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Volumn 69, Issue 6, 2014, Pages 438-446

Pharmacological management of osteogenesis

Author keywords

Antiresorptive Drugs; Bone formation; Osteoblasts; Osteogenesis; RANKL inhibitors

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; BONE DENSITY CONSERVATION AGENT; DENOSUMAB; MONOCLONAL ANTIBODY; PARATHYROID HORMONE[1-34]; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STRONTIUM RANELATE; THIOPHENE DERIVATIVE;

EID: 84903318590     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.6061/clinics/2014(06)12     Document Type: Review
Times cited : (45)

References (141)
  • 1
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998;93(2):165-76. http://dx.doi.org/10.1016/S0092-8674(00)81569-X
    • (1998) Cell , vol.93 , Issue.2 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3    Kelley, M.J.4    Dunstan, C.R.5    Burgess, T.6
  • 2
    • 0035206443 scopus 로고    scopus 로고
    • Minireview: The OPG/RANKL/RANK system
    • Khosla S. Minireview: the OPG/RANKL/RANK system. Endocrinology. 2001;142(12):5050-5. http://dx.doi.org/10.1210/endo.142.12.8536
    • (2001) Endocrinology , vol.142 , Issue.12 , pp. 5050-5055
    • Khosla, S.1
  • 3
    • 9344246863 scopus 로고    scopus 로고
    • Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin
    • Collin-Osdoby P. Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 2004;95(11): 1046-57. http://dx.doi.org/10.1161/01.RES.0000149165.99974.12
    • (2004) Circ Res , vol.95 , Issue.11 , pp. 1046-1057
    • Collin-Osdoby, P.1
  • 4
    • 18144388685 scopus 로고    scopus 로고
    • Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat
    • Silvestrini G, Ballanti P, Patacchioli F, Leopizzi M, Gualtieri N, Monnazzi P, et al. Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat. J Mol Histol. 2005;36(1-2):59-67. http://dx.doi.org/10.1007/s10735-004-3839-1
    • (2005) J Mol Histol , vol.36 , Issue.1-2 , pp. 59-67
    • Silvestrini, G.1    Ballanti, P.2    Patacchioli, F.3    Leopizzi, M.4    Gualtieri, N.5    Monnazzi, P.6
  • 5
    • 80053938104 scopus 로고    scopus 로고
    • Evidence for osteocyte regulation of bone homeostasis through RANKL expression
    • Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng QJ, et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 2011;17(10):1231-4. http://dx.doi.org/10.1038/nm.2452
    • (2011) Nat Med , vol.17 , Issue.10 , pp. 1231-1234
    • Nakashima, T.1    Hayashi, M.2    Fukunaga, T.3    Kurata, K.4    Oh-Hora, M.5    Feng, Q.J.6
  • 6
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, et al. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A. 1999;96(7):3540-5. http://dx.doi.org/10.1073/pnas.96.7.3540
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.7 , pp. 3540-3545
    • Hsu, H.1    Lacey, D.L.2    Dunstan, C.R.3    Solovyev, I.4    Colombero, A.5    Timms, E.6
  • 7
    • 45749103255 scopus 로고    scopus 로고
    • Rebalancing bone turnover in favour of formation with strontium ranelate: Implications for bone strength
    • Fonseca JE Rebalancing bone turnover in favour of formation with strontium ranelate: Implications for bone strength. Rheumatology (Oxford). 2008;47 Suppl 4:iv17-19
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.SUPPL. 4
    • Fonseca, J.E.1
  • 8
    • 34548454049 scopus 로고    scopus 로고
    • Biology of RANK, RANKL, and osteoprotegerin
    • Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 2007;9 Suppl 1:S1. http://dx.doi.org/10.1186/ar2165
    • (2007) Arthritis Res Ther , vol.9 , Issue.SUPPL. 1
    • Boyce, B.F.1    Xing, L.2
  • 9
    • 0034937704 scopus 로고    scopus 로고
    • Heufelder AE Role of receptor activator of nuclear factorkappa B ligand and osteopr otegerin in bone cell biology
    • Hofbauer LC, Heufelder AE Role of receptor activator of nuclear factorkappa B ligand and osteopr otegerin in bone cell biology. J Mol Med. 2001;79(5-6):243-53. http://dx.doi.org/10.1007/s001090100226
    • (2001) J Mol Med , vol.79 , Issue.5-6 , pp. 243-253
    • Hofbauer, L.C.1
  • 10
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003;423(6937):337-42. http://dx.doi.org/10.1038/nature01658
    • (2003) Nature , vol.423 , Issue.6937 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 11
    • 3242781731 scopus 로고    scopus 로고
    • Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
    • Hofbauer LC, Schoppet M. Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA. 2004;292(4):490-5. http://dx.doi.org/10.1001/jama.292.4.490
    • (2004) JAMA , vol.292 , Issue.4 , pp. 490-495
    • Hofbauer, L.C.1    Schoppet, M.2
  • 12
    • 0028109510 scopus 로고
    • Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: A double blind placebo controlled study
    • Eggelmeijer F, Papapoulos SE, Van Paassen HC, Dijkmans BA, Breedveld FC. Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study. J Rheumatol. 1994;21(11):2016-20
    • (1994) J Rheumatol , vol.21 , Issue.11 , pp. 2016-2020
    • Eggelmeijer, F.1    Papapoulos, S.E.2    van Paassen, H.C.3    Dijkmans, B.A.4    Breedveld, F.C.5
  • 13
    • 0034094966 scopus 로고    scopus 로고
    • Pamidronate treatment of bone fibrous dysplasia in nine children with McCune-Albright sindrome
    • Lala R, Matarazzo P, Bertelloni S, Buzi F, Rigon F, De Sanctis C. Pamidronate treatment of bone fibrous dysplasia in nine children with McCune-Albright sindrome. Acta Paediatr. 2000;89(2):188-93. http://dx.doi.org/10.1111/j.1651-2227.2000.tb01214.x.
    • (2000) Acta Paediatr , vol.89 , Issue.2 , pp. 188-193
    • Lala, R.1    Matarazzo, P.2    Bertelloni, S.3    Buzi, F.4    Rigon, F.5    de Sanctis, C.6
  • 14
    • 0034284550 scopus 로고    scopus 로고
    • Martin TJ Therapeutic approaches to bone diseases
    • Rodan GA, Martin TJ Therapeutic approaches to bone diseases. Science. 2000;289(5484):1508-14. http://dx.doi.org/10.1126/science.289.5484.1508
    • (2000) Science , vol.289 , Issue.5484 , pp. 1508-1514
    • Rodan, G.A.1
  • 16
    • 0038235983 scopus 로고    scopus 로고
    • Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro
    • Tassone P, Tagliaferri P, Viscomi C, Palmieri C, Caraglia M, D'Alessandro A, et al. Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br J Cancer. 2003;88(12):1971-8
    • (2003) Br J Cancer , vol.88 , Issue.12 , pp. 1971-1978
    • Tassone, P.1    Tagliaferri, P.2    Viscomi, C.3    Palmieri, C.4    Caraglia, M.5    D'Alessandro, A.6
  • 17
    • 0034659773 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of action of bisphosphonates
    • Rogers MJ, Gordon S, Benford HL, Coxon FP, Luckman SP, Monkkonen J, et al. Cellular and molecular mechanisms of action of bisphosphonates. Cancer. 2000;88(12 Suppl):2961-78. http://dx.doi.org/10.1002/1097-0142(20000615)88:12+,2961::AID-CNCR12.3.0.CO;2-L.
