, A. Bongrain, E. Scorsone, A. Bendali, L. Rousseau, G. Lissorgues, P. Mailley, Y. Li, T. Kauffmann, F. Goy, B. Yvert, J.A. Sahel, and S. Picaud 3D shaped mechanically flexible diamond microelectrode arrays for eye implant applications: the MEDINAS project IRBM 32 2011 91 94
118. 3-Parylene C bilayer coating for neural interfaces using accelerated age testing and electrochemical characterization Acta Biomater. 10 2014 960 967
119. A. Fraczek-Szczypta Carbon nanomaterials for nerve tissue stimulation and regeneration Mater. Sci. Eng. C Mater. Biol. Appl. 1 2014 35 49
120. V. Lovat, D. Pantarotto, L. Lagostena, B. Cacciari, M. Grandolfo, M. Righi, G. Spalluto, M. Prato, and L. Ballerini Carbon nanotube substrates boost neuronal electrical signaling Nano Lett. 5 2005 1107 1110 (Pubitemid 40925424)
121. T.C. Pappas, W.M.S. Wickramanyake, E. Jan, M. Motamedi, M. Brodwick, and N.A. Kotov Nanoscale engineering of a cellular interface with semiconductor nanoparticle films for photoelectric stimulation of neurons Nano Lett. 7 2007 513 519 (Pubitemid 46383624)
122. E. Gultepe, D. Nagesha, S. Sridhar, and M. Amiji Nanoporous inorganic membranes or coatings for sustained drug delivery in implantable devices Adv. Drug Deliv. Rev. 62 2010 305 315
123. S. Mátéfi-Tempfli, and M. Mátéfi-Tempfli Vertically aligned nanowires on flexible silicone using a supported alumina template prepared by pulsed anodization Adv. Mater. 21 2009 4005 4010
124. F. Johansson, L. Wallman, N. Danielsen, J. Schouenborg, and M. Kanje Porous silicon as a potential electrode material in a nerve repair setting: tissue reactions Acta Biomater. 5 2009 2230 2237
125. K.A. Moxon, N.M. Kalkhoran, M. Markert, M.A. Sambito, J.L. McKenzie, and J.T. Webster Nanostructured surface modification of ceramic-based microelectrodes to enhance biocompatibility for a direct brain-machine interface Biomed. Eng. 51 2004 881 889 (Pubitemid 38661438)
126. S. Tao, M.T. Wei, and P. Woo-Tae Drug release from porous silicon for stable neural interface Appl. Surf. Sci. 2013 10.1016/j.apsusc.2013.12.060
127. G. Cellot, E. Cilia, S. Cipollone, V. Rancic, A. Sucapane, S. Giordani, L. Gambazzi, H. Markram, M. Grandolfo, D. Scaini, F. Gelain, L. Casalis, M. Prato, M. Giugliano, and L. Ballerini Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts Nat. Nanotechnol. 4 2009 126 133
128. G. Cellot, F.M. Toma, Z.K. Varley, J. Laishram, A. Villari, M. Quintana, S. Cipollone, M. Prato, and L. Ballerini Carbon nanotube scaffolds tune synaptic strength in cultured neural circuits: novel frontiers J. Neurosci. 31 2011 12945 12953
129. A. Fabbro, M. Prato, and L. Ballerini Carbon nanotubes in neuroregeneration and repair Adv. Drug Deliv. Rev. 65 2013 2034 2044
130. S. Frank, P. Poncharal, Z.L. Wang, and W.A. de Heer Carbon nanotube quantum resistors Science 280 1998 1744 1746 (Pubitemid 28283496)
131. R.J. Andrews Neuroprotection at the nanolevel - part I: introduction to nanoneurosurgery Ann. N. Y. Acad. Sci. 1122 2007 169 184 (Pubitemid 350249547)
132. R.J. Andrews Neuroprotection at the nanolevel - part II: nanodevices for neuromodulation - deep brain stimulation and spinal cord injury Ann. N. Y. Acad. Sci. 1122 2007 185 196 (Pubitemid 350249548)
133. M.L. Heien, M.A. Johnson, and R.M. Wightman Resolving neurotransmitters detected by fast-scan cyclic voltammetry Anal. Chem. 76 2004 5697 5704 (Pubitemid 39313316)
134. T.I. Chao, S. Xiang, J.F. Lipstate, C. Wang, and J. Lu Poly(methacrylic acid)-grafted carbon nanotube scaffolds enhance differentiation of hESCs into neuronal cells Adv. Mater. 22 2010 3542 3547
