Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation

Cell Metabolism

Volumn 11, Issue 2, 2010, Pages 161-171

  Guo, Jun ^a   Liu, Minlin ^a   Yang, Dehong ^a   Bouxsein, Mary L ^b   Saito, Hiroaki ^c   Galvin, R J Sells ^d   Kuhstoss, Stuart A ^d   Thomas, Clare C ^a   Schipani, Ernestina ^a   Baron, Roland ^c   Bringhurst, F Richard ^a   Kronenberg, Henry M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

HUMDISEASE

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; LYMPHOID ENHANCER FACTOR 1; PARATHYROID HORMONE; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM INTAKE; CELL FUNCTION; CONTROLLED STUDY; EMBRYO; HORMONE ACTION; MOUSE; NONHUMAN; OSSIFICATION; OSTEITIS FIBROSA; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; SECONDARY HYPERPARATHYROIDISM; SIGNAL TRANSDUCTION; STROMA CELL;

ANIMALS; BONE MARROW CELLS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; PARATHYROID HORMONE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STROMAL CELLS; WNT PROTEINS;

MUS;

EID: 75149150831     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2009.12.007     Document Type: Article

References (40)

1. Babij P., Zhao W., Small C., Kharode Y., Yaworsky P.J., Bouxsein M.L., Reddy P.S., Bodine P.V., Robinson J.A., Bhat B., et al. High bone mass in mice expressing a mutant LRP5 gene. J. Bone Miner. Res. 18 (2003) 960-974
2. Bellido T. Downregulation of SOST/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes. J. Musculoskelet. Neuronal Interact. 6 (2006) 358-359
3. Bellido T., Ali A.A., Gubrij I., Plotkin L.I., Fu Q., O'Brien C.A., Manolagas S.C., and Jilka R.L. Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology 146 (2005) 4577-4583
4. Boyden L.M., Mao J., Belsky J., Mitzner L., Farhi A., Mitnick M.A., Wu D., Insogna K., and Lifton R.P. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346 (2002) 1513-1521
5. Calvi L.M., Sims N.A., Hunzelman J.L., Knight M.C., Giovannetti A., Saxton J.M., Kronenberg H.M., Baron R., and Schipani E. Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J. Clin. Invest. 107 (2001) 277-286
6. Castellone M.D., Teramoto H., Williams B.O., Druey K.M., and Gutkind J.S. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 310 (2005) 1504-1510
7. DasGupta R., and Fuchs E. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126 (1999) 4557-4568
8. Day T.F., Guo X., Garrett-Beal L., and Yang Y. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev. Cell 8 (2005) 739-750
9. Fleming H.E., Janzen V., Lo Celso C., Guo J., Leahy K.M., Kronenberg H.M., and Scadden D.T. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2 (2008) 274-283
10. Glass II D.A., Bialek P., Ahn J.D., Starbuck M., Patel M.S., Clevers H., Taketo M.M., Long F., McMahon A.P., Lang R.A., and Karsenty G. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev. Cell 8 (2005) 751-764
11. Glinka A., Wu W., Delius H., Monaghan A.P., Blumenstock C., and Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391 (1998) 357-362
12. Goessling W., North T.E., Loewer S., Lord A.M., Lee S., Stoick-Cooper C.L., Weidinger G., Puder M., Daley G.Q., Moon R.T., and Zon L.I. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 136 (2009) 1136-1147
13. Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., Wang H., Cundy T., Glorieux F.H., Lev D., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107 (2001) 513-523
14. Guo J., Chung U.I., Kondo H., Bringhurst F.R., and Kronenberg H.M. The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev. Cell 3 (2002) 183-194
15. He X., Semenov M., Tamai K., and Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development 131 (2004) 1663-1677
16. Hill T.P., Spater D., Taketo M.M., Birchmeier W., and Hartmann C. Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev. Cell 8 (2005) 727-738
17. Hino S., Tanji C., Nakayama K.I., and Kikuchi A. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. Mol. Cell. Biol. 25 (2005) 9063-9072
18. Hodsman A.B., Bauer D.C., Dempster D.W., Dian L., Hanley D.A., Harris S.T., Kendler D.L., McClung M.R., Miller P.D., Olszynski W.P., et al. Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use. Endocr. Rev. 26 (2005) 688-703
