Sirolimus-loaded stealth colloidal systems attenuate neointimal hyperplasia after balloon injury: A comparison of phospholipid micelles and liposomes

International Journal of Pharmaceutics

Volumn 455, Issue 1-2, 2013, Pages 320-330

  Haeri, Azadeh ^a   Sadeghian, Saeed ^b   Rabbani, Shahram ^b   Anvari, Maryam Sotoudeh ^b   Lavasanifar, Afsaneh ^c   Amini, Mohsen ^d   Dadashzadeh, Simin ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF ALBERTA   (Canada)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

DSPE PEG micelles; Local delivery; PEGylated liposomes; Restenosis; Sirolimus

Indexed keywords

LIPOSOME; MACROGOL; NANOCARRIER; PHOSPHATIDYLETHANOLAMINE; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; IN-STENT RESTENOSIS; INFRARED SPECTROSCOPY; INTERMETHOD COMPARISON; LIPID COMPOSITION; LIPOSOMAL DELIVERY; MALE; MICELLE; MORPHOLOGY; NEOINTIMA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SOLUBILIZATION; SURFACE CHARGE; ZETA POTENTIAL;

CHOL; CHOLESTEROL; DES; DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-[METHOXY(POLYETHYLENE GLYCOL)-2000]; DISTEAROYL-SN-GLYCEROPHOSPHOGLYCEROL; DRUG-ELUTING STENT; DSPE-PEG; DSPE-PEG MICELLES; DSPG; EE; EEL; EGG PHOSPHATIDYLCHOLINE; EL; EMPTY LIPOSOME; ENTRAPMENT EFFICIENCY; EPC; EXTERNAL ELASTIC LAMINA; FOURIER TRANSFORM INFRARED; FTIR; IEL; IHC; IMMUNOHISTOCHEMISTRY; INTERNAL ELASTIC LAMINA; LOCAL DELIVERY; NMR; NUCLEAR MAGNETIC RESONANCE; PEGYLATED LIPOSOMES; RBC; RED BLOOD CELLS; RESTENOSIS; SERUM GLUTAMIC OXALOACETIC TRANSAMINASE; SERUM GLUTAMIC PYRUVIC TRANSAMINASE; SGOT; SGPT; SIR; SIROLIMUS; SMA; SMOOTH MUSCLE ACTIN; TEM; TRANSMISSION ELECTRON MICROSCOPY; WBC; WHITE BLOOD CELL;

ANGIOPLASTY, BALLOON, CORONARY; ANIMALS; CAROTID ARTERY INJURIES; HYPERPLASIA; LIPIDS; LIPOSOMES; MALE; MICELLES; NEOINTIMA; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SIROLIMUS;

EID: 84884151277     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.07.003     Document Type: Article

References (47)