    • (2000) Cancer , vol.88 , Issue.12 SUPPL. , pp. 2961-2978
    • Rogers, M.J.1    Gordon, S.2    Benford, H.L.3    Coxon, F.P.4    Luckman, S.P.5    Monkkonen, J.6
  • 18
    • 0015939609 scopus 로고
    • The binding of pyrophosphate and two diphosphonates on hydroxyapatite crystals
    • Jung A, Bisaz S, Fleisch H. The binding of pyrophosphate and two diphosphonates on hydroxyapatite crystals. Calcif Tissue Res. 1973;11(4):269-80. http://dx.doi.org/10.1007/BF02547227
    • (1973) Calcif Tissue Res , vol.11 , Issue.4 , pp. 269-280
    • Jung, A.1    Bisaz, S.2    Fleisch, H.3
  • 19
    • 0142120125 scopus 로고    scopus 로고
    • Zoledronic acid inhibits osteoclastogenesis in vitro and in a mouse model of inflammatory osteolysis
    • Sudhoff H, Jung JY, Ebmeyer J, Faddis BT, Hildmann H, Chole RA. Zoledronic acid inhibits osteoclastogenesis in vitro and in a mouse model of inflammatory osteolysis. Ann Otol Rhinol Laryngol. 2003;112(9 Pt 1):780-6
    • (2003) Ann Otol Rhinol Laryngol , vol.112 , Issue.9 PART 1 , pp. 780-786
    • Sudhoff, H.1    Jung, J.Y.2    Ebmeyer, J.3    Faddis, B.T.4    Hildmann, H.5    Chole, R.A.6
  • 20
    • 0141455522 scopus 로고    scopus 로고
    • Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis
    • Evdokiou A, Labrinidis A, Bouralexis S, Hay S, Findlay DM. Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis. Bone. 2003;33(2):216-28. http://dx.doi.org/10.1016/S8756-3282(03)00223-0
    • (2003) Bone , vol.33 , Issue.2 , pp. 216-228
    • Evdokiou, A.1    Labrinidis, A.2    Bouralexis, S.3    Hay, S.4    Findlay, D.M.5
  • 21
    • 5444242637 scopus 로고    scopus 로고
    • Bisphosphonates: Preclinical review
    • Green JR. Bisphosphonates: preclinical review. Oncologist. 2004;9 Suppl 4:3-13. http://dx.doi.org/10.1634/theoncologist.9-90004-3
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 4 , pp. 3-13
    • Green, J.R.1
  • 22
    • 0036727151 scopus 로고    scopus 로고
    • Bisphosphonate mechanism of action
    • Rodan GA, Reszka AA. Bisphosphonate mechanism of action. Curr Mol Med. 2002;2(6):571-7. http://dx.doi.org/10.2174/1566524023362104
    • (2002) Curr Mol Med , vol.2 , Issue.6 , pp. 571-577
    • Rodan, G.A.1    Reszka, A.A.2
  • 23
    • 0033672020 scopus 로고    scopus 로고
    • Etidronate (HEBP) promotes osteoblast differentiation and wound closure in rat calvaria
    • D'Aoust P, McCulloch CA, Tenenbaum HC, Lekic PC. Etidronate (HEBP) promotes osteoblast differentiation and wound closure in rat calvaria. Cell Tissue Res. 2000;302(3):353-63. http://dx.doi.org/10.1007/s004419900165
    • (2000) Cell Tissue Res , vol.302 , Issue.3 , pp. 353-363
    • D'Aoust, P.1    McCulloch, C.A.2    Tenenbaum, H.C.3    Lekic, P.C.4
  • 24
    • 0024406012 scopus 로고
    • Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow
    • Hughes D.E., MacDonald BR, Russell RGG, and Gowen M. Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. J Clin Invest. 1989;83(6):1930-5. http://dx.doi.org/10.1172/JCI114100
    • (1989) J Clin Invest , vol.83 , Issue.6 , pp. 1930-1935
    • Hughes, D.E.1    Macdonald, B.R.2    Russell, R.G.G.3    Gowen, M.4
  • 25
    • 23244462780 scopus 로고    scopus 로고
    • Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells
    • Von Knoch F, Jaquiery C, Kowalsky M, Schaeren S, Alabre C, Martin I, et al. Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells. Biomaterials. 2005;26(34):6941-9. http://dx.doi.org/10.1016/j.biomaterials.2005.04.059
    • (2005) Biomaterials , vol.26 , Issue.34 , pp. 6941-6949
    • von Knoch, F.1    Jaquiery, C.2    Kowalsky, M.3    Schaeren, S.4    Alabre, C.5    Martin, I.6
  • 26
    • 0041766815 scopus 로고    scopus 로고
    • Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro
    • Still K, Phipps RJ, Scutt A. Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. Calcif Tissue Int. 2003;72(2):143-50. http://dx.doi.org/10.1007/s00223-001-2066-y.
    • (2003) Calcif Tissue Int , vol.72 , Issue.2 , pp. 143-150
    • Still, K.1    Phipps, R.J.2    Scutt, A.3
  • 27
    • 0036210879 scopus 로고    scopus 로고
    • Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: Identity of a potent new bisphosphonate analogue
    • Reinholz GG, Getz B, Sanders ES, Karpeisky MY, Padyukova NS, Mikhailov SN, et al. Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue. Breast Cancer Res Treat. 2002;71(3):257-68. http://dx.doi.org/10.1023/A:1014418017382
    • (2002) Breast Cancer Res Treat , vol.71 , Issue.3 , pp. 257-268
    • Reinholz, G.G.1    Getz, B.2    Sanders, E.S.3    Karpeisky, M.Y.4    Padyukova, N.S.5    Mikhailov, S.N.6
  • 28
    • 0034326253 scopus 로고    scopus 로고
    • Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts
    • Reinholz GG, Getz B, Pederson L, Sanders ES, Subramaniam M, Ingle JN, et al. Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts. Cancer Res. 2000;60(21):6001-7
    • (2000) Cancer Res , vol.60 , Issue.21 , pp. 6001-6007
    • Reinholz, G.G.1    Getz, B.2    Pederson, L.3    Sanders, E.S.4    Subramaniam, M.5    Ingle, J.N.6
  • 29
    • 0027193759 scopus 로고
    • Bisphosphonates act on rat bone resorption through the mediation of osteoblasts
    • Sahni M, Guenther HL, Fleisch H, Collin P, Martin TJ. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. J Clin Invest. 1993;91(5):2004-11. http://dx.doi.org/10.1172/JCI116422
    • (1993) J Clin Invest , vol.91 , Issue.5 , pp. 2004-2011
    • Sahni, M.1    Guenther, H.L.2    Fleisch, H.3    Collin, P.4    Martin, T.J.5
  • 30
    • 0030028473 scopus 로고    scopus 로고
    • Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures
    • Nishikawa M, Akatsu T, Katayama Y, Yasutomo Y, Kado S, Kugal N, et al. Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures. Bone. 1996;18(1):9-14. http://dx.doi.org/10.1016/8756-3282(95)00426-2
    • (1996) Bone , vol.18 , Issue.1 , pp. 9-14
    • Nishikawa, M.1    Akatsu, T.2    Katayama, Y.3    Yasutomo, Y.4    Kado, S.5    Kugal, N.6
  • 31
  • 32
    • 0033747980 scopus 로고    scopus 로고
    • Etidronate inhibits human osteoblast apoptosis by inhibition of pro-apoptotic factor(s) produced by activated T cells
    • Y Abe Y, Kawakami A, Nakashima T, Ejima E, Fujiyama K, Kiriyama T, et al. Etidronate inhibits human osteoblast apoptosis by inhibition of pro-apoptotic factor(s) produced by activated T cells. J Lab Clin Med. 2000;136(5):344-54. http://dx.doi.org/10.1067/mlc.2000.109757
    • (2000) J Lab Clin Med , vol.136 , Issue.5 , pp. 344-354
    • Abe, Y.Y.1    Kawakami, A.2    Nakashima, T.3    Ejima, E.4    Fujiyama, K.5    Kiriyama, T.6
  • 33
    • 0031907663 scopus 로고    scopus 로고
    • Bisphosphonates inhibit IL-6 production by human osteoblast-like cells
    • Giuliani N, Pedrazzoni M, Passeri G, Girasole G. Bisphosphonates inhibit IL-6 production by human osteoblast-like cells. Scand. J. Rheumatol. 1998;27(1):38-41
    • (1998) Scand. J. Rheumatol , vol.27 , Issue.1 , pp. 38-41
    • Giuliani, N.1    Pedrazzoni, M.2    Passeri, G.3    Girasole, G.4
  • 34
    • 1642395138 scopus 로고    scopus 로고
    • Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures
    • Itoh F, Aoyagi S, Furihata-Komatsu H, Aoki M, Kusama H, Kojima M, et al. Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures. Eur J Pharmacol. 2003;477(1): 9-16
    • (2003) Eur J Pharmacol , vol.477 , Issue.1 , pp. 9-16
    • Itoh, F.1    Aoyagi, S.2    Furihata-Komatsu, H.3    Aoki, M.4    Kusama, H.5    Kojima, M.6
  • 35
    • 0036295812 scopus 로고    scopus 로고
    • Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts
    • Viereck V, Emons G, Lauck V, Frosch KH, Blaschke S, Grundker C, et al. Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun. 2002;291(3):680-6. http://dx.doi.org/10.1006/bbrc.2002.6510
    • (2002) Biochem Biophys Res Commun , vol.291 , Issue.3 , pp. 680-686
    • Viereck, V.1    Emons, G.2    Lauck, V.3    Frosch, K.H.4    Blaschke, S.5    Grundker, C.6
  • 36
    • 3042843179 scopus 로고    scopus 로고
    • The nitrogencontaining bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblastlike cells by activating TNF-alpha converting enzyme (TACE)
    • Pan B, Farrugia AN, To LB, Findlay DM, Green J, Lynch K, et al. The nitrogencontaining bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblastlike cells by activating TNF-alpha converting enzyme (TACE). J Bone Miner Res. 2004;19(1):147-54. http://dx.doi.org/10.1359/jbmr.2004.19.1.147
    • (2004) J Bone Miner Res , vol.19 , Issue.1 , pp. 147-154
    • Pan, B.1    Farrugia, A.N.2    To, L.B.3    Findlay, D.M.4    Green, J.5    Lynch, K.6
  • 37
    • 1642306206 scopus 로고    scopus 로고
    • Osteoblast proliferation and maturation by bisphosphonates
    • Im GI, Qureshi SA, Kenney J, Rubash HE, Shanbhag AS. Osteoblast proliferation and maturation by bisphosphonates. Biomaterials. 2004;25(18):4105-15. http://dx.doi.org/10.1016/j.biomaterials.2003.11.024
    • (2004) Biomaterials , vol.25 , Issue.18 , pp. 4105-4115
    • Im, G.I.1    Qureshi, S.A.2    Kenney, J.3    Rubash, H.E.4    Shanbhag, A.S.5
  • 38
    • 66649092722 scopus 로고    scopus 로고
    • Effects of alendronate on the proliferation and osteogenic differentiation of MG-63 cells
    • Xiong Y, Yang HJ, Feng J, Shi ZL, Wu LD. Effects of alendronate on the proliferation and osteogenic differentiation of MG-63 cells. J Int Med Res. 2009;37(2):407-16
    • (2009) J Int Med Res , vol.37 , Issue.2 , pp. 407-416
    • Xiong, Y.1    Yang, H.J.2    Feng, J.3    Shi, Z.L.4    Wu, L.D.5
  • 39
    • 0031979896 scopus 로고    scopus 로고
    • Bisphosphonates stimulate formation of osteoblast precursors and mineralized nodules in murine and human bone marrow cultures in vitro and promote early osteoblastogenesis in young and aged mice in vivo
    • Giuliani N, Pedrazzoni M, Negri G, Passeri G, Impicciatore M, Girasole G. Bisphosphonates stimulate formation of osteoblast precursors and mineralized nodules in murine and human bone marrow cultures in vitro and promote early osteoblastogenesis in young and aged mice in vivo. Bone. 1998;22(5):455-61. http://dx.doi.org/10.1016/S8756-3282(98) 00033-7
    • (1998) Bone , vol.22 , Issue.5 , pp. 455-461
    • Giuliani, N.1    Pedrazzoni, M.2    Negri, G.3    Passeri, G.4    Impicciatore, M.5    Girasole, G.6
  • 40
    • 0031974325 scopus 로고    scopus 로고
    • Structurally different bisphosphonates exert opposing effects on alkaline
    • Klein BY, Ben-Bassat H, Breuer E, Solomon V, Golomb G, Structurally different bisphosphonates exert opposing effects on alkaline. J Cell Biochem. 1998;68(2):186-94. http://dx.doi.org/10.1002/(SICI)1097-4644(19980201)68:2,186::AID-JCB5.3.0.CO;2-R.
