Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures

Bone

Volumn 18, Issue 1, 1996, Pages 9-14

  Nishikawa, M ^a   Akatsu, T ^a   Katayama, Y ^a   Yasutomo, Y ^a   Kado, S ^a   Kugai, N ^a   Yamamoto, M ^a   Nagata, Naokazu ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Bisphosphonates; Bone resorption; Marrow cultures; Osteoblasts; Osteoclasts; Spleen cells

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CALCITRIOL; INCADRONIC ACID; METHYLCELLULOSE; PAMIDRONIC ACID;

ANIMAL CELL; ARTICLE; BONE MARROW CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; DRUG MECHANISM; FEMALE; MALE; MOUSE; MULTINUCLEAR CELL; NEWBORN; NONHUMAN; OSTEOBLAST; OSTEOCLAST; SPLEEN CELL;

EID: 0030028473     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/8756-3282(95)00426-2     Document Type: Article

References (29)

1. Boonekamp, P. M., van der Wee-Pals, L. J. A., van Wijk-van Lennep, M. M. L., Thesing, C. W., and Bijvoet, O. L. M. Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix. Bone Miner 1:27-39; 1986.
2. Burstone, M. S. Histochemical demonstration of acid phosphatase with naphthol AS-phosphate. J Natl Cancer Inst 21:523-539; 1958.
3. Cecchini, M. G., Felix, R., Fleisch, H., and Cooper, P. H. Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages. J Bone Miner Res 2:135-142; 1987.
4. Cecchini, M. G. and Fleisch, H. Bisphosphonates in vitro specifically inhibit, among the hematopoietic series, the development of the mouse mononuclear phagocyte lineage. J Bone Miner Res 5:1019-1027; 1990.
5. Chambers, T. J. Diphosphonates inhibit bone resorption by macrophages in vitro. J Pathol 132:255-262; 1980.
6. Chappard, D., Alexandre, C., Palle, S., Vico, L., Morukov, B. V., Rodinova, S. S., Minaire, P., and Riffat, G. Effects of a bisphosphonate (1-hydroxy ethylene-1,1-bisphosphonic acid) on osteoclast number during prolonged bed rest in healthy humans. Metabolism 38:822-825; 1989.
7. Evans, C. E. and Braidman, I. P. Effects of two novel bisphosphonates on bone cells in vitro. Bone Miner 26:95-107; 1994.
8. 2MBP-coated bone. Bone Miner 6:33-43; 1989.
9. Flanagan, A. M. and Chambers, T. J. Inhibition of bone resorption by bisphosphonates: Interactions between bisphosphonates, osteoclasts, and bone. Calcif Tissue Int 49:407-415; 1991.
10. Fleisch, H. Bisphosphonates: Mechanisms of action and clinical applications. Bone Miner Res 1:319-357; 1983.
11. Fleisch, H. Bisphosphonates: Pharmacology and use in the treatment of tumor-induced hypercalcemia and metastatic bone disease. Drugs 42:919-944; 1991.
12. Fukumoto, S., Matsumoto, T., Takabe, K., Onaya, T., Eto, S., Nawata, H., and Ogata, E. Treatment of malignancy-associated hypercalcemia with YM175, a new bisphosphonate: Elevated threshold for parathyroid hormone secretion in hypercalcemic patients. J Clin Endocrinol Metab 79:165-170; 1994.
13. Green, J. R., Muller, K., and Jaeggi, K. A. Preclinical pharmacology of CGP42′446, a new, potent, heterocyclic bisphosphonate compound. J Bone Miner Res 9:745-751; 1994.
14. Hughes, D. E., MacDonald, B. R., Russel, R. G. G., and Gowen, M. Inhibition of osteoclast-like cell formation by bisphosphonates in long-term culture of human bone marrow. J Clin Invest 83:1930-1935; 1989.
15. Kurihara, N., Suda, T., Miura, Y., Nakauchi, H., Kodama, H., Hiura, K., Hakeda, Y., and Kumegawa, M. Generation of osteoclasts from isolated hematopoietic progenitor cells. Blood 74:1295-1302; 1989.
16. Marshall, M. J., Holt, I., and Davie, M. W. J. Osteoclast recruitment in mice is stimulated by (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate. Calcif Tissue Int 52:21-25; 1993.
17. Muchlbauer, R. C., Bauss, F., Schenk, R., Janner, M., Bosies, E., Strein, K., and Fleisch, H. BM 21.0955, a potent new bisphosphonate to inhibit bone resorption. J Bone Miner Res 9:1003-1011; 1991.
18. Murakami, H., Takahashi, N., Udagawa, N., Tanaka, S., Nakamura, I., Zhang, D., and Suda, T. Tildronate affects polarized osteoclasts but not unpolarized ones [abstract]. Bone Miner 25:S67; 1994.
19. Ohya, K., Yamada, S., Felix, R., and Fleisch, H. Effect of bisphosphonates on prostaglandin synthesis by rat bone cells and mouse calvaria in culture. Clin Sci 69:403-411; 1985.
20. Passeri, G., Girasole, G., Giuliani, N., Pedrazzoni, M., Ulietti, V., and Passeri, M. The effect of bisphosphonates on the secretion of IL-6 by the MG-63 osteoblastic cell line and the formation of CFU-F and CFU-OB in murine bone marrow [abstract]. Bone 16(suppl.):169S; 1995.
21. Sahni, M., Guenther, H. L., Fleisch, H., Collin, P., and Martin, T. J. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. J Clin Invest 91:2004-2011; 1993.
22. Sato, M. and Grasser, W. Effects of bisphosphonate on isolated osteoclasts as examined by reflected light microscopy. J Bone Miner Res 5:31-40; 1990.
23. Sato, M., Grasser, W., Endo, N., Akins, R., Simmons, H., Thompson, D. D., Golub, E., and Rodan, G. A. Bisphosphonate action: Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88:2095-2105; 1991.
24. 3-induced increase of osteocalcin in plasma of rats in vivo and in culture medium. Calcif Tissue Int 42:248-254; 1988.
25. Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J. M., Martin, T. J., and Suda, T. Osteoblastic cells are involved in osteoclast formation. Endocrinology 123:2600-2602; 1988.
26. Takahashi, N., Udagawa, N., Akatsu, T., Tanaka, H., Shionome, M., and Suda, T. Role of colony-stimulating factors in osteoclast development. J Bone Miner Res 6:977-985; 1991.
27. Takahashi, N., Yamana, H., Yoshiki, S., Roodman, G. D., Mundy, G. R., Jones, S. J., Boyde, A., and Suda, T. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse marrow cultures. Endocrinology 122:1373-1382; 1988.
28. Taube, T., Elomaa, I., Blonqvist, C., Beneton, M. N. C., and Kanis, J. A. Histomorphometric evidence for osteoclast-mediated bone resorption in metastatic breast cancer. Bone 15:161-166; 1994.
29. Vitte, C., Fleisch, H., and Guenther, H. L. Osteoblasts mediate the bisphosphonate inhibition of bone resorption through synthesis of an osteoclast-inhibiting activity [abstract]. J Bone Miner Res 9(suppl. 1):S142; 1994.