Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures

Journal of Bone and Mineral Research

Volumn 22, Issue 12, 2007, Pages 1903-1912

  Kakar, Sanjeev ^a   Einhorn, Thomas A ^a   Vora, Siddharth ^b   Miara, Lincoln J ^a   Hon, Gregory ^a   Wigner, Nathan A ^a   Toben, Daniel ^a   Jacobsen, Kimberly A ^a   Al Sebaei, Maisa O ^a,b   Song, Michael ^a   Trackman, Philip C ^b   Morgan, Elise F ^a,b   Gerstenfeld, Louis C ^a   Barnes, George L ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

catenin; Chondrogenesis; Endochondral bone repair; Fracture; Osteogenesis; PTH; Wnts

Indexed keywords

BETA CATENIN; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; SODIUM CHLORIDE; UNCLASSIFIED DRUG; WNT PROTEIN; WNT10B PROTEIN; WNT4 PROTEIN; WNT5A PROTEIN; WNT5B PROTEIN; BONE DENSITY CONSERVATION AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REMODELING; CALLUS; CHONDROGENESIS; CONTROLLED STUDY; DRUG MECHANISM; ENCHONDRAL OSSIFICATION; FEMUR FRACTURE; FRACTURE; FRACTURE HEALING; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOPOROSIS; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; WESTERN BLOTTING; ANIMAL; CARTILAGE CELL; CELL DIFFERENTIATION; DISEASE MODEL; DRUG EFFECT; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; CELL DIFFERENTIATION; CHONDROCYTES; CHONDROGENESIS; DISEASE MODELS, ANIMAL; FEMORAL FRACTURES; FRACTURE HEALING; MALE; MICE; SIGNAL TRANSDUCTION; TERIPARATIDE; WNT PROTEINS;

EID: 38749144432     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070724     Document Type: Article

References (44)