1. Acharya, G., Park, K., 2006. Mechanisms of controlled drug release from drug-eluting stents. Adv. Drug Deliv. Rev. 58, 387-401. (Pubitemid 43816741)
2. Azarbal, B., Currier, J.W., 2006. Allergic reactions after the implantation of drugeluting stents: is it the pill or the polymer? J. Am. Coll. Cardiol. 47, 182-183. (Pubitemid 43005184)
3. Banai, S., Chorny, M., Gertz, S.D., Fishbein, I., Gao, J., Perez, L., Lazarovichi, G., Gazit, A., Levitzki, A., Golomb, G., 2005. Locally delivered nanoencapsulated tyrphostin (AGL-2043) reduces neointima formation in balloon-injured rat carotid and stented porcine coronary arteries. Biomaterials 26, 451-461. (Pubitemid 38951112)
4. Burt, H.M., Hunter, W.L., 2006. Drug-eluting stents: an innovative multidisciplinary drug delivery platform. Adv. Drug Deliv. Rev. 58, 345-346. (Pubitemid 43816736)
5. Chandran, T., Katragadda, U., Teng, Q., Tan, C., 2010. Design and evaluation of micellar nanocarriers for 17-allyamino-17-demethoxygeldanamycin (17-AAG). Int. J. Pharm. 392, 170-177.
6. Cyrus, T., Zhang, H., Allen, J.S., Williams, T.A., Hu, G., Caruthers, S.D., Wickline, S.A., Lanza, G.M., 2008. Intramural delivery of rapamycin with alphavbeta3-targeted paramagnetic nanoparticles inhibits stenosis after balloon injury. Arterioscler. Thromb. Vasc. Biol. 28, 820-826. (Pubitemid 351544094)
7. Dabholkar, R.D., Sawant, R.M., Mongayt, D.A., Devarajan, P.V., Torchilin, V.P., 2006. Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)- based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux. Int. J. Pharm. 315, 148-157. (Pubitemid 43674120)
8. Drummond, D.C., Noble, C.O., Hayes, M.E., Park, J.W., Kirpotin, D.B., 2008. Pharmacokinetics and in vivo drug release rates in liposomal nanocarrier development. J. Pharm. Sci. 97, 4696-4740.
9. Finn, A.V., Kolodgie, F.D., Harnek, J., Guerrero, L.J., Acampado, E., Tefera, K., Skorija, K., Weber, D.K., Gold, H.K., Virmani, R., 2005. Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimusor paclitaxel-eluting stents. Circulation 112, 270-278. (Pubitemid 40982311)
10. Genereux, P., Mehran, R., 2009. Are drug-eluting stents safe in the long term? Can. Med. Assoc. J. 180, 154-155.
11. Gerdes, J., 1990. Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies. Semin. Cancer Biol. 1, 199-206.
12. Gradus-Pizlo, I., Wilensky, R.L., March, K.L., Fineberg, N., Michaels, M., Sandusky, G.E., Hathaway, D.R., 1995. Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: effects on restenosis and implications for catheter-based drug delivery. J. Am. Coll. Cardiol. 26, 1549-1557.
13. Haeri, A., Sadeghian, S., Rabbani, S., Anvari, M.S., Boroumand, M.A., Dadashzadeh, S., 2011. Use of remote film loading methodology to entrap sirolimus into liposomes: preparation, characterization and in vivo efficacy for treatment of restenosis. Int. J. Pharm. 414, 16-27.
14. Hunter, W.L., 2006. Drug-eluting stents: beyond the hyperbole. Adv. Drug Deliv. Rev. 58, 347-349. (Pubitemid 43816737)
15. Katragadda, U., Teng, Q., Rayaprolu, B.M., Chandran, T., Tan, C., 2011. Multidrug delivery to tumor cells via micellar nanocarriers. Int. J. Pharm. 419, 281-286.
16. Kedar, U., Phutane, P., Shidhaye, S., Kadam, V., 2010. Advances in polymeric micelles for drug delivery and tumor targeting. Nanomedicine 6, 714-729.
17. Lee, Y.S., 2008. Self-Assembly and Nanotechnology: A Force Balance Approach. John Wiley & Sons Inc., Hoboken.
18. Lukyanov, A.N., Gao, Z., Mazzola, L., Torchilin, V.P., 2002. Polyethylene glycoldiacyllipid micelles demonstrate increased acculumation in subcutaneous tumors in mice. Pharm. Res. 19, 1424-1429. (Pubitemid 35266545)
19. Lukyanov, A.N., Hartner, W.C., Torchilin, V.P., 2004. Increased accumulation of PEGPE micelles in the area of experimental myocardial infarction in rabbits. J. Control. Release 94, 187-193. (Pubitemid 37542388)
20. Luscher, T.F., Steffel, J., Eberli, F.R., Joner, M., Nakazawa, G., Tanner, F.C., Virmani, R., 2007. Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation 115, 1051-1058. (Pubitemid 46328299)
21. Mahalati, K., Kahan, B.D., 2001. Clinical pharmacokinetics of sirolimus. Clin. Pharmacokinet. 40, 573-585. (Pubitemid 32758580)
22. McFadden, E.P., Stabile, E., Regar, E., Cheneau, E., Ong, A.T., Kinnaird, T., Suddath, W.O., Weissman, N.J., Torguson, R., Kent, K.M., Pichard, A.D., Satler, L.F., Waksman, R., Serruys, P.W., 2004. Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy. Lancet 364, 1519-1521. (Pubitemid 39410418)
23. Mei, L., Sun, H., Jin, X., Zhu, D., Sun, R., Zhang, M., Song, C., 2007. Modified paclitaxelloaded nanoparticles for inhibition of hyperplasia in a rabbit arterial balloon injury model. Pharm. Res. 24, 955-962. (Pubitemid 46675396)
24. Melikian, N., Airoldi, F., Di Mario, C., 2004. Coronary bifurcation stenting: current techniques, outcome and possible future developments. Minerva Cardioangiol. 52, 365-378. (Pubitemid 39457518)
25. Melikian, N., Wijns, W., 2008. Drug-eluting stents: a critique. Heart 94, 145-152. (Pubitemid 351211718)
