메뉴 건너뛰기




Volumn 32, Issue 4, 2014, Pages 370-377

Crohn's disease: Loss of tolerance or a disorder of autophagy?

Author keywords

Autophagy; Bacteria; Crohn's disease; IL 10; Intestinal macrophages; TLR4

Indexed keywords

BACTERIAL ANTIGEN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PATTERN RECOGNITION RECEPTOR; PROTEIN ATG16L1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IRGM; UNCLASSIFIED DRUG; CARRIER PROTEIN;

EID: 84903439237     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000358140     Document Type: Article
Times cited : (23)

References (66)
  • 1
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier RJ, Podolsky DK: Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434.
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 2
    • 78650973052 scopus 로고    scopus 로고
    • High-throughput clone library analysis of the mucosa-Associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease
    • Walker AW, Sanderson JD, Churcher C, Parkes GC, Hudspith BN, Rayment N, Brostoff J, Parkhill J, Dougan G, Petrovska L: High-throughput clone library analysis of the mucosa-Associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease. BMC Microbiol 2011; 11: 7.
    • (2011) BMC Microbiol , vol.11 , pp. 7
    • Walker, A.W.1    Sanderson, J.D.2    Churcher, C.3    Parkes, G.C.4    Hudspith, B.N.5    Rayment, N.6    Brostoff, J.7    Parkhill, J.8    Dougan, G.9    Petrovska, L.10
  • 3
    • 84873717548 scopus 로고    scopus 로고
    • The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease
    • Sha S, Xu B, Wang X, Zhang Y, Wang H, Kong X, Zhu H, Wu K: The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease. Diagn Microbiol Infect Dis 2013; 75: 245-251.
    • (2013) Diagn Microbiol Infect Dis , vol.75 , pp. 245-251
    • Sha, S.1    Xu, B.2    Wang, X.3    Zhang, Y.4    Wang, H.5    Kong, X.6    Zhu, H.7    Wu, K.8
  • 6
    • 77949471940 scopus 로고    scopus 로고
    • Association of the nod2 genotype with bacterial translocation via altered cell-cell contacts in crohn's disease patients
    • Kosovac K, Brenmoehl J, Holler E, Falk W, Schoelmerich J, Hausmann M, Rogler G: Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients. Inflamm Bowel Dis 2010; 16: 1311-1321.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1311-1321
    • Kosovac, K.1    Brenmoehl, J.2    Holler, E.3    Falk, W.4    Schoelmerich, J.5    Hausmann, M.6    Rogler, G.7
  • 7
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active crohn's disease
    • Zeissig S, Burgel N, Gunzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD: Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007; 56: 61-72.
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6    Kroesen, A.J.7    Zeitz, M.8    Fromm, M.9    Schulzke, J.D.10
  • 8
    • 0038316325 scopus 로고    scopus 로고
    • Anatomical basis of tolerance and immunity to intestinal antigens
    • Mowat AM: Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003; 3: 331-341.
    • (2003) Nat Rev Immunol , vol.3 , pp. 331-341
    • Mowat, A.M.1
  • 11
    • 3242662009 scopus 로고    scopus 로고
    • Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease
    • Bilsborough J, Viney JL: Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease. Gastroenterology 2004; 127: 300-309.
    • (2004) Gastroenterology , vol.127 , pp. 300-309
    • Bilsborough, J.1    Viney, J.L.2
  • 14
    • 0032920054 scopus 로고    scopus 로고
    • Glucocorticoid receptors are down-regulated in inflamed colonic mucosa but not in peripheral blood mononuclear cells from patients with inflammatory bowel disease
    • Rogler G, Meinel A, Lingauer A, Michl J, Zietz B, Gross V, Lang B, Andus T, Scholmerich J, Palitzsch KD: Glucocorticoid receptors are down-regulated in inflamed colonic mucosa but not in peripheral blood mononuclear cells from patients with inflammatory bowel disease. Eur J Clin Invest 1999; 29: 330-336.
    • (1999) Eur J Clin Invest , vol.29 , pp. 330-336
    • Rogler, G.1    Meinel, A.2    Lingauer, A.3    Michl, J.4    Zietz, B.5    Gross, V.6    Lang, B.7    Andus, T.8    Scholmerich, J.9    Palitzsch, K.D.10
  • 19
    • 84857365925 scopus 로고    scopus 로고
    • Nod2: A key regulator linking microbiota to intestinal mucosal immunity