    • (1998) J Cell Biochem , vol.68 , Issue.2 , pp. 186-194
    • Klein, B.Y.1    Ben-Bassat, H.2    Breuer, E.3    Solomon, V.4    Golomb, G.5
  • 41
    • 70449532477 scopus 로고    scopus 로고
    • Alendronate enhances osteogenic differentiation of bone marrow stromal cells: A preliminary study
    • Kim HK, Kim JH, Abbas AA, Yoon TR. Alendronate enhances osteogenic differentiation of bone marrow stromal cells: a preliminary study. Clin Orthop Relat Res. 2009;467(12):3121-8. http://dx.doi.org/10.1007/s11999-008-0409-y
    • (2009) Clin Orthop Relat Res , vol.467 , Issue.12 , pp. 3121-3128
    • Kim, H.K.1    Kim, J.H.2    Abbas, A.A.3    Yoon, T.R.4
  • 42
    • 9144233505 scopus 로고    scopus 로고
    • The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro
    • Pan B, To LB, Farrugia AN, Findlay DM, Green J, Gronthos S, et al. The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro. Bone. 2004;34(1):112-23. http://dx.doi.org/10.1016/j.bone.2003.08.013
    • (2004) Bone , vol.34 , Issue.1 , pp. 112-123
    • Pan, B.1    To, L.B.2    Farrugia, A.N.3    Findlay, D.M.4    Green, J.5    Gronthos, S.6
  • 43
    • 41049084067 scopus 로고    scopus 로고
    • Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro
    • Idris AI, Rojas J, Greig IR, Van't Hof RJ, Ralston SH. Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro. Calcif Tissue Int. 2008;82(3):191-201. http://dx.doi.org/10.1007/s00223-008-9104-y.
    • (2008) Calcif Tissue Int , vol.82 , Issue.3 , pp. 191-201
    • Idris, A.I.1    Rojas, J.2    Greig, I.R.3    Van't Hof, R.J.4    Ralston, S.H.5
  • 44
    • 58649122908 scopus 로고    scopus 로고
    • Inhibition of osteoblast function in vitro by aminobisphosphonates
    • Orriss IR, Key ML, Colston KW, Arnett TR. Inhibition of osteoblast function in vitro by aminobisphosphonates. J Cell Biochem. 2009; 106(1):109-18. http://dx.doi.org/10.1002/jcb.21983
    • (2009) J Cell Biochem , vol.106 , Issue.1 , pp. 109-118
    • Orriss, I.R.1    Key, M.L.2    Colston, K.W.3    Arnett, T.R.4
  • 45
    • 79958764505 scopus 로고    scopus 로고
    • Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability
    • Bellido T, Plotkin LI. Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability. Bone. 2011;49(1):50-5. http://dx.doi.org/10.1016/j.bone.2010.08.008
    • (2011) Bone , vol.49 , Issue.1 , pp. 50-55
    • Bellido, T.1    Plotkin, L.I.2
  • 46
    • 34247866550 scopus 로고    scopus 로고
    • Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
    • Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007;356(18):1809-22
    • (2007) N Engl J Med , vol.356 , Issue.18 , pp. 1809-1822
    • Black, D.M.1    Delmas, P.D.2    Eastell, R.3    Reid, I.R.4    Boonen, S.5    Cauley, J.A.6
  • 47
    • 0034530951 scopus 로고    scopus 로고
    • Fracture risk reduction with alendronate in women with osteoporosis: The Fracture Intervention Trial. FIT Research Group
    • Black DM, Thompson DE, Bauer DC, Ensrud K, Musliner T, Hochberg MC, et al. Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group. J Clin Endocrinol Metab. 2000;85(11):4118-24. http://dx.doi.org/10.1210/jcem.85.11.6953
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.11 , pp. 4118-4124
    • Black, D.M.1    Thompson, D.E.2    Bauer, D.C.3    Ensrud, K.4    Musliner, T.5    Hochberg, M.C.6
  • 48
    • 0035253489 scopus 로고    scopus 로고
    • Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group
    • McClung MR, Geusens P, Miller PD, Zippel H, Bensen WG, Roux C, et al. Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. N Engl J Med. 2001;344(5):333-40
    • (2001) N Engl J Med , vol.344 , Issue.5 , pp. 333-340
    • McClung, M.R.1    Geusens, P.2    Miller, P.D.3    Zippel, H.4    Bensen, W.G.5    Roux, C.6
  • 49
    • 0033552255 scopus 로고    scopus 로고
    • Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: A randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group
    • Harris ST, Watts NB, Genant HK, McKeever CD, Hangartner T, Keller M, et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. JAMA. 1999;282(14):1344-52. http://dx.doi.org/10.1001/jama.282.14.1344
    • (1999) JAMA , vol.282 , Issue.14 , pp. 1344-1352
    • Harris, S.T.1    Watts, N.B.2    Genant, H.K.3    McKeever, C.D.4    Hangartner, T.5    Keller, M.6
  • 50
    • 33845890326 scopus 로고    scopus 로고
    • Effects of continuing or stopping alendronate after 5 years of treatment: The Fracture Intervention Trial Long-term Extension (FLEX): A randomized trial
    • Black DM, Schwartz AV, Ensrud KE, Cauley JA, Levis S, Quandt SA, et al. Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA. 2006;296(24):2927-38. http://dx.doi.org/10.1001/jama.296.24.2927
    • (2006) JAMA , vol.296 , Issue.24 , pp. 2927-2938
    • Black, D.M.1    Schwartz, A.V.2    Ensrud, K.E.3    Cauley, J.A.4    Levis, S.5    Quandt, S.A.6
  • 51
    • 41949097526 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis
    • Rizzoli R, Burlet N, Cahall D, Delmas PD, Eriksen EF, Felsenberg D, et al. Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis. Bone. 2008;42(5):841-7. http://dx.doi.org/10.1016/j.bone.2008.01.003
    • (2008) Bone , vol.42 , Issue.5 , pp. 841-847
    • Rizzoli, R.1    Burlet, N.2    Cahall, D.3    Delmas, P.D.4    Eriksen, E.F.5    Felsenberg, D.6
  • 52
    • 78751576040 scopus 로고    scopus 로고
    • Subtrochanteric fractures after long-term treatment with bisphosphonates: A european society on clinical and economic aspects of osteoporosis and osteoarthritis, and international osteoporosis foundation working group report
    • Rizzoli R, Akesson K, Bouxsein M, Kanis JA, Napoli N, Papapoulos S, et al. Subtrochanteric fractures after long-term treatment with bisphosphonates: a european society on clinical and economic aspects of osteoporosis and osteoarthritis, and international osteoporosis foundation working group report. Osteoporos Int. 2011;22(2):373-90. http://dx.doi.org/10.1007/s00198-010-1453-5
    • (2011) Osteoporos Int , vol.22 , Issue.2 , pp. 373-390
    • Rizzoli, R.1    Akesson, K.2    Bouxsein, M.3    Kanis, J.A.4    Napoli, N.5    Papapoulos, S.6
  • 53
    • 78349249359 scopus 로고    scopus 로고
    • Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research
    • Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, et al. Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2010;25(11):2267-94. http://dx.doi.org/10.1002/jbmr. 253
    • (2010) J Bone Miner Res , vol.25 , Issue.11 , pp. 2267-2294
    • Shane, E.1    Burr, D.2    Ebeling, P.R.3    Abrahamsen, B.4    Adler, R.A.5    Brown, T.D.6
  • 54
    • 0346837985 scopus 로고    scopus 로고
    • A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • Body JJ, Greipp P, Coleman RE, Facon T, Geurs F, Fermand JP, et al. A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer. 2003;97(3 Suppl):887-92. http://dx.doi.org/10.1002/cncr.11138
    • (2003) Cancer , vol.97 , Issue.3 SUPPL. , pp. 887-892
    • Body, J.J.1    Greipp, P.2    Coleman, R.E.3    Facon, T.4    Geurs, F.5    Fermand, J.P.6
  • 55
    • 24644434101 scopus 로고    scopus 로고
    • RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis
    • Stolina M, Adamu S, Ominsky MS, Dzamba BJ, Asuncion F, Geng Z, et al. RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis. J Bone Miner Res 2005;20(10):1756-65. http://dx.doi.org/10.1359/JBMR.050601