1. Beaver R, Brinker MR, Barrack RL 1997 An analysis of the actual cost of tibial nonunions. J La State Med Soc 149:200-206.
2. Andreassen TT, Ejersted C, Oxlund H 1499 Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures. J Bone Miner Res 14:960-968.
3. Holzer G, Majeska RJ, Lundy MW, Hartke JR, Einhorn TA 1999 Parathyroid hormone enhances fracture healing. Clin Orthop 366:258-263.
4. Nakajima A, Shimoji N, Shiomi K, Shimizu S, Moriya H, Einhorn TA, Yamazaki M 7002 Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). J Bone Miner Res 17:2038-2047.
5. Kim HW, Jahng JS 1999 Effect of intermittent administration of parathyroid hormone on fracture healing in ovariectomized rats. Iowa Orthop J 19:71-77.
6. Bostrom MP, Gamradt SC, Asnis P, Vickery BH, Hill E, Avnur Z, Waters RV 2000 Parathyroid hormone-related protein protein analog RS-66271 is an effective therapy for impaired bone healing in rabbits on corticosteroid therapy. Bone 2:437-442.
7. Hock JM, Krishnan V, Onyia JE, Bidwell JP, Milas J, Stanislaus D 2001 Osteoblast apoptosis and bone turnover. J Bone Miner Res 16:975-984.
8. Hock JM 2001 Anabolic actions of PTH in the skeletons of animals. J Musculoskelet Neuronal Interact 2:33-47.
9. Hodsman AB, Bauer DC, Dempster DW, Dian L, Hanley DA, Harris ST, Kendler DL, McClung MR, Miller PD, Olszynski WP 2005 Parathyroid hormone and teriparatide for the treatment of osteoporosis: A review of the evidence and suggested guidelines for its use. Endocrinol Rev 26:688-703.
10. Alkhiary YM, Gerstenfeld LC, Krall E, Westmore M, Sato M, Mitlak BH, Einhorn TA 2005 Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg Am 87:731-741.
11. Andreassen TT, Ejersted C, Oxlund H 1999 Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures. J Bone Miner Res 14:960-968.
12. Andreassen TT, Fledelius C, Ejersted C, Oxlund H 2001 Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone. Acta Orthop Scand 72:304-307.
13. Komatsubara S, Mori S, Mashiba T, Nonaka K, Seki A, Akiyama T, Miyamoto K, Cao Y, Manabe T, Norimatsu H 2005. Human parathyroid hormone (1-34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora. Bone 36:678-687.
14. Nakajima A, Shimoji N, Shiomi K, Shimizu S, Moriya H, Einhorn TA, Yamazaki M 2002. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). J Bone Miner Res 17:2038-2047.
15. Nakazawa T, Nakajima A, Shiomi K, Moriya H, Einhorn TA, Yamazuki M 2005 Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing. Bone 37:711-719.
16. Chung U, Lanske B, Lee K, Li E, Kronenberg H 1998 The parathyroid hormone / parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci USA 95:13030-13035.
17. Kobayashi T, Soegiarto DW, Yang Y, Lanske B, Schipani E, McMahon AP, Kronenberg HM 2005 Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest 115:1734-1742.
18. Long F, Chung U, Ohba S, McMahon J, Kronenberg HM, McMahon AP 2003 Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131:1309-1318.
19. Miao D, He B, Karaplis AC, Goltzman D 2002 Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109:1173-1182.
20. Rodda SJ, McMahon AP 2006 Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133:3231-3244.
21. Huang W, Chung UI, Kronenberg HM, de Crombrugghe B 2001 The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci USA 98:160-165.
22. Ferguson CM, Miclau T, Hu D, Alpern E, Helms JA 1998 Common molecular pathways in skeletal morphogenesis and repair. Ann NY Acad Sci 857:33-42.
23. Ferguson C, Alpern E, Miclau T, Helms JA 1999 Does adult fracture repair recapitulate embryonic skeletal formation. Mech Dev 87:57-66.
24. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Juppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML. Osteoporosis-Pseudoglioma Syndrome Collaborative Group 2001 LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107:513-523.
25. Ferrari SL, Deutsch S, Antonaraski SE 2005 Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass. Curr Opin Lipidol 16:207-214.
26. Rawadi G, Vaysierre B, Dunn F, Baron R, Roman Roman S 2003 BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 18:1842-1853.
27. Westendorf JJ, Kahler R, Schroeder TM 2004 Wnt signaling in osteoblast and bone diseases. Gene 341:19-39.
28. Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C 2005 Canonical Wnt /beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8:727-738.
29. Day TF, Guo X, Garrett-Beal L, Yang Y 2005 Wnt /betacatenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8:739-750.
30. Glass DA, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G 2005 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8:751-764.
31. Hu H, Hilton MJ, Tu X, Yn K, Ornitz DM, Long F 2004 Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132:49-60.
32. Kon T, Cho TJ, Aizawa T, Yamazaki M, Nooh N, Graves D, Gerstenfeld LC, Einhorn TA 2001 Expression of osteoprofogerin, receptor activator of NF-KappaB ligand and related proinflammatory cytokines during fracture healing. J Bone Miner Res 16:1004-1014.
33. Bonnarens F, Einhorn TA 1984 Production of a standard closed fracture in laboratory annual bone. J Orthop Res 2:97-101.
34. Gerstenfeld LC, Cho TJ, Kon T, Aizawa T, Tsay A, Fitch J, Barnes GL, Graves DT, Einhorn TA 2003 Impaired fracture healing in the absence of TNF-alpha signaling: The role of TNF-alpha in endochondral cartilage resorption. J Bone Miner Res 18:1584-1592.
35. Wang K, Vishwanath P, Eichler GS, Al-Sebaei MO, Edgar CM, Einhorn TA, Smith TF, Gerstenfeld LC 2006 Analysis of fracture healing by large-scale transcriptional profile identified temporal relation ships between metalloproteinase and ADAMTS mRNA expression. Matrix Biol 25:771-281.
36. Hadjiargyrou M, Lombardo F, Zhao S, Ahrens W, Joo J, Ahn H, Jurman M, White DW, Rubin CT 2002 Transcriptional pro filing of bone regeneration. Insight into the molecular complexity of wound repair. J Biol Chem 277:30177- 30182.
37. Zhong N, Gersch RP, Hadjiargyrou M 2006 Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation. Bone 39:5-16.
38. Yates KE, Shortkroff S, Reish RG 2005 Wnt influence on chondrocyte differentiation and cartilage function. DNA. Cell Biol 24:446-457.
39. Church V, Nohno T, Linker C, Marcelle C, Francis West P 2002 Wnt regulation of chondrocyte differentiation. J Cell Sci 115:4809-1818.
40. Ryu J, Kim S, Kim S, Oh CD, Hwang SG, Chun CH, Oh SH, Seong JK, Huh TL, Chun JS 2002 Regulation of the chondrocyte phenotype by beta-catenin. Development 129:5541-5550.
41. Yang Y, Topol L, Lee H, Wu J 2003 Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development 130:1003-1015.
42. Bennett CN, Longo KA, Wright WS, Suva LJ, Lane TF, Hankenson KD, MacDougald OA 2005 Regulation of osteoblastogenesis and bone mass by Wnt 10b. Proc Natl Acad Sci USA 102:3324-3329.
43. Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y 2003 Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol 162:899-908.
44. 2+ pathway to antagonize wnt / beta catenin signaling. Mol Cell Biol 23:131-139.