    • Biswas A, Petnicki-Ocwieja T, Kobayashi KS: NOD2: a key regulator linking microbiota to intestinal mucosal immunity. J Mol Med (Berl) 2012; 90: 15-24.
    • (2012) J Mol Med (Berl , vol.90 , pp. 15-24
    • Biswas, A.1    Petnicki-Ocwieja, T.2    Kobayashi, K.S.3
  • 20
    • 79956319462 scopus 로고    scopus 로고
    • The nod2 sensor promotes intestinal pathogen eradication via the chemokine ccl2-dependent recruitment of inflammatory monocytes
    • Kim YG, Kamada N, Shaw MH, Warner N, Chen GY, Franchi L, Nunez G: The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity 2011; 34: 769-780.
    • (2011) Immunity , vol.34 , pp. 769-780
    • Kim, Y.G.1    Kamada, N.2    Shaw, M.H.3    Warner, N.4    Chen, G.Y.5    Franchi, L.6    Nunez, G.7
  • 21
    • 77950002937 scopus 로고    scopus 로고
    • The nlrp3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD: The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010; 32: 379-391.
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1    Boyd, K.L.2    Vogel, P.3    Kastan, M.B.4    Lamkanfi, M.5    Kanneganti, T.D.6
  • 24
    • 84969213492 scopus 로고    scopus 로고
    • Wellcome trust case control consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 26
    • 78651070199 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase n2 regulates tnf-induced signalling and cytokine secretion in human intestinal epithelial cells
    • Scharl M, McCole DF, Weber A, Vavricka SR, Frei P, Kellermeier S, Pesch T, Fried M, Rogler G: Protein tyrosine phosphatase N2 regulates TNF-induced signalling and cytokine secretion in human intestinal epithelial cells. Gut 2011; 60: 189-197.
    • (2011) Gut , vol.60 , pp. 189-197
    • Scharl, M.1    McCole, D.F.2    Weber, A.3    Vavricka, S.R.4    Frei, P.5    Kellermeier, S.6    Pesch, T.7    Fried, M.8    Rogler, G.9
  • 28
    • 78649605952 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase non-receptor type 2 regulates ifn-induced cytokine signaling in thp-1 monocytes
    • Scharl M, Hruz P, McCole DF: Protein tyrosine phosphatase non-receptor type 2 regulates IFN-induced cytokine signaling in THP-1 monocytes. Inflamm Bowel Dis 2010; 16: 2055-2064.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 2055-2064
    • Scharl, M.1    Hruz, P.2    McCole, D.F.3
  • 29
    • 84883082859 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase non-receptor type 22 modulates nod2-induced cytokine release and autophagy
    • Spalinger MR, Lang S, Vavricka SR, Fried M, Rogler G, Scharl M: Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy. PLoS One 2013; 8:e72384.
    • (2013) PLoS One , vol.8
    • Spalinger, M.R.1    Lang, S.2    Vavricka, S.R.3    Fried, M.4    Rogler, G.5    Scharl, M.6
  • 31
    • 84876463917 scopus 로고    scopus 로고
    • Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-induced signaling in human monocytes
    • e10
    • Spalinger MR, Lang S, Weber A, Frei P, Fried M, Rogler G, Scharl M: Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-induced signaling in human monocytes. Gastroenterology 2013; 144: 978-988.e10.
    • (2013) Gastroenterology , vol.144 , pp. 978-988
    • Spalinger, M.R.1    Lang, S.2    Weber, A.3    Frei, P.4    Fried, M.5    Rogler, G.6    Scharl, M.7
  • 33
    • 58149296036 scopus 로고    scopus 로고
    • Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens
    • Curtis MM, Way SS: Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 2009; 126: 177-185.
    • (2009) Immunology , vol.126 , pp. 177-185
    • Curtis, M.M.1    Way, S.S.2
  • 36
    • 67649170980 scopus 로고    scopus 로고
    • Foxp3+ regulatory t cells: Differentiation, specification, subphenotypes
    • Feuerer M, Hill JA, Mathis D, Benoist C: Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009; 10: 689-695.
    • (2009) Nat Immunol , vol.10 , pp. 689-695
    • Feuerer, M.1    Hill, J.A.2    Mathis, D.3    Benoist, C.4
  • 37
    • 65749103989 scopus 로고    scopus 로고
    • Regulatory lymphocytes and intestinal inflammation
    • Izcue A, Coombes JL, Powrie F: Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 2009; 27: 313-338.
    • (2009) Annu Rev Immunol , vol.27 , pp. 313-338
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 38
    • 65549098640 scopus 로고    scopus 로고
    • Cd4 tcell differentiation and inflammatory bowel disease
