The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) in breast cancer

Journal of Biological Chemistry

Volumn 288, Issue 13, 2013, Pages 9396-9407

  Zhang, Ning ^a   Wang, Xiaolong ^a   Huo, Qiang ^a   Li, Xiaoyan ^a   Wang, Huiyun ^b   Schneider, Pascal ^c   Hu, Guohong ^d   Yang, Qifeng ^a  

^a SHANDONG UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AKT PHOSPHORYLATION; APOPTOTIC PATHWAYS; BREAST CANCER CELLS; DEATH-INDUCING SIGNALING COMPLEXES; MCF-7 BREAST CANCER CELLS; PROTECTIVE FUNCTION; TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGANDS; TUMOR NECROSIS FACTORS;

CELL CULTURE; DISEASES; GLYCOPROTEINS; KETONES; LIGANDS; MACROPHAGES;

CELL DEATH;

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; DEATH RECEPTOR; MICRORNA 16; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; PROTEIN BCL 2; PROTEIN KINASE B; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; METADHERIN GENE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; UPREGULATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CASPASE 8; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEMBRANE PROTEINS; MICE; MICE, NUDE; MICRORNAS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875980153     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.395913     Document Type: Article

References (44)

1. Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C. P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673-682
2. Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., and Ashkenazi, A. (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271, 12687-12690
3. Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., DeForge, L., Koumenis, I. L., Lewis, D., Harris, L., Bussiere, J., Koeppen, H., Shahrokh, Z., and Schwall, R. H. (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155-162
4. Walczak, H., Miller, R. E., Ariail, K., Gliniak, B., Griffith, T. S., Kubin, M., Chin, W., Jones, J., Woodward, A., Le, T., Smith, C., Smolak, P., Goodwin, R. G., Rauch, C. T., Schuh, J. C., and Lynch, D. H. (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat. Med. 5, 157-163
5. Newsom-Davis, T., Prieske, S., and Walczak, H. (2009) Is TRAIL the holy grail of cancer therapy? Apoptosis 14, 607-623
6. Mahalingam, D., Szegezdi, E., Keane, M., de Jong, S., and Samali, A. (2009) TRAIL receptor signalling and modulation: Are we on the right TRAIL? Cancer Treat. Rev. 35, 280-288
7. Zhang, L., and Fang, B. (2005) Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther. 12, 228-237
8. Pallares, J., Llobet, D., Santacana, M., Eritja, N., Velasco, A., Cuevas, D., Lopez, S., Palomar-Asenjo, V., Yeramian, A., Dolcet, X., and Matias-Guiu, X. (2009) CK2β is expressed in endometrial carcinoma and has a role in apoptosis resistance and cell proliferation. Am. J. Pathol. 174, 287-296
9. Kim, E. H., Kim, S. U., Shin, D. Y., and Choi, K. S. (2004) Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP. Oncogene 23, 446-456
10. Rahman, M., Davis, S. R., Pumphrey, J. G., Bao, J., Nau, M. M., Meltzer, P. S., and Lipkowitz, S. (2009) TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype. Breast Cancer Res. Treat. 113, 217-230
11. Li, J., Zhang, N., Song, L. B., Liao, W. T., Jiang, L. L., Gong, L. Y., Wu, J., Yuan, J., Zhang, H. Z., Zeng, M. S., and Li, M. (2008) Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin. Cancer Res. 14, 3319-3326
12. Li, C., Li, R., Song, H., Wang, D., Feng, T., Yu, X., Zhao, Y., Liu, J., Yu, X., Wang, Y., and Geng, J. (2011) Significance of AEG-1 expression in correlation with VEGF, microvessel density, and clinicopathological characteristics in triple-negative breast cancer. J. Surg. Oncol. 103, 184-192
13. Kikuno, N., Shiina, H., Urakami, S., Kawamoto, K., Hirata, H., Tanaka, Y., Place, R. F., Pookot, D., Majid, S., Igawa, M., and Dahiya, R. (2007) Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 26, 7647-7655
14. Lee, S. G., Jeon, H. Y., Su, Z. Z., Richards, J. E., Vozhilla, N., Sarkar, D., Van Maerken, T., and Fisher, P. B. (2009) Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 28, 2476-2484
15. Yoo, B. K., Emdad, L., Su, Z. Z., Villanueva, A., Chiang, D. Y., Mukhopadhyay, N. D., Mills, A. S., Waxman, S., Fisher, R. A., Llovet, J. M., Fisher, P. B., and Sarkar, D. (2009) Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J. Clin. Invest. 119, 465-477
16. Liu, X., Zhang, N., Li, X., Moran, M. S., Yuan, C., Yan, S., Jiang, L., Ma, T., Haffty, B. G., and Yang, Q. (2011) Identification of novel variants of metadherin in breast cancer. PLoS One 6, e17582
17. Li, X., Kong, X., Huo, Q., Guo, H., Yan, S., Yuan, C., Moran, M. S., Shao, C., and Yang, Q. (2011) Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Sci. 102, 1151-1157
18. Li, J., Yang, L., Song, L., Xiong, H., Wang, L., Yan, X., Yuan, J., Wu, J., and Li, M. (2009) Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 28, 3188-3196