    • (2005) J Bone Miner Res , vol.20 , Issue.10 , pp. 1756-1765
    • Stolina, M.1    Adamu, S.2    Ominsky, M.S.3    Dzamba, B.J.4    Asuncion, F.5    Geng, Z.6
  • 56
    • 30844439149 scopus 로고    scopus 로고
    • The receptor activator of nuclear factor-kB ligand inhibitor osteoprotegerin is a bone-protective agent in a rat model of chronic renal insufficiency and hyperparathyroidism
    • Padagas J, Colloton M, Shalhoub V, Kostenuik PJ, Morony S, Munyakazi L, et al. The receptor activator of nuclear factor-kB ligand inhibitor osteoprotegerin is a bone-protective agent in a rat model of chronic renal insufficiency and hyperparathyroidism. Calcif Tissue Int 2006;78(1):35-44. http://dx.doi.org/10.1007/s00223-005-0161-1
    • (2006) Calcif Tissue Int , vol.78 , Issue.1 , pp. 35-44
    • Padagas, J.1    Colloton, M.2    Shalhoub, V.3    Kostenuik, P.J.4    Morony, S.5    Munyakazi, L.6
  • 57
    • 33845206554 scopus 로고    scopus 로고
    • RANKL inhibition: A novel strategy to decrease femoral head deformity after ischemic necrosis
    • Kim H, Morgan-Bagley S, Kostenuik PJ. RANKL inhibition: A novel strategy to decrease femoral head deformity after ischemic necrosis. J Bone Miner Res. 2006;21(12):1946-54. http://dx.doi.org/10.1359/jbmr. 060905
    • (2006) J Bone Miner Res , vol.21 , Issue.12 , pp. 1946-1954
    • Kim, H.1    Morgan-Bagley, S.2    Kostenuik, P.J.3
  • 58
    • 34347394402 scopus 로고    scopus 로고
    • The RANKL inhibitor OPG-Fc increases cortical and trabecular bone mass in intact cynomolgus monkeys
    • Ominsky MS, Kostenuik PJ, Cranmer P, Smith SY, Atkinson JE. The RANKL inhibitor OPG-Fc increases cortical and trabecular bone mass in intact cynomolgus monkeys. Osteoporos Int 2007;18(8):1073-82. http://dx.doi.org/10.1007/s00198-007-0363-7
    • (2007) Osteoporos Int , vol.18 , Issue.8 , pp. 1073-1082
    • Ominsky, M.S.1    Kostenuik, P.J.2    Cranmer, P.3    Smith, S.Y.4    Atkinson, J.E.5
  • 59
  • 60
    • 85173030302 scopus 로고    scopus 로고
    • European Public Assessment Report. Available at, last accessed 2011
    • European Public Assessment Report. Available at http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/001120/human_med_001324.jsp&murl=menus/medicines/medicines.jsp&mid=WC0b01ac058001d124 (last accessed 2011).
  • 62
    • 84855517766 scopus 로고    scopus 로고
    • Denosumab (Prolia): A new option in the treatment of osteoporosis
    • Belavic JM. Denosumab (Prolia): a new option in the treatment of osteoporosis. Nurse Pract. 2011;36(1):11-2. http://dx.doi.org/10.1097/01.NPR.0000391178.47878.73
    • (2011) Nurse Pract , vol.36 , Issue.1 , pp. 11-12
    • Belavic, J.M.1
  • 63
    • 78650397541 scopus 로고    scopus 로고
    • Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis
    • Lipton A, Goessl C. Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis. Bone. 2011;48(1):96-9. http://dx.doi.org/10.1016/j.bone.2010.10.161
    • (2011) Bone , vol.48 , Issue.1 , pp. 96-99
    • Lipton, A.1    Goessl, C.2
  • 64
    • 52449112052 scopus 로고    scopus 로고
    • Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: A randomized blinded phase 2 clinical trial
    • Miller PD, Bolognese MA, Lewiecki EM, McClung MR, Ding B, Austin M, et al. Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial. Bone. 2008;43(2):222-9. http://dx.doi.org/10.1016/j.bone. 2008.04.007
    • (2008) Bone , vol.43 , Issue.2 , pp. 222-229
    • Miller, P.D.1    Bolognese, M.A.2    Lewiecki, E.M.3    McClung, M.R.4    Ding, B.5    Austin, M.6
  • 65
    • 77952744612 scopus 로고    scopus 로고
    • Treatment of osteoporosis with denosumab
    • Lewiecki EM. Treatment of osteoporosis with denosumab. Maturitas. 2010;66(2):182-6. http://dx.doi.org/10.1016/j.maturitas.2010.02.008
    • (2010) Maturitas , vol.66 , Issue.2 , pp. 182-186
    • Lewiecki, E.M.1
  • 68
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-kB ligant inhibitor, Denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • Body JJ, Facon T, Coleman RE, Lipton A, Geurs F, Fan M, et al. A study of the biological receptor activator of nuclear factor-kB ligant inhibitor, Denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res. 2006;12(4):1221-8. http://dx.doi.org/10.1158/1078-0432.CCR-05-1933
    • (2006) Clin Cancer Res , vol.12 , Issue.4 , pp. 1221-1228
    • Body, J.J.1    Facon, T.2    Coleman, R.E.3    Lipton, A.4    Geurs, F.5    Fan, M.6
  • 69
    • 79960580658 scopus 로고    scopus 로고
    • Drugs for the management of osteoporosis: A review
    • Khajuria DK, Razdan R, Mahapatra DR. Drugs for the management of osteoporosis: a review. Rev Bras Reumatol. 2011;51(4):365-71
    • (2011) Rev Bras Reumatol , vol.51 , Issue.4 , pp. 365-371
    • Khajuria, D.K.1    Razdan, R.2    Mahapatra, D.R.3
  • 70
    • 0037398261 scopus 로고    scopus 로고
    • Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
    • Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest. 2003;111(8):1221-30. http://dx.doi.org/10.1172/JCI200317215
    • (2003) J Clin Invest , vol.111 , Issue.8 , pp. 1221-1230
    • Eghbali-Fatourechi, G.1    Khosla, S.2    Sanyal, A.3    Boyle, W.J.4    Lacey, D.L.5    Riggs, B.L.6
  • 71
    • 0037292208 scopus 로고    scopus 로고
    • The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts
    • Bord S, Ireland DC, Beavan SR, Compston JE. The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts. Bone. 2003;32(2):136-41. http://dx.doi.org/10.1016/S8756-3282(02)00953-5
    • (2003) Bone , vol.32 , Issue.2 , pp. 136-141
    • Bord, S.1    Ireland, D.C.2    Beavan, S.R.3    Compston, J.E.4
  • 72
    • 0028841891 scopus 로고
    • Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause -a clinical research center study
    • McKane WR, Khosla S, Burritt MF, Kao PC, Wilson DM, Ory SJ, et al. Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause -a clinical research center study. J Clin Endocrinol Metab. 1995;80(12):3458-64
    • (1995) J Clin Endocrinol Metab , vol.80 , Issue.12 , pp. 3458-3464
    • McKane, W.R.1    Khosla, S.2    Burritt, M.F.3    Kao, P.C.4    Wilson, D.M.5    Ory, S.J.6
  • 73
    • 0025185276 scopus 로고
    • Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women
    • Gennari C, Agnusdei D, Nardi P, Civitelli R. Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women. J Clin Endocrinol Metab. 1990;71(5):1288-93. http://dx.doi.org/10.1210/jcem-71-5-1288
    • (1990) J Clin Endocrinol Metab , vol.71 , Issue.5 , pp. 1288-1293
    • Gennari, C.1    Agnusdei, D.2    Nardi, P.3    Civitelli, R.4
  • 74
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998;90(18):1371-88. http://dx.doi.org/10.1093/jnci/90.18.1371
    • (1998) J Natl Cancer Inst , vol.90 , Issue.18 , pp. 1371-1388
    • Fisher, B.1    Costantino, J.P.2    Wickerham, D.L.3    Redmond, C.K.4    Kavanah, M.5    Cronin, W.M.6
  • 75
    • 0033305454 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators: Clinical spectrum
    • Cosman F, Lindsay R. Selective estrogen receptor modulators: Clinical spectrum. Endocr Rev. 1999;20(3):418-34
    • (1999) Endocr Rev , vol.20 , Issue.3 , pp. 418-434
    • Cosman, F.1    Lindsay, R.2
  • 76