    • Zenewicz LA, Antov A, Flavell RA: CD4 Tcell differentiation and inflammatory bowel disease. Trends Mol Med 2009; 15: 199-207.
    • (2009) Trends Mol Med , vol.15 , pp. 199-207
    • Zenewicz, L.A.1    Antov, A.2    Flavell, R.A.3
  • 40
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W: Interleukin-10- deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 45
    • 70349991886 scopus 로고    scopus 로고
    • Lrrk2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
    • Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, Ansorge O, Wade-Martins R: LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet 2009; 18: 4022-4034.
    • (2009) Hum Mol Genet , vol.18 , pp. 4022-4034
    • Alegre-Abarrategui, J.1    Christian, H.2    Lufino, M.M.3    Mutihac, R.4    Venda, L.L.5    Ansorge, O.6    Wade-Martins, R.7
  • 46
    • 80054933395 scopus 로고    scopus 로고
    • The kinase lrrk2 is a regulator of the transcription factor nfat that modulates the severity of inflammatory bowel disease
    • Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ: The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol 2011; 12: 1063-1070.
    • (2011) Nat Immunol , vol.12 , pp. 1063-1070
    • Liu, Z.1    Lee, J.2    Krummey, S.3    Lu, W.4    Cai, H.5    Lenardo, M.J.6
  • 48
    • 0037166241 scopus 로고    scopus 로고
    • Formation of the approximately 350-kda apg12-Apg5.apg16 multimeric complex, mediated by apg16 oligomerization, is essential for autophagy in yeast
    • Kuma A, Mizushima N, Ishihara N, Ohsumi Y: Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 2002; 277: 18619-18625.
    • (2002) J Biol Chem , vol.277 , pp. 18619-18625
    • Kuma, A.1    Mizushima, N.2    Ishihara, N.3    Ohsumi, Y.4
  • 49
    • 84861186087 scopus 로고    scopus 로고
    • Defects in autophagy favour adherent-invasive escherichia coli persistence within macrophages leading to increased pro-inflammatory response
    • Lapaquette P, Bringer MA, Darfeuille-Michaud A: Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response. Cell Microbiol 2012; 14: 791-807.
    • (2012) Cell Microbiol , vol.14 , pp. 791-807
    • Lapaquette, P.1    Bringer, M.A.2    Darfeuille-Michaud, A.3
  • 53
    • 84888217213 scopus 로고    scopus 로고
    • Mir-106b fine tunes atg16l1 expression and autophagic activity in intestinal epithelial hct116 cells
    • Zhai Z, Wu F, Chuang AY, Kwon JH: miR-106b fine tunes ATG16L1 expression and autophagic activity in intestinal epithelial HCT116 cells. Inflamm Bowel Dis 2013; 19: 2295-2301.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2295-2301
    • Zhai, Z.1    Wu, F.2    Chuang, A.Y.3    Kwon, J.H.4
  • 61
    • 0142240338 scopus 로고    scopus 로고
    • Immune control of tuberculosis by ifn-gamma-inducible lrg-47
    • MacMicking JD, Taylor GA, McKinney JD: Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 2003; 302: 654-659.
    • (2003) Science , vol.302 , pp. 654-659
    • Macmicking, J.D.1    Taylor, G.A.2    McKinney, J.D.3
  • 63
    • 0035898464 scopus 로고    scopus 로고
    • Inactivation of lrg-47 and irg-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection
    • Collazo CM, Yap GS, Sempowski GD, Lusby KC, Tessarollo L, Woude GF, Sher A, Taylor GA: Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med 2001; 194: 181-188.
    • (2001) J Exp Med , vol.194 , pp. 181-188
    • Collazo, C.M.1    Yap, G.S.2    Sempowski, G.D.3    Lusby, K.C.4    Tessarollo, L.5    Woude, G.F.6    Sher, A.7    Taylor, G.A.8
  • 64
    • 33748506089 scopus 로고    scopus 로고
    • Human irgm induces autophagy to eliminate intracellular mycobacteria
    • Singh SB, Davis AS, Taylor GA, Deretic V: Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006; 313: 1438-1441.
    • (2006) Science , vol.313 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 65
    • 77649194674 scopus 로고    scopus 로고
    • Crohn's disease-Associated adherent-invasive e. Coli are selectively favoured by impaired autophagy to replicate intracellularly
    • Lapaquette P, Glasser AL, Huett A, Xavier RJ, Darfeuille-Michaud A: Crohn's disease-Associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol 2010; 12: 99-113.
    • (2010) Cell Microbiol , vol.12 , pp. 99-113
    • Lapaquette, P.1    Glasser, A.L.2    Huett, A.3    Xavier, R.J.4    Darfeuille-Michaud, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.