135. C.S. Chen, S. Soni, C. Le, M. Biasca, E. Farr, E.Y. Chen, and W.C. Chin Human stemcell neuronal differentiation on silkcarbon nanotube composite Nanoscale Res. Lett. 7 2012 126 132
136. G.Z. Jin, M. Kim, U.S. Shin, and H.W. Kim Neurite outgrowth of dorsal root ganglia neurons is enhanced on aligned nanofibrous biopolymer scaffold with carbon nanotube coating Neurosci. Lett. 501 2011 10 14
137. E.W. Keefer, B.R. Botterman, M.I. Romero, A.F. Rossi, and G.W. Gross Carbon nanotube coating improves neuronal recordings Nat. Nanotechnol. 3 2008 434 439 (Pubitemid 351948248)
138. K. Wang, H.A. Fishman, H.J. Dai, and J.S. Harris Neural stimulation with a carbon nanotube microelectrode array Nano Lett. 6 2006 2006 2043 2048 (Pubitemid 44555252)
139. H. Zhou, X. Cheng, L. Rao, T. Li, and Y.Y. Duan Poly(3,4 ethylenedioxythiophene)/multiwall carbon nanotube composite coatings for improving the stability of microelectrodes in neural prostheses applications Acta Biomater. 9 2013 6439 6449
140. M.H. Bolin, K. Svennersten, X. Wang, I.S. Chronakis, A. Richter-Dahlfors, E.W.H. Jager, and M. Berggren Nano-fiber scaffold electrodes based on PEDOT for cell stimulation Sensors Actuators B Chem. 142 2009 451 456
141. H.C. Tian, J.Q. Liu, D.X. Wei, X.Y. Kang, C. Zhang, J.C. Du, B. Yang, X. Chen, H.Y. Zhu, Y.N. Nuli, and C.S. Yang Graphene oxide doped conducting polymer nanocomposite film for electrode-tissue interface Biomaterials 35 2014 2120 2129
142. H. Hu, Y. Ni, V. Montana, R.C. Haddon, and V. Parpura Chemically functionalized carbon nanotubes as substrates for neuronal growth Nano Lett. 4 2004 507 511 (Pubitemid 38402642)
143. M.P. Mattson, R.C. Haddon, and A.M. Rao Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth J. Mol. Neurosci. 14 2000 175 182 (Pubitemid 30660807)
144. K. Matsumoto, C. Sato, Y. Naka, A. Kitazawa, R.L. Whitby, and N. Shimizu Neurite outgrowths of neurons with neurotrophin-coated carbon nanotubes J. Biosci. Bioeng. 103 2007 216 220 (Pubitemid 46552271)
145. F. Tan, P. Walshe, L. Viani, and M. Al-Rubeai Surface biotechnology for refining cochlear implants Trends Biotechnol. 31 2013 678 687
146. K. Kang, I.S. Choi, and Y. Nam A biofunctionalization scheme for neural interfaces using polydopamine polymer Biomaterials 32 2011 6374 6380
147. S. Roy, A.H. Johnston, T.A. Newman, R. Glueckert, J. Dudas, M. Bitsche, E. Corbacella, G. Rieger, A. Martini, and A. Schrott-Fischer Cell-specific targeting in the mouse inner ear using nanoparticles conjugated with a neurotrophin-derived peptide ligand: potential tool for drug delivery Int. J. Pharm. 390 2010 214 224
148. E. Margalit, M. Maia, J.D. Weiland, R.J. Greenberg, G.Y. Fujii, G. Torres, D.V. Piyathaisere, T.M. O'Hearn, W. Liu, G. Lazzi, G. Dagnelie, D.A. Scribner, E. de Juan Jr., and M.S. Humayun Retinal prosthesis for the blind Surv. Ophthalmol. 47 2002 335 356 (Pubitemid 34879925)
149. www.neurons-on-diamond.org (as accessed on 15th February 2014)
150. A.E. Hadjinicolaou, R.T. Leung, D.J. Garrett, K. Ganesan, K. Fox, D.A. Nayagam, M.N. Shivdasani, H. Meffin, M.R. Ibbotson, S. Prawer, and B.J. O'Brien Electrical stimulation of retinal ganglion cells with diamond and the development of an all diamond retinal prosthesis Biomaterials 33 2012 5812 5820
151. W.T. Bourque, M. Gross, and B.K. Hall A reproducible method for producing and quantifying the stages of fracture repair Lab. Anim. Sci. 42 1992 369 374
152. G. Cox, T.A. Einhorn, C. Tzioupis, and P.V. Giannoudis Bone-turnover markers in fracture healing J. Bone Joint Surg. (Br.) 92 2010 329 334
153. J.E. Schroeder, and R. Mosheiff Tissue engineering approaches for bone repair: concepts and evidence Injury 42 2011 609 613