    • 0033781929 scopus 로고    scopus 로고
    • Raloxifene: A Selective Estrogen Receptor Modulator (SERM) with Multiple Target System Effects
    • Muchmore DB. Raloxifene: A Selective Estrogen Receptor Modulator (SERM) with Multiple Target System Effects. Oncologist. 2000;5(5):388-92. http://dx.doi.org/10.1634/theoncologist.5-5-388
    • (2000) Oncologist , vol.5 , Issue.5 , pp. 388-392
    • Muchmore, D.B.1
  • 77
    • 72649098090 scopus 로고    scopus 로고
    • Histomorphometric analysis and immunolocalization of RANKL and OPG during the alveolar healing process in female ovariectomized rats treated with oestrogen or raloxifene
    • Luvizuto ER, Queiroz TP, Dias SM, Okamoto T, Dornelles RC, Garcia IR Jr, et al. Histomorphometric analysis and immunolocalization of RANKL and OPG during the alveolar healing process in female ovariectomized rats treated with oestrogen or raloxifene. Arch Oral Biol. 2010;55: 52-9. http://dx.doi.org/10.1016/j.archoralbio.2009.11.001
    • (2010) Arch Oral Biol , vol.55 , pp. 52-59
    • Luvizuto, E.R.1    Queiroz, T.P.2    Dias, S.M.3    Okamoto, T.4    Dornelles, R.C.5    Garcia Jr., I.R.6
  • 78
    • 14644422181 scopus 로고    scopus 로고
    • Sodium nitroprusside-induced osteoblast apoptosis is mediated by long chain ceramide and is decreased by raloxifene
    • Olivier S, Fillet M, Malaise M, Piette J, Bours V, Merville MP, et al. Sodium nitroprusside-induced osteoblast apoptosis is mediated by long chain ceramide and is decreased by raloxifene. Biochem Pharmacol. 2005;69(6):891-901. http://dx.doi.org/10.1016/j.bcp.2004.11.030
    • (2005) Biochem Pharmacol , vol.69 , Issue.6 , pp. 891-901
    • Olivier, S.1    Fillet, M.2    Malaise, M.3    Piette, J.4    Bours, V.5    Merville, M.P.6
  • 79
    • 0036171788 scopus 로고    scopus 로고
    • The selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro
    • Taranta A, Brama M, Teti A, De luca V, Scandurra R, Spera G, Agnusdeiet al. The selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro. Bone 2002;30(2): 368-76. http://dx.doi.org/10.1016/S8756-3282(01)00685-8
    • (2002) Bone , vol.30 , Issue.2 , pp. 368-376
    • Taranta, A.1    Brama, M.2    Teti, A.3    de Luca, V.4    Scandurra, R.5    Spera, G.A.6
  • 80
    • 0141564591 scopus 로고    scopus 로고
    • Raloxifene concurrently stimulates osteoprotegerin and inhibits interleukin-6 production by human trabecular osteoblasts
    • Viereck V, Grundker C, Blaschke S, Niederkleine B, Siggelkow H, Frosch KH, et al. Raloxifene concurrently stimulates osteoprotegerin and inhibits interleukin-6 production by human trabecular osteoblasts. J Clin Endocrinol Metab. 2003;88(9):4206-13. http://dx.doi.org/10.1210/jc.2002-021877
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.9 , pp. 4206-4213
    • Viereck, V.1    Grundker, C.2    Blaschke, S.3    Niederkleine, B.4    Siggelkow, H.5    Frosch, K.H.6
  • 81
    • 0036006712 scopus 로고    scopus 로고
    • Effects of oestrogen deficiency on osteoclastogenesis in the rat periodontium
    • Kawamoto S, Ejiri S, Nagaoka E, Ozawa H. Effects of oestrogen deficiency on osteoclastogenesis in the rat periodontium. Arch Oral Bio. 2002;47(1):67-73. http://dx.doi.org/10.1016/S0003-9969(01)00086-3
    • (2002) Arch Oral Bio , vol.47 , Issue.1 , pp. 67-73
    • Kawamoto, S.1    Ejiri, S.2    Nagaoka, E.3    Ozawa, H.4
  • 82
    • 34249690772 scopus 로고    scopus 로고
    • Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro
    • Michael HL, Härkönen PL, Kangas L, Väänänen HK, Hentunen TA. Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro. Br J Pharmacol. 2007;151(3):384-95
    • (2007) Br J Pharmacol , vol.151 , Issue.3 , pp. 384-395
    • Michael, H.L.1    Härkönen, P.L.2    Kangas, L.3    Väänänen, H.K.4    Hentunen, T.A.5
  • 83
    • 84873600944 scopus 로고    scopus 로고
    • Estradiol and Raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR30
    • Noda-Seino H, Sawada K, Hayakawa J, Ohyagi-Hara C, Mabuchi S, Takahashi K, et al. Estradiol and Raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR30. J Endocrinol Invest. 2013;36(1):21-7
    • (2013) J Endocrinol Invest , vol.36 , Issue.1 , pp. 21-27
    • Noda-Seino, H.1    Sawada, K.2    Hayakawa, J.3    Ohyagi-Hara, C.4    Mabuchi, S.5    Takahashi, K.6
  • 84
    • 0035837553 scopus 로고    scopus 로고
    • Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
    • Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344(19):1434-41
    • (2001) N Engl J Med , vol.344 , Issue.19 , pp. 1434-1441
    • Neer, R.M.1    Arnaud, C.D.2    Zanchetta, J.R.3    Prince, R.4    Gaich, G.A.5    Reginster, J.Y.6
  • 85
    • 0027765508 scopus 로고
    • Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid
    • Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature. 1993;366(6455):575-80. http://dx.doi.org/10.1038/366575a0
    • (1993) Nature , vol.366 , Issue.6455 , pp. 575-580
    • Brown, E.M.1    Gamba, G.2    Riccardi, D.3    Lombardi, M.4    Butters, R.5    Kifor, O.6
  • 86
    • 34248577022 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
    • Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone. 2007;40(6):1434-46. http://dx.doi.org/10.1016/j.bone.2007.03.017
    • (2007) Bone , vol.40 , Issue.6 , pp. 1434-1446
    • Jilka, R.L.1
  • 87
    • 77953611907 scopus 로고    scopus 로고
    • Orthopedic uses of teriparatide
    • Bukata SV, Puzas JE. Orthopedic uses of teriparatide. Curr Osteoporos Rep. 2010;8(1):28-33. http://dx.doi.org/10.1007/s11914-010-0006-3
    • (2010) Curr Osteoporos Rep , vol.8 , Issue.1 , pp. 28-33
    • Bukata, S.V.1    Puzas, J.E.2
  • 88
    • 0033022388 scopus 로고    scopus 로고
    • Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures
    • Andreassen TT, Ejersted C, Oxlund H. Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures. J Bone Miner Res. 1999;14(6):960-8. http://dx.doi.org/10.1359/jbmr.1999.14.6.960
    • (1999) J Bone Miner Res , vol.14 , Issue.6 , pp. 960-968
    • Andreassen, T.T.1    Ejersted, C.2    Oxlund, H.3
  • 89
    • 34248544958 scopus 로고    scopus 로고
    • Skeletal actions of intermittent parathyroid hormone: Effects on bone remodelling and structure
    • Compston JE. Skeletal actions of intermittent parathyroid hormone: effects on bone remodelling and structure. Bone. 2007;40(6):1447-52. http://dx.doi.org/10.1016/j.bone.2006.09.008
    • (2007) Bone , vol.40 , Issue.6 , pp. 1447-1452
    • Compston, J.E.1
  • 90
    • 51849095384 scopus 로고    scopus 로고
    • Teriparatide (1-34 human PTH) regulation of osterix during fracture repair
    • Kaback LA, Soung do Y, Naik A, Geneau G, Schwarz EM, Rosier RN, et al. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. J Cell Biochem. 2008;105(1):219-26. http://dx.doi.org/10.1002/jcb.21816
    • (2008) J Cell Biochem , vol.105 , Issue.1 , pp. 219-226
    • Kaback, L.A.1    Soung do, Y.2    Naik, A.3    Geneau, G.4    Schwarz, E.M.5    Rosier, R.N.6
  • 91
    • 0036828498 scopus 로고    scopus 로고
    • Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34)
    • Nakajima A, Shimoji N, Shiomi K, Shimizu S, Moriya H, Einhorn TA, et al. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). J Bone Miner Res. 2002;17(11):2038-47. http://dx.doi.org/10.1359/jbmr. 2002.17.11.2038