19. Hu, G., Wei, Y., and Kang, Y. (2009) The multifaceted role of MTDH/ AEG-1 in cancer progression. Clin. Cancer Res. 15, 5615-5620
20. Yoo, B. K., Gredler, R., Vozhilla, N., Su, Z. Z., Chen, D., Forcier, T., Shah, K., Saxena, U., Hansen, U., Fisher, P. B., and Sarkar, D. (2009) Identification of genes conferring resistance to 5-fluorouracil. Proc. Natl. Acad. Sci. U.S.A. 106, 12938-12943
21. Wei, Y., Hu, G., and Kang, Y. (2009) Metadherin as a link between metastasis and chemoresistance. Cell Cycle 8, 2132-2133
22. Hu, G., Chong, R. A., Yang, Q., Wei, Y., Blanco, M. A., Li, F., Reiss, M., Au, J. L., Haffty, B. G., and Kang, Y. (2009)MTDHactivation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 15, 9-20
23. Bossen, C., Tardivel, A., Willen, L., Fletcher, C. A., Perroud, M., Beermann, F., Rolink, A. G., Scott, M. L., Mackay, F., and Schneider, P. (2011) Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses. Eur. J. Immunol. 41, 787-797
24. Kim, S. H., Kim, K., Kwagh, J. G., Dicker, D. T., Herlyn, M., Rustgi, A. K., Chen, Y., and El-Deiry, W. S. (2004) Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells. J. Biol. Chem. 279, 40044-40052
25. Schneider, P. (2000) Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins. Methods Enzymol. 322, 325-345
26. Yang, Q. F., Sakurai, T., Yoshimura, G., Shan, L., Suzuma, T., Tamaki, T., Umemura, T., Kokawa, Y., Nakamura, Y., Nakamura, M., Tang, W., Utsunomiya, H., Mori, I., and Kakudo, K. (2000) Expression of Bcl-2 but not Bax or p53 correlates with in vitro resistance to a series of anticancer drugs in breast carcinoma. Breast Cancer Res. Treat. 61, 211-216
27. Chen, C., Zhou, Z., Liu, R., Li, Y., Azmi, P. B., and Seth, A. K. (2008) The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. Oncogene 27, 6845-6855
28. Shankar, S., Davis, R., Singh, K. P., Kurzrock, R., Ross, D. D., and Srivastava, R. K. (2009) Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice. Mol. Cancer Ther. 8, 1596-1605
29. Lu, M., Strohecker, A., Chen, F., Kwan, T., Bosman, J., Jordan, V. C., and Cryns, V. L. (2008) Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels. Clin. Cancer Res. 14, 3168-3176
30. Zhou, Z., Liu, R., and Chen, C.(2012) The WWP1 ubiquitin E3 ligase increases TRAIL resistance in breast cancer. Int. J. Cancer 130, 1504-1510
31. Walczak, H., and Haas, T. L. (2008) Biochemical analysis of the native TRAIL death-inducing signaling complex. Methods Mol. Biol. 414, 221-239
32. Wang, H., Ach, R. A., and Curry, B. (2007) Direct and sensitive miRNA profiling from low-input total RNA. RNA 13, 151-159
33. Wang, H. Y., Luo, M., Tereshchenko, I. V., Frikker, D. M., Cui, X., Li, J. Y., Hu, G., Chu, Y., Azaro, M. A., Lin, Y., Shen, L., Yang, Q., Kambouris, M. E., Gao, R., Shih, W., and Li, H. (2005) A genotyping system capable of simultaneously analyzing >1000 single nucleotide polymorphisms in a haploid genome. Genome Res. 15, 276-283
34. Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., Gottlieb, E., Green, D. R., Hengartner, M. O., Kepp, O., Knight, R. A., Kumar, S., Lipton, S. A., Lu, X., Madeo, F., Malorni, W., Mehlen, P., Nuñez, G., Peter, M. E., Piacentini, M., Rubinsztein, D. C., Shi, Y., Simon, H. U., Vandenabeele, P., White, E., Yuan, J., Zhivotovsky, B., Melino, G., and Kroemer, G. (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 19, 107-120
35. Wu, G. S. (2009) TRAIL as a target in anti-cancer therapy. Cancer Lett. 285, 1-5
36. Maksimovic-Ivanic, D., Stosic-Grujicic, S., Nicoletti, F., and Mijatovic, S. (2012) Resistance to TRAIL and how to surmount it. Immunol. Res. 52, 157-168
37. Yoon, M. J., Park, S. S., Kang, Y. J., Kim, I. Y., Lee, J. A., Lee, J. S., Kim, E. G., Lee, C. W., and Choi, K. S. (2012) Aurora B confers cancer cell resistance to TRAIL-induced apoptosis via phosphorylation of survivin. Carcinogenesis 33, 492-500
38. Keane, M. M., Ettenberg, S. A., Nau, M. M., Russell, E. K., and Lipkowitz, S. (1999) Chemotherapy augments TRAIL-induced apoptosis in breast cell lines. Cancer Res. 59, 734-741
39. Lee, S. G., Su, Z. Z., Emdad, L., Sarkar, D., Franke, T. F., and Fisher, P. B. (2008) Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27, 1114-1121
40. Xu, J., Zhou, J.-Y., Wei, W.-Z., and Wu, G. S. (2010) Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells. PLoS One 5, e10226
41. Fulda, S., Meyer, E., and Debatin, K.-M. (2002) Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. Oncogene 21, 2283-2294
42. Bartel, D. P. (2009) MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233
43. Mehta, K., Devarajan, E., Chen, J., Multani, A., and Pathak, S. (2002) Multidrug- resistant MCF-7 cells: an identity crisis? J. Natl. Cancer Inst. 94, 1652-1654; author reply 1654
44. Seol, D. W., Li, J., Seol, M. H., Park, S. Y., Talanian, R. V., and Billiar, T. R. (2001) Signaling events triggered by tumor necrosis factor-related apoptosis- inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis. Cancer Res. 61, 1138-1143