Strontium ranelate: New insights into its dual mode of action

Bone

Volumn 40, Issue 5 SUPPL., 2007, Pages

  Marie, Pierre J ^a  

^a INSERM   (France)

Author keywords

Calcium sensing receptor; Osteoblast; Osteoclast; Prostaglandin E2; Receptor activator of nuclear factor kappa B ligand osteoprotegerin; Strontium ranelate

Indexed keywords

CALCIUM SENSING RECEPTOR; COLONY STIMULATING FACTOR 1; CYCLOOXYGENASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PLACEBO; PROSTAGLANDIN E2; STRONTIUM RANELATE;

ARTICLE; BONE DEVELOPMENT; BONE MASS; BONE METABOLISM; BONE STRENGTH; CALCIUM SIGNALING; CLINICAL TRIAL; CORTICAL BONE; DRUG EFFICACY; DRUG MECHANISM; HUMAN; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; POSTMENOPAUSE OSTEOPOROSIS; PROSTAGLANDIN SYNTHESIS; SIGNAL TRANSDUCTION; TRABECULAR BONE;

EID: 34147177628     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.02.003     Document Type: Article

References (38)

1. Khosla S., and Riggs B.L. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol. Metab. Clin. N. Am. 34 (2005) 1015-1030
2. Rodan G.A., and Martin T.J. Therapeutic approaches to bone diseases. Science 289 (2000) 1508-1514
3. Riggs B.L., and Parfitt A.M. Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling. J. Bone Miner. Res. 20 (2005) 177-184
4. Marie P.J., Ammann P., Boivin G., and Rey C. Mechanisms of action and therapeutic potential of strontium in bone. Calcif. Tissue Int. 69 (2001) 121-129
5. Marie P.J., Garba M.T., Hott M., and Miravet L. Effect of low doses of stable strontium on bone metabolism in rats. Miner. Electrolyte Metab. 11 (1985) 5-13
6. Marie P.J., and Hott M. Short-term effects of fluoride and strontium on bone formation and resorption in the mouse. Metabolism 35 (1986) 547-551
7. Grynpas M.D., and Marie P.J. Effects of low doses of strontium on bone quality and quantity in rats. Bone 11 (1990) 313-319
8. Grynpas M.D., Hamilton E., Cheung R., Tsouderos Y., Deloffre P., Hott M., et al. Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 18 (1996) 253-259
9. Canalis E., Hott M., Deloffre P., Tsouderos Y., and Marie P.J. The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone 18 (1996) 517-523
10. Barbara A., Delannoy P., Denis B.G., and Marie P.J. Normal matrix mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells. Metabolism 53 (2004) 532-537
11. Bonnelye E., Lalande A., and Judric P. Strontium ranelate stimulates murine osteoblast differentiation while decreasing their osteoclastogenic abilities. J. Bone Miner. Res. 21 Suppl. 1 (2006) S426
12. Baron R., and Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur. J. Pharmacol. 450 (2002) 11-17
13. Takahashi S. 12911-2 inhibits osteoclastic bone resorption in vitro. J. Bone Miner. Res. 18 (2003) 1082-1087
14. Mentaverri R., Chattopadhyay N., Lemaire-Hurtel A.S., Kamel S., Brazier M., and Brown E.M. The effects of strontium ranelate on osteoclasts are calcium-sensing receptor dependent. J. Bone Miner. Res. 20 (2005) S309 [Suppl.]
15. Marie P.J. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr. Opin. Rheumatol. 18 Suppl. 1 (2006) S11-S15
16. Delannoy P., Bazot D., and Marie P.J. Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice. Metabolism 51 (2002) 906-911
17. Ammann P., Shen V., Robin B., Mauras Y., Bonjour J.P., and Rizzoli R. Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. J. Bone Miner. Res. 19 (2004) 2012-2020
18. Buehler J., Chappuis P., Saffar J.L., Foos E., and Vignery A. Strontium ranelate inhibits bone resorption whilst maintaining bone formation in alveolar bone in monkeys. Bone 29 (2001) 176-179