    • (2002) J Bone Miner Res , vol.17 , Issue.11 , pp. 2038-2047
    • Nakajima, A.1    Shimoji, N.2    Shiomi, K.3    Shimizu, S.4    Moriya, H.5    Einhorn, T.A.6
  • 92
    • 26944497581 scopus 로고    scopus 로고
    • Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing
    • Nakazawa T, Nakajima A, Shiomi K, Moriya H, Einhorn TA, Yamazaki M. Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing. Bone. 2005;37(5):711-9. http://dx.doi.org/10.1016/j.bone.2005.06.013
    • (2005) Bone , vol.37 , Issue.5 , pp. 711-719
    • Nakazawa, T.1    Nakajima, A.2    Shiomi, K.3    Moriya, H.4    Einhorn, T.A.5    Yamazaki, M.6
  • 93
    • 77953611907 scopus 로고    scopus 로고
    • Orthopedic Uses of Teriparatide
    • Bukata SV, Puzas JE. Orthopedic Uses of Teriparatide. Curr Osteoporos Rep. 2010;8(1):28-33. http://dx.doi.org/10.1007/s11914-010-0006-3
    • (2010) Curr Osteoporos Rep , vol.8 , Issue.1 , pp. 28-33
    • Bukata, S.V.1    Puzas, J.E.2
  • 95
    • 21344454577 scopus 로고    scopus 로고
    • Parathyroid hormone and teriparatide for the treatment of osteoporosis: A review of the evidence and suggested guidelines for its use
    • Hodsman AB, Bauer DC, Dempster DW, Dian L, Hanley DA, Harris ST, et al. Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use. Endocr Rev. 2005;26(5):688-703. http://dx.doi.org/10.1210/er. 2004-0006
    • (2005) Endocr Rev , vol.26 , Issue.5 , pp. 688-703
    • Hodsman, A.B.1    Bauer, D.C.2    Dempster, D.W.3    Dian, L.4    Hanley, D.A.5    Harris, S.T.6
  • 96
    • 77954553687 scopus 로고    scopus 로고
    • Of mice and men: Divergent risks of teriparatide-induced osteosarcoma
    • Subbiah V, Madsen VS, Raymond AK, Benjamin RS, Ludwig JA. Of mice and men: divergent risks of teriparatide-induced osteosarcoma. Osteoporos Int. 2010;21(6):1041-5. http://dx.doi.org/10.1007/s00198-009-1004-0
    • (2010) Osteoporos Int , vol.21 , Issue.6 , pp. 1041-1045
    • Subbiah, V.1    Madsen, V.S.2    Raymond, A.K.3    Benjamin, R.S.4    Ludwig, J.A.5
  • 97
    • 36148958951 scopus 로고    scopus 로고
    • Teriparatide or alendronate in glucocorticoid-induced osteoporosis
    • Saag KG, Shane E, Boonen S, Marin F, Donley DW, Taylor KA, et al. Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N Engl J Med. 2007;357(20):2028-39
    • (2007) N Engl J Med , vol.357 , Issue.20 , pp. 2028-2039
    • Saag, K.G.1    Shane, E.2    Boonen, S.3    Marin, F.4    Donley, D.W.5    Taylor, K.A.6
  • 98
    • 3242887547 scopus 로고    scopus 로고
    • Bone neoplasms in F344 rats given teriparatide [rhPTH(1-34)] are dependent on duration of treatment and dose
    • Vahle JL, Long GG, Sandusky G, Westmore M, Ma YL, Sato M. Bone neoplasms in F344 rats given teriparatide [rhPTH(1-34)] are dependent on duration of treatment and dose. Toxicol Pathol. 2004;32(4):426-38
    • (2004) Toxicol Pathol , vol.32 , Issue.4 , pp. 426-438
    • Vahle, J.L.1    Long, G.G.2    Sandusky, G.3    Westmore, M.4    Ma, Y.L.5    Sato, M.6
  • 99
    • 33646795236 scopus 로고    scopus 로고
    • A no observable carcinogenic effect dose level identified in Fischer 344 rats following daily treatment with PTH(1-84) for 2 years: Role of the Cterminal PTH receptor?
    • Wilker C, Jolette J, Smith S, Doyle N, Hardisty J, Metcalfe AJ, et al. A no observable carcinogenic effect dose level identified in Fischer 344 rats following daily treatment with PTH(1-84) for 2 years: role of the Cterminal PTH receptor?. J Bone Miner Res. 2004;19 Supp 1:SA435
    • (2004) J Bone Miner Res , vol.19 , Issue.SUPPL. 1
    • Wilker, C.1    Jolette, J.2    Smith, S.3    Doyle, N.4    Hardisty, J.5    Metcalfe, A.J.6
  • 100
    • 77952479638 scopus 로고    scopus 로고
    • Teriparatide is safe and effectively increases bone biomarkers in institutionalized individuals with osteoporosis
    • Ryder KM, Tanner SB, Carbone L, Williams JE, Taylor HM, Bush A, et al. Teriparatide is safe and effectively increases bone biomarkers in institutionalized individuals with osteoporosis. J Bone Miner Metab. 2010;28(2):233-9. http://dx.doi.org/10.1007/s00774-009-0123-1
    • (2010) J Bone Miner Metab , vol.28 , Issue.2 , pp. 233-239
    • Ryder, K.M.1    Tanner, S.B.2    Carbone, L.3    Williams, J.E.4    Taylor, H.M.5    Bush, A.6
  • 101
    • 58949102062 scopus 로고    scopus 로고
    • Active comparator trial of teriparatide vs alendronate for treating glucocorticoid-induced osteoporosis: Results from the Hispanic and non-Hispanic cohorts
    • Losada B, Zanchetta J, Zerbini C, Molina J, de la Pena P, Liu C, et al. Active comparator trial of teriparatide vs alendronate for treating glucocorticoid-induced osteoporosis: results from the Hispanic and non-Hispanic cohorts. J Clin Densitom. 2009;12(1):63-70. http://dx.doi.org/10.1016/j.jocd.2008.10.002
    • (2009) J Clin Densitom , vol.12 , Issue.1 , pp. 63-70
    • Losada, B.1    Zanchetta, J.2    Zerbini, C.3    Molina, J.4    de la Pena, P.5    Liu, C.6
  • 103
    • 77953466429 scopus 로고    scopus 로고
    • Strontium ranelate in postmenopausal osteoporosis treatment: A critical appraisal
    • Cesareo R, Napolitano C, Iozzino M. Strontium ranelate in postmenopausal osteoporosis treatment: a critical appraisal. Int J Womens Health. 2010;2:1-6
    • (2010) Int J Womens Health , vol.2 , pp. 1-6
    • Cesareo, R.1    Napolitano, C.2    Iozzino, M.3
  • 104
    • 56749180405 scopus 로고    scopus 로고
    • Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis
    • Roux C, Fechtenbaum J, Kolta S, Isaia G, Andia JB, Devogelaer JP. Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis. Ann Rheum Dis. 2008;67(12):1736-8. http://dx.doi.org/10.1136/ard.2008.094516
    • (2008) Ann Rheum Dis , vol.67 , Issue.12 , pp. 1736-1738
    • Roux, C.1    Fechtenbaum, J.2    Kolta, S.3    Isaia, G.4    Andia, J.B.5    Devogelaer, J.P.6
  • 105
    • 20044361853 scopus 로고    scopus 로고
    • Strontium ranelate: A novel mode of action optimizing bone formation and resorption
    • Marie P. Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporos Int. 2005;16:7-10. http://dx.doi.org/10.1007/s00198-004-1753-8
    • (2005) Osteoporos Int , vol.16 , pp. 7-10
    • Marie, P.1
  • 107
    • 34147177628 scopus 로고    scopus 로고
    • Strontium ranelate: New insights into its dual mode of action
    • 40-S5-8
    • Marie PJ. Strontium ranelate: new insights into its dual mode of action. Bone. 2007;40-S5-8
    • (2007) Bone
    • Marie, P.J.1
  • 108
    • 37349123534 scopus 로고    scopus 로고
    • Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro
    • Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008;42(1):129-38. http://dx.doi.org/10.1016/j.bone.2007.08.043
    • (2008) Bone , vol.42 , Issue.1 , pp. 129-138
    • Bonnelye, E.1    Chabadel, A.2    Saltel, F.3    Jurdic, P.4
  • 109
    • 0037118899 scopus 로고    scopus 로고
    • In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation
    • Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol. 2002;450(1):11-7
    • (2002) Eur J Pharmacol , vol.450 , Issue.1 , pp. 11-17
    • Baron, R.1    Tsouderos, Y.2
  • 110
    • 0142122898 scopus 로고    scopus 로고
    • S 12911-2 Inhibits osteoclastic bone resorption in vitro
    • Takahashi N, Sasaki T, Tsouderos Y, Suda T. S 12911-2 Inhibits osteoclastic bone resorption in vitro. J Bone Miner Res. 2003;18(6):1082-7. http://dx.doi.org/10.1359/jbmr.2003.18.6.1082
