Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Spalinger, Marianne R ^a   Lang, Silvia ^a   Vavricka, Stephan R ^a,b,c   Fried, Michael ^a,b   Rogler, Gerhard ^a,b   Scharl, Michael ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c Division of Gastroenterology and Hepatology   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MURAMYL DIPEPTIDE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; CARD15 PROTEIN, MOUSE; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; NOD2 PROTEIN, HUMAN; PTPN22 PROTEIN, HUMAN; PTPN22 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL LINE; CELL STRAIN THP 1; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WILD TYPE; ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; GENE SILENCING; GENETICS; IRRITABLE COLON; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ANIMALS; AUTOPHAGY; CELL LINE; CYTOKINES; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCKDOWN TECHNIQUES; HUMANS; IRRITABLE BOWEL SYNDROME; MICE; MICE, KNOCKOUT; NOD2 SIGNALING ADAPTOR PROTEIN; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84883082859     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072384     Document Type: Article

References (40)

1. Rogler G, Hausmann M, Vogl D, Aschenbrenner E, Andus T, et al. (1998) Isolation and phenotypic characterization of colonic macrophages. Clin Exp Immunol 112: 205-215.
2. Chen G, Shaw MH, Kim YG, Nunez G, (2009) NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol 4: 365-398.
3. Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278: 8869-8872.
4. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606.
5. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603.
6. Petnicki-Ocwieja T, Hrncir T, Liu YJ, Biswas A, Hudcovic T, et al. (2009) Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A 106: 15813-15818.
7. Ting JPY, Duncan JA, Lei Y, (2010) How the Noninflammasome NLRs Function in the Innate Immune System. Science 327: 286-290.
8. Cooney R, Baker J, Brain O, Danis B, Pichulik T, et al. (2010) NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 16: 90-97.
9. Saitoh T, Fujita N, Jang MH, Uematsu S, Yang B-G, et al. (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1[bgr] production. Nature 456: 264-268.
10. Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, et al. (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39: 207-211.
11. Diaz-Gallo LM, Espino-Paisan L, Fransen K, Gomez-Garcia M, van Sommeren S, et al. (2011) Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 17: 2287-2294.
12. Cloutier JF, Veillette A, (1996) Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J 15: 4909-4918.
13. Rieck M, Arechiga A, Onengut-Gumuscu S, Greenbaum C, Concannon P, et al. (2007) Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes. J Immunol 179: 4704-4710.
14. Douroudis K, Shcherbakova A, Everaus H, Aints A, (2010) PTPN22 gene regulates natural killer cell proliferation during in vitro expansion. Tissue Antigens 76: 315-318.
15. Zhang J, Zahir N, Jiang Q, Miliotis H, Heyraud S, et al. (2011) The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet 43: 902-907.
16. Spalinger MR, Lang S, Weber A, Frei P, Fried M, et al. (2013) Loss of Protein Tyrosine Phosphatase Nonreceptor Type 22 Regulates Interferon-γ-Induced Signaling in Human Monocytes. Gastroenterology 144: 978-988.e910.
17. Scharl M, Wojtal KA, Becker HM, Fischbeck A, Frei P, et al. (2011) Protein tyrosine phosphatase nonreceptor type 2 regulates autophagosome formation in human intestinal cells. Inflamm Bowel Dis.
18. Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, et al. (2004) PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 303: 685-689.
19. Moynagh PN, (2005) The NF-kappaB pathway. J Cell Sci 118: 4589-4592.
20. Komatsu M, Ichimura Y, (2010) Physiological significance of selective degradation of p62 by autophagy. FEBS Letters 584: 1374-1378.
21. Ren S, Zhang S, Li M, Huang C, Liang R, et al. (2012) NF-kappaB p65 and c-Rel subunits promote phagocytosis and cytokine secretion by splenic macrophages in cirrhotic patients with hypersplenism. Int J Biochem Cell Biol 45: 335-343.
22. Kang YJ, Chen J, Otsuka M, Mols J, Ren S, et al. (2008) Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J Immunol 180: 5075-5082.
23. Himes SR, Sester DP, Ravasi T, Cronau SL, Sasmono T, et al. (2006) The JNK are important for development and survival of macrophages. J Immunol 176: 2219-2228.
24. Sanchez-Tillo E, Comalada M, Xaus J, Farrera C, Valledor AF, et al. (2007) JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation. J Biol Chem 282: 12566-12573.
25. Rugtveit J, Nilsen EM, Bakka A, Carlsen H, Brandtzaeg P, et al. (1997) Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease. Gastroenterology 112: 1493-1505.
26. Mahida YR, Kurlac L, Gallagher A, Hawkey CJ, (1991) High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis. Gut 32: 1531-1534.
27. Banks C, Bateman A, Payne R, Johnson P, Sheron N, (2003) Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. J Pathol 199: 28-35.
28. Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, et al. (2001) Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14: 705-714.
29. Korn T, Bettelli E, Oukka M, Kuchroo VK, (2009) IL-17 and Th17 Cells. Annu Rev Immunol 27: 485-517.
30. Olsen T, Rismo R, Cui G, Goll R, Christiansen I, et al. (2011) TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation. Cytokine 56: 633-640.
31. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123-1132.
32. Jin Y, Lin Y, Lin L, Zheng C (2012) IL-17/IFN-gamma Interactions Regulate Intestinal Inflammation in TNBS-Induced Acute Colitis. J Interferon Cytokine Res.
33. Cao Y, Yang J, Colby K, Hogan SL, Hu Y, et al. (2012) High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. PLoS One 7: e42783.
34. Zhang J, Zahir N, Jiang Q, Miliotis H, Heyraud S, et al. (2011) The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet 43: 902-907.
35. Huang G, Wang Y, Vogel P, Kanneganti T-D, Otsu K, et al. (2012) Signaling via the kinase p38[alpha] programs dendritic cells to drive TH17 differentiation and autoimmune inflammation. Nat Immunol 13: 152-161.
36. Neurath MF, Weigmann B, Finotto S, Glickman J, Nieuwenhuis E, et al. (2002) The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med 195: 1129-1143.
37. Travassos LH, Carneiro LAM, Ramjeet M, Hussey S, Kim Y-G, et al. (2010) Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 11: 55-62.
38. Zhang Y, Morgan MJ, Chen K, Choksi S, Liu Z-g, (2012) Induction of autophagy is essential for monocyte-macrophage differentiation. Blood 119: 2895-2905.
39. Matsuzawa T, Kim B-H, Shenoy AR, Kamitani S, Miyake M, et al. (2012) IFN-γ Elicits Macrophage Autophagy via the p38 MAPK Signaling Pathway. The Journal of Immunology 189: 813-818.
40. Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, et al. (2006) Identification of substrates of human protein-tyrosine phosphatase PTPN22. J Biol Chem 281: 11002-11010.