Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

Journal of Bone and Mineral Research

Volumn 21, Issue 6, 2006, Pages 934-945

  Morvan, Frederic ^a   Boulukos, Kim ^b   Clément Lacroix, Philippe ^c   Roman, Sergio Roman ^c   Suc Royer, Isabelle ^c   Vayssière, Béatrice ^c   Ammann, Patrick ^d   Martin, Patrick ^b   Pinho, Sonia ^e   Pognonec, Philippe ^b   Mollat, Patrick ^c   Niehrs, Christof ^e   Baron, Roland ^a,c   Rawadi, Georges ^c,f  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CNRS   (France)

^c Prostrakan Pharmaceuticals   (France)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^e GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^f Prostrakan Pharmaceuticals   (France)

Author keywords

Dickkopf; LRP5; Osteoblast; Osteoporosis; Wnt

Indexed keywords

ALKALINE PHOSPHATASE; DICKKOPF PROTEIN; KREMEN PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; PROTEIN; RECOMBINANT DKK1 PROTEIN; RECOMBINANT PROTEIN; REGULATOR PROTEIN; RETROVIRUS VECTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ADIPOCYTE; ADIPOGENESIS; AGED; ANIMAL CELL; ARTICLE; BIOSYNTHESIS; BONE MASS; BONE METABOLISM; BONE REMODELING; CALVARIA; CELL DENSITY; CELL DIFFERENTIATION; CELL STRAIN; CELL STRAIN MC3T3 E1 CELL; CONTROLLED STUDY; DKK1 GENE; EMBRYO MORTALITY; GENE; GENE DELETION; GENE DOSAGE; GENE EXPRESSION; HETEROZYGOSITY; HOMOZYGOUS DELETION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; MINERAL APPOSITION; MINERALIZATION; NEWBORN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; PHENOTYPE; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ADIPOGENESIS; ALLELES; ANIMALS; BONE DENSITY; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; DOWN-REGULATION; GENE DELETION; HEDGEHOG PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; OSTEOBLASTS; OSTEOGENESIS; RATS; RECOMBINANT PROTEINS; SKULL; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 33646856033     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.060311     Document Type: Article

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