Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 732, Issue 1, 1999, Pages 203-212

  Tucker, Christopher E ^a   Chen, Long Shiuh ^b   Judkins, Mark B ^c   Farmer, James A ^c   Gill, Stanley C ^a   Drolet, Daniel W ^a  

^a GILEAD SCIENCES   (United States)

^b Medinox Inc   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

Aptamer; NX1838

Indexed keywords

APTAMER; OLIGONUCLEOTIDE; OLIGONUCLEOTIDE LIGAND; PEGAPTANIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SYNTHESIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PLASMA; PRIORITY JOURNAL; RHESUS MONKEY; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ENDOTHELIAL GROWTH FACTORS; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; LYMPHOKINES; MACACA MULATTA; OLIGONUCLEOTIDES; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032876515     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(99)00285-6     Document Type: Article

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