Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression

Chinese Medical Journal

Volumn 124, Issue 21, 2011, Pages 3546-3550

  Zhang, Xin ^a   Zhang, Ning ^a   Zhang, Mei Xin ^b  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Provincial Family Planning Institute of Science and Technology   (China)

Author keywords

Astrocyte elevated gene 1; Breast cancer; HER2 neu; Invasion

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ARG 1 GENE; ARTICLE; BREAST CARCINOGENESIS; CANCER CELL; CANCER GROWTH; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; ONCOGENE; PROTEIN EXPRESSION; UPREGULATION;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; NEOPLASM INVASIVENESS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

EID: 82255161958     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.21.020     Document Type: Article

References (33)

1. Igene H. Global health inequalities and breast cancer: an impending public health problem for developing countries. Breast J 2008; 14: 428-434.
2. Croce CM. Oncogenes and cancer. N Engl J Med 2008; 358: 502-511.
3. Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ, et al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 2002; 21: 3592-3602.
4. Brown DM, Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004; 5: 365-374.
5. Britt DE, Yang DF, Yang DQ, Flanagan D, Callanan H, Lim YP, et al. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp Cell Res 2004; 300: 134-148.
6. Sutherland HG, Lam YW, Briers S, Lamond AI, Bickmore WA. 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res 2004; 294: 94-105.
7. Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ, Fisher PB. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 2005; 353: 8-15.
8. Liu L, Wu J, Ying Z, Chen B, Han A, Liang Y, et al. Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Res 2010; 70: 3750-3759.
9. Lee SG, Su ZZ, Emdad L, Sarkar D, Fisher PB. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci U S A 2006; 103: 17390-17395.
10. Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y, et al. Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 2007; 26: 7647-7655.
11. Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF, Fisher PB. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 2008; 27: 1114-1121.
12. Emdad L, Sarkar D, Su ZZ, Lee SG, Kang DC, Bruce JN, et al. Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacol Ther 2007; 114: 155-170.
13. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 2008; 68: 1478-1484.
14. Yoo BK, Emdad L, Su ZZ, Villanueva A, Chiang DY, Mukhopadhyay ND, et al. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 2009; 119: 465-477.
15. Liu X, Zhang N, Li X, Moran MS, Yuan C, Yan S, et al. Identification of novel variants of metadherin in breast cancer. PLoS One 2011; 6: e17582.
16. Li X, Kong X, Huo Q, Guo H, Yan S, Yuan C, et al. Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Sci 2011; 102: 1151-1157.
17. Su P, Zhang Q, Yang Q. Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue. Diagn Pathol 2010; 5: 38.
18. Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, et al. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009; 15: 9-20.
19. Li J, Yang L, Song L, Xiong H, Wang L, Yan X, et al. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 2009; 28: 3188-3196.
20. Nizamutdinova IT, Lee GW, Son KH, Jeon SJ, Kang SS, Kim YS, et al. Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells. Int J Oncol 2008; 33: 485-491.
21. Sarkar D, Emdad L, Lee SG, Yoo BK, Su ZZ, Fisher PB. Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes. Cancer Res 2009; 69: 8529-8535.
22. Eccles SA. The Role of c-erbB-2/HER2/neu in Breast Cancer Progression and Metastasis. J Mammary Gland Biol Neoplasia 2001; 6: 393-406.
23. Ménard S, Tagliabue E, Campiglio M, Pupa SM. Role of HER2 gene overexpression in breast carcinoma. J Cell Physiol 2000; 182: 150-162.
24. Moasser MM. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 2007; 26: 6469-6487.
25. Ménard S, Pupa SM, Campiglio M, Tagliabue E. Biologic and therapeutic role of HER2 in cancer. Oncogene 2003; 22: 6570-6578.
26. Wang HQ, Qian ZZ, Liu XM, Zhang HL, Li LF, Qiu LH, et al. Capecitabine combined with weekly docetaxel in Chinese patients > 65 years with anthracycline-resistant metastatic breast cancer. Chin Med J 2010; 123: 3212-3216.
27. Yuan Z, Qu X, Zhang ZT, Wang Y. Neoadjuvant chemotherapy in patients with stages II and III breast cancer. Chin Med J 2009; 122: 2993-2997.
28. Li ZS, Yao L, Liu YQ, Ouyang T, Li JF. Breast cancer subtypes and survival in Chinese women with operable primary breast cancer. Chin J Cancer Res (Chin) 2011; 23; 134-139.
29. Albanell J, Codony J, Rovira A, Mellado B, Gascon P. Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4. Adv Exp Med Biol 2003; 532: 253-268.
30. Bange J, Zwick E, Ullrich A. Molecular targets for breast cancer therapy and prevention. Nat Med 2001; 7: 548-552.
31. Hu G, Wei Y, Kang Y. The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res 2009; 15: 5615-5620.
32. Li C, Li R, Song H, Wang D, Feng T, Yu X, et al. Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer. J Surg Oncol 2011; 103: 184-192.
33. Emdad L, Lee SG, Su ZZ, Jeon HY, Boukerche H, Sarkar D, et al. Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci U S A 2009; 106: 21300-21305.