19. Marie P.J., Hott M., Modrowski D., de Pollak C., Guillemain J., Deloffre P., et al. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J. Bone Miner. Res. 8 (1993) 607-615
20. Ammann P., Badoud I., Shen V., Bain S., Dupin-Roger I., and Rizzoli R. Strontium ranelate prevents alteration of bone strength in OVX rats by improving intrinsic bone tissue quality. Calcif. Tissue Int. 78 Suppl 1 (2006) S126
21. Hott M., Deloffre P., Tsouderos Y., and Marie P.J. S12911-2 reduces bone loss induced by short-term immobilization in rats. Bone 33 (2003) 115-123
22. Geoffroy V., Marty C., Lalande A., and De Vernejoul M.C. Strontium ranelate reduces new vertebral fractures in a severe osteoporotic mice model with spontaneous fractures by improving bone microarchitecture. Calcif. Tissue Int. 78 Suppl. 1 (2006) S38
23. Meunier P.J., Roux C., Seeman E., Ortolani S., Badurski J.E., Spector T.D., et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N. Engl. J. Med. 350 (2004) 459-468
24. Reginster J.Y., Seeman E., De Vernejoul M.C., Adami S., Compston J., Phenekos C., et al. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of peripheral osteoporosis (TROPOS) study. J. Clin. Endocrinol. Metab. 90 (2005) 2816-2822
25. Arlot M.E., Delmas P., Burt-Pichat B., Roux J.P., Portero N., and Meunier P.J. The effects of strontium ranelate on bone remodeling and bone safety assessed by histomorphometry in patients with postmenopausal osteoporosis. J. Bone Miner. Res. 20 Suppl. 1 (2005) S22
26. Jiang Y., Genant H., and Zhao J. Effect of strontium ranelate on 3D cortical and trabecular microstructure in postmenopausal osteoporis in multicenter, double-blind, and placebo controlled studies. J. Bone Miner. Res. 21 Suppl. 1 (2006) S1160
27. Brown E.M. Is the calcium receptor a molecular target for the actions of strontium on bone?. Osteoporos. Int. 14 Suppl. 3 (2003) S25-S34
28. Coulombe J., Faure H., Robin B., and Ruat M. In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor. Biochem. Biophys. Res. Commun. 323 (2004) 1184-1190
29. Fromigué O., Barbara A., Hay E., Petrel C., Traiffort E., Ruat M., et al. Strontium ranelate stimulates murine osteoblast replication independently of calcium sensing receptor-mediated ERK1/2 activation. Calcif. Tissue Res. 78 Suppl. 1 (2006) 417
30. Pi M., and Quarles L.D. A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium. J. Bone Miner. Res. 19 (2004) 862-869
31. Choudhary S., Wadhwa S., Raisz L.G., Alander C., and Pilbeam C.C. Extracellular calcium is a potent inducer of cyclo-oxygenase-2 in murine osteoblasts through an ERK signaling pathway. J. Bone Miner. Res. 18 (2003) 1813-1824
32. Choudhary S., Halbout P., Alander C., Raisz L.G., and Pilbeam C.C. Strontium ranelate effects on osteoblastic differentiation: involvement of prostaglandins. J. Bone Miner. Res. 21 Suppl. 1 (2006) S301
33. Suda T., Takahashi N., Udagawa N., Jimi E., Gillespie M.T., and Martin T.J. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20 (1999) 345-357
34. Hofbauer L.C., and Heufelder A.E. Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology. J. Mol. Med. 79 (2001) 243-253
35. Kostenuik P.J., and Shaloub V. Osteoprotegerin: a physiological and pharmacological inhibitor of bone resorption. Curr. Pharm. Des. 7 (2001) 613-635
36. Eghbali-Fatourechi G., Khosla S., Sanyal A., Boyle W.J., Lacey D.L., and Riggs B.L. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J. Clin. Invest. 111 (2003) 1221-1230
37. Hofbauer L.C., and Schoppet M. Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA 292 (2004) 490-495
38. Brennan T., Rybchyn M.S., Conigrave A.D., and Mason R.S. Strontium ranelate effect on proliferation and OPG expression in osteoblasts. Calcif. Tissue Int. 78 Suppl. 1 (2006) 129