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Volumn 42, Issue 1, 2008, Pages 129-138

Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro

Author keywords

Bone formation; Cytoskeleton; Osteoblast; Osteoclast; Strontium ranelate

Indexed keywords

ACTIN; ANABOLIC AGENT; BIOLOGICAL MARKER; STRONTIUM RANELATE;

EID: 37349123534     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.08.043     Document Type: Article
Times cited : (726)

References (43)
  • 1
    • 17644382533 scopus 로고    scopus 로고
    • Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats
    • Ammann P., Shen V., Robin B., Mauras Y., Bonjour J.P., and Rizzoli R. Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. J Bone Miner Res 19 (2004) 2012-2020
    • (2004) J Bone Miner Res , vol.19 , pp. 2012-2020
    • Ammann, P.1    Shen, V.2    Robin, B.3    Mauras, Y.4    Bonjour, J.P.5    Rizzoli, R.6
  • 2
    • 33744942990 scopus 로고    scopus 로고
    • The effects of strontium ranelate on bone remodeling and bone safety assessed by histomorphometry in patients with postmenopausal osteoporosis
    • Arlot M.E., Delmas P., Burt-Pichat B., Roux J.P., Portero N., and Meunier P.J. The effects of strontium ranelate on bone remodeling and bone safety assessed by histomorphometry in patients with postmenopausal osteoporosis. J Bone Miner Res 20 (2005) S22
    • (2005) J Bone Miner Res , vol.20
    • Arlot, M.E.1    Delmas, P.2    Burt-Pichat, B.3    Roux, J.P.4    Portero, N.5    Meunier, P.J.6
  • 3
    • 33845210921 scopus 로고    scopus 로고
    • Mesenchymal stem cells and osteoblast differentiation
    • Bilezikian J.P., Raisz L.G., and Rodan G.A. (Eds), Academic Press, San Diego
    • Aubin J., and TJT. Mesenchymal stem cells and osteoblast differentiation. In: Bilezikian J.P., Raisz L.G., and Rodan G.A. (Eds). Principles of Bone Biology (2002), Academic Press, San Diego 59-81
    • (2002) Principles of Bone Biology , pp. 59-81
    • Aubin, J.1    TJT2
  • 4
    • 1842531000 scopus 로고    scopus 로고
    • Normal matrix mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells
    • Barbara A., Delannoy P., Denis B.G., and Marie P.J. Normal matrix mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells. Metabolism 53 (2004) 532-537
    • (2004) Metabolism , vol.53 , pp. 532-537
    • Barbara, A.1    Delannoy, P.2    Denis, B.G.3    Marie, P.J.4
  • 5
    • 0037118899 scopus 로고    scopus 로고
    • In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation
    • Baron R., and Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 450 (2002) 11-17
    • (2002) Eur J Pharmacol , vol.450 , pp. 11-17
    • Baron, R.1    Tsouderos, Y.2
  • 6
    • 0022569874 scopus 로고
    • Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations
    • Bellows C.G., Aubin J.E., Heersche J.N.M., and Antosz M.E. Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations. Calcif Tissue Int 38 (1986) 143-154
    • (1986) Calcif Tissue Int , vol.38 , pp. 143-154
    • Bellows, C.G.1    Aubin, J.E.2    Heersche, J.N.M.3    Antosz, M.E.4
  • 7
    • 0035947765 scopus 로고    scopus 로고
    • The orphan nuclear estrogen receptor-related receptor (ERR) is expressed throughout osteoblast differentiation and regulates bone formation in vitro
    • Bonnelye E., Merdad L., Kung V., and Aubin J.E. The orphan nuclear estrogen receptor-related receptor (ERR) is expressed throughout osteoblast differentiation and regulates bone formation in vitro. J Cell Biol 153 (2001) 971-983
    • (2001) J Cell Biol , vol.153 , pp. 971-983
    • Bonnelye, E.1    Merdad, L.2    Kung, V.3    Aubin, J.E.4
  • 8
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle W.J., Simonet W.S., and Lacey D.L. Osteoclast differentiation and activation. Nature 423 (2003) 337-342
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 9
    • 0141499869 scopus 로고    scopus 로고
    • Is the calcium receptor a molecular target for the actions of strontium on bone?