19. Holmen S.L., Zylstra C.R., Mukherjee A., Sigler R.E., Faugere M.C., Bouxsein M.L., Deng L., Clemens T.L., and Williams B.O. Essential role of beta-catenin in postnatal bone acquisition. J. Biol. Chem. 280 (2005) 21162-21168
20. Jilka R.L. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40 (2007) 1434-1446
21. Kulkarni N.H., Halladay D.L., Miles R.R., Gilbert L.M., Frolik C.A., Galvin R.J., Martin T.J., Gillespie M.T., and Onyia J.E. Effects of parathyroid hormone on Wnt signaling pathway in bone. J. Cell. Biochem. 95 (2005) 1178-1190
22. Leupin O., Kramer I., Collette N.M., Loots G.G., Natt F., Kneissel M., and Keller H. Control of the SOST bone enhancer by PTH using MEF2 transcription factors. J. Bone Miner. Res. 22 (2007) 1957-1967
23. Li J., Sarosi I., Cattley R.C., Pretorius J., Asuncion F., Grisanti M., Morony S., Adamu S., Geng Z., Qiu W., et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 39 (2006) 754-766
24. Liu Z., and Habener J.F. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J. Biol. Chem. 283 (2008) 8723-8735
25. Lotinun S., Sibonga J.D., and Turner R.T. Evidence that the cells responsible for marrow fibrosis in a rat model for hyperparathyroidism are preosteoblasts. Endocrinology 146 (2005) 4074-4081
26. Marvin M.J., Di Rocco G., Gardiner A., Bush S.M., and Lassar A.B. Inhibition of Wnt activity induces heart formation from posterior mesoderm. Genes Dev. 15 (2001) 316-327
27. Miao D., He B., Jiang Y., Kobayashi T., Soroceanu M.A., Zhao J., Su H., Tong X., Amizuka N., Gupta A., et al. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J. Clin. Invest. 115 (2005) 2402-2411
28. Morvan F., Boulukos K., Clement-Lacroix P., Roman Roman S., Suc-Royer I., Vayssiere B., Ammann P., Martin P., Pinho S., Pognonec P., et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J. Bone Miner. Res. 21 (2006) 934-945
29. Mukhopadhyay M., Shtrom S., Rodriguez-Esteban C., Chen L., Tsukui T., Gomer L., Dorward D.W., Glinka A., Grinberg A., Huang S.P., et al. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev. Cell 1 (2001) 423-434
30. Rodda S.J., and McMahon A.P. Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133 (2006) 3231-3244
31. Suzuki A., Ozono K., Kubota T., Kondou H., Tachikawa K., and Michigami T. PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells. J. Cell. Biochem. 104 (2008) 304-317
32. Taurin S., Sandbo N., Qin Y., Browning D., and Dulin N.O. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. J. Biol. Chem. 281 (2006) 9971-9976
33. Taurin S., Hogarth K., Sandbo N., Yau D.M., and Dulin N.O. Gbetagamma-mediated prostacyclin production and cAMP-dependent protein kinase activation by endothelin-1 promotes vascular smooth muscle cell hypertrophy through inhibition of glycogen synthase kinase-3. J. Biol. Chem. 282 (2007) 19518-19525
34. Taurin S., Sandbo N., Yau D.M., Sethakorn N., and Dulin N.O. Phosphorylation of beta-catenin by PKA promotes ATP-induced proliferation of vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 294 (2008) C1169-C1174
35. Tobimatsu T., Kaji H., Sowa H., Naito J., Canaff L., Hendy G.N., Sugimoto T., and Chihara K. Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells. Endocrinology 147 (2006) 2583-2590
36. Wan M., Yang C., Li J., Wu X., Yuan H., Ma H., He X., Nie S., Chang C., and Cao X. Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev. 22 (2008) 2968-2979
37. Wang F.S., Ko J.Y., Lin C.L., Wu H.L., Ke H.J., and Tai P.J. Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats. Bone 40 (2007) 485-492
38. Yaccoby S., Ling W., Zhan F., Walker R., Barlogie B., and Shaughnessy Jr. J.D. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 109 (2007) 2106-2111
39. Yadav V.K., Ryu J.H., Suda N., Tanaka K.F., Gingrich J.A., Schutz G., Glorieux F.H., Chiang C.Y., Zajac J.D., Insogna K.L., et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135 (2008) 825-837
40. Yang D., Singh R., Divieti P., Guo J., Bouxsein M.L., and Bringhurst F.R. Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone. Bone 40 (2007) 1453-1461