    • (2003) J Bone Miner Res , vol.18 , Issue.6 , pp. 1082-1087
    • Takahashi, N.1    Sasaki, T.2    Tsouderos, Y.3    Suda, T.4
  • 111
    • 37349081565 scopus 로고    scopus 로고
    • Extracellular concentrations of strontium directly stimulates osteoclast apoptosis
    • Mentaverri R, Hurtel AS, Kamel S, Robin B, Brazier M. Extracellular concentrations of strontium directly stimulates osteoclast apoptosis. J Bone Min Res. 2003;18:M237. http://dx.doi.org/10.1359/jbmr.2003.18.2.237
    • (2003) J Bone Min Res , vol.18
    • Mentaverri, R.1    Hurtel, A.S.2    Kamel, S.3    Robin, B.4    Brazier, M.5
  • 112
    • 34250870142 scopus 로고    scopus 로고
    • The calciumsensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation
    • Chattopadhyay N, Quinn SJ, Kifor O, Ye C, Brown EM. The calciumsensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation. Biochem Pharmacol. 2007;74(3):438-47. http://dx.doi.org/10.1016/j.bcp.2007.04.020
    • (2007) Biochem Pharmacol , vol.74 , Issue.3 , pp. 438-447
    • Chattopadhyay, N.1    Quinn, S.J.2    Kifor, O.3    Ye, C.4    Brown, E.M.5
  • 113
    • 33847162089 scopus 로고    scopus 로고
    • Induction of a program gene expression during osteoblast differentiation with strontium ranelate
    • Zhu LL, Zaidi S, Peng Y, Zhou H, Moonga BS, Blesius A, et al. Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Biochem Biophys Res Commun. 2007;355(2):307-11. http://dx.doi.org/10.1016/j.bbrc.2007.01.120
    • (2007) Biochem Biophys Res Commun , vol.355 , Issue.2 , pp. 307-311
    • Zhu, L.L.1    Zaidi, S.2    Peng, Y.3    Zhou, H.4    Moonga, B.S.5    Blesius, A.6
  • 114
    • 34247546662 scopus 로고    scopus 로고
    • Osteoblast Differentiation and Bone Formation Gene Expression in Strontium-inducing Bone Marrow Mesenchymal Stem Cell
    • Sila-Asna M, Bunyaratvej A, Maeda S, Kitaguchi H, Bunyaratavej N. Osteoblast Differentiation and Bone Formation Gene Expression in Strontium-inducing Bone Marrow Mesenchymal Stem Cell. Kobe J Med Sci. 2007;53(1-2):25-35
    • (2007) Kobe J Med Sci , vol.53 , Issue.1-2 , pp. 25-35
    • Sila-Asna, M.1    Bunyaratvej, A.2    Maeda, S.3    Kitaguchi, H.4    Bunyaratavej, N.5
  • 115
    • 84861146688 scopus 로고    scopus 로고
    • Evaluation of osteoinduction and proliferation on nano-Sr-HAP: A novel orthopedic biomaterial for bone tissue regeneration
    • Hao Y, Yan H, Wang X, Zhu B, Ning C, Ge S. Evaluation of osteoinduction and proliferation on nano-Sr-HAP: a novel orthopedic biomaterial for bone tissue regeneration. J Nanosci Nanotechnol. 2012;12(1):207-12. http://dx.doi.org/10.1166/jnn.2012.5125
    • (2012) J Nanosci Nanotechnol , vol.12 , Issue.1 , pp. 207-212
    • Hao, Y.1    Yan, H.2    Wang, X.3    Zhu, B.4    Ning, C.5    Ge, S.6
  • 116
    • 80051672618 scopus 로고    scopus 로고
    • The effect of strontium incorporation in hydroxyapatite on osteoblasts in vitro
    • Ni GX, Yao ZP, Huang GT, Liu WG, Lu WW. The effect of strontium incorporation in hydroxyapatite on osteoblasts in vitro. J Mater Sci Mater Med. 2011;22(4):961-7. http://dx.doi.org/10.1007/s10856-011-4264-0
    • (2011) J Mater Sci Mater Med , vol.22 , Issue.4 , pp. 961-967
    • Ni, G.X.1    Yao, Z.P.2    Huang, G.T.3    Liu, W.G.4    Lu, W.W.5
  • 117
    • 79960686859 scopus 로고    scopus 로고
    • Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells
    • Isaac J, Nohra J, Lao J, Jallot E, Nedelec JM, Berdal A, et al. Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells. Eur Cell Mater. 2011;21:130-43
    • (2011) Eur Cell Mater , vol.21 , pp. 130-143
    • Isaac, J.1    Nohra, J.2    Lao, J.3    Jallot, E.4    Nedelec, J.M.5    Berdal, A.6
  • 118
    • 79958143346 scopus 로고    scopus 로고
    • In vitro study in stimulating the secretion of angiogenic growth factors of strontium-doped calcium polyphosphate for bone tissue engineering
    • Liu F, Zhang X, Yu X, Xu Y, Feng T, Ren D. In vitro study in stimulating the secretion of angiogenic growth factors of strontium-doped calcium polyphosphate for bone tissue engineering. J Mater Sci Mater Med. 2011;22(3):683-92. http://dx.doi.org/10.1007/s10856-011-4247-1
    • (2011) J Mater Sci Mater Med , vol.22 , Issue.3 , pp. 683-692
    • Liu, F.1    Zhang, X.2    Yu, X.3    Xu, Y.4    Feng, T.5    Ren, D.6
  • 119
    • 78650718376 scopus 로고    scopus 로고
    • Effects of strontium in modified biomaterials
    • Zhang W, Shen Y, Pan H, Lin K, Liu X, Darvell BW, et al. Effects of strontium in modified biomaterials. Acta Biomater. 2011;7(2):800-8. http://dx.doi.org/10.1016/j.actbio.2010.08.031
    • (2011) Acta Biomater , vol.7 , Issue.2 , pp. 800-808
    • Zhang, W.1    Shen, Y.2    Pan, H.3    Lin, K.4    Liu, X.5    Darvell, B.W.6
  • 120
    • 84866235196 scopus 로고    scopus 로고
    • Osteodifferentiation of human preadipocytes induced by strontium released from hydrogels
    • Nardone V, Fabbri S, Marini F, Zonefrati R, Galli G, Carossino A, et al. Osteodifferentiation of human preadipocytes induced by strontium released from hydrogels. Int J Biomater. 2012;2012:865-291
    • (2012) Int J Biomater , vol.2012 , pp. 865291
    • Nardone, V.1    Fabbri, S.2    Marini, F.3    Zonefrati, R.4    Galli, G.5    Carossino, A.6
  • 121
    • 33646433058 scopus 로고    scopus 로고
    • Regulation of bone mass by Wnt signalling
    • Krishnan V, Bryant HU, Macdougald OA. Regulation of bone mass by Wnt signalling. J Clin Invest. 2006;116(5):1202-9. http://dx.doi.org/10.1172/JCI28551
    • (2006) J Clin Invest , vol.116 , Issue.5 , pp. 1202-1209
    • Krishnan, V.1    Bryant, H.U.2    Macdougald, O.A.3
  • 122
    • 33845981499 scopus 로고    scopus 로고
    • Wnt signaling and osteoblastogenesis
    • Bodine PV and Komm BS. Wnt signaling and osteoblastogenesis. Rev Endocr Metab Disord. 2006;7(1-2):33-9
    • (2006) Rev Endocr Metab Disord , vol.7 , Issue.1-2 , pp. 33-39
    • Bodine, P.V.1    Komm, B.S.2
  • 123
    • 37749036681 scopus 로고    scopus 로고
    • Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells
    • Qiu W, Andersen TE, Bollerslev J, Mandrup S, Abdallah BM, Kassem M. Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells. J Bone Miner Res. 2007;22(11):1720-31. http://dx.doi.org/10.1359/jbmr.070721
    • (2007) J Bone Miner Res , vol.22 , Issue.11 , pp. 1720-1731
    • Qiu, W.1    Andersen, T.E.2    Bollerslev, J.3    Mandrup, S.4    Abdallah, B.M.5    Kassem, M.6
  • 124
    • 34250823973 scopus 로고    scopus 로고
    • Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton
    • Baron R, Rawadi G. Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology. 2007;148(6):2635-43. http://dx.doi.org/10.1210/en.2007-0270
    • (2007) Endocrinology , vol.148 , Issue.6 , pp. 2635-2643
    • Baron, R.1    Rawadi, G.2
  • 125
    • 35648929883 scopus 로고    scopus 로고
    • Gone with the Wnts: Beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism
    • Manolagas SC & Almeida M. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Molecular Endocrinology. 2007; 21(11):2605-14. http://dx.doi.org/10.1210/me.2007-0259
    • (2007) Molecular Endocrinology , vol.21 , Issue.11 , pp. 2605-2614
    • Manolagas, S.C.1    Almeida, M.2