    • Brown E. Is the calcium receptor a molecular target for the actions of strontium on bone?. Osteoporosis Int 14 (2003) S34-S35
    • (2003) Osteoporosis Int , vol.14
    • Brown, E.1
  • 10
    • 0030176233 scopus 로고    scopus 로고
    • The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro
    • Canalis E., Hott M., Deloffre P., Tsouderos Y., and Marie P.J. The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone 18 (1996) 517-523
    • (1996) Bone , vol.18 , pp. 517-523
    • Canalis, E.1    Hott, M.2    Deloffre, P.3    Tsouderos, Y.4    Marie, P.J.5
  • 11
    • 4644294488 scopus 로고    scopus 로고
    • In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor
    • Coulombe J., Faure H., Robin B., and Ruat M. In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor. Biochem Biophys Res Commun 323 (2004) 1184-1190
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 1184-1190
    • Coulombe, J.1    Faure, H.2    Robin, B.3    Ruat, M.4
  • 12
    • 0038780897 scopus 로고    scopus 로고
    • Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities
    • Delaisse J.M., Andersen T.L., Engsig M.T., Henriksen K., Troen T., and Blavier L. Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities. Microsc Res Tech 61 (2003) 504-513
    • (2003) Microsc Res Tech , vol.61 , pp. 504-513
    • Delaisse, J.M.1    Andersen, T.L.2    Engsig, M.T.3    Henriksen, K.4    Troen, T.5    Blavier, L.6
  • 13
    • 0037329229 scopus 로고    scopus 로고
    • Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein
    • Destaing O., Saltel F., Geminard J.C., Jurdic P., and Bard F. Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein. Mol Biol Cell 14 (2003) 407-416
    • (2003) Mol Biol Cell , vol.14 , pp. 407-416
    • Destaing, O.1    Saltel, F.2    Geminard, J.C.3    Jurdic, P.4    Bard, F.5
  • 14
    • 0036774692 scopus 로고    scopus 로고
    • Three-dimensional distribution of the clear zone of migrating osteoclasts on dentin slices in vitro
    • Domon T., Yamazaki Y., Fukui A., Ohnishi Y., Takahashi S., Yamamoto T., and Wakita M. Three-dimensional distribution of the clear zone of migrating osteoclasts on dentin slices in vitro. Tissue Cell 34 (2002) 326-336
    • (2002) Tissue Cell , vol.34 , pp. 326-336
    • Domon, T.1    Yamazaki, Y.2    Fukui, A.3    Ohnishi, Y.4    Takahashi, S.5    Yamamoto, T.6    Wakita, M.7
  • 15
    • 33747890716 scopus 로고    scopus 로고
    • Strontium ranelate stimulates murine osteoblast replication independently of calcium sensing receptor-mediated ERK1/2 activation
    • Fromigué O., Barbara A., Hay E., Petrel C.E., Traiffort E., Ruat M., et al. Strontium ranelate stimulates murine osteoblast replication independently of calcium sensing receptor-mediated ERK1/2 activation. Calcif Tissues Int 78 (2006) 147
    • (2006) Calcif Tissues Int , vol.78 , pp. 147
    • Fromigué, O.1    Barbara, A.2    Hay, E.3    Petrel, C.E.4    Traiffort, E.5    Ruat, M.6
  • 16
    • 0028989486 scopus 로고
    • Macrophage inflammatory protein-1 alpha and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts
    • Fuller K., Owens J.M., and Chambers T.J. Macrophage inflammatory protein-1 alpha and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts. J Immunol 154 (1995) 6065-6072
    • (1995) J Immunol , vol.154 , pp. 6065-6072
    • Fuller, K.1    Owens, J.M.2    Chambers, T.J.3
  • 17
    • 0027368962 scopus 로고
    • Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts
    • Fuller K., Owens J.M., Jagger C.J., Wilson A., Moss R., and Chambers T.J. Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts. J Exp Med 178 (1993) 1733-1744
    • (1993) J Exp Med , vol.178 , pp. 1733-1744
    • Fuller, K.1    Owens, J.M.2    Jagger, C.J.3    Wilson, A.4    Moss, R.5    Chambers, T.J.6
  • 18
    • 0042707618 scopus 로고    scopus 로고
    • S12911-2 reduces bone loss induced by short-term immobilization in rats
    • Hott M., Deloffre P., Tsouderos Y., and Marie P.J. S12911-2 reduces bone loss induced by short-term immobilization in rats. Bone 33 (2003) 115-123