154. T. Einhorn Mechanisms of fracture healing Hosp. Pract. (Off. Ed.) 26 1991 41 45
155. T.A. Einhorn The cell and molecular biology of fracture healing Clin. Orthop. Relat. Res. 355 1998 S7 S27
156. Y. Liu, J. Lim, and S.-H. Teoh Review: development of clinically relevant scaffolds for vascularised bone tissue engineering Biotechnol. Adv. 31 2013 688 705
157. D. Kaigler, Z. Wang, K. Horger, D.J. Mooney, and P.H. Krebsbach VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects J. Bone Miner. Res. 21 2006 735 744
158. S. Weiss, G. Zimmermann, T. Pufe, D. Varoga, and P. Henle The systemic angiogenic response during bone healing Arch. Orthop. Trauma Surg. 129 2009 989 997
159. P.C. Bessa, M. Casal, and R.L. Reis Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts) J. Tissue Eng. Regen. Med. 2 2008 1 13
160. P.C. Bessa, M. Casal, and R.L. Reis Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery) J. Tissue Eng. Regen. Med. 2 2008 81 96
161. J.A. Planell, S.M. Best, D. Lacroix, and A. Merolli Bone Repair Biomaterials 2009 Woodhead Publishing Limited, CRC Press LLC. Cambridge, UK
162. S.H. Teoh Engineering Materials for Biomedical Applications 2004 Mainland Press Singapore
163. J.C. Frician, S. Schlaubitz, C. Le Visage, I. Arnault, S.M. Derkaoui, R. Siadous, S. Catros, C. Lalande, R. Bareille, M. Renard, T. Fabre, S. Cornet, M. Durand, A. Leonard, N. Sahraoui, D. Letourneur, and J. Amedee A nano-hydroxyapatite-pullulan/dextran polysaccharide composite macroporous material for bone tissue engineering Biomaterials 34 2013 2947 2959
164. A. Tripathi, S. Saravanan, S. Pattnaik, A. Moorthi, N.C. Patridge, and A.N. Selvamurugan Bio composite scaffolds containing chitosan/nano- hydroxyapatite/nano-copper-zinc for bone tissue engineering Int. J. Biol. Macromol. 50 2012 294 299
165. J.A. Sowjanya, J. Singh, T. Mohita, S. Sarvanan, A. Moorthi, N. Srinivasan, and N. Selvamurugan Biocomposite scaffolds containing chitosan/alginate/nano-silica for bone tissue engineering Colloids Surf. B: Biointerfaces 109 2013 294 300
166. 2 nanotubes for bone regeneration Trends Biotechnol. 30 2012 315 322
167. G.A. Abrams, S.L. Goodman, P.F. Nealey, M. Franco, and C.J. Murphy Nanoscale topography of the basement membrane underlying the corneal epithelium of the rhesus macaque Cell Tissue Res. 299 2000 39 46 (Pubitemid 30028721)
168. P.D. Benya, and J.D. Shaffer Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels Cell 30 1982 215 224 (Pubitemid 13237099)
169. H. Yuan, K. Kurashina, J.D. de Bruijn, Y. Li, K. de Groot, and X. Zhang A preliminary study on osteoinduction of two kinds of calcium phosphate ceramics Biomaterials 20 1999 1799 1806 (Pubitemid 29421729)
170. P.X. Ma, and R. Zhang Synthetic nano-scale fibrous extracellular matrix J. Biomed. Mater. Res. 46 1999 60 72 (Pubitemid 29233181)
171. R.M. Kuntz, and W.M. Saltzman Neutrophil motility in extracellular matrix gels: mesh size and adhesion affect speed of migration Biophys. J. 72 1997 1472 1480 (Pubitemid 27113669)
172. L.A. Smith, X. Liu, J. Hu, and P.X. Ma The enhancement of human embryonic stem cell osteogenic differentiation with nano-fibrous scaffolding Biomaterials 31 2010 5526 5535
173. H. Sun, K. Feng, J. Hu, S. Soker, A. Atala, and P.X. Ma Osteogenic differentiation of human amniotic fluid-derived stem cells induced by bone morphogenetic protein-7 and enhanced by nanofibrous scaffolds Biomaterials 31 2010 1133 1139
174. K.M. Woo, J.H. Jun, V.J. Chen, J. Seo, J.H. Baek, H.M. Ryoo, G.S. Kim, M.J. Somerman, and P.X. Ma Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization Biomaterials 28 2007 335 343 (Pubitemid 44537377)