  • 126
    • 28444438846 scopus 로고    scopus 로고
    • Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
    • Clément-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssière B, Belleville C, et al. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A. 2005;102(48):17406-11. http://dx.doi.org/10.1073/pnas.0505259102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.48 , pp. 17406-17411
    • Clément-Lacroix, P.1    Ai, M.2    Morvan, F.3    Roman-Roman, S.4    Vayssière, B.5    Belleville, C.6
  • 127
    • 33646414025 scopus 로고    scopus 로고
    • Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo
    • Kulkarni NH, Onyia JE, Zeng Q, Tian X, Liu M, Halladay DL, Frolik CA et al. Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo. J Bone Miner Res. 2006;21(6):910-20. http://dx.doi.org/10.1359/jbmr.060316
    • (2006) J Bone Miner Res , vol.21 , Issue.6 , pp. 910-920
    • Kulkarni, N.H.1    Onyia, J.E.2    Zeng, Q.3    Tian, X.4    Liu, M.5    Halladay, D.L.6    Frolik, C.A.7
  • 128
    • 79959412176 scopus 로고    scopus 로고
    • Osteoblasts in osteoporosis: Past, emerging, and future anabolic targets
    • Marie PJ, Kassem M. Osteoblasts in osteoporosis: past, emerging, and future anabolic targets. Eur J Endocrinol. 2011;165(1):1-10
    • (2011) Eur J Endocrinol , vol.165 , Issue.1 , pp. 1-10
    • Marie, P.J.1    Kassem, M.2
  • 129
    • 44449099165 scopus 로고    scopus 로고
    • Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    • Li X, Ominsky MS, Niu QT, Sun N, Daugherty B, D'Agostin D, et al. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res. 2008;23(6):860-9. http://dx.doi.org/10.1359/jbmr.080216
    • (2008) J Bone Miner Res , vol.23 , Issue.6 , pp. 860-869
    • Li, X.1    Ominsky, M.S.2    Niu, Q.T.3    Sun, N.4    Daugherty, B.5    D'Agostin, D.6
  • 130
    • 73949153978 scopus 로고    scopus 로고
    • Wnt modulators in the biotech pipeline
    • Rey JP, Ellies DL. Wnt modulators in the biotech pipeline. Dev Dyn. 2010;239(1):102-14
    • (2010) Dev Dyn , vol.239 , Issue.1 , pp. 102-114
    • Rey, J.P.1    Ellies, D.L.2
  • 131
    • 65249158429 scopus 로고    scopus 로고
    • Wnt therapy for bone loss: Golden goose or Trojan horse?
    • Enders GH. Wnt therapy for bone loss: golden goose or Trojan horse?. J Clin Invest. 2009;119(4):758-60. http://dx.doi.org/10.1172/JCI38973
    • (2009) J Clin Invest , vol.119 , Issue.4 , pp. 758-760
    • Enders, G.H.1
  • 132
    • 33646856033 scopus 로고    scopus 로고
    • Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass
    • Morvan F, Boulukos K, Clément-Lacroix P, Roman Roman S, Suc-Royer I, Vayssière B, et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res. 2006;21(6):934-45. http://dx.doi.org/10.1359/jbmr.060311
    • (2006) J Bone Miner Res , vol.21 , Issue.6 , pp. 934-945
    • Morvan, F.1    Boulukos, K.2    Clément-Lacroix, P.3    Roman Roman, S.4    Suc-Royer, I.5    Vayssière, B.6
  • 133
    • 33748156090 scopus 로고    scopus 로고
    • Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
    • Li J, Sarosi I, Cattley RC, Pretorius J, Asuncion F, Grisanti M, et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone. 2006;39(4):754-66. http://dx.doi.org/10.1016/j.bone. 2006.03.017
    • (2006) Bone , vol.39 , Issue.4 , pp. 754-766
    • Li, J.1    Sarosi, I.2    Cattley, R.C.3    Pretorius, J.4    Asuncion, F.5    Grisanti, M.6
  • 134
    • 75149150831 scopus 로고    scopus 로고
    • Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation
    • Guo J, Liu M, Yang D, Bouxsein ML, Saito H, Galvin RJ, et al. Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab. 2010; 11(2):161-71. http://dx.doi.org/10.1016/j.cmet.2009.12.007
    • (2010) Cell Metab , vol.11 , Issue.2 , pp. 161-171
    • Guo, J.1    Liu, M.2    Yang, D.3    Bouxsein, M.L.4    Saito, H.5    Galvin, R.J.6
  • 135
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    • Li X, Ominsky MS, Warmington KS, Morony S, Gong J, Cao J, et al. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res. 2009;24(4):578-88. http://dx.doi.org/10.1359/jbmr.081206
    • (2009) J Bone Miner Res , vol.24 , Issue.4 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3    Morony, S.4    Gong, J.5    Cao, J.6
  • 136
    • 78650958526 scopus 로고    scopus 로고
    • Single-dose, placebocontrolled, randomized study of AMG 785, a sclerostin monoclonal antibody
    • Padhi D, Jang G, Stouch B, Fang L, Posvar E. Single-dose, placebocontrolled, randomized study of AMG 785, a sclerostin monoclonal antibody. J Bone Miner Res. 2011;26(1):19-26. http://dx.doi.org/10.1002/jbmr.173
    • (2011) J Bone Miner Res , vol.26 , Issue.1 , pp. 19-26
    • Padhi, D.1    Jang, G.2    Stouch, B.3    Fang, L.4    Posvar, E.5
  • 137
    • 77953481395 scopus 로고    scopus 로고
    • Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength
    • Ominsky MS, Vlasseros F, Jolette J, Smith SY, Stouch B, Doellgast G, et al. Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength. J Bone Miner Res. 2010;25(5):948-59. http://dx.doi.org/10.1002/jbmr. 14
    • (2010) J Bone Miner Res , vol.25 , Issue.5 , pp. 948-959
    • Ominsky, M.S.1    Vlasseros, F.2    Jolette, J.3    Smith, S.Y.4    Stouch, B.5    Doellgast, G.6
  • 138
    • 77956815310 scopus 로고    scopus 로고
    • Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats
    • Li X, Warmington KS, Niu QT, Asuncion FJ, Barrero M, Grisanti M, et al. Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats. J Bone Miner Res. 2010;25(12):2647-56. http://dx.doi.org/10.1002/jbmr.182
    • (2010) J Bone Miner Res , vol.25 , Issue.12 , pp. 2647-2656
    • Li, X.1    Warmington, K.S.2    Niu, Q.T.3    Asuncion, F.J.4    Barrero, M.5    Grisanti, M.6
  • 139
    • 70350660877 scopus 로고    scopus 로고
    • Recent advances toward the clinical application of PTH (1-34) in fracture healing
    • Cipriano CA, Issack PS, Shindle L, Werner CM, Helfet DL, Lane JM. Recent advances toward the clinical application of PTH (1-34) in fracture healing. HSS J. 2009;5(2):149-53
    • (2009) HSS J , vol.5 , Issue.2 , pp. 149-153
    • Cipriano, C.A.1    Issack, P.S.2    Shindle, L.3    Werner, C.M.4    Helfet, D.L.5    Lane, J.M.6
  • 140
    • 20844432225 scopus 로고    scopus 로고
    • Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters
    • Arlot M, Meunier PJ, Boivin G, Haddock L, Tamayo J, Correa-Rotter R, et al. Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters. Bone Miner Res. 2005;20(7):1244-53. http://dx.doi.org/10.1359/JBMR.050309
    • (2005) Bone Miner Res , vol.20 , Issue.7 , pp. 1244-1253
    • Arlot, M.1    Meunier, P.J.2    Boivin, G.3    Haddock, L.4    Tamayo, J.5    Correa-Rotter, R.6
  • 141
    • 84860492889 scopus 로고    scopus 로고
    • Hip cortical thickness assessment in postmenopausal women with osteoporosis and strontium ranelate effect on hip geometry
    • Briot K, Benhamou CL, Roux C. Hip cortical thickness assessment in postmenopausal women with osteoporosis and strontium ranelate effect on hip geometry. J Clin Densitom. 2012;15(2):176-85. http://dx.doi.org/10.1016/j.jocd.2011.11.006.
    • (2012) J Clin Densitom , vol.15 , Issue.2 , pp. 176-185
    • Briot, K.1    Benhamou, C.L.2    Roux, C.3


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