26. Mu, L., Elbayoumi, T.A., Torchilin, V.P., 2005. Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and d-alpha-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camptothecin. Int. J. Pharm. 306, 142-149. (Pubitemid 41643148)
27. Nebeker, J.R., Virmani, R., Bennett, C.L., Hoffman, J.M., Samore, M.H., Alvarez, J., Davidson, C.J., McKoy, J.M., Raisch, D.W., Whisenant, B.K., Yarnold, P.R., Belknap, S.M., West, D.P., Gage, J.E., Morse, R.E., Gligoric, G., Davidson, L., Feldman, M.D., 2006. Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. J. Am. Coll. Cardiol. 47, 175-181. (Pubitemid 43005183)
28. Nguyen, K.T., Shukla, K.P., Moctezuma, M., Braden, A.R., Zhou, J., Hu, Z., Tang, L., 2009. Studies of the cellular uptake of hydrogel nanospheres and microspheres by phagocytes, vascular endothelial cells, and smooth muscle cells. J. Biomed. Mater. Res. A 88, 1022-1030.
29. Ong, A.T., McFadden, E.P., Regar, E., de Jaegere, P.P., van Domburg, R.T., Serruys, P.W., 2005. Late angiographic stent thrombosis (LAST) events with drug-eluting stents. J. Am. Coll. Cardiol. 45, 2088-2092. (Pubitemid 40814135)
30. Parry, T.J., Brosius, R., Thyagarajan, R., Carter, D., Argentieri, D., Falotico, R., Siekierka, J., 2005. Drug-eluting stents: sirolimus and paclitaxel differentially affect cultured cells and injured arteries. Eur. J. Pharmacol. 524, 19-29. (Pubitemid 41606808)
31. Pires, N.M., van der Hoeven, B.L., de Vries, M.R., Havekes, L.M., van Vlijmen, B.J., Hennink, W.E., Quax, P.H., Jukema, J.W., 2005. Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(epsilon- caprolactone) stent cuff. Biomaterials 26, 5386-5394. (Pubitemid 40462353)
32. Popma, J.J., Califf, R.M., Topol, E.J., 1991. Clinical trials of restenosis after coronary angioplasty. Circulation 84, 1426-1436.
33. Preusch, M.R., Vanakaris, A., Bea, F., Ieronimakis, N., Shimizu, T., Konstandin, M., Morris-Rosenfeld, S., Albrecht, C., Kranzhofer, A., Katus, H.A., Blessing, E., Kranzhofer, R., 2010. Rosuvastatin reduces neointima formation in a rat model of balloon injury. Eur. J. Med. Res. 15, 461-467.
34. Reddy, M.K., Vasir, J.K., Sahoo, S.K., Jain, T.K., Yallapu, M.M., Labhasetwar, V., 2008. Inhibition of apoptosis through localized delivery of rapamycin-loaded nanoparticles prevented neointimal hyperplasia and reendothelialized injured artery. Circ. Cardiovasc. Interv. 1, 209-216.
35. Ritger, P.L., Peppas, N.A., 1987. A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J. Control. Release 5, 23-36. (Pubitemid 17106643)
36. Rome, J.J., Shayani, V., Flugelman, M.Y., Newman, K.D., Farb, A., Virmani, R., Dichek, D.A., 1994. Anatomic barriers influence the distribution of in vivo gene transfer into the arterial wall: modeling with microscopic tracer particles and verification with a recombinant adenoviral vector. Arterioscler. Thromb. 14, 148-161.
37. Sadzuka, Y., Takabe, H., Sonobe, T., 2005. Liposomalization of SN-38 as active metabolite of CPT-11. J. Control. Release 108, 453-459. (Pubitemid 41608676)
38. Salam, A.M., Al Suwaidi, J., Holmes Jr., D.R., 2006. Drug-eluting coronary stents. Curr. Probl. Cardiol. 31, 8-119. (Pubitemid 43017767)
39. Schwaiberger, A.V., Heiss, E.H., Cabaravdic, M., Oberan, T., Zaujec, J., Schachner, D., Uhrin, P., Atanasov, A.G., Breuss, J.M., Binder, B.R., Dirsch, V.M., 2010. Indirubin- 3′-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo. Arterioscler. Thromb. Vasc. Biol. 30, 2475-2481.
40. Steffel, J., Tanner, F.C., 2007. Biological effects of drug-eluting stents in the coronary circulation. Herz 32, 268-273. (Pubitemid 47047280)
41. Sukhija, R., Mehta, J.L., Sachdeva, R., 2008. Present status of coronary bifurcation stenting. Clin. Cardiol. 31, 63-66. (Pubitemid 351317214)
42. Torchilin, V.P., 2007. Micellar nanocarriers: pharmaceutical perspectives. Pharm. Res. 24, 1-16. (Pubitemid 44902565)
43. Tulis, D.A., 2007. Rat carotid artery balloon injury model. Methods Mol. Med. 139, 1-30.
44. Uwatoku, T., Shimokawa, H., Abe, K., Matsumoto, Y., Hattori, T., Oi, K., Matsuda, T., Kataoka, K., Takeshita, A., 2003. Application of nanoparticle technology for the prevention of restenosis after balloon injury in rats. Circ. Res. 92, e62-e69.
45. van der Giessen, W.J., Lincoff, A.M., Schwartz, R.S., van Beusekom, H.M., Serruys, P.W., Holmes Jr., D.R., Ellis, S.G., Topol, E.J., 1996. Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries. Circulation 94, 1690-1697. (Pubitemid 26320276)
46. Weissig, V., Whiteman, K.R., Torchilin, V.P., 1998. Accumulation of protein-loaded long-circulating micelles and liposomes in subcutaneous Lewis lung carcinoma in mice. Pharm. Res. 15, 1552-1556. (Pubitemid 28465741)
47. Westedt, U., Barbu-Tudoran, L., Schaper, A.K., Kalinowski, M., Alfke, H., Kissel, T., 2002. Deposition of nanoparticles in the arterial vessel by porous balloon catheters: localization by confocal laser scanning microscopy and transmission electron microscopy. AAPS PharmSci. 4, E41.