175. K.C. Popat, L. Leoni, C.A. Grimes, and T.A. Desai Influence of engineered titania nanotubular surfaces on bone cells Biomaterials 28 2007 3188 3197 (Pubitemid 46654214)
176. E.E.L. Swan, K.C. Popat, C.A. Grimes, and T.A. Desai Fabrication and evaluation of nanoporous alumina membranes for osteoblast culture J. Biomed. Mater. Res. A 72 2005 288 295 (Pubitemid 40270999)
177. L. Zhao, L. Liu, Z. Wu, Y. Zhang, and P.K. Chu Effects of micropitted/nanotubular titania topographies on bone mesenchymal stem cell osteogenic differentiation Biomaterials 33 2012 2629 2641
178. B.D. Boyan, T.W. Hummert, D.D. Dean, and Z. Schwartz Role of material surfaces in regulating bone and cartilage cell response Biomaterials 17 1996 137 146 (Pubitemid 26031369)
179. Z. Schwartz, C.H. Lohmann, J. Oefinger, L.F. Bonewald, D.D. Dean, and B.D. Boyan Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage Adv. Dent. Res. 13 1999 38 48
180. D. Khang, J. Choi, Y.-M. Im, Y.-J. Kim, J.-H. Jang, S.S. Kang, T.-H. Nam, J. Song, and J.-W. Park Role of subnano-, nano- and submicron-surface features on osteoblast differentiation of bone marrow mesenchymal stem cells Biomaterials 33 2012 5997 6007
181. M. Rai, A. Yadav, and A. Gade Silver nanoparticles as a new generation of antimicrobials Biotechnol. Adv. 27 2009 76 83
182. H.H. Lara, E.N. Garza-Trevino, L. Ixtepan-Turrent, and D.K. Singh Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds J. Nanobiotechnology 9 2011 30 37
183. H. Liu, and T.J. Webster Nanomedicine for implants: a review of studies and necessary experimental tools Biomaterials 28 2006 354 369
184. H. Liu, and T.J. Webster Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopaedic applications Int. J. Nanomedicine 5 2010 299 313
185. T. Kohgo, Y. Yamada, K. Ito, A. Yajima, R. Yoshimi, K. Okabe, S. Baba, and M. Ueda Bone regeneration with self-assembling peptide nanofiber scaffolds in tissue engineering for osseointegration of dental implants Int. J. Periodontics Restorative Dent. 2011 e9 e16
186. T.D. Sargeant, M.O. Guler, S.M. Oppenheimer, A. Mata, R.L. Satcher, D.C. Dunand, and S.I. Stupp Hybrid bone implants: self-assembly of peptide amphiphile nanofibers within porous titanium Biomaterials 29 2008 161 171 (Pubitemid 350016293)
187. X. Deng, F. Wang, and Z. Chen A novel electrochemical sensor based on nano-structured film electrode for monitoring nitric oxide in living tissues Talanta 82 2010 1218 1224
188. B.J. Nelson, L. Dong, and F. Arai Micro/nanorobots Springer Handbook of Robotics 2008 411 450
189. S. Kim, F. Qiu, S. Kim, A. Ghanbari, C. Moon, L. Zhang, B.J. Nelson, and H. Choi Fabrication and characterization of magnetic microrobots for three-dimensional cell culture and targeted transportation Adv. Mater. 25 2013 5863 5868
190. B.J. Nelson, I.K. Kaliakatsos, and J.J. Abbott Microrobots for minimally invasive medicine Annu. Rev. Biomed. Eng. 12 2010 55 85
191. L. Zhang, J.J. Abbott, L. Dong, B.E. Kratochvil, D. Bell, and B.J. Nelson Artificial bacterial flagella: fabrication and magnetic control Appl. Phys. Lett. 94 2009 064107
192. B.J. Lambert, T.A. Mendelson, and M.D. Craven Radiation and ethylene oxide terminal sterilization experiences with drug eluting stent products AAPS PharmSciTech 12 2011 1116 1126
193. W.S. Pietrzak Effects of ethylene oxide sterilization on 82: 18 PLLA/PGA copolymer craniofacial fixation plates J. Craniofac. Surg. 21 2010 177 181
194. S. Hofmann, K.S. Stok, T. Kohler, A.J. Meinel, and R. Müller Effect of sterilization on structural and material properties of 3-D silk fibroin scaffolds Acta Biomater. 10 2014 308 317
