The use of submicron/nanoscale PLGA implants to deliver paclitaxel with enhanced pharmacokinetics and therapeutic efficacy in intracranial glioblastoma in mice

Biomaterials

Volumn 31, Issue 19, 2010, Pages 5199-5207

  Ranganath, Sudhir H ^a   Fu, Yilong ^a   Arifin, Davis Y ^a   Kee, Irene ^b   Zheng, Lin ^b   Lee, How Sung ^a   Chow, Pierce K H ^c,d   Wang, Chi Hwa ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d DIVISION OF MEDICAL ONCOLOGY   (Singapore)

Author keywords

Chemotherapy; Glioblastoma; Paclitaxel; Polymers; Submicron nanoscale

Indexed keywords

BALB/C MICE; BIODISTRIBUTIONS; BIOLUMINESCENCE IMAGING; GLIOBLASTOMAS; INTRATUMORAL INJECTION; MORPHOLOGY AND SIZE; MOUSE BRAIN; NUDE MICE; PACLITAXEL; PLACEBO CONTROL; PLGA MICROSPHERES; POLY-LACTIDE-CO-GLYCOLIDE; POST-IMPLANTATION; SUBMICRON; THERAPEUTIC EFFICACY; TREATMENT RESPONSE; TUMOR INHIBITION; TUMOR PROLIFERATION;

ANIMALS; CHEMOTHERAPY; ENZYME INHIBITION; PHARMACOKINETICS; POLYMERS; TUMORS;

HYDROGELS;

KI 67 ANTIGEN; PACLITAXEL; PLACEBO; POLYGLACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CANCER INHIBITION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; GLIOBLASTOMA; MALE; MOUSE; NANOPHARMACEUTICS; NONHUMAN; PRIORITY JOURNAL; TUMOR NECROSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CELL LINE, TUMOR; DRUG IMPLANTS; GLIOBLASTOMA; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED BALB C; NANOSTRUCTURES; PACLITAXEL; TREATMENT OUTCOME;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 77952291471     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.03.002     Document Type: Article

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