    • (2003) Bone , vol.33 , pp. 115-123
    • Hott, M.1    Deloffre, P.2    Tsouderos, Y.3    Marie, P.J.4
  • 19
    • 33644950260 scopus 로고    scopus 로고
    • Podosome and sealing zone: specificity of the osteoclast model
    • Jurdic P., Saltel F., Chabadel A., and Destaing O. Podosome and sealing zone: specificity of the osteoclast model. Eur J Cell Biol. 85 (2006) 195-202
    • (2006) Eur J Cell Biol. , vol.85 , pp. 195-202
    • Jurdic, P.1    Saltel, F.2    Chabadel, A.3    Destaing, O.4
  • 20
    • 0038688373 scopus 로고    scopus 로고
    • The complexities of skeletal biology
    • Karsenty G. The complexities of skeletal biology. Nature 423 (2003) 316-318
    • (2003) Nature , vol.423 , pp. 316-318
    • Karsenty, G.1
  • 21
    • 33751197049 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation by transcription factors
    • Komori T. Regulation of osteoblast differentiation by transcription factors. J Cell Biochem 99 (2006) 1233-1239
    • (2006) J Cell Biochem , vol.99 , pp. 1233-1239
    • Komori, T.1
  • 22
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 (1998) 165-176
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3    Kelley, M.J.4    Dunstan, C.R.5    Burgess, T.6
  • 23
    • 0027316220 scopus 로고
    • An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats
    • Marie P.J., Hott M., Modrowski D., De Pollak C., Guillemain J., Deloffre P., et al. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J Bone Miner Res 8 (1993) 607-615
    • (1993) J Bone Miner Res , vol.8 , pp. 607-615
    • Marie, P.J.1    Hott, M.2    Modrowski, D.3    De Pollak, C.4    Guillemain, J.5    Deloffre, P.6
  • 24
    • 37349081565 scopus 로고    scopus 로고
    • Extracellular concentrations of strontium directly stimulates osteoclast apoptosis
    • Mentaverri R., Hurtel A.S., Kamel S., Robin B., and Brazier M. Extracellular concentrations of strontium directly stimulates osteoclast apoptosis. J Bone Miner Res 18 (2003) M237
    • (2003) J Bone Miner Res , vol.18
    • Mentaverri, R.1    Hurtel, A.S.2    Kamel, S.3    Robin, B.4    Brazier, M.5
  • 25
    • 9144233479 scopus 로고    scopus 로고
    • The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    • Meunier P.J., Roux C., Seeman E., Ortolani S., Badurski J.E., Spector T.D., et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350 (2004) 459-468
    • (2004) N Engl J Med , vol.350 , pp. 459-468
    • Meunier, P.J.1    Roux, C.2    Seeman, E.3    Ortolani, S.4    Badurski, J.E.5    Spector, T.D.6
  • 26
    • 18344379873 scopus 로고    scopus 로고
    • Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis-a 2-year randomized placebo controlled trial
    • Meunier P.J., Slosman D.O., Delmas P.D., Sebert J.L., Brandi M.L., Albanese C., et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis-a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 87 (2002) 2060-2066
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2060-2066
    • Meunier, P.J.1    Slosman, D.O.2    Delmas, P.D.3    Sebert, J.L.4    Brandi, M.L.5    Albanese, C.6
  • 28
    • 28844442189 scopus 로고    scopus 로고
    • Identification of a novel extracellular cation-sensing G-protein-coupled receptor
    • Pi M., Faber P., Ekema G., Jackson P.D., Ting A., Wang N., et al. Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem 280 (2005) 40201-40209
    • (2005) J Biol Chem , vol.280 , pp. 40201-40209
    • Pi, M.1    Faber, P.2    Ekema, G.3    Jackson, P.D.4    Ting, A.5    Wang, N.6
  • 29
    • 3242810659 scopus 로고    scopus 로고
    • A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium
    • Pi M., and Quarles L.D. A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium. J Bone Miner Res 19 (2004) 862-869
    • (2004) J Bone Miner Res , vol.19 , pp. 862-869
    • Pi, M.1    Quarles, L.D.2
  • 30
    • 0031980097 scopus 로고    scopus 로고
    • Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in vitro
    • Pilkington M.F., Sims S.M., and Dixon S.J. Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in vitro. J Bone Miner Res 13 (1998) 688-694
    • (1998) J Bone Miner Res , vol.13 , pp. 688-694
    • Pilkington, M.F.1    Sims, S.M.2    Dixon, S.J.3
  • 31
    • 21044447888 scopus 로고    scopus 로고
    • Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study
    • Reginster J.Y., Seeman E., De Vernejoul M.C., Adami S., Compston J., Phenekos C., et al. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90 (2005) 2816-2822
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2816-2822
    • Reginster, J.Y.1    Seeman, E.2    De Vernejoul, M.C.3    Adami, S.4    Compston, J.5    Phenekos, C.6
  • 33
  • 34
    • 0031930170 scopus 로고    scopus 로고
    • The migration of purified osteoclasts through collagen is inhibited by matrix metalloproteinase inhibitors
    • Sato T., Foged N.T., and Delaisse J.M. The migration of purified osteoclasts through collagen is inhibited by matrix metalloproteinase inhibitors. J Bone Miner Res 13 (1998) 59-66
    • (1998) J Bone Miner Res , vol.13 , pp. 59-66
    • Sato, T.1    Foged, N.T.2    Delaisse, J.M.3
  • 35
    • 0033997495 scopus 로고    scopus 로고
    • Use of glass slides coated with apatite-collagen complexes for measurement of osteoclastic resorption activity
    • Shibutani T., Iwanaga H., Imai K., Kitago M., Doi Y., and Iwayama Y. Use of glass slides coated with apatite-collagen complexes for measurement of osteoclastic resorption activity. J Biomed Mater Res 50 (2000) 153-159
    • (2000) J Biomed Mater Res , vol.50 , pp. 153-159
    • Shibutani, T.1    Iwanaga, H.2    Imai, K.3    Kitago, M.4    Doi, Y.5    Iwayama, Y.6
  • 36
    • 0023882543 scopus 로고
    • Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts
    • Silver I.A., Murrills R.J., and Etherington D.J. Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res 175 (1988) 266-276
    • (1988) Exp Cell Res , vol.175 , pp. 266-276
    • Silver, I.A.1    Murrills, R.J.2    Etherington, D.J.3
  • 37
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    • Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Luthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89 (1997) 309-319
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3    Kelley, M.4    Chang, M.S.5    Luthy, R.6
  • 38
    • 0142122898 scopus 로고    scopus 로고
    • S 12911-2 inhibits osteoclastic bone resorption in vitro
    • Takahashi N., Sasaki T., Tsouderos Y., and Suda T. S 12911-2 inhibits osteoclastic bone resorption in vitro. J Bone Miner Res 18 (2003) 1082-1087
    • (2003) J Bone Miner Res , vol.18 , pp. 1082-1087
    • Takahashi, N.1    Sasaki, T.2    Tsouderos, Y.3    Suda, T.4
  • 39
    • 0030989969 scopus 로고    scopus 로고
    • Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
    • Tsuda E., Goto M., Mochizuki S., Yano K., Kobayashi F., Morinaga T., et al. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 234 (1997) 137-142
    • (1997) Biochem Biophys Res Commun , vol.234 , pp. 137-142
    • Tsuda, E.1    Goto, M.2    Mochizuki, S.3    Yano, K.4    Kobayashi, F.5    Morinaga, T.6
  • 42
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Mochizuki S., et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A 95 (1998) 3597-3602
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3597-3602
    • Yasuda, H.1    Shima, N.2    Nakagawa, N.3    Yamaguchi, K.4    Kinosaki, M.5    Mochizuki, S.6
  • 43
    • 33847162089 scopus 로고    scopus 로고
    • Induction of a program gene expression during osteoblast differentiation with strontium ranelate
    • Zhu L.L., Zaidi S., Peng Y., Zhou H., Moonga B.S., Blesius A., et al. Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Biochem Biophys Res Commun 355 (2007) 307-311
    • (2007) Biochem Biophys Res Commun , vol.355 , pp. 307-311
    • Zhu, L.L.1    Zaidi, S.2    Peng, Y.3    Zhou, H.4    Moonga, B.S.5    Blesius, A.6


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