195. A. Godara, D. Raab, and S. Green The influence of sterilization processes on the micromechanical properties of carbon fiber-reinforced PEEK composites for bone implant applications Acta Biomater. 3 2007 209 220 (Pubitemid 46223903)
196. L. Zhao, S. Mei, W. Wang, P.K. Chu, Z. Wu, and Y. Zhang The role of sterilization in the cytocompatibility of titania nanotubes Biomaterials 31 2010 2055 2063
197. V.E. Kagan, H. Bayir, and A.A. Shvedova Nanomedicine and nanotoxicology: two sides of the same coin Nanomedicine 1 2005 313 316 (Pubitemid 43963640)
198. P. Wick, P. Manser, L.K. Limbach, U. Dettlaff-Weglikowska, F. Krumeich, S. Roth, W.J. Stark, and A. Bruinink The degree and kind of agglomeration affect carbon nanotube cytotoxicity Toxicol. Lett. 168 2007 121 131 (Pubitemid 46054362)
199. T. Coccini, E. Roda, D.A. Sarigiannis, P. Mustarelli, E. Quartarone, A. Profumo, and L. Manzo Effects of water-soluble functionalized multi-walled carbon nanotubes examined by different cytotoxicity methods in human astrocyte D384 and lung A549 cells Toxicology 269 2010 41 53
200. Y. Sato, A. Yokoyama, K. Shibata, Y. Akimoto, S. Ogino, Y. Nodasaka, T. Kohgo, K. Tamura, T. Akasaka, M. Uo, K. Motomiya, B. Jeyadevan, M. Ishiguro, R. Hatakeyama, F. Watari, and K. Tohji Influence of length on cytotoxicity of multiwalled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo Mol. BioSyst. 1 2005 176 182 (Pubitemid 43362245)
201. K.L. Aillon, Y. Xie, N. El-Gendy, C.J. Berkland, and M.L. Forrest Effects of nanomaterial physicochemical properties on in vivo toxicity Adv. Drug Deliv. Rev. 61 2009 457 466
202. L. Belyanskaya, S. Weigel, C. Hirsch, U. Tobler, H.F. Krug, and P. Wick Effects of carbon nanotubes on primary neurons and glial cells Neurotoxicology 30 2009 702 711
203. Z. Liu, S. Tabakman, K. Welsher, and H. Dai Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery Nano Res. 2 2009 85 120
204. D. Wu, E.S. Pak, C.J. Wingard, and A.K. Murashov Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice Neurosci. Lett. 507 2012 72 77
205. B. Sha, W. Gao, S. Wang, W. Li, X. Liang, F. Xu, and T.J. Lu Nano-titanium dioxide induced cardiac injury in rat under oxidative stress Food Chem. Toxicol. 58 2013 280 288
206. www.cardiovasculardevices.medicaldevices-business-review.com (as accessed on 26th May 2014)
207. P.P. Desai, A.A. Date, and V.B. Patravale Overcoming poor oral bioavailability using nanoparticle formulations - opportunities and limitations Drug Discov. Today Technol. 9 2012 e87 e95
208. www.envisionscientific.com (as accessed on 15th February 2014)
209. www.en.lepumedical.com (as accessed on 15th February 2014)
210. www.mivtindia.com (as accessed on 15th February 2014)
211. www.biosensors.com/intl (as accessed on 15th February 2014)
212. www.translumina.de (as accessed on 15th February 2014)
213. www.gliadel.com (as accessed on 15th February 2014)
214. www.cyberkinetics.com (as accessed on 15th February 2014)
215. www.2-sight.eu/en/patients-families-en (as accessed on 15th February 2014)
216. www.nano-retina.com/ (as accessed on 15th February 2014)
217. www.biomet3i.com (as accessed on 15th February 2014)
218. www.biomet.com.tr/tr-medical/extremities/Comprehensive-Nano (as accessed on 15th February 2014)
219. D.H. Kim, J.A. Wiler, D.J. Anderson, D.R. Kipke, and D.C. Martin Conducting polymers on hydrogel-coated neural electrode provide sensitive neural recordings in auditory cortex Acta Biomater. 6 2010 57 62
220. X. Liu, Z. Yue, M.J. Higgins, and G.G. Wallace Conducting polymers with immobilised fibrillar collagen for enhanced neural interfacing Biomaterials 32 